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Information on EC 2.3.1.87 - aralkylamine N-acetyltransferase and Organism(s) Macaca mulatta and UniProt Accession O97756

for references in articles please use BRENDA:EC2.3.1.87
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EC Tree
IUBMB Comments
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.
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This record set is specific for:
Macaca mulatta
UNIPROT: O97756
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Word Map
The taxonomic range for the selected organisms is: Macaca mulatta
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
aanat, aa-nat, snat2, arylalkylamine n-acetyltransferase, snat1, aanat2, aanat1, serotonin-n-acetyltransferase, aralkylamine n-acetyltransferase, bm-iaanat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AA-NAT
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AANAT
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acetyl-CoA:aralkylamine N-acetyltransferase
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-
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acetyltransferase, arylalkylamine N-
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-
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arylalkylamine N-acetyltransferase
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N-acetyltransferase
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serotonin acetylase
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serotonin acetyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:2-arylethylamine N-acetyltransferase
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
92941-56-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
4fold increase at night
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SNAT_MACMU
204
0
22891
Swiss-Prot
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Coon, S.L.; Del Olmo, E.; Young, W.S.; Klein, D.C.
Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87)
J. Clin. Endocrinol. Metab.
87
4699-4706
2002
Macaca mulatta (O97756), Macaca mulatta
Manually annotated by BRENDA team
Tosini, G.; Chaurasia, S.S.; Michael Iuvone, P.
Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina
Chronobiol. Int.
23
381-391
2006
Macaca mulatta (O97756), Gallus gallus (P79774), Rattus norvegicus (Q64666), Rattus norvegicus Fischer (Q64666)
Manually annotated by BRENDA team