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Information on EC 2.3.1.B34 - [protein]-L-lysine N-acetyltransferase and Organism(s) Bacillus subtilis and UniProt Accession P39065

for references in articles please use BRENDA:EC2.3.1.B34
preliminary BRENDA-supplied EC number
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Bacillus subtilis
UNIPROT: P39065 not found.
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The taxonomic range for the selected organisms is: Bacillus subtilis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
[an AMP-forming acyl-CoA synthase]-L-lysine
=
+
[an AMP-forming acyl-CoA synthase]-N6-acetyl-L-lysine
Synonyms
msmeg_5458, acetyltransferase pat, saacua, acetoin utilization protein, mxan_3215, micau_1670, type-iv bgnat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetoin utilization protein
UniProt
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:AMP-forming acyl-CoA synthase acetyltransferase
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + [AcsA]-L-Lys
CoA + [SaAcsA]-N6-acetyl-L-Lys
show the reaction diagram
SaAcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus, lysine residue K546 is acetylated
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-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
show the reaction diagram
ACS is Nepsilon-lysine-acetylated AcCoA synthase
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-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
show the reaction diagram
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis
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-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
show the reaction diagram
SeAcs is AMP-forming acetyl-CoA synthetase from Salmonella enterica
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-
?
additional information
?
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enzyme BsAcuA acetylates BsAcsA and also SaAcsA from Staphylococcus aureus, as well as SeAcs from Salmonella enterica
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
show the reaction diagram
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
show the reaction diagram
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
enzyme acetylation by Pat is reversed by deacetylase enzymes, including the NAD+-dependent sirtuin-like deacetylases, which allows for the rapid response and adaptation to new metabolic needs or physiological changes. The ACS gene and AcuABC operon are adjacent to each other, with AcuA functioning as the acetylase and AcuC as an NAD+-independent deacetylase
physiological function
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jeffers, V.; Gao, H.; Checkley, L.A.; Liu, Y.; Ferdig, M.T.; Sullivan, W.J.
Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii
Antimicrob. Agents Chemother.
60
2164-2170
2016
Bacillus subtilis (P39065), Bacillus subtilis 168 (P39065), Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZMX2), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZMX2), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (Q8ZMX2), Staphylococcus aureus (A0A0D3Q886), Staphylococcus aureus HG001 (A0A0D3Q886)
Manually annotated by BRENDA team
Favrot, L.; Blanchard, J.; Vergnolle, O.
Bacterial GCN5-related N-acetyltransferases from resistance to regulation
Biochemistry
55
989-1002
2016
Bacillus subtilis (P39065), Bacillus subtilis 168 (P39065), Mycobacterium tuberculosis (O05581), Mycobacterium tuberculosis ATCC 25618 (O05581), Mycobacterium tuberculosis H37Rv (O05581), Mycolicibacterium smegmatis (A0R3F9), Mycolicibacterium smegmatis ATCC 700084 (A0R3F9), Mycolicibacterium smegmatis mc(2)155 (A0R3F9), Rhodopseudomonas palustris, Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZMX2), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZMX2), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (Q8ZMX2), Streptomyces coelicolor, Streptomyces lividans
Manually annotated by BRENDA team