Information on EC 2.3.2.1 - D-glutamyltransferase

for references in articles please use BRENDA:EC2.3.2.1
Word Map on EC 2.3.2.1
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

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EC NUMBER
COMMENTARY hide
2.3.2.1
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RECOMMENDED NAME
GeneOntology No.
D-glutamyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glutamine + D-glutamate = NH3 + gamma-D-glutamyl-D-glutamate
show the reaction diagram
(1)
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-
-
L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = NH3 + (gamma-D-glutamyl)n+1-[peptide]
show the reaction diagram
(2)
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminoacyl group transfer
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-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-Glutamine and D-glutamate metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
glutamine:D-glutamyl-peptide 5-glutamyltransferase
The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
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CAS REGISTRY NUMBER
COMMENTARY hide
9030-02-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 9945
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glutamine + D-glutamyl-peptide
NH3 + 5-glutamyl-D-glutamyl-peptide
show the reaction diagram
-
-
-
?
L-glutamine + D-glutamic acid
NH3 + gamma-L-glutamyl-D-glutamate
show the reaction diagram
-
-
-
?
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
neonatal
Manually annotated by BRENDA team
-
neonatal
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.2.1)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)