Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase and Organism(s) Enterococcus faecalis and UniProt Accession P0A0C2

for references in articles please use BRENDA:EC2.3.1.82
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Enterococcus faecalis
UNIPROT: P0A0C2
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Enterococcus faecalis
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
aac(6')-ib-cr, aac(6')-ib, aaca-aphd, aac(6'), aac(6')-i, aac(6')-ii, aminoglycoside 6'-n-acetyltransferase, aac(6')-im, aac(6')-ie, aac(6')-iy, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AAC(6')-Ie/APH(2'')-Ia
-
aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia
-
AAC(6')
-
-
-
-
acetyltransferase, aminoglycoside 6'-N-
-
-
-
-
acetyltransferase, kanamycin
-
-
-
-
aminoglycoside 6'-N-acetyltransferase
-
-
-
-
aminoglycoside-6'-acetyltransferase
-
-
-
-
aminoglycoside-6'-N-acetyltransferase
-
-
-
-
aminoglycoside-6-N-acetyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:kanamycin-B N6'-acetyltransferase
The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated.
CAS REGISTRY NUMBER
COMMENTARY hide
56467-65-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, additionally catalyzes reaction of EC 2.7.1.190
UniProt
Manually annotated by BRENDA team
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
apication of the aacA-aphD gene as an efficient marker for plastid transformation. It produces similar numbers of transplastomic lines as the spectinomycin resistance gene aadA. When tethered to plastid expression signals, the aac6-aph2 gene provides sufficiently strong resistance to tobramycin and gentamicin to select plastid transformants in tobacco
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Filipova, M.; Bujdakova, H.; Drahovska, H.; Liskova, A.; Hanzen, J.
Occurrence of aminoglycoside-modifying-enzyme genes aac(6)-aph(2"), aph(3), ant(4) and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin
Folia Microbiol. (Praha)
51
57-61
2006
Enterococcus faecalis
Manually annotated by BRENDA team
Tabatabaei, I.; Ruf, S.; Bock, R.
A bifunctional aminoglycoside acetyltransferase/phosphotransferase conferring tobramycin resistance provides an efficient selectable marker for plastid transformation
Plant Mol. Biol.
93
269-281
2017
Enterococcus faecalis (P0A0C2), Enterococcus faecalis ATCC 700802 (P0A0C2)
Manually annotated by BRENDA team