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IUBMB CommentsThe enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.
Synonyms
acetoacetyl-coa thiolase, acetyl-coa acetyltransferase, erg10, acoat, acetyl-coa c-acetyltransferase, cytosolic acetoacetyl-coa thiolase, osat1, 2-methylacetoacetyl-coa thiolase, acetoacetyl coa thiolase, aact2,
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2-methylacetoacetyl-CoA thiolase
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3-ketoacyl-CoA (T1)-like thiolase
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3-ketoacyl-coenzyme A thiolase
acetoacetyl-CoA acetyltransferase
acetoacetyl-CoA C-acetyltransferase
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acetoacetyl-CoA thiolase T2
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acetyl coenzyme A thiolase
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acetyl-CoA acetyltransferase
acetyl-CoA C-acetyltransferase
acetyl-CoA:N-acetyltransferase
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acetyltransferase, acetyl coenzyme A
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beta-acetoacetyl coenzyme A thiolase
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beta-ketoacyl-CoA thiolase
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cytosolic acetoacetyl-CoA thiolase
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cytosolic acetoacetyl-CoA thiolase 1
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cytosolic acetoacetyl-CoA thiolase 2
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3-ketoacyl-CoA thiolase
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3-ketoacyl-CoA thiolase
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3-ketoacyl-CoA thiolase
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3-ketoacyl-coenzyme A thiolase
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3-ketoacyl-coenzyme A thiolase
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A1887
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AACT
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AACT1
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ACAT
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ACAT1
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isoform
ACAT2
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ACCT
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acetoacetyl CoA thiolase
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acetoacetyl CoA thiolase
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acetoacetyl CoA thiolase
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acetoacetyl-CoA acetyltransferase
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acetoacetyl-CoA acetyltransferase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
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acetoacetyl-CoA thiolase
Vitis vinifera x Vitis vinifera
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acetyl-CoA acetyltransferase
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acetyl-CoA acetyltransferase
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acetyl-CoA C-acetyltransferase
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acetyl-CoA C-acetyltransferase
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ACTRANS
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ACTRANS
Vitis vinifera x Vitis vinifera
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AFUB_000550
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beta-ketothiolase
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ERG10
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Erg10A
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HFX_1022
locus name, subunit PhaAbeta
HFX_1022
locus name, subunit PhaAbeta
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HFX_1023
locus name, subunit PhaAalpha
HFX_1023
locus name, subunit PhaAalpha
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HFX_6003
locus name, subunit BktBbeta
HFX_6003
locus name, subunit BktBbeta
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HFX_6004
locus name, subunit BktBalpha
HFX_6004
locus name, subunit BktBalpha
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KACT
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Msed_0656
locus name
phaA
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thiolase II
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Tneu_0249
locus name
type II thiolase
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2 acetyl-CoA = CoA + acetoacetyl-CoA
acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA
(1a)
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[acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + acetyl-CoA = acetoacetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine
(1b)
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2 acetyl-CoA = CoA + acetoacetyl-CoA
mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
ping-pong mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
ping-pong mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
bi bi ping pong mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
reaction involves 2 chemically distinct steps: acetyl group transfer from acetyl-CoA to Cys89, and transfer of this acetyl group to a second acetyl-CoA in the Claisen condensation step to form acetoacetyl-CoA
2 acetyl-CoA = CoA + acetoacetyl-CoA
proposed two-step ping pong mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
Claisen condensation, mechanism
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2 acetyl-CoA = CoA + acetoacetyl-CoA
Claisen condensation, mechanism
2 acetyl-CoA = CoA + acetoacetyl-CoA
Claisen condensation, mechanism
2 acetyl-CoA = CoA + acetoacetyl-CoA
overall reaction
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acetyl-CoA:acetyl-CoA C-acetyltransferase
The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 acetyl-CoA
acetoacetyl-CoA + CoA
2 acetyl-CoA
CoA + acetoacetyl-CoA
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
acetoacetyl-CoA + CoA
2 acetyl-CoA
acetoacetyl-S-pantetheine + acetyldithio-CoA
acetyl-S-pantetheine + 3-ketobutyryldithio-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
acetyl-CoA + acetyldithio-CoA
CoA + 3-ketobutyryldithio-CoA
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r
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
CoA + acetoacetyl-10-bis-demethylpantetheine 11-pivaloate
acetyl-CoA + acetyl-10-bis-demethylpantetheine 11-pivaloate
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-S-(11-methoxymethyl)pantetheine
acetyl-CoA + acetyl-S-(11-methoxymethyl)pantetheine
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CoA + acetoacetyl-S-(11-t-butyldimethylsilyl)pantetheine
acetyl-CoA + acetyl-S-(11-t-butyldimethylsilyl)pantetheine
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?
CoA + acetoacetyl-S-(D-pantetheine) 11-pivalate
acetyl-CoA + acetyl-S-(D-pantetheine) 11-pivalate
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?
CoA + acetoacetyl-S-(L-pantetheine) 11-pivalate
acetyl-CoA + acetyl-S-(L-pantetheine) 11-pivalate
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CoA + acetoacetyl-S-homopantetheine 12-pivalate
acetyl-CoA + acetyl-S-homopantetheine 12-pivalate
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CoA + acetoacetyl-S-pantetheine
acetyl-CoA + acetyl-S-pantetheine
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?
additional information
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2 acetyl-CoA
acetoacetyl-CoA + CoA
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2 acetyl-CoA
acetoacetyl-CoA + CoA
the thiolase is involved in the synthesis and catabolism of fatty acids
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme is responsible for supplying the precursors for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
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2 acetyl-CoA
CoA + acetoacetyl-CoA
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2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme is responsible for supplying the precursors for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
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2 acetyl-CoA
CoA + acetoacetyl-CoA
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2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme catalyzes a reaction in the mevalonate pathway
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2 acetyl-CoA
CoA + acetoacetyl-CoA
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2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme catalyzes a reaction in the mevalonate pathway
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2 acetyl-CoA
CoA + acetoacetyl-CoA
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ir
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
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?
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
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cleavage of 2-methylacetoacetyl-CoA in the isoleucine catabolism
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acetoacetyl-CoA + CoA
2 acetyl-CoA
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the enzyme shows preference for the thiolytic reaction direction
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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?
acetoacetyl-CoA + CoA
2 acetyl-CoA
coupled reaction assay in which the product of the thiolase reaction, acetyl-CoA, becomes the substrate for citrate synthase
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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interconversion of 2 acetyl-CoA into acetoacetyl-CoA in the ketone body metabolism
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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?
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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enzyme deficiency affects isoleucine and ketone body metabolism
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
involved in fatty acid synthesis
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
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?
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA binding mode, overview
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA substrate binding structure, overview
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA substrate binding structure, overview
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA binding mode, overview
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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CoA + acetoacetyl-CoA
2 acetyl-CoA
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CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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CoA + acetoacetyl-CoA
2 acetyl-CoA
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CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in autotrophic carbon fixation
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CoA + acetoacetyl-CoA
2 acetyl-CoA
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CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in autotrophic carbon fixation
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CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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the enzyme of the biosynthetic pathway for polyhydroxyalkanoates
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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rate of synthesis is 0.31 and 0.08 the rate of thiolysis for isoenzyme A and B, respectively
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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specific for acetoacetyl-CoA, no activity with ketodecanoyl-CoA, dithiothreitol and 2-mercaptoethanol
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
cytosolic thiolase I is essential for the mevalonate pathway
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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enzyme of fatty acid oxidation cycle
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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enzyme has both thiolase and 3-hydroxy-3-methylglutaryl-CoA reductase activity
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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thiolase II from constitutive mutant is specific for acetoacetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, ir
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
2.3.1.9 acetyl-CoA C-acetyltransferase
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