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acetyl-CoA + 2,5-dimethoxyphenylethylamine
CoA + ?
24% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2,5-dimethoxyphenylethylamine
CoA + N-acetyl-2,5-dimethoxyphenylethylamine
-
68% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine
CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
acetyl-CoA + 2-(2-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(2-chlorophenyl)-ethylamine
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
acetyl-CoA + 2-(3-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(3-chlorophenyl)-ethylamine
acetyl-CoA + 2-(3-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(3-fluorophenyl)-ethylamine
acetyl-CoA + 2-(4-bromophenyl)-ethylamine
CoA + N-acetyl-2-(4-bromophenyl)-ethylamine
acetyl-CoA + 2-(4-chlorophenyl)ethylamine
CoA + N-acetyl-2-(4-chlorophenyl)ethylamine
acetyl-CoA + 2-(4-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(4-fluorophenyl)-ethylamine
acetyl-CoA + 2-(p-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(p-fluorophenyl)-ethylamine
acetyl-CoA + 2-(p-nitrophenyl)-ethylamine
CoA + N-acetyl-2-(p-nitrophenyl)-ethylamine
acetyl-CoA + 2-(p-tolyl)-ethylamine
CoA + N-acetyl-2-(p-tolyl)-ethylamine
acetyl-CoA + 2-fluorophenylethylamine
CoA + ?
69% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-fluorophenylethylamine
CoA + N-acetyl-2-fluorophenylethylamine
-
52% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-methoxyphenylethylamine
CoA + N-acetyl-2-methoxyphenylethylamine
acetyl-CoA + 2-phenylethylamine
CoA + N-acetyl-2-phenylethylamine
acetyl-CoA + 3-(trifluoromethyl)phenethylamine
CoA + N-acetyl-3-(trifluoromethyl)phenethylamine
-
-
-
-
?
acetyl-CoA + 3-hydroxy-4-methoxyphenethylamine
CoA + ?
1% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxy-4-methoxyphenethylamine
CoA + N-acetyl-3-hydroxy-4-methoxyphenethylamine
-
7.2% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxyphenethylamine
CoA + ?
24% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxyphenethylamine
CoA + N-acetyl-3-hydroxyphenethylamine
-
36% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-indolebutylamine
CoA + N-acetyl-(3-indol-3-yl-butyl)-amine
-
60-fold less efficiently than serotonin
-
-
?
acetyl-CoA + 3-indolepropylamine
CoA + N-acetyl-(3-indol-3-yl-propyl)-amine
-
20-fold less efficiently than serotonin
-
-
?
acetyl-CoA + 3-methoxy-2-phenylethylamine
CoA + ?
23% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxy-2-phenylethylamine
CoA + N-acetyl-3-methoxy-2-phenylethylamine
-
55% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxyphenethylamine
CoA + N-acetyl-3-methoxyphenethylamine
-
-
-
-
?
acetyl-CoA + 3-methoxytyramine
CoA + ?
17% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxytyramine
CoA + N-acetyl-3-methoxytyramine
-
73% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonamide
CoA + ?
-
1% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonyl fluoride
CoA + ?
acetyl-CoA + 4-methoxyphenylethylamine
CoA + N-acetyl-4-methoxyphenylethylamine
acetyl-CoA + 5-benzyloxytryptamine
CoA + N-acetyl-5-benzyloxytryptamine
-
-
-
-
?
acetyl-CoA + 5-hydroxydopamine
CoA + N-acetyl-5-hydroxydopamine
-
4.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 5-hydroxytryptamine
CoA + N-acetyl-5-hydroxytryptamine
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
acetyl-CoA + 6-fluorotryptamine
CoA + N-acetyl-6-fluorotryptamine
acetyl-CoA + 6-hydroxydopamine
CoA + ?
51% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 6-hydroxydopamine
CoA + N-acetyl-6-hydroxydopamine
-
1.5% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
acetyl-CoA + alpha-methyltryptamine
CoA + N-acetyl-alpha-methyltryptamine
-
racemic, 9:1 stereoselectivity for R-enantiomer, less efficiently than serotonin
-
-
?
acetyl-CoA + beta-methylphenethylamine
CoA + N-acetyl-beta-methylphenethylamine
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
acetyl-CoA + dopamine
CoA + N-acetyldopamine
acetyl-CoA + histamine
CoA + N-acetylhistamine
acetyl-CoA + methoxytryptamine
CoA + N-acetylmethoxytryptamine
-
-
-
-
?
acetyl-CoA + Nomega-methyltryptamine
CoA + ?
-
less efficiently than serotonin
-
-
?
acetyl-CoA + norepinephrine
CoA + N-acetylnorepinephrine
acetyl-CoA + norepinephrine
CoA + N-acetyltyramine
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-aecetamide
-
-
-
-
?
acetyl-CoA + phenethylamine
CoA + N-acetyl-phenethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetyl-phenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
acetyl-CoA + phenylethylamine
N-acetyl-phenylethylamine
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
acetyl-CoA + tryptamine
N-acetyltryptamine + CoA
-
-
-
-
?
acetyl-CoA + tryptophol
CoA + N-acetyltryptophol
-
structural analogue to tryptamine
-
-
?
acetyl-CoA + tyramine
CoA + ?
8% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
arachidonoyl-CoA + octopamine
CoA + N-arachidonoyloctopamine
-
-
-
?
butanoyl-CoA + dopamine
CoA + N-butanoyldopamine
-
-
-
?
butanoyl-CoA + histamine
CoA + N-butanoylhistamine
-
-
-
-
?
hexanoyl-CoA + histamine
CoA + N-hexanoylhistamine
-
-
-
-
?
oleoyl-CoA + octopamine
CoA + N-oleoyloctopamine
-
-
-
?
palmitoyl-CoA + octopamine
CoA + N-palmitoyloctopamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
propionyl-CoA + tyramine
CoA + N-propionyltyramine
stearoyl-CoA + octopamine
CoA + N-stearoyloctopamine
-
-
-
?
additional information
?
-
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine

CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
78% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine
CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
-
84% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2-chlorophenyl)-ethylamine

CoA + N-acetyl-2-(2-chlorophenyl)-ethylamine
130% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(2-chlorophenyl)-ethylamine
-
102% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine

CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
7% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
-
64% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine

CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
4.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
-
15% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-chlorophenyl)-ethylamine

CoA + N-acetyl-2-(3-chlorophenyl)-ethylamine
67% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(3-chlorophenyl)-ethylamine
-
110% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-fluorophenyl)-ethylamine

CoA + N-acetyl-2-(3-fluorophenyl)-ethylamine
65% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(3-fluorophenyl)-ethylamine
-
93% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-bromophenyl)-ethylamine

CoA + N-acetyl-2-(4-bromophenyl)-ethylamine
48% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-bromophenyl)-ethylamine
CoA + N-acetyl-2-(4-bromophenyl)-ethylamine
-
87% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-chlorophenyl)ethylamine

CoA + N-acetyl-2-(4-chlorophenyl)ethylamine
68% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-chlorophenyl)ethylamine
CoA + N-acetyl-2-(4-chlorophenyl)ethylamine
-
91% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-fluorophenyl)-ethylamine

CoA + N-acetyl-2-(4-fluorophenyl)-ethylamine
116% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(4-fluorophenyl)-ethylamine
-
60% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-fluorophenyl)-ethylamine

CoA + N-acetyl-2-(p-fluorophenyl)-ethylamine
56% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(p-fluorophenyl)-ethylamine
-
as active as with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-nitrophenyl)-ethylamine

CoA + N-acetyl-2-(p-nitrophenyl)-ethylamine
9% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-nitrophenyl)-ethylamine
CoA + N-acetyl-2-(p-nitrophenyl)-ethylamine
-
53% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-tolyl)-ethylamine

CoA + N-acetyl-2-(p-tolyl)-ethylamine
60% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-tolyl)-ethylamine
CoA + N-acetyl-2-(p-tolyl)-ethylamine
-
87% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-methoxyphenylethylamine

CoA + N-acetyl-2-methoxyphenylethylamine
52% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-methoxyphenylethylamine
CoA + N-acetyl-2-methoxyphenylethylamine
-
97% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-phenylethylamine

CoA + N-acetyl-2-phenylethylamine
-
-
-
?
acetyl-CoA + 2-phenylethylamine
CoA + N-acetyl-2-phenylethylamine
-
-
-
-
?
acetyl-CoA + 2-phenylethylamine
CoA + N-acetyl-2-phenylethylamine
-
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonyl fluoride

CoA + ?
8% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonyl fluoride
CoA + ?
-
7.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-methoxyphenylethylamine

CoA + N-acetyl-4-methoxyphenylethylamine
11% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-methoxyphenylethylamine
CoA + N-acetyl-4-methoxyphenylethylamine
-
10% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 5-hydroxytryptamine

CoA + N-acetyl-5-hydroxytryptamine
-
-
-
-
?
acetyl-CoA + 5-hydroxytryptamine
CoA + N-acetyl-5-hydroxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine

CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 6-fluorotryptamine

CoA + N-acetyl-6-fluorotryptamine
-
-
-
-
?
acetyl-CoA + 6-fluorotryptamine
CoA + N-acetyl-6-fluorotryptamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine

CoA + an N-acetyl-2-arylethylamine
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine

CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
also substrate: phenylethylamine derivatives without a beta-hydroxy group
-
-
?
acetyl-CoA + dopamine

CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + histamine

CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
?
acetyl-CoA + norepinephrine

CoA + N-acetylnorepinephrine
-
-
-
-
?
acetyl-CoA + norepinephrine
CoA + N-acetylnorepinephrine
-
-
-
?
acetyl-CoA + norepinephrine
CoA + N-acetylnorepinephrine
-
-
-
?
acetyl-CoA + norepinephrine

CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + norepinephrine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + octopamine

CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + phenylethylamine

CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + serotonin

CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
rate-limiting in melatonin, i.e. N-acetyl-5-methoxytryptamine synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
best substrate
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
key enzyme of circadian rhythm of melatonin synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
rate-limiting in melatonin synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
the enzyme catalyzes the first step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
initial reaction in melatonin synthesis from serotonin
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
penultimate enzyme in melatonin pathway
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
penultimate step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
reaction mechanism involving Pro64 that plays a critical role in structure and catalysis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
initial reaction in melatonin synthesis from serotonin
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
first step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
AANAT2 acetylates serotonin about 10times faster than AANAT1
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + tryptamine

CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
Esox sp.
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
trout
-
-
-
-
?
acetyl-CoA + tyramine

CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
very poor substrate
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
10% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
propionyl-CoA + histamine

CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + tyramine

CoA + N-propionyltyramine
-
-
-
?
propionyl-CoA + tyramine
CoA + N-propionyltyramine
-
-
-
?
propionyl-CoA + tyramine
CoA + N-propionyltyramine
-
-
-
-
?
additional information

?
-
aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
-
-
?
additional information
?
-
-
aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
-
-
?
additional information
?
-
-
substrate specificity, aaNAT1 and aaNAT2 show a broad substrate specificity and their affinity and catalytic efficiency to each of the seven arylalkylamines tested. The affinity between aaNAT1 and aaNAT2 to most of the arylalkylamines is similar except that aaNAT2 has less affinity than aaNAT1 to norepinephrine. Also aaNAT1 is more efficient in catalyzing all the tested substrates than that of aaNAT2
-
-
?
additional information
?
-
no substrate: sulfamethazine
-
-
?
additional information
?
-
-
no substrate: sulfamethazine
-
-
?
additional information
?
-
-
ordered sequential mechanism, with acetyl-CoA binding first followed by histamine to generate an AANATL7-acetyl-CoA-histamine ternary complex prior to catalysis. An ionizable group with a pKa of 7.1 is assigned to Glu-26 as a general base and a second with a pKa of 9.5 is assigned to the protonation of the thiolate of the coenzyme A product
-
-
?
additional information
?
-
-
enzyme activity in cultured cells is suppressed by light, as it is in vivo. The ability to express circadian regulation of the enzyme activity is an intrinsic property of retinal cells that can develop in vitro
-
-
?
additional information
?
-
-
further substrates: selected synthetic amines
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate-limiting step in melatonin synthesis
-
-
?
additional information
?
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine, 5-hydroxydopamine, 4-(2-aminoethyl)-benzenesulfonamide or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine, 5-hydroxydopamine, 4-(2-aminoethyl)-benzenesulfonamide or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
enzyme light and diurnal regulation involves phosphorylation on key AANAT Ser and Thr residues, which results in 14-3-3 protein recruitment and changes in catalytic activity and protein stability
-
-
?
additional information
?
-
the enzyme catalyzes the limiting step for melatonin synthesis
-
-
?
additional information
?
-
-
the enzyme catalyzes the limiting step for melatonin synthesis
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
NAT could be a clock-controlled gene functioning as an output regulator of the circadian clock
-
-
?
additional information
?
-
-
no substrates are phenylethanolamine derivatives with a beta-hydroxy group
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
overexpression of inducible cAMP early repressor can suppress the norepinephrine induction of aa-nat
-
-
?
additional information
?
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
-
AANAT is a key regulatory enzyme in the melatonin biosynthetic pathway
-
-
?
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2-bromo-N-[2-(5-fluoro-1-benzothien-3-yl)ethyl]acetamide
-
IC50: 0.00039 mM
9-carboxy-11-nor-delta-9-tetrahydrocannabinol
significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity
alpha-trifluoromethyltryptamine
-
modest, competitive
cannabidiol
significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity
cannabinoid
cannabinoids inhibit AANAT activity and attenuate melatonin biosynthesis through intracellular actions without involvement of classical cannabinoid receptor-dependent signaling cascades
cannabinol
significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity
catechin
-
poorest inhibitor tested, 0.1 mM, 1.6fold inhibition of isoform SNAT1 at 0.1 mM
CoA-S-N-acetyl-7-hydroxynaphthylethylamine
fluorescent variant of CoA-T, a bisubstrate inhibitor, synthesis and enzyme binding structure, molecular modelling, overview
CoA-S-N-acetyltryptamine
total inhibition of N-acetyldopamine synthesis in presence of acetyl coenzyme-A and dopamine occurs in the presence of CoA-S-N-acetyltryptamine in liver
desulfo-CoA
-
dead end inhibitor analog, competitive versus CoA
glutathione
reversible, acetyl-CoA protects
methyl 3-[2-[(bromoacetyl)amino]ethyl]-1-benzothiophene-5-carboxylate
-
IC50: 0.00225 mM
N-acetylserotonin
IC50: 0.68 mM; very slightly
N-ethylmaleimide
irreversible, acetyl-CoA protects
N-[2-(2-benzyl-5-methoxy-benzofuran-3-yl)ethyl]iodoacetamide
-
IC50: 0.0087 mM
N-[2-(2-phenyl-benzo [b]thiophen-3-yl)ethyl]bromoacetamide
-
IC50: 0.001 mM
N-[2-(3-ethyl-7-methoxy-napht-1-yl)ethyl]iodoacetamide
-
IC50: 0.0006 mM
N-[2-(5-bromo-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
-
IC50: 0.00378 mM
N-[2-(5-chloro-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
-
IC50: 0.00018 mM
N-[2-(5-ethyl-1-benzothien-3-yl)ethyl]-2-iodoacetamide
-
IC50: 0.002 mM
N-[2-(5-ethyl-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
-
IC50: 0.00071 mM
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]bromoacetamide
-
IC50: 0.0056 mM
N-[2-(5-hydroxy-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
-
IC50: 0.00018 mM
N-[2-(7-ethyl-1,2,3,4-tetrahydronapht-1-yl)ethyl]iodooacetamide
-
IC50: above 0.1 mM
N-[2-(7-ethyl-napht-1-yl)ethyl]-bromoacetamide
-
IC50: 0.00177 mM
N-[2-(7-hydroxy-naphth-1-yl)ethyl]bromoacetamide
-
IC50: 0.00072 mM
N-[2-(7-methoxy-3-(3-trifluoromethylphenyl)-napht-1-yl)ethyl]iodoacetamide
-
IC50: 0.045 mM
N-[2-(7-methoxy-8-propenyl-napht-1-yl)ethyl]-iodoacetamide
-
IC50: above 0.1 mM
N-[2-(7-methoxy-napht-1-yl)ethyl]bromoacetamide
-
IC50: 0.002 mM
N-[2-(7-propoxy-napht-1-yl)ethyl]iodoacetamide
-
IC50: 0.0042 mM
oxygen
reversible, acetyl-CoA protects
p-chloro-mercuribenzoate
-
-
Peptides containing a disulfide bond
-
tryptamine-coenzyme A
a bisubstrate inhibitor, enzyme binding structure, molecular modelling, overview
tryptophol
-
dead end inhibitor analog, competitive versus tryptamine
UV light
-
NAT activity and melatonin content are suppressed by blue light of 450 nm wavelength, no effects of red light at 650 nm.UV radiation has intensity-dependent dual effects on the NAT activity and melatonin content: it is supressing at low intensity and activating at high intensity irradiation, overview
-
acetyl-CoA-tryptamine

IC50: 0.00041 mM, GST-AANAT fusion protein
acetyl-CoA-tryptamine
-
IC50: 0.00062 mM, GST-AANAT fusion protein
acetyl-CoA-tryptamine
IC50: 0.0008 mM, GST-AANAT fusion protein
bromoacetyltryptamine

-
IC50: 0.0014 mM
bromoacetyltryptamine
IC50: 0.00143 mM, GST-AANAT fusion protein
bromoacetyltryptamine
-
IC50: 0.00128 mM, GST-AANAT fusion protein
bromoacetyltryptamine
IC50: 0.0051 mM, GST-AANAT fusion protein
Disulfides

-
in vivo and in vitro, reversible by dithiothreitol
Disulfides
-
in vivo and in vitro, reversible by dithiothreitol
Melatonin

-
-
morin

-
0.1 mM, 2fold inhibition
morin
0.1 mM, 2fold inhibition
myricetin

-
best inhibitor tested, 8fold inhibition of isoform SNAT1 at 0.1 mM
myricetin
0.1 mM, 1.6fold inhibition
Peptides containing a disulfide bond

-
-
-
Peptides containing a disulfide bond
-
-
-
quercetin

-
-
quercetin
0.1 mM, 1.2fold inhibition
S 20251

IC50: 0.002 mM, GST-AANAT fusion protein
S 20251
-
IC50: 0.0013 mM, GST-AANAT fusion protein
S 20251
IC50: 0.0024 mM, GST-AANAT fusion protein
S 23823

IC50: 0.005 mM, GST-AANAT fusion protein
-
S 23823
IC50: 0.031 mM, GST-AANAT fusion protein
-
S 27244

IC50: 0.00072 mM, GST-AANAT fusion protein
S 27244
-
IC50: 0.00026 mM, GST-AANAT fusion protein
S 27244
IC50: 0.00036 mM, GST-AANAT fusion protein
S 27481

IC50: 0.00018 mM, GST-AANAT fusion protein
S 27481
-
IC50: 0.0004 mM, GST-AANAT fusion protein
S 27481
IC50: 0.0004 mM, GST-AANAT fusion protein
S 28036

IC50: 0.0056 mM,GST-AANAT fusion protein
S 28036
-
IC50: 0.00073 mM, GST-AANAT fusion protein
S 28036
IC50: 0.0017 mM, GST-AANAT fusion protein
serotonin

-
strong, mixed kinetics
tryptamine

inhbitory above 0.03 mM
Zn2+

-
at low concentration
Zn2+
-
at low concentration
additional information

both white and blue light pulses significantly inhibit AA-NAT activity at zeitgeber time ZT18, detailed overview
-
additional information
-
both white and blue light pulses significantly inhibit AA-NAT activity at zeitgeber time ZT18, detailed overview
-
additional information
-
strong substrate inhibition at 45°C
-
additional information
-
strong substrate inhibition at 45°C
-
additional information
-
inhibition values of peptide inhibitors
-
additional information
-
strong substrate inhibition at 45°C
-
additional information
-
strong substrate inhibition at 45°C
-
additional information
no inhibition by serotonin or tryptamin above 1 mM. No inhibition by melatonin
-
additional information
no inhibition by serotonin or tryptamin above 1 mM. No inhibition by melatonin
-
additional information
-
no inhibition by serotonin or tryptamin above 1 mM. No inhibition by melatonin
-
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Acidosis
Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells.
Acidosis
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
aralkylamine n-acetyltransferase deficiency
Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
aralkylamine n-acetyltransferase deficiency
Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice.
Arthus Reaction
Serotonin metabolism in the arthus reaction.
Asthma
N-acetyltransferases as markers for asthma and allergic/atopic disorders.
Astrocytoma
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Brain Injuries
Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats.
Brain Neoplasms
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Breast Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Breast Neoplasms
Altered Umbilical Cord Blood Nutrient Levels, Placental Cell Turnover and Transporter Expression in Human Term Pregnancies Conceived by Intracytoplasmic Sperm Injection (ICSI).
Breast Neoplasms
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
Breast Neoplasms
Melatonin pathway genes and breast cancer risk among Chinese women.
Breast Neoplasms
Polymorphisms in circadian genes, night work and breast cancer: results from the GENICA study.
Breast Neoplasms
SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?
Carcinogenesis
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Carcinogenesis
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
Carcinoma, Hepatocellular
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.
Carcinoma, Hepatocellular
Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells.
Choriocarcinoma
Human placental trophoblasts synthesize melatonin and express its receptors.
Chronobiology Disorders
The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase.
Colorectal Neoplasms
AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
Colorectal Neoplasms
Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-??
Colorectal Neoplasms
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
Endometrial Neoplasms
ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma.
Epilepsy
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy.
Glioma
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Infections
Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation.
Infections
Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa.
Infections
Structure of Mycobacterium smegmatis Eis in complex with paromomycin.
Infections
The Amino Acid-mTORC1 Pathway Mediates APEC TW-XM-Induced Inflammation in bEnd.3 Cells.
Insulin Resistance
Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night.
Insulin Resistance
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
Intestinal Volvulus
Characterization of the arylalkylamine N-acetyltransferase in Onchocerca volvulus.
Ischemic Attack, Transient
Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia.
Klatskin Tumor
Overexpression of Prdx1 in hilar cholangiocarcinoma: a predictor for recurrence and prognosis.
Liver Cirrhosis
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Liver Cirrhosis
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
Melanoma
Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.
Melanoma
Running for time: circadian rhythms and melanoma.
Melanoma
Serotoninergic and melatoninergic systems are fully expressed in human skin.
Melanoma
Serotoninergic system in hamster skin.
Melanosis
A New Arylalkylamine N-Acetyltransferase in Silkworm (Bombyx mori) Affects Integument Pigmentation.
Melanosis
Mutations of an arylalkylamine-n-acetyl transferase, BM-IAANAT, are responsible for the silkworm melanism mutant.
Neoplasm Metastasis
Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target.
Neoplasms
AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Neoplasms
Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth.
Neoplasms
ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma.
Neoplasms
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Neoplasms
Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing.
Neoplasms
Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells.
Neoplasms
STAT1-NF?B crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.
Neoplasms
The transport of glutamine into mammalian cells.
Neoplasms
TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway.
Nervous System Diseases
Selective tonicity-induced expression of the neutral amino-acid transporter SNAT2 in oligodendrocytes in rat brain following systemic hypertonicity.
Obesity
Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors.
Osteosarcoma
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Osteosarcoma
Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target.
Paraproteinemias
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
Peritonitis
Pineal arylalkylamine N-acetyl-transferase (Aanat) gene expression as a target of inflammatory mediators in the chicken.
Pulmonary Edema
Sodium coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance.
Retinoblastoma
Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells.
Retinoblastoma
The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression.
Rett Syndrome
Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity.
Sarcopenia
Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure.
Scoliosis
Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese.
Seizures
Differential molecular regulation of glutamate in kindling resistant rats.
Seizures
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy.
Sepsis
Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
Sleep Deprivation
AANAT1 functions in astrocytes to regulate sleep homeostasis.
Sleep Disorders, Circadian Rhythm
Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis.
Sleep Disorders, Circadian Rhythm
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome.
Sleep Disorders, Circadian Rhythm
The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population.
Sleep Wake Disorders
Computational Analysis of N-acetyl transferase in Tribolium castaneum.
Sleep Wake Disorders
Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism.
Squamous Cell Carcinoma of Head and Neck
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma.
Starvation
Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
Starvation
Characterization and Regulation of the Amino Acid Transporter SNAT2 in the Small Intestine of Piglets.
Starvation
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Starvation
Effects of starvation, re-feeding and timing of food supply on daily rhythm features of gut melatonin in carp (Catla catla).
Starvation
Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter-2 (SNAT2) cDNA expression in myoblasts.
Starvation
Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.
Starvation
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation.
Starvation
The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity.
Stroke
Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
Tuberculosis
Structure of Mycobacterium smegmatis Eis in complex with paromomycin.
Uterine Cervical Neoplasms
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Vitamin A Deficiency
Regulation of the expression of serotonin N-acetyltransferase gene in Japanese quail (Coturnix japonica): II. Effect of vitamin A deficiency.
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0.47
2,5-dimethoxyphenylethylamine
-
pH 6.8, 37°C
0.34 - 3.46
2-(2,3-dichlorophenyl)-ethylamine
0.9 - 2.74
2-(2-chlorophenyl)-ethylamine
1.76
2-(3,4-dihydroxyphenyl)-ethylamine
-
pH 6.8, 37°C
0.62 - 1.31
2-(3-chlorophenyl)-ethylamine
1.1 - 1.65
2-(3-fluorophenyl)-ethylamine
0.75 - 1.55
2-(4-bromophenyl)-ethylamine
2.33
2-(4-chlorophenyl)ethylamine
-
pH 6.8, 37°C
1.28 - 2.2
2-(4-fluorophenyl)-ethylamine
0.98 - 1.91
2-(p-fluorophenyl)-ethylamine
1.405
2-(p-nitrophenyl)-ethylamine
-
pH 6.8, 37°C
1.17 - 1.58
2-(p-tolyl)-ethylamine
1.37
2-fluorophenylethylamine
0.49 - 1.3
2-methoxyphenylethylamine
0.17 - 9.5
2-Phenylethylamine
0.18
3-(trifluoromethyl)phenethylamine
-
wild-type, pH 8.0, 22°C
2.07
3-methoxy-2-phenylethylamine
-
pH 6.8, 37°C
0.061
3-methoxyphenethylamine
-
wild-type, pH 8.0, 22°C
1.815
3-methoxytyramine
-
pH 6.8, 37°C
0.009
5-benzyloxytryptamine
-
wild-type, pH 8.0, 22°C
0.024
5-hydroxytryptamine
-
-
0.042 - 0.63
5-methoxytryptamine
1.9
6-Hydroxydopamine
pH 6.8, 37°C
0.00031 - 1.11
acetyl-CoA
0.0019
Arachidonoyl-CoA
pH 8.0, temperature not specified in the publication
0.26
beta-methylphenethylamine
-
wild-type, pH 8.0, 22°C
0.009 - 0.173
beta-phenylethylamine
0.0018 - 0.006
butanoyl-CoA
0.04
hexanoyl-CoA
-
wild-type, pH 8.0, 22°C
0.18 - 0.23
methoxytryptamine
0.05 - 0.17
norepinephrine
0.0036
oleoyl-CoA
pH 8.0, temperature not specified in the publication
0.0099
palmitoyl-CoA
pH 8.0, temperature not specified in the publication
0.32
phenethylamine
-
wild-type, pH 8.0, 22°C
0.34 - 11
Phenylethylamine
0.066 - 0.47
propionyl-CoA
0.006
stearoyl-CoA
pH 8.0, temperature not specified in the publication
additional information
additional information
-
0.34
2-(2,3-dichlorophenyl)-ethylamine

pH 6.8, 37°C
3.46
2-(2,3-dichlorophenyl)-ethylamine
-
pH 6.8, 37°C
0.9
2-(2-chlorophenyl)-ethylamine

-
pH 6.8, 37°C
2.74
2-(2-chlorophenyl)-ethylamine
pH 6.8, 37°C
0.62
2-(3-chlorophenyl)-ethylamine

pH 6.8, 37°C
1.31
2-(3-chlorophenyl)-ethylamine
-
pH 6.8, 37°C
1.1
2-(3-fluorophenyl)-ethylamine

pH 6.8, 37°C
1.65
2-(3-fluorophenyl)-ethylamine
-
pH 6.8, 37°C
0.75
2-(4-bromophenyl)-ethylamine

pH 6.8, 37°C
1.55
2-(4-bromophenyl)-ethylamine
-
pH 6.8, 37°C
1.28
2-(4-fluorophenyl)-ethylamine

-
pH 6.8, 37°C
2.2
2-(4-fluorophenyl)-ethylamine
pH 6.8, 37°C
0.98
2-(p-fluorophenyl)-ethylamine

pH 6.8, 37°C
1.91
2-(p-fluorophenyl)-ethylamine
-
pH 6.8, 37°C
1.17
2-(p-tolyl)-ethylamine

pH 6.8, 37°C
1.58
2-(p-tolyl)-ethylamine
-
pH 6.8, 37°C
1.37
2-fluorophenylethylamine

-
pH 6.8, 37°C
1.37
2-fluorophenylethylamine
pH 6.8, 37°C
0.49
2-methoxyphenylethylamine

-
pH 6.8, 37°C
1.3
2-methoxyphenylethylamine
pH 6.8, 37°C
0.17
2-Phenylethylamine

pH 6.8, 37°C
1.8
2-Phenylethylamine
-
pH 6.8, 37°C
9.5
2-Phenylethylamine
pH 6.8, 37°C
0.042
5-methoxytryptamine

-
wild-type, pH 8.0, 22°C
0.2
5-methoxytryptamine
-
-
0.63
5-methoxytryptamine
-
pH 7.8, 45°C
0.00031
acetyl-CoA

-
-
0.00142
acetyl-CoA
pH 7.4, 37°C
0.0061
acetyl-CoA
pH 8.0, temperature not specified in the publication
0.013
acetyl-CoA
-
mutant E26A, pH 8.0, 22°C
0.019
acetyl-CoA
-
mutant S171A, pH 8.0, 22°C
0.0287
acetyl-CoA
-
cosubstrate tryptamine
0.029
acetyl-CoA
-
wild-type, pH 8.0, 22°C
0.029
acetyl-CoA
-
mutant T167A/S171A, pH 8.0, 22°C
0.05
acetyl-CoA
-
cosubstrate tryptamine, pineal gland
0.12
acetyl-CoA
cosubstrate histamine, pH 7.0, 25°C
0.125
acetyl-CoA
-
cosubstrate tryptamine, liver
0.14
acetyl-CoA
-
mutant T167A, pH 8.0, 22°C
0.21
acetyl-CoA
-
mutant H206A, pH 8.0, 22°C
0.265
acetyl-CoA
-
pH 6.8, 37°C
0.27
acetyl-CoA
cosubstrate tyramine, pH 7.0, 25°C
0.48
acetyl-CoA
-
cosubstrate octopamine, pH 7.0, 25°C
0.53
acetyl-CoA
pH 6.8, 37°C
0.55
acetyl-CoA
-
mutant R138A, pH 8.0, 22°C
0.65
acetyl-CoA
pH 6.8, 37°C
1.11
acetyl-CoA
pH 6.8, 27°C
0.009
beta-phenylethylamine

-
-
0.173
beta-phenylethylamine
-
-
0.0018
butanoyl-CoA

pH 8.0, temperature not specified in the publication
0.006
butanoyl-CoA
-
wild-type, pH 8.0, 22°C
0.11
dopamine

pH not specified in the publication, temperature not specified in the publication
0.17
dopamine
-
wild-type, pH 8.0, 22°C
0.19
dopamine
-
pH 7.3, 22°C, recombinant aaNAT1
0.27
dopamine
-
pH 7.3, 22°C, recombinant aaNAT2
11
dopamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.0023
histamine

-
mutant H206A, pH 8.0, 22°C
0.0034
histamine
-
mutant S171A, pH 8.0, 22°C
0.0049
histamine
-
mutant R138A, pH 8.0, 22°C
0.0067
histamine
-
mutant T167A, pH 8.0, 22°C
0.013
histamine
-
mutant T167A/S171A, pH 8.0, 22°C
0.016
histamine
-
mutant E26A, pH 8.0, 22°C
0.52
histamine
-
cosubstrate acetyl-CoA, wild-type, pH 8.0, 22°C
1.92
histamine
-
pH 7.5, 22°C
2.8
histamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
2.9
histamine
-
cosubstrate butanoyl-CoA, wild-type, pH 8.0, 22°C
15
histamine
-
cosubstrate hexanoyl-CoA, wild-type, pH 8.0, 22°C
16
histamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.18
methoxytryptamine

-
pH 7.3, 22°C, recombinant aaNAT1
0.23
methoxytryptamine
-
pH 7.3, 22°C, recombinant aaNAT2
0.05
norepinephrine

pH not specified in the publication, temperature not specified in the publication
0.16
norepinephrine
-
pH 7.3, 22°C, recombinant aaNAT1
0.17
norepinephrine
-
pH 7.3, 22°C, recombinant aaNAT2
0.002
octopamine

-
-
0.07
octopamine
pH not specified in the publication, temperature not specified in the publication
0.12
octopamine
-
wild-type, pH 8.0, 22°C
0.13
octopamine
-
pH 7.3, 22°C, recombinant aaNAT2
0.14
octopamine
-
pH 7.3, 22°C, recombinant aaNAT1
0.94
octopamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
6.2
octopamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
30
octopamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.34
Phenylethylamine

-
11
Phenylethylamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.066
propionyl-CoA

-
cosubstrate octopamine, pH 7.0, 25°C
0.098
propionyl-CoA
cosubstrate tyramine, pH 7.0, 25°C
0.47
propionyl-CoA
cosubstrate histamine, pH 7.0, 25°C
0.05
serotonin

-
0.06
serotonin
-
wild-type enzyme
0.096
serotonin
-
wild-type enzyme with 14-3-3 protein
0.106
serotonin
-
wild-type enzyme with protein kinase A
0.16
serotonin
-
wild-type, pH 8.0, 22°C
0.23
serotonin
-
pH 7.3, 22°C, recombinant aaNAT1
0.232
serotonin
-
pH 7.8, 45°C
0.371
serotonin
pH 8.8, 45°C
0.42
serotonin
-
pH 7.3, 22°C, recombinant aaNAT2
0.467
serotonin
-
pH 8.8, 55°C
0.64
serotonin
-
pH 6.8, 37°C
1.35
serotonin
pH 6.8, 37°C
1.7
serotonin
pH 6.8, 37°C
2.05
serotonin
pH 6.8, 27°C
13
serotonin
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.0017
tryptamine

-
0.00331
tryptamine
pH 7.4, 37°C
0.026
tryptamine
-
wild-type, pH 8.0, 22°C
0.1
tryptamine
pH not specified in the publication, temperature not specified in the publication
0.16
tryptamine
-
pH 7.3, 22°C, recombinant aaNAT1
0.17
tryptamine
-
pH 6.8, 30°C, phosphorylated T31, unphosphorylated S205
0.17
tryptamine
-
pH 7.3, 22°C, recombinant aaNAT2
0.18
tryptamine
-
pH 6.8, 30°C, unphosphorylated enzyme
0.25
tryptamine
-
pH 6.8, 30°C, mutant enzyme S205A, phosphorylated T31
0.28
tryptamine
-
pH 6.8, 30°C, mutant enzyme S205A, unphosphorylated
0.291
tryptamine
-
pH 6.8, 37°C, mutant enzyme S192V
0.3
tryptamine
-
pH 6.8, 30°C, mutant enzyme T31A, phosphorylated S205
0.31
tryptamine
-
pH 6.8, 30°C, mutant enzyme T31A, unphosphorylated
0.317
tryptamine
-
pH 6.8, 37°C, mutant enzyme T29V/S203G
0.33
tryptamine
pH 6.8, 37°C, recombinant wild-type enzyme
0.344
tryptamine
-
pH 6.8, 37°C, mutant enzyme T127V
0.361
tryptamine
-
pH 6.8, 37°C, wild-type enzyme
0.413
tryptamine
-
pH 6.8, 37°C, mutant enzyme T29V
0.417
tryptamine
-
pH 6.8, 37°C, mutant enzyme S203G
0.53
tryptamine
-
pineal gland
1.4
tryptamine
pH 6.8, 27°C
2.3
tryptamine
pH 6.8, 37°C, recombinant mutant I57A/V59A
4
tryptamine
above, pH 6.8, 37°C, recombinant mutants P64A, P64G, P64W, and recombinant truncation mutants
4.3
tryptamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.0015
tyramine

-
-
0.042
tyramine
-
wild-type, pH 8.0, 22°C
0.17
tyramine
-
pH 7.3, 22°C, recombinant aaNAT1
0.23
tyramine
-
pH 7.3, 22°C, recombinant aaNAT2
0.56
tyramine
pH not specified in the publication, temperature not specified in the publication
57
tyramine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
additional information
additional information

-
apparent Km-values
-
additional information
additional information
-
apparent Km-values
-
additional information
additional information
formation and cleavage of a disulfide bond produce active/inactive states of enzyme
-
additional information
additional information
-
exposing chickens to light in the middle of the night increased the apparent Km of AANAT for tryptamine by about 10fold. The Km began to increase within 5 min of exposure to light and reached a maximum at about 30 min
-
additional information
additional information
-
kinetics of recombinant partially phosphorylated wild-type and mutant enzymes, overview
-
additional information
additional information
kinetics of recombinant wild-type and mutant enzymes, substrate tryptamine, overview
-
additional information
additional information
-
AANAT2 kinetic constants as a function of temperature, overview
-
additional information
additional information
-
AANAT2 kinetic constants as a function of temperature, overview
-
additional information
additional information
-
AANAT2 kinetic constants as a function of temperature, overview
-
additional information
additional information
-
AANAT2 kinetics in relation to temperature, overview
-
additional information
additional information
-
AANAT2 kinetics in relation to temperature, overview
-
additional information
additional information
-
Michaelis-Menten kinetic analysis
-
additional information
additional information
both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b
-
additional information
additional information
both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b
-
additional information
additional information
both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b
-
additional information
additional information
-
both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
40
3-(trifluoromethyl)phenethylamine
-
wild-type, pH 8.0, 22°C
26
3-methoxyphenethylamine
-
wild-type, pH 8.0, 22°C
5.7
5-benzyloxytryptamine
-
wild-type, pH 8.0, 22°C
13.1
5-methoxytryptamine
-
wild-type, pH 8.0, 22°C
0.043
Arachidonoyl-CoA
pH 8.0, temperature not specified in the publication
29
beta-methylphenethylamine
-
wild-type, pH 8.0, 22°C
0.093
hexanoyl-CoA
-
wild-type, pH 8.0, 22°C
3.74 - 7.69
methoxytryptamine
3.17 - 7.76
norepinephrine
0.075
oleoyl-CoA
pH 8.0, temperature not specified in the publication
0.16
palmitoyl-CoA
pH 8.0, temperature not specified in the publication
42
phenethylamine
-
wild-type, pH 8.0, 22°C
7.2
Phenylethylamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.059
stearoyl-CoA
pH 8.0, temperature not specified in the publication
1.01
acetyl-CoA

-
mutant E26A, pH 8.0, 22°C
1.3
acetyl-CoA
pH 8.0, temperature not specified in the publication
1.61
acetyl-CoA
-
mutant T167A/S171A, pH 8.0, 22°C
1.84
acetyl-CoA
-
mutant T167A, pH 8.0, 22°C
5.6
acetyl-CoA
cosubstrate histamine, pH 7.0, 25°C
8.6
acetyl-CoA
-
mutant S171A, pH 8.0, 22°C
9.6
acetyl-CoA
-
mutant H206A, pH 8.0, 22°C
29
acetyl-CoA
cosubstrate tyramine, pH 7.0, 25°C
32
acetyl-CoA
-
wild-type, pH 8.0, 22°C
38
acetyl-CoA
-
cosubstrate octopamine, pH 7.0, 25°C
88
acetyl-CoA
-
mutant R138A, pH 8.0, 22°C
0.53
butanoyl-CoA

pH 8.0, temperature not specified in the publication
0.66
butanoyl-CoA
-
wild-type, pH 8.0, 22°C
2.8
dopamine

-
cosubstrate acetyl-CoA, pH 7.0, 25°C
3.65
dopamine
-
pH 7.3, 22°C, recombinant aaNAT2
7.3
dopamine
-
pH 7.3, 22°C, recombinant aaNAT1
21
dopamine
-
wild-type, pH 8.0, 22°C
0.1
histamine

-
cosubstrate hexanoyl-CoA, wild-type, pH 8.0, 22°C
0.48
histamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.5
histamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
0.87
histamine
-
cosubstrate butanoyl-CoA, wild-type, pH 8.0, 22°C
1.39
histamine
-
mutant E26A, pH 8.0, 22°C
1.9
histamine
-
mutant T167A, pH 8.0, 22°C
2.2
histamine
-
mutant T167A/S171A, pH 8.0, 22°C
7.7
histamine
-
mutant H206A, pH 8.0, 22°C
10.4
histamine
-
mutant S171A, pH 8.0, 22°C
30
histamine
-
cosubstrate acetyl-CoA, wild-type, pH 8.0, 22°C
71
histamine
-
mutant R138A, pH 8.0, 22°C
3.74
methoxytryptamine

-
pH 7.3, 22°C, recombinant aaNAT2
7.69
methoxytryptamine
-
pH 7.3, 22°C, recombinant aaNAT1
3.17
norepinephrine

-
pH 7.3, 22°C, recombinant aaNAT2
7.76
norepinephrine
-
pH 7.3, 22°C, recombinant aaNAT1
1.8
octopamine

cosubstrate acetyl-CoA, pH 7.0, 25°C
2.56
octopamine
-
pH 7.3, 22°C, recombinant aaNAT2
3.1
octopamine
cosubstrate acetyl-CoA, pH 7.0, 25°C
4
octopamine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
7.26
octopamine
-
pH 7.3, 22°C, recombinant aaNAT1
16
octopamine
-
wild-type, pH 8.0, 22°C
0.6
propionyl-CoA

cosubstrate histamine, pH 7.0, 25°C
2.3
propionyl-CoA
-
cosubstrate octopamine, pH 7.0, 25°C
2.7
propionyl-CoA
cosubstrate tyramine, pH 7.0, 25°C
1.5
serotonin

-
cosubstrate acetyl-CoA, pH 7.0, 25°C
3.47
serotonin
-
pH 7.3, 22°C, recombinant aaNAT2
7.545
serotonin
-
pH 7.3, 22°C, recombinant aaNAT1
17
serotonin
-
wild-type, pH 8.0, 22°C
17.3
serotonin
-
wild-type enzyme
20.3
serotonin
-
wild-type enzyme with 14-3-3 protein
25.9
serotonin
-
wild-type enzyme with protein kinase A
3
tryptamine

-
cosubstrate acetyl-CoA, pH 7.0, 25°C
3.05
tryptamine
-
pH 7.3, 22°C, recombinant aaNAT2
7.345
tryptamine
-
pH 7.3, 22°C, recombinant aaNAT1
16
tryptamine
-
wild-type, pH 8.0, 22°C
3.16
tyramine

-
pH 7.3, 22°C, recombinant aaNAT2
6.775
tyramine
-
pH 7.3, 22°C, recombinant aaNAT1
18
tyramine
-
cosubstrate acetyl-CoA, pH 7.0, 25°C
238
tyramine
-
wild-type, pH 8.0, 22°C
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