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Disease on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
[Expression of enterotoxigenic Bacteroides fragilis and polyketide synthase gene-expressing Escherichia coli in colorectal adenoma patients].
Bacterial Infections
Marine macroalgae-associated heterotrophic Firmicutes and Gamma-proteobacteria: prospective anti-infective agents against multidrug resistant pathogens.
Buruli Ulcer
Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
IFN-? and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.
Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro.
Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.
Colorectal Neoplasms
MATE transport of the E. coli-derived genotoxin colibactin.
Mucosal cancer-associated microbes and anastomotic leakage after resection of colorectal carcinoma.
Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults.
The Escherichia coli colibactin resistance protein ClbS is a novel DNA binding protein that protects DNA from nucleolytic degradation.
Cystic Fibrosis
Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism.
Dehydration
pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.
Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.
The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: direct evidence for beta,gamma dehydration by a trans-acyltransferase polyketide synthase.
Infections
An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.
IFN-? and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.
Molecular analysis of Mycobacterium tuberculosis strains with an intact pks15/1 gene in a rural community of Mexico.
Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection.
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial.
Total Biosynthesis and Diverse Applications of the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin.
Transcriptome Study of an Exophiala dermatitidis PKS1 Mutant on an ex Vivo Skin Model: Is Melanin Important for Infection?
Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.
Melanoma
Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity.
Neoplasms
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota.
Nocardia Infections
Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase.
Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis.
Starvation
Stimulation of bikaverin production by sucrose and by salt starvation in Fusarium fujikuroi.
Tuberculosis
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
Characterisation of pks15/1 in clinical isolates of Mycobacterium tuberculosis from Mexico.
Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Detection of soluble co-factor dependent protein expression in vivo: Application to the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis.
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Experimental mapping of soluble protein domains using a hierarchical approach.
Genes required for intrinsic multidrug resistance in Mycobacterium avium.
Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads.
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis.
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex.
Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13.
Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.
Mutants of Mycobacterium smegmatis impaired in stationary-phase survival.
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
The optimization of in vitro high-throughput chemical lysis of Escherichia coli. Application to ACP domain of the polyketide synthase ppsC from Mycobacterium tuberculosis.
Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis.
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis.