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Information on EC 2.3.1.84 - alcohol O-acetyltransferase
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EC Tree
2.3.1.84 alcohol O-acetyltransferaseIUBMB Comments
Acts on a range of short-chain aliphatic alcohols, including methanol and ethanol
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Word Map
- 2.3.1.84
-
isoamyl
-
sake
- fruity
-
kyokai
- tatase
-
2-phenylethyl
- uvarum
-
wickerhamomyces
- l-asp
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self-cloning
- synthesis
- hanseniaspora
-
acetate-producing
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brewery
- biotechnology
- nutrition
- analysis
- food industry
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
aatase, alcohol acetyltransferase, lg-atf1, phcfat, aatfase, cfat1, alcohol acetyltransferase atf1, rhaat, coniferyl alcohol acetyltransferase, alcohol acetyl transferase i, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AAT
AATFase
acetyltransferase, alcohol
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-
-
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alcohol acetyl-transferase
alcohol acetyltransferase
ATF1
ATF2
alcohol acetyltransferase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + a primary alcohol = CoA + an acetyl ester
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
esterification
Acyl group transfer
Acyl group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:alcohol O-acetyltransferase
Acts on a range of short-chain aliphatic alcohols, including methanol and ethanol
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CAS REGISTRY NUMBER
COMMENTARY
80237-89-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-methylthio-1-propanol + acetyl-CoA
3-(methylthio)propyl acetate + CoA
-
-
-
?
acetyl-CoA + (-)-beta-citronellol
CoA + (-)-beta-citronellyl acetate
-
-
-
-
?
acetyl-CoA + (Z)-11-tetradecen-1-ol
CoA + (Z)-11-tetradecenyl acetate
-
-
-
?
acetyl-CoA + (Z)-9-dodecen-1-ol
CoA + (Z)-9-dodecenyl acetate
-
-
-
?
acetyl-CoA + (Z)-9-hexadecen-1-ol
CoA + (Z)-9-hexadecenyl acetate
-
-
-
?
acetyl-CoA + (Z)-9-tetradecen-1-ol
CoA + (Z)-9-tetradecenyl acetate
-
-
-
?
acetyl-CoA + 2-phenylethyl alcohol
CoA + 2-phenylethyl acetate
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relative activity: 100%
-
-
?
acetyl-CoA + geranyl alcohol
CoA + geranyl acetate
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about 12% of the activity with benzyl alcohol. Product not found in papaya fruit
-
?
acetyl-CoA + n-butanol
CoA + butyl acetate
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relative activity: 17%
-
-
?
acetyl-CoA + phenylethanol
CoA + phenylethyl acetate
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about 3% of the activity with benzyl alcohol. Product not found in papaya fruit
-
?
butanoyl-CoA + butanol
CoA + butyl butanoate
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product is found in papaya fruit
-
?
butanoyl-CoA + ethanol
CoA + ethyl butanoate
poor substrates
product is found in papaya fruit
-
?
hexanoyl-CoA + butanol
CoA + butyl hexanoate
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product is found in papaya fruit
-
?
hexanoyl-CoA + ethanol
CoA + ethyl hexanoate
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product is found in papaya fruit
-
?
hexanoyl-CoA + methanol
CoA + methyl hexanoate
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product is found in papaya fruit
-
?
propionyl-CoA + cinnamyl alcohol
CoA + cinnamyl propionate
-
-
-
?
sinapyl alcohol + acetyl-CoA
sinapyl acetate + CoA
71% of the activity with coniferyl alcohol
-
-
?
acetyl-CoA + 2-phenylethanol
CoA + 2-phenylethyl acetate
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-
-
-
?
acetyl-CoA + 2-phenylethanol
CoA + 2-phenylethyl acetate
Saccharomyces kudriavzevii IFO1802
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-
-
-
?
acetyl-CoA + benzyl alcohol
CoA + benzyl acetate
-
-
-
?
acetyl-CoA + butanol
CoA + butyl acetate
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less than 0.01% of the activity with benzyl alcohol. Product is found in papaya fruit
-
?
acetyl-CoA + cinnamyl alcohol
CoA + cinnamyl acetate
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about 7.5% of the activity with benzyl alcohol. Product not found in papaya fruit
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?
acetyl-CoA + ethanol
CoA + ethyl acetate
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relative activity: 27%
-
-
?
acetyl-CoA + ethanol
CoA + ethyl acetate
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very poor substrate. Product is found in papaya fruit
-
?
acetyl-CoA + hexanol
CoA + hexyl acetate
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about 0.1% of the activity with benzyl alcohol. Product is found in papaya fruit
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?
acetyl-CoA + indole-3-ethanol
CoA + indole-3-ethanol acetate
-
-
-
-
?
acetyl-CoA + indole-3-ethanol
CoA + indole-3-ethanol acetate
Saccharomyces cerevisiae YPH499
-
-
-
-
?
acetyl-CoA + isoamyl alcohol
CoA + isoamyl acetate
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relative activity: 73%
-
-
?
acetyl-CoA + octanol
CoA + octyl acetate
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about 0.2% of the activity with benzyl alcohol. Product is found in papaya fruit
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?
isoamylalcohol + acetyl-CoA
isoamyl acetate + CoA
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-
-
-
?
isoamylalcohol + acetyl-CoA
isoamyl acetate + CoA
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slightly higher activity with straight-chain alcohols than with branched-chain alcohols, activity with straight-chain alcohols in descending order: pentanol, butanol, propanol, very low activity with ethanol, activity with branched-chain alcohols in descending order of carbon number: C5, C4, C3
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?
isoamylalcohol + acetyl-CoA
isoamyl acetate + CoA
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alcohol acetyltransferase 2 is probably the key enzyme in a steroid detoxification mechanism, alcohol acetyltransferase 1 accounts for 80% of isoamyl acetate production and 30% of ethyl acetate production and might be involved in fatty acid metabolism
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?
additional information
?
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no sustrates: methanol, ethanol, isopropanol, isoamylalcohol, linalool, menthol, carveol, 1-phenylethanol, tertiary butyl alcohol
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?
additional information
?
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activity of alcohol acyl-CoA transferase, a key enzyme in ester biosynthesis, shows an ethylene dependent pattern of regulation
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?
additional information
?
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alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways, ATF1 is repressed by heat and ethanol stress
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?
additional information
?
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expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters
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?
additional information
?
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expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters
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?
additional information
?
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localization of Atf1p in lipid particles may indicate that Atf1p has a specific role in the lipid and/or sterol metabolism that takes place in these particles
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?
additional information
?
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isoform ATF1 is capable of acetylating moth pheromone fatty alcohols with chain lengths from 10 to 18 carbons with up to 27- and 10-fold higher in vivo and in vitro efficiency, respectiviely, compared to plant-derived diacylglycerol acetyltransferase EaDAcT, EC 2.3.1.20
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-
?
additional information
?
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isoform ATF1 is capable of acetylating moth pheromone fatty alcohols with chain lengths from 10 to 18 carbons with up to 27- and 10-fold higher in vivo and in vitro efficiency, respectiviely, compared to plant-derived diacylglycerol acetyltransferase EaDAcT, EC 2.3.1.20
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-
?
additional information
?
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Atf1 uses acetyl-CoA to synthesize acetate esters from all of the alcohols tested. Atf1 is specific for acetyl-CoA. Additionally, Atf1 can hydrolyse all of the acyl-CoA substrates tested, with a clear preference for C8 chain lengths
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additional information
?
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no activity is registered for the formation of hexyl hexanoate
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
isoamylalcohol + acetyl-CoA
isoamyl acetate + CoA
-
alcohol acetyltransferase 2 is probably the key enzyme in a steroid detoxification mechanism, alcohol acetyltransferase 1 accounts for 80% of isoamyl acetate production and 30% of ethyl acetate production and might be involved in fatty acid metabolism
-
?
acetyl-CoA + indole-3-ethanol
CoA + indole-3-ethanol acetate
-
-
-
-
?
acetyl-CoA + indole-3-ethanol
CoA + indole-3-ethanol acetate
Saccharomyces cerevisiae YPH499
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-
-
-
?
additional information
?
-
-
activity of alcohol acyl-CoA transferase, a key enzyme in ester biosynthesis, shows an ethylene dependent pattern of regulation
-
-
?
additional information
?
-
-
alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways, ATF1 is repressed by heat and ethanol stress
-
-
?
additional information
?
-
expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters
-
-
?
additional information
?
-
-
expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters
-
-
?
additional information
?
-
-
localization of Atf1p in lipid particles may indicate that Atf1p has a specific role in the lipid and/or sterol metabolism that takes place in these particles
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
not stimulatory: Li+, K+, Na+, Ni+, Mn2+, Hg2+, Zn2+ and Cu2++
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
oxygen
-
inhibits activity to a greater extent for isoamylacetate production than for ethyl acetate production
5,5'-dithiobis(2-nitrobenzoate)