Reference on EC 2.3.1.B41 - protein-long-chain fatty-acyl-lysine deacylase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhu, A.Y.; Zhou, Y.; Khan, S.; Deitsch, K.W.; Hao, Q.; Lin, H.
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine
ACS Chem. Biol.
7
155-159
2012
Plasmodium falciparum (Q8IE47), Plasmodium falciparum isolate 3D7 (Q8IE47)
Manually annotated by BRENDA team
Chen, X.; Hao, B.; Liu, Y.; Dai, D.; Han, G.; Li, Y.; Wu, X.; Zhou, X.; Yue, Z.; Wang, L.; Cao, Y.; Liu, J.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma
Biochem. Biophys. Res. Commun.
446
364-369
2014
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Liu, R.; Liu, H.; Ha, Y.; Tilton, R.G.; Zhang, W.
Oxidative stress induces endothelial cell senescence via downregulation of Sirt6
Biomed Res. Int.
2014
0000
2014
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Ming, M.; Han, W.; Zhao, B.; Sundaresan, N.R.; Deng, C.X.; Gupta, M.P.; He, Y.Y.
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer
Cancer Res.
74
5925-5933
2014
Homo sapiens, Homo sapiens (Q8N6T7), Mus musculus, Mus musculus (P59941)
Manually annotated by BRENDA team
Merrick, C.J.; Duraisingh, M.T.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity
Eukaryot. Cell
6
2081-291
2007
Plasmodium falciparum (Q8IE47), Plasmodium falciparum isolate 3D7 (Q8IE47)
Manually annotated by BRENDA team
Kokkonen, P.; Rahnasto-Rilla, M.; Mellini, P.; Jarho, E.; Lahtela-Kakkonen, M.; Kokkola, T.
Studying SIRT6 regulation using H3K56 based substrate and small molecules
Eur. J. Pharm. Sci.
0
0000
2014
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Wu, M.; Dickinson, S.I.; Wang, X.; Zhang, J.
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder
Int. J. Clin. Exp. Pathol.
7
6504-6513
2014
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Pan, P.W.; Feldman, J.L.; Devries, M.K.; Dong, A.; Edwards, A.M.; Denu, J.M.
Structure and biochemical functions of SIRT6
J. Biol. Chem.
286
14575-14587
2011
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Feldman, J.L.; Baeza, J.; Denu, J.M.
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
J. Biol. Chem.
288
31350-31356
2013
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Jedrusik-Bode, M.; Studencka, M.; Smolka, C.; Baumann, T.; Schmidt, H.; Kampf, J.; Paap, F.; Martin, S.; Tazi, J.; Müller, K.M.; Krüger, M.; Braun, T.; Bober, E.
The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
J. Cell Sci.
126
5166-5177
2013
Mus musculus (P59941)
Manually annotated by BRENDA team
Avalos, J.L.; Bever, K.M.; Wolberger, C.
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
Mol. Cell
17
855-868
2005
Archaeoglobus fulgidus (O30124)
Manually annotated by BRENDA team
Jiang, H.; Khan, S.; Wang, Y.; Charron, G.; He, B.; Sebastian, C.; Du, J.; Kim, R.; Ge, E.; Mostoslavsky, R.; Hang, H.C.; Hao, Q.; Lin, H.
SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine
Nature
496
110-113
2013
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Cardinale, A.; de Stefano, M.C.; Mollinari, C.; Racaniello, M.; Garaci, E.; Merlo, D.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response
Neurochem. Res.
40
59-69
2015
Mus musculus (P59941)
Manually annotated by BRENDA team
Gil, R.; Barth, S.; Kanfi, Y.; Cohen, H.Y.
SIRT6 exhibits nucleosome-dependent deacetylase activity
Nucleic Acids Res.
41
8537-8545
2013
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Ardestani, P.M.; Liang, F.
Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells
Nucleus
3
442-451
2012
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Fischer, F.; Gertz, M.; Suenkel, B.; Lakshminarasimhan, M.; Schutkowski, M.; Steegborn, C.
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
PLoS One
7
e45098
2012
Archaeoglobus fulgidus (O30124)
Manually annotated by BRENDA team
Silberman, D.M.; Ross, K.; Sande, P.H.; Kubota, S.; Ramaswamy, S.; Apte, R.S.; Mostoslavsky, R.
SIRT6 is required for normal retinal function
PLoS One
9
e98831
2014
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Ringel, A.E.; Roman, C.; Wolberger, C.
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2
Protein Sci.
23
1686-1697
2014
Archaeoglobus fulgidus (O30124)
Manually annotated by BRENDA team
Piao, J.; Tsuji, K.; Ochi, H.; Iwata, M.; Koga, D.; Okawa, A.; Morita, S.; Takeda, S.; Asou, Y.
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
Sci. Rep.
3
0000
2013
Mus musculus (P59941)
Manually annotated by BRENDA team
Cea, M.; Cagnetta, A.; Adamia, S.; Acharya, C.; Tai, Y.T.; Fulciniti, M.; Ohguchi, H.; Munshi, A.; Acharya, P.; Bhasin, M.K.; Zhong, L.; Carrasco, R.; Monacelli, F.; Ballestrero, A.; Richardson, P.; Gobbi, M.; Lemoli, R.M.; Munshi, N.; Hideshima, T.; Nencioni, A.; Chauhan, D.; Anderson, K.C.
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
Blood
127
1138-1150
2016
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Hwang, B.J.; Jin, J.; Gao, Y.; Shi, G.; Madabushi, A.; Yan, A.; Guan, X.; Zalzman, M.; Nakajima, S.; Lan, L.; Lu, A.L.
SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp
BMC Mol. Biol.
16
12
2015
Mus musculus, Mus musculus (P59941)
Manually annotated by BRENDA team
Feng, X.X.; Luo, J.; Liu, M.; Yan, W.; Zhou, Z.Z.; Xia, Y.J.; Tu, W.; Li, P.Y.; Feng, Z.H.; Tian, D.A.
Sirtuin 6 promotes transforming growth factor-beta1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
Cancer Sci.
106
559-566
2015
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Rahnasto-Rilla, M.; Kokkola, T.; Jarho, E.; Lahtela-Kakkonen, M.; Moaddel, R.
N-acylethanolamines bind to SIRT6
ChemBioChem
17
77-81
2016
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Zhang, J.; Yin, X.J.; Xu, C.J.; Ning, Y.X.; Chen, M.; Zhang, H.; Chen, S.F.; Yao, L.Q.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression
Eur. Rev. Med. Pharmacol. Sci.
19
818-824
2015
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Maksin-Matveev, A.; Kanfi, Y.; Hochhauser, E.; Isak, A.; Cohen, H.Y.; Shainberg, A.
Sirtuin 6 protects the heart from hypoxic damage
Exp. Cell Res.
330
81-90
2015
Mus musculus, Mus musculus (P59941)
Manually annotated by BRENDA team
Hu, S.; Liu, H.; Ha, Y.; Luo, X.; Motamedi, M.; Gupta, M.P.; Ma, J.X.; Tilton, R.G.; Zhang, W.
Posttranslational modification of Sirt6 activity by peroxynitrite
Free Radic. Biol. Med.
79
176-185
2015
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Etchegaray, J.P.; Chavez, L.; Huang, Y.; Ross, K.N.; Choi, J.; Martinez-Pastor, B.; Walsh, R.M.; Sommer, C.A.; Lienhard, M.; Gladden, A.; Kugel, S.; Silberman, D.M.; Ramaswamy, S.; Mostoslavsky, G.; Hochedlinger, K.; Goren, A.; Rao, A.; Mostoslavsky, R.
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
Nat. Cell Biol.
17
545-557
2015
Mus musculus (P59941)
Manually annotated by BRENDA team
Zhang, X.; Khan, S.; Jiang, H.; Antonyak, M.A.; Chen, X.; Spiegelman, N.A.; Shrimp, J.H.; Cerione, R.A.; Lin, H.
Identifying the functional contribution of the defatty-acylase activity of SIRT6
Nat. Chem. Biol.
12
614-620
2016
Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Tasselli, L.; Xi, Y.; Zheng, W.; Tennen, R.I.; Odrowaz, Z.; Simeoni, F.; Li, W.; Chua, K.F.
SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cellular senescence
Nat. Struct. Mol. Biol.
23
434-440
2016
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Liu, J.; Zheng, W.
Cyclic peptide-based potent human SIRT6 inhibitors
Org. Biomol. Chem.
14
5928-5935
2016
Homo sapiens, Homo sapiens (Q8N6T7)
Manually annotated by BRENDA team
Tian, K.; Liu, Z.; Wang, J.; Xu, S.; You, T.; Liu, P.
Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappaB signaling
Transl. Res.
165
374-386
2015
Rattus norvegicus (Q4FZY2)
Manually annotated by BRENDA team