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Information on EC 2.3.1.75 - long-chain-alcohol O-fatty-acyltransferase and Organism(s) Homo sapiens and UniProt Accession Q6ZPD8

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EC Tree
IUBMB Comments
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q6ZPD8
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
acyl-coa:retinol acyltransferase, wax synthase, wax ester synthase, awat2, wax ester synthase/diacylglycerol acyltransferase, atfa1, awat1, wax ester synthase/acyl-coenzyme a:diacylglycerol acyltransferase, maqu_0168, acyl-coa:alcohol transacylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acyl CoA wax alcohol acyltransferase 1
280889
-
acyl CoA wax alcohol acyltransferase 2
277361
-
acyl-CoA wax alcohol acyltransferase
277361, 280820, 280889
-
acyl-CoA wax alcohol acyltransferase 2
247
-
acyl-CoA wax alcohol acyltransferases
277361, 280889
-
acyl-CoA:fatty acyl alcohol acyltransferase
247, 277361
-
acyl-CoA:retinol acyltransferase
247
-
acyltransferase, long-chain alcohol
-
-
-
0
ArAT
247
-
AWAT
277361, 280820, 280889
-
AWAT 1
280889
-
AWAT 2
277361, 280889
-
AWAT1
280889
-
AWAT2
multifunctional O-acyltransferase
wax synthase
wax-ester synthase
-
-
-
0
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
0
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:long-chain-alcohol O-acyltransferase
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
CAS REGISTRY NUMBER
COMMENTARY hide
64060-40-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + long-chain diacylglycerol
CoA + long-chain triacylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain fatty alcohol
CoA + long-chain fatty ester
show the reaction diagram
-
-
-
?
1,2-hexadecandiol + palmitoyl-CoA
?
show the reaction diagram
-
-
-
?
1-hexadecanol + palmitoyl-CoA
CoA + hexadecylpalmitate
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain diacylglycerol
CoA + long-chain triacylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain fatty alcohol
CoA + long-chain fatty ester
show the reaction diagram
-
-
-
?
cetyl alcohol + oleoyl-CoA
CoA + cetyloleate
show the reaction diagram
-
-
-
?
linear long-chain alcohol + oleoyl-CoA
?
show the reaction diagram
-
-
-
?
linear long-chain alcohol + palmitoleoyl-CoA
?
show the reaction diagram
-
-
-
?
linear long-chain alcohol + palmitoyl-CoA
?
show the reaction diagram
-
-
-
?
linear long-chain alcohol + stearoyl-CoA
?
show the reaction diagram
-
-
-
?
oleoyl-CoA + (9Z)-hexadec-9-en-1-ol
CoA + (9Z)-hexadec-9-en-1-yl (9Z)-octadec-9-enoate
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-decanol
CoA + decyl oleate
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-octadecanol
CoA + octadecyl oleate
show the reaction diagram
-
-
-
?
oleoyl-CoA + cetyl alcohol
CoA + cetyl oleate
show the reaction diagram
-
-
-
?
oleoyl-CoA + decanol
CoA + decyl oleate
show the reaction diagram
-
-
-
?
oleoyl-CoA + eicosanol
CoA + icosyl (9Z)-octadec-9-enoate
show the reaction diagram
-
-
-
?
oleoyl-CoA + oleic alcohol
CoA + (9Z)-octadec-9-en-1-yl (9Z)-octadec-9-enoate
show the reaction diagram
-
-
-
?
palmitoleoyl-CoA + cetyl alcohol
CoA + cetyl palmitoleate
show the reaction diagram
-
-
-
?
palmitoleyl alcohol + oleoyl-CoA
CoA + palmitoleyl oleate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1,2-hexadecandiol
?
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 11-cis-retinol
11-cis-retinyl palmitate + CoA
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + all-trans-retinol
?
show the reaction diagram
-
-
-
?
palmitoyl-CoA + cetyl alcohol
CoA + cetyl palmitate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + dioleoylglycerol
?
show the reaction diagram
-
-
-
?
palmitoyl-CoA + hexadecanol
CoA + hexadecyl palmitate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + monooleoylglycerol
?
show the reaction diagram
-
-
-
?
stearoyl-CoA + cetyl alcohol
CoA + cetyl stearate
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + long-chain diacylglycerol
CoA + long-chain triacylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain fatty alcohol
CoA + long-chain fatty ester
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain diacylglycerol
CoA + long-chain triacylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + long-chain fatty alcohol
CoA + long-chain fatty ester
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 11-cis-retinol
11-cis-retinyl palmitate + CoA
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.1
AWAT1, sequence calculation
9.4
AWAT2, sequence calculation
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene DGAT2L6; isozyme DC3
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
predominant expression
Manually annotated by BRENDA team
very low expression level
Manually annotated by BRENDA team
very low expression level
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DG2L6_HUMAN
337
0
38593
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37759
x * 37759, AWAT1, sequence calculation
38094
x * 38094, AWAT2, sequence calculation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene DC3, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae
chromosomal location, expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells and in COS-7 cells
gene AWAT1, i.e. DGA2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae
gene DC4, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae
gene DC4, i.e. AWAT2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae
gene DGAT2, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae
isozyme AWAT1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
isozyme AWAT2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
MFAT, DNA and amino acid sequence determination and analysis, localized on the X chromosome, expression of the N-terminally FLAG-tagged enzyme in Spodoptera frugierda Sf9 cells using the baculovirus transfection system, or in COS-7 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheng, J.B.; Russell, D.W.
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family
J. Biol. Chem.
279
37798-37807
2004
Mus musculus (Q6E1M8), Mus musculus, Homo sapiens (Q6E213)
Manually annotated by BRENDA team
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens, Homo sapiens (Q6E213)
Manually annotated by BRENDA team
Turkish, A.R.; Henneberry, A.L.; Cromley, D.; Padamsee, M.; Oelkers, P.; Bazzi, H.; Christiano, A.M.; Billheimer, J.T.; Sturley, S.L.
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily
J. Biol. Chem.
280
14755-14764
2005
Homo sapiens (Q58HT5), Homo sapiens (Q6E213), Homo sapiens (Q6ZPD8), Homo sapiens
Manually annotated by BRENDA team
Holmes, R.
Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT)
Comp. Biochem. Physiol. D
5
45-54
2010
Monodelphis domestica, Mus musculus (A2ADU9), Mus musculus (Q6E1M8), Mus musculus, Homo sapiens (Q58HT5), Homo sapiens (Q6E213), Homo sapiens
Manually annotated by BRENDA team
Blaner, W.
Acyl-CoA wax alcohol acyltransferase 2 Its regulation and actions in support of color vision
J. Lipid Res.
58
633-635
2017
Homo sapiens
Manually annotated by BRENDA team
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