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EC Tree
IUBMB Comments The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
+
(gamma-D-glutamyl)n-[peptide]
=
+
(gamma-D-glutamyl)n+1-[peptide]
Synonyms
D-gamma-glutamyl transpeptidase, D-glutamyl transpeptidase, gamma-GT, glutamyltransferase, D-,
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D-gamma-glutamyl transpeptidase
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-
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D-glutamyl transpeptidase
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-
-
-
glutamyltransferase, D-
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-
-
-
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D-glutamine + D-glutamate = NH3 + gamma-D-glutamyl-D-glutamate
(1)
-
-
-
L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = NH3 + (gamma-D-glutamyl)n+1-[peptide]
(2)
-
-
-
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aminoacyl group transfer
-
-
-
-
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glutamine:D-glutamyl-peptide 5-glutamyltransferase
The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
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D-glutamine + D-glutamyl-peptide
NH3 + 5-glutamyl-D-glutamyl-peptide
-
-
-
?
L-glutamine + D-glutamic acid
NH3 + gamma-L-glutamyl-D-glutamate
-
-
-
?
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ATCC 9945
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-
brenda
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-
brenda
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-
neonatal
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neonatal
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-
brenda
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-
brenda
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A0A1C2CT03_STREQ
751
1
82608
TrEMBL
-
A0A448DGE4_STREQ
751
1
82712
TrEMBL
-
A0A509DHW3_9STRE
751
1
82608
TrEMBL
-
A0A2X2Z2W1_STRDY
751
1
82608
TrEMBL
-
A0A4V0C3Z9_STRCB
751
1
82727
TrEMBL
-
A0A380JXA1_STRDY
751
1
82800
TrEMBL
-
C5WIJ2_STRDG
Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124)
751
1
82594
TrEMBL
-
A0A4V0EE92_STRDY
751
1
82647
TrEMBL
-
A0A2T7YWV7_BACTU
567
0
64145
TrEMBL
-
M4YZF8_STREQ
755
1
83349
TrEMBL
-
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Williams, W.J.; Litwin, J.; Thorne, C.B.
Further studies on the biosynthesis of gamma-glutamyl peptides by transfer reactions
J. Biol. Chem.
212
427-438
1955
Bacillus subtilis
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Lackmann, G.M.
Reference values for selected enzyme activities in serum from healthy human neonates
Clin. Biochem.
29
599-602
1996
Homo sapiens
brenda
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