Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Synonyms
n-myristoyltransferase, nmt-1, myristoyl-coa:protein n-myristoyltransferase, n-myristoyl transferase, nmt1p, n-myristoyltransferase 1, myristoyltransferase, canmt, myristoyl-coa protein n-myristoyltransferase, tbnmt,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
-
-
?
tetradecanoyl-CoA + glycyl-pp60cSrc
CoA + N-tetradecanoyl-glycyl-pp60cSrc
i.e. myristoyl-CoA
-
-
?
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Arg-Arg
N-myristoyl-Gly-Asn-Ala-Ala-Ala-Arg-Arg + CoA
-
-
-
-
?
myristoyl-CoA + Gly-Gln-Thr-Val-Thr-Thr-Pro-Leu
N-myristoyl-Gly-Gln-Thr-Val-Thr-Thr-Pro-Leu + CoA
-
-
-
-
?
myristoyl-CoA + Gly-Ser-Ser-Lys-Pro-Lys-Asp-Lys-Asp-Pro
N-myristoyl-Gly-Ser-Ser-Lys-Pro-Lys-Asp-Lys-Asp-Pro + CoA
-
-
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
tetradecanoyl-CoA + glycyl-pp60c Src
CoA + N-tetradecanoyl-glycyl-pp60c Src
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + glycylpeptide
CoA + N-tetradecanoylglycylpeptide
additional information
?
-
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA
-
-
-
-
?
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA
-
-
-
?
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA
-
-
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
-
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
substrate specificity
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
overview peptides and proteins
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
specific for Gly at N-terminus
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
diverse protein substrates, protein biosynthesis
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
N-myristoyltransferase 1 is not essential for the viability of mammalian cells but is required for development, likely because it is the principal N-myristoyltransferase in early embryogenesis
-
-
?
tetradecanoyl-CoA + glycylpeptide
CoA + N-tetradecanoylglycylpeptide
-
-
-
-
?
tetradecanoyl-CoA + glycylpeptide
CoA + N-tetradecanoylglycylpeptide
-
covalent attachment of the myristoyl group, generally to the N-terminal glycine residue of proteins. N-myristoylation occurs absolutely on an exposed N-terminal glycine and on a general consesus motif of GXXXS/T, where X is any amino acid
-
-
?
additional information
?
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
tetradecanoyl-CoA + glycyl-pp60cSrc
CoA + N-tetradecanoyl-glycyl-pp60cSrc
i.e. myristoyl-CoA
-
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
tetradecanoyl-CoA + glycyl-pp60c Src
CoA + N-tetradecanoyl-glycyl-pp60c Src
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + glycylpeptide
CoA + N-tetradecanoylglycylpeptide
-
covalent attachment of the myristoyl group, generally to the N-terminal glycine residue of proteins. N-myristoylation occurs absolutely on an exposed N-terminal glycine and on a general consesus motif of GXXXS/T, where X is any amino acid
-
-
?
additional information
?
-
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
specific for Gly at N-terminus
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
diverse protein substrates, protein biosynthesis
-
?
myristoyl-CoA + glycylpeptide
N-myristoylglycylpeptide + CoA
-
N-myristoyltransferase 1 is not essential for the viability of mammalian cells but is required for development, likely because it is the principal N-myristoyltransferase in early embryogenesis
-
-
?
additional information
?
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
-
isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
additional information
?
-
-
isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
enzyme knockout leads to defective myelopoesis
physiological function
NMT1 is required in the development of monocytic lineage and essential for the early development of mouse embryo
evolution
-
N-myristoyltransferase is an ubiquitously distributed enzyme and belongs to the GCN5 acetyltransferase superfamily. NMT exists as a single copy gene in lower eukaryotes, whereas in higher eukaryotes, two genes encoding for the two isoforms of NMT have been identified. The NMT1 isoform is homologous to the NMT from lower eukaryotes
malfunction
enzyme knockout leads to defective myelopoesis
malfunction
-
NMT2 is not able to rescue N-myristoylation of proteins for the proper development of the embryos in NMT1-/- mice knockouts, the embryos die during early embryogenesis. Bone marrow cells taken from wild-type and heterozygous Nmt1-deficient mice and cultured in the presence of mouse macrophage colony-stimulating factor for differentiation into monocytes/macrophages develop in a different manner, overview
physiological function
-
isozyme NMT1 is essential for growth and development, during which rapid cellular proliferation is required, in a variety of organisms. NMT1 is also reported to be elevated in many cancerous states, which also involve rapid cellular growth, albeit in an unwanted and uncontrolled manner. During the co-translational protein myristoylation, the initiator methionine at the N-terminus is removed by methionine aminopeptidase thus allowing the exposure of a glycine residue on an available myristoylation site. Myristoylation increases protein lipophilicity and controls the functioning of proteins by targeting them to specific localizations, promoting specific protein-protein and protein-lipid interactions and ligand-induced conformational changes. Roles of NMT in leukocytic differentiation processes and the roles of NMT1 in neutrophil apoptosis
physiological function
-
membrane protein calnexin interacts with N-myristoyltransferase 1 at the endoplasmic reticulum. NMT activity is not affected by presence of absence of calnexin
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Towler, D.A.; Gordon, J.I.; Adams, S.P.; Glaser, L.
The biology and enzymology of eukaryotic protein acylation
Annu. Rev. Biochem.
57
69-99
1988
Saccharomyces cerevisiae, Mus musculus, Rattus norvegicus, Triticum aestivum
brenda
Boutin, J.A.; Clarenc, J.P.; Ferry, G.; Ernould, A.P.; Remond, G.; Vincent, M.; Atassi, G.
N-myristoyl-transferase activity in cancer cells. Solubilization, specificity and enzymatic inhibition of a N-myristoyl transferase from L1210 microsomes
Eur. J. Biochem.
201
257-263
1991
Saccharomyces cerevisiae, Mus musculus, Rattus norvegicus
brenda
Paige, L.A.; Zheng, G.Q.; DeFrees, S.A.; Cassady, J.M.; Geahlen, R.L.
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase
Biochemistry
29
10566-10573
1990
Mus musculus
brenda
Paige, L.A.; Chafin, D.R.; Cassady, J.M.; Geahlen, R.L.
Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography
Anal. Biochem.
181
254-258
1989
Mus musculus
brenda
Towler, D.A.; Eubanks, S.R.; Towery, D.S.; Adams, S.P.; Glaser, L.
Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase
J. Biol. Chem.
262
1030-1036
1987
Saccharomyces cerevisiae, Mus musculus
brenda
Giang, D.K.; Cravatt, B.F.
A second mammalian N-myristoyltransferase
J. Biol. Chem.
273
6595-6598
1998
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
brenda
Yang, S.H.; Shrivastav, A.; Kosinski, C.; Sharma, R.K.; Chen, M.H.; Berthiaume, L.G.; Peters, L.L.; Chuang, P.T.; Young, S.G.; Bergo, M.O.
N-myristoyltransferase 1 is essential in early mouse development
J. Biol. Chem.
280
18990-18995
2005
Mus musculus
brenda
Selvakumar, P.; Lakshmikuttyamma, A.; Charavaryamath, C.; Singh, B.; Tuchek, J.; Sharma, R.K.
Expression of myristoyltransferase and its interacting proteins in epilepsy
Biochem. Biophys. Res. Commun.
335
1132-1139
2005
Bos taurus, Saccharomyces cerevisiae, Candida sp. (in: Saccharomycetales), Oryctolagus cuniculus, Dictyostelium sp., Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Shrivastav, A.; Varma, S.; Lawman, Z.; Yang, S.H.; Ritchie, S.A.; Bonham, K.; Singh, S.M.; Saxena, A.; Sharma, R.K.
Requirement of N-myristoyltransferase 1 in the development of monocytic lineage
J. Immunol.
180
1019-1028
2008
Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
brenda
Kumar, S.; Singh, B.; Dimmock, J.R.; Sharma, R.K.
N-myristoyltransferase in the leukocytic development processes
Cell Tissue Res.
345
203-211
2011
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Dudek, E.; Millott, R.; Liu, W.X.; Beauchamp, E.; Berthiaume, L.G.; Michalak, M.
N-myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum
Biochem. Biophys. Res. Commun.
468
889-893
2015
Mus musculus
brenda