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Information on EC 2.3.1.79 - maltose O-acetyltransferase and Organism(s) Escherichia coli and UniProt Accession P77791
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2.3.1.79 maltose O-acetyltransferaseIUBMB Comments
Not identical with EC 2.3.1.18, galactoside O-acetyltransferase. The acetyl group is added exclusively to the C6 position of glucose and to the C6 position of the non-reducing glucose residue of maltose . Other substrates of this enzyme are glucose, which is a better substrate than maltose , and mannose and frucose, which are poorer substrates than maltose . Isopropyl-beta-thio-galactose, which is a good substrate for EC 2.3.1.118 is a poor substrate for this enzyme .
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Word Map
- 2.3.1.79
-
left-handed
-
acetyl-coa-dependent
-
beta-helix
- maltotriose
-
acetyl-coenzyme
- amylomaltase
- phosphorylase
-
glucosyl
- maltodextrins
- nutrition
The taxonomic range for the selected organisms is: Escherichia coli
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
maltose o-acetyltransferase, maltose transacetylase, maa gene product, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
maltose transacetylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:maltose O-acetyltransferase
Not identical with EC 2.3.1.18, galactoside O-acetyltransferase. The acetyl group is added exclusively to the C6 position of glucose and to the C6 position of the non-reducing glucose residue of maltose [3]. Other substrates of this enzyme are glucose, which is a better substrate than maltose [2], and mannose and frucose, which are poorer substrates than maltose [2]. Isopropyl-beta-thio-galactose, which is a good substrate for EC 2.3.1.118 is a poor substrate for this enzyme [3].
CAS REGISTRY NUMBER
COMMENTARY
81295-47-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 3-O-methyl-D-glucopyranose
CoA + 6-O-acetyl-3-O-methyl-D-glucopyranose
-
-
-
?
acetyl-CoA + 4-nitrophenyl alpha-D-glucopyranoside
CoA + 4-nitrophenyl 6-O-acetyl-alpha-D-glucopyranoside
-
-
-
?
acetyl-CoA + 4-nitrophenyl alpha-D-maltoside
CoA + 4-nitrophenyl 4-O-(6-O-acetyl-alpha-D-glucopyranosyl)-alpha-D-glucopyranoside
-
-
-
?
acetyl-CoA + 4-nitrophenyl beta-D-glucopyranoside
CoA + 4-nitrophenyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + 4-nitrophenyl beta-D-maltoside
CoA + 4-nitrophenyl 4-O-(6-O-acetyl-alpha-D-glucopyranosyl)-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + isomaltose
CoA + 6-O-(6-O-acetyl-alpha-D-glucopyranosyl)-D-glucopyranose
-
-
-
?
acetyl-CoA + isopropyl beta-D-thiogalactoside
CoA + isopropyl 6-O-acetyl-beta-D-thiogalactoside
-
-
-
?
acetyl-CoA + isopropyl beta-D-thioglucopyranoside
CoA + isopropyl 6-O-acetyl-beta-D-thioglucopyranoside
-
-
-
?
acetyl-CoA + lactose
CoA + 4-O-(6-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranose
-
-
-
?
acetyl-CoA + maltopentaose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
-
-
-
?
acetyl-CoA + maltose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose
-
-
-
?
acetyl-CoA + maltotetraose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
-
-
-
?
acetyl-CoA + methyl alpha-D-glucopyranoside
CoA + methyl 6-O-acetyl-alpha-D-glucopyranoside
-
-
-
?
acetyl-CoA + methyl beta-D-glucopyranoside
CoA + methyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-decyl beta-D-glucopyranoside
CoA + n-decyl 6-O-acetyl-beta-D-glucopyranoside
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-
-
?
acetyl-CoA + n-decyl beta-D-maltoside
CoA + n-decyl 4-O-(6-O-acetyl-alpha-D-glucopyranosyl)-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-dodecyl beta-D-maltoside
CoA + n-dodecyl 4-O-(6-O-acetyl-alpha-D-glucopyranosyl)-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-heptyl beta-D-glucopyranoside
CoA + n-heptyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-heptyl beta-D-thioglucopyranoside
CoA + n-heptyl 6-O-acetyl-beta-D-thioglucopyranoside
-
-
-
?
acetyl-CoA + n-hexyl beta-D-glucopyranoside
CoA + n-hexyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-nonyl beta-D-glucopyranoside
CoA + n-nonyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-octyl alpha-glucopyranoside
CoA + n-octyl 6-O-acetyl-alpha-glucopyranoside
-
-
-
?
acetyl-CoA + n-octyl beta-D-glucopyranoside
CoA + n-octyl 6-O-acetyl-beta-D-glucopyranoside
-
-
-
?
acetyl-CoA + n-octyl beta-D-thioglucopyranoside
CoA + n-octyl 6-O-acetyl-beta-D-thioglucopyranoside
-
-
-
?
acetyl-CoA + nigerose
CoA + 3-O-(6-O-acetyl-alpha-D-glucopyranosyl)-D-glucopyranose
-
-
-
?
acetyl-CoA + sucrose
CoA + beta-D-fructofuranosyl 6-O-acetyl-alpha-D-glucopyranoside
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-
-
?
acetyl-CoA + maltotriose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
-
-
-
-
?
acetyl-CoA + thiomaltose
CoA + 4-S-(6-O-acetyl-alpha-D-glucopyranosyl)-4-thio-D-glucopyranose
-
-
-
-
?
acetyl-CoA + maltose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose
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-
-
-
?
acetyl-CoA + maltose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose
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enzyme does not use maltodextrins larger than maltose as a substrate
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-
?
additional information
?
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fucose and myo-inositol are not substrates, glucose-1-phosphate, UDP-glucose or ADP-glucose are very poor substrates or nonsubstrates, C6 glucose derivatives are not substrates
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?
additional information
?
-
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fucose and myo-inositol are not substrates, glucose-1-phosphate, UDP-glucose or ADP-glucose are very poor substrates or nonsubstrates, C6 glucose derivatives are not substrates
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-
?
additional information
?
-
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rhamnose, arabinose, lactose, isopropyl-1-thio-beta-D-galactoside and trehalose are not substrates
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-
?
additional information
?
-
-
strains lacking MalQ and maltose transacetylase are tested for their ability to accumulate maltose. At 1.8 nM external maltose, the ratio of internal to external maltose concentration under equilibrium conditions reaches 10ooooo to 1 but declines at higher external maltose concentrations. The maximal internal level of maltose at increasing external maltose concentrations is around 100 mM
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + maltose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose
-
-
-
?
acetyl-CoA + maltose
CoA + 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose
-
-
-
-
?
additional information
?
-
-
strains lacking MalQ and maltose transacetylase are tested for their ability to accumulate maltose. At 1.8 nM external maltose, the ratio of internal to external maltose concentration under equilibrium conditions reaches 10ooooo to 1 but declines at higher external maltose concentrations. The maximal internal level of maltose at increasing external maltose concentrations is around 100 mM
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystals belong to space group C222(1), a 64.7 A, b 106.6 A and c 0 176.0 A
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, enzyme stored frozen in presence of 0.1% 2-mercaptoethanol and 40% glycerol without appreciable loss of activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nutrition
biotechnologically attractive for the modification of starch and maltooligosaccharides
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Freundlieb, S.; Boos, W.
Maltose transacetylase of Escherichia coli: A preliminary report
Ann. Microbiol.
133 A
181-189
1982
Escherichia coli
Brand, B.; Boos, W.
Maltose transacetylase of Escherichia coli. Mapping and cloning of its structural, gene, mac, and characterization of the enzyme as a dimer of identical polypeptides with a molecular weight of 20,000
J. Biol. Chem.
266
14113-14118
1991
Escherichia coli
Lo Leggio, L.; Dal Degan, F.; Poulsen, P.; Moeller Andersen, S.; Larsen, S.
The structure and specificity of Escherichia coli maltose acetyltransferase give new insight into the LacA family of acyltransferases
Biochemistry
42
5225-5235
2003
Bacillus subtilis (P37515), Escherichia coli (P77791), Escherichia coli
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