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Information on EC 2.3.1.75 - long-chain-alcohol O-fatty-acyltransferase and Organism(s) Mus musculus and UniProt Accession Q6E1M8

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EC Tree
IUBMB Comments
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
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Select one or more organisms in this record:
This record set is specific for:
Mus musculus
UNIPROT: Q6E1M8
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The taxonomic range for the selected organisms is: Mus musculus
Synonyms
acyl CoA wax alcohol acyltransferase 1, acyl CoA wax alcohol acyltransferase 2, acyl CoA:long-chain fatty alcohol O-acyltransferase, acyl-CoA wax alcohol acyltransferase, acyl-CoA wax alcohol acyltransferases, acyl-CoA:alcohol transacylase, acyl-CoA:fatty acyl alcohol acyltransferase, acyltransferase, long-chain alcohol, ATF, AtfA, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acyl CoA wax alcohol acyltransferase 1
290247
-
acyl CoA wax alcohol acyltransferase 2
277360
-
acyl CoA:long-chain fatty alcohol O-acyltransferase
244
-
acyltransferase, long-chain alcohol
-
-
-
-
AWAT1
290247
-
AWAT2
277360
-
wax monoester synthase
244
-
wax synthase
wax-ester synthase
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:long-chain-alcohol O-acyltransferase
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
CAS REGISTRY NUMBER
COMMENTARY hide
64060-40-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
lauryl-CoA + tetradecanol
tetradecanyl laurate + CoA
show the reaction diagram
-
-
-
-
?
myristoyl-CoA + dodecan-1-ol
dodecan-1-yl myristate + CoA
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + hexadecanol
hexadecanyl palmitate + CoA
show the reaction diagram
-
-
-
-
?
1,2-hexadecandiol + palmitoyl-CoA
?
show the reaction diagram
-
-
-
-
?
1-hexadecanol + palmitoyl-CoA
CoA + hexadecylpalmitate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1,2-hexadecandiol + palmitoyl-CoA
?
show the reaction diagram
-
-
-
-
?
1-hexadecanol + palmitoyl-CoA
CoA + hexadecylpalmitate
show the reaction diagram
-
-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.5
AWAT2, sequence calculation
8.9
AWAT1, sequence calculation
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
membrane of endoplasmic reticulum
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
AWAT2_MOUSE
333
1
38145
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
38145
x * 38145, AWAT2, sequence calculation
37573
x * 37573, AWAT1, sequence calculation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 38145, AWAT2, sequence calculation
?
x * 37573, AWAT1, sequence calculation
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N36R
-
mutant enzyme is capable of synthesizing very long chain fatty acyl-harboring wax esters
additional information
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
-
isozyme AWAT2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
isozyme AWAT1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheng, J.B.; Russell, D.W.
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family
J. Biol. Chem.
279
37798-37807
2004
Homo sapiens (Q6E213), Mus musculus, Mus musculus (Q6E1M8)
Manually annotated by BRENDA team
Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
1502-1511
2005
Mus musculus
Manually annotated by BRENDA team
Holmes, R.
Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT)
Comp. Biochem. Physiol. D
5
45-54
2010
Homo sapiens, Homo sapiens (Q58HT5), Homo sapiens (Q6E213), Monodelphis domestica, Mus musculus (A2ADU9), Mus musculus, Mus musculus (Q6E1M8)
Manually annotated by BRENDA team
Miklaszewska, M.; Kawinski, A.; Banas, A.
Detailed characterization of the substrate specificity of mouse wax synthase
Acta Biochim. Pol.
60
209-215
2013
Mus musculus, Mus musculus (Q6E1M8)
Manually annotated by BRENDA team
Kawelke, S.; Feussner, I.
Two predicted transmembrane domains exclude very long chain fatty acyl-CoAs from the active site of mouse wax synthase
PLoS ONE
10
e0145797
2015
Mus musculus, Mus musculus (Q6E1M8)
Manually annotated by BRENDA team
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