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Disease on EC 2.3.2.12 - peptidyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Gram-Negative Bacterial Infections
Septal Class A Penicillin-Binding Protein Activity and ld-Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii.
Hepatitis
RNA catalysis.
Hepatitis C
Structural and functional topography of the human ribosome.
Hypersensitivity
Hypersensitivity of Rhodobacter sphaeroides ribosomes to protein synthesis inhibitors: structural and functional implications.
Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation.
Infections
In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.
Infertility
Independent evolution of a new allele of F(1) pollen sterility gene S27 encoding mitochondrial ribosomal protein L27 in Oryza nivara.
Mitochondrial gene in the nuclear genome induces reproductive barrier in rice.
Neoplasms
Protein synthesis in tumor host. II. Increased activity of peptide elongation factor 1 in experimental rat tumors and in host liver.
peptidyltransferase deficiency
Non-Stressful Death of 23S rRNA Mutant G2061C Defective in Puromycin Reaction.
Starvation
Changes in ribosomal activity of Escherichia coli cells during prolonged culture in sea salts medium.
Tuberculosis
A Fluorescence-based Assay for Screening ?-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2.
Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of ?-Lactamase Inhibitors.
Building a Full-Atom Model of L,Dtranspeptidase 2 from Mycobacterium tuberculosis for Screening New Inhibitors.
Catalytic mechanism of L,D-transpeptidase 2 from Mycobacterium tuberculosis described by a computational approach: insights for the design of new antibiotics drugs.
Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis.
Isolation, Purification and Characterization of L,D-transpeptidase 2 from Mycobacterium tuberculosis.
Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
Molecular insight on the non-covalent interactions between carbapenems and L,D-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study.
Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.
Structural and biochemical analyses of the LdtMt2-panipenem adduct provide new insights into the effect of the 1-?-methyl group on carbapenems.
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
Targeting the cell wall of Mycobacterium tuberculosis: A molecular modelling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.
Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.
The 1-?-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem.
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin.
Typhoid Fever
Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin.