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EC Tree
The expected taxonomic range for this enzyme is: Saccharopolyspora erythraea
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methylmalonyl-CoA + an [acyl-carrier protein] = CoA + a methylmalonyl-[acyl-carrier protein]
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methylmalonyl-CoA:[acyl-carrier protein] S-methylmalonyltransferase
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ethylmalonyl-CoA + an [acyl-carrier protein]
CoA + a methylmalonyl-[acyl-carrier protein]
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malonyl-CoA + an [acyl-carrier protein]
CoA + a methylmalonyl-[acyl-carrier protein]
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methylmalonyl-CoA + an [acyl-carrier protein]
CoA + a methylmalonyl-[acyl-carrier protein]
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additional information
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the cis-acyltransferase domain from DEBS module 3 transfers a methylmalonyl extender unit from the corresponding carboxyacyl-CoA precursor onto the phosphopantetheine arm of the acyl carrier protein within the same module. The presence of the acyl carrier protein has little effect on the specificity of the cis-acyltransferase domain of 6-deoxyerythronolide B synthase for carboxyacyl-CoA substrates, but has a marked influence on the corresponding specificity parameters for the trans-acyltransferases from the disorazole and kirromycin synthases. Comparative analysis of the substrate specificity
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0.002
methylmalonyl-CoA
pH 7.6, temperature not specified in the publication
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0.033
methylmalonyl-CoA
pH 7.6, temperature not specified in the publication
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0.8
ethylmalonyl-CoA
below 0.8 per sec and mM, pH 7.6, temperature not specified in the publication
0.8
malonyl-CoA
pH 7.6, temperature not specified in the publication
16.7
methylmalonyl-CoA
pH 7.6, temperature not specified in the publication
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Q03132, i.e. modules 3 and 4, of 6-deoxyerythronolide B synthase, EC 2.3.1.94
UniProt
brenda
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ERYA2_SACER
3567
0
374421
Swiss-Prot
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Dunn, B.J.; Watts, K.R.; Robbins, T.; Cane, D.E.; Khosla, C.
Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases
Biochemistry
53
3796-3806
2014
Saccharopolyspora erythraea (Q03132)
brenda
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Enzyme Nomenclature
2.3.1.B32 [acyl-carrier-protein] S-methylmalonyltransferase
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