Disease on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase
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Adenoma
[Expression of enterotoxigenic Bacteroides fragilis and polyketide synthase gene-expressing Escherichia coli in colorectal adenoma patients].
Bacterial Infections
Marine macroalgae-associated heterotrophic Firmicutes and Gamma-proteobacteria: prospective anti-infective agents against multidrug resistant pathogens.
Buruli Ulcer
Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
Buruli Ulcer
IFN-? and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.
Buruli Ulcer
Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro.
Buruli Ulcer
Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.
Colorectal Neoplasms
Mucosal cancer-associated microbes and anastomotic leakage after resection of colorectal carcinoma.
Colorectal Neoplasms
Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults.
Colorectal Neoplasms
The Escherichia coli colibactin resistance protein ClbS is a novel DNA binding protein that protects DNA from nucleolytic degradation.
Cystic Fibrosis
Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism.
Dehydration
pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.
Dehydration
Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.
Dehydration
The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: direct evidence for beta,gamma dehydration by a trans-acyltransferase polyketide synthase.
Infections
An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.
Infections
IFN-? and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.
Infections
Molecular analysis of Mycobacterium tuberculosis strains with an intact pks15/1 gene in a rural community of Mexico.
Infections
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection.
Infections
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Infections
The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial.
Infections
Total Biosynthesis and Diverse Applications of the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin.
Infections
Transcriptome Study of an Exophiala dermatitidis PKS1 Mutant on an ex Vivo Skin Model: Is Melanin Important for Infection?
Infections
Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.
Melanoma
Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity.
Nocardia Infections
Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase.
Nocardia Infections
Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis.
Starvation
Stimulation of bikaverin production by sucrose and by salt starvation in Fusarium fujikuroi.
Tuberculosis
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
Tuberculosis
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
Tuberculosis
Characterisation of pks15/1 in clinical isolates of Mycobacterium tuberculosis from Mexico.
Tuberculosis
Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
Tuberculosis
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.
Tuberculosis
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Tuberculosis
Detection of soluble co-factor dependent protein expression in vivo: Application to the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis.
Tuberculosis
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Tuberculosis
Experimental mapping of soluble protein domains using a hierarchical approach.
Tuberculosis
Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads.
Tuberculosis
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis.
Tuberculosis
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
Tuberculosis
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.
Tuberculosis
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
Tuberculosis
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex.
Tuberculosis
Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13.
Tuberculosis
Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.
Tuberculosis
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Tuberculosis
The optimization of in vitro high-throughput chemical lysis of Escherichia coli. Application to ACP domain of the polyketide synthase ppsC from Mycobacterium tuberculosis.
Tuberculosis
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Tuberculosis
Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.
Tuberculosis
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis.
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