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Information on EC 2.3.1.75 - long-chain-alcohol O-fatty-acyltransferase
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EC Tree
2.3.1.75 long-chain-alcohol O-fatty-acyltransferaseIUBMB Comments
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
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Word Map
- 2.3.1.75
- acyl-coas
- esterification
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retinyl
-
arats
-
biodiesels
-
lubricant
- marinobacter
- jojoba
-
retinol-binding
-
3hretinol
-
lecithin:retinol
-
simmondsia
- faees
- aquaeolei
- synthesis
- baylyi
-
acyl-coa-dependent
- hexadecanol
- analysis
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
acyl-coa:retinol acyltransferase, wax synthase, wax ester synthase, awat2, awat1, wax ester synthase/diacylglycerol acyltransferase, atfa1, maqu_0168, wax ester synthase/acyl-coenzyme a:diacylglycerol acyltransferase, acyl-coa wax alcohol acyltransferases, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acyl CoA wax alcohol acyltransferase 1
acyl CoA wax alcohol acyltransferase 2
acyl-CoA wax alcohol acyltransferase 2
acyltransferase, long-chain alcohol
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-
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ATF
ATF1
AtfA
AWAT1
AWAT2
Maqu_0168
MFAT
multifunctional O-acyltransferase
unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase
wax ester synthase
wax ester synthase/acyl-CoA diacylglycerol acyltransferase
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wax ester synthase/acyl-CoA:diacylglycerol acyltransferase
wax ester synthase/acyl-coenzyme A:diacylglycerol acyltransferase
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wax ester synthase/diacylglycerol acyltransferase
wax ester synthases/acyl-CoA:diacylglycerol acyltransferase
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wax synthase
wax-ester synthase
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-
-
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waxester/diacylglycerol acyltransferase
WE synthase
WS/DGAT
WS2
WSD1
WSD4
WSD5
additional information
unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase
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unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase
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-
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wax ester synthase/acyl-CoA:diacylglycerol acyltransferase
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wax ester synthase/diacylglycerol acyltransferase
bifunctional enzyme
wax ester synthase/diacylglycerol acyltransferase
bifunctional enzyme
wax synthase
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-
-
-
wax synthase
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additional information
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cf. EC 2.3.1.20, the enzyme belongs to the WS/DGAT family
additional information
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the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family
additional information
cf. EC 2.3.1.20, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase, DGAT, 2 gene superfamily
additional information
the enzyme belongs to the diacylglycerol acyltransferase 2, DGAT2, gene superfamily, cf. EC 2.3.1.20
additional information
cf. EC 2.3.1.20 and EC 2.3.1.22, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family
additional information
cf. EC 2.3.1.20, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase, DGAT, 2 gene superfamily
additional information
the enzyme belongs to the diacylglycerol acyltransferase 2, DGAT2, gene superfamily, cf. EC 2.3.1.20
additional information
the enzyme belongs to the diacylglycerol acyltransferase 2, DGAT2, gene superfamily, cf. EC 2.3.1.20
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + a long-chain alcohol = CoA + a long-chain ester
reaction mechanism
-
acyl-CoA + a long-chain alcohol = CoA + a long-chain ester
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol
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-
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acyl-CoA + a long-chain alcohol = CoA + a long-chain ester
the catalytic domain contains the highly conserved HHXXXDG motif
Marinobacter nauticus
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:long-chain-alcohol O-acyltransferase
Transfers saturated or unsaturated acyl residues of chain-length C18 to C20 to long-chain alcohols, forming waxes. The best acceptor is cis-icos-11-en-1-ol.
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CAS REGISTRY NUMBER
COMMENTARY
64060-40-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,8-octanedithiol + palmitoyl-CoA
1-S-monopalmitoyloctanedithiol + CoA
59.3% the rate of hexadecanol, plus minor amounts of 1,8-dipalmitoyloctanedithiol
-
-
?
1-decanol + palmitoyl-CoA
decyl palmitate + CoA
48% the rate of hexacedanol
-
-
?
1-hexadecanethiol + palmitoyl-CoA
palmitic acid hexadecane thio ester + CoA
10.4% the rate of hexanol
-
-
?
1-S-monopalmitoyloctanedithiol + palmitoyl-CoA
1,8-dipalmitoyloctanedithiol + CoA
13.4% the rate of hexanol
-
-
?
2 1,8-octanedithiol + 3 palmitoyl-CoA
1-S-monopalmitoyloctanedithiol + 1,8-S-dipalmitoyloctanedithiol + 3 CoA
2-cyclohexylethanol + palmitoyl-CoA
2-cyclohexylethyl palmitate + CoA
44.8% the rate of hexacedanol
-
-
?
2-decanol + palmitoyl-CoA
dec-2-yl palmitate + CoA
38.8% the rate of hexacedanol
-
-
?
4-decanol + palmitoyl-CoA
4-decyl palmitate + CoA
15.6% the rate of hexacedanol
-
-
?
acyl-CoA + decanol
CoA + decanyl acylester
-
-
-
?
acyl-CoA + dodecanol
CoA + dodecanyl acylester
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-
-
?
acyl-CoA + hexadecanol
CoA + hexadecanyl acylester
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-
-
?
acyl-CoA + octadecanol
CoA + octadecanyl acylester
-
-
-
?
arachidonoyl-CoA + hexadecan-1-ol
CoA + hexadecyl arachidonoate
-
-
-
?
arachidonoyl-CoA + hexadecanol
CoA + hexadecyl arachidonoate
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-
-
?
arachidoyl-CoA + hexadecanol
hexadecyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + hexadecenol
hexadecenyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + linolenyl alcohol
linolenyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + linoleyl alcohol
linoleyl arachidonate + CoA
Marinobacter nauticus
-
-
-
?
arachidoyl-CoA + octadecanol
octadecyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + octadecenol
octadecenyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + ricinoleyl alcohol
ricinoleyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + tetracosanol
tetracosyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + tetracosenol
tetracosenyl arachidonate + CoA
Marinobacter nauticus
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-
-
?
arachidoyl-CoA + tetradecanol
tetradecyl arachidonate + CoA
Marinobacter nauticus
-
-
-
?
cyclododecanol + palmitoyl-CoA
cyclododecyl palmitate + CoA
79.7% the rate of hexacedanol
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-
?
cyclohexandiol + palmitoyl-CoA
? + CoA
4.1% the rate of hexacedanol
-
-
?
cyclohexanol + palmitoyl-CoA
cyclohexyl palmitate + CoA
32% the rate of hexacedanol
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-
?
cyclohexanone oxime + palmitoyl-CoA
? + CoA
5.2% the rate of hexacedanol
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-
?
decanol + palmitoyl-CoA
decanyl palmitate + CoA
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and undecanol, best substrates
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-
?
decanoyl-CoA + docosanol
docosyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + docosenol
docosenyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + dodecanol
dodecyl decanoate + CoA
Marinobacter nauticus
low activity
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-
?
decanoyl-CoA + eicosanol
eicosanyl decanoate + CoA
Marinobacter nauticus
low activity
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-
?
decanoyl-CoA + eicosenol
eicosenyl decanoate + CoA
Marinobacter nauticus
low activity
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-
?
decanoyl-CoA + hexadecanol
CoA + hexadecyl decanoate
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-
-
?
decanoyl-CoA + hexadecanol
hexadecyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + hexadecenol
hexadecenyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + linolenyl alcohol
linolenyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + linoleyl alcohol
linoleyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + octadecanol
octadecyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + octadecenol
octadecenyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + phytol
phytyl decanoate + CoA
Marinobacter nauticus
very low activity
-
-
?
decanoyl-CoA + ricinoleyl alcohol
ricinoleyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + tetracosanol
tetracosyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + tetracosenol
tetracosenyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
decanoyl-CoA + tetradecanol
tetradecyl decanoate + CoA
Marinobacter nauticus
low activity
-
-
?
eicosanoyl-CoA + cis-11-eicosenol
cis-11-eicosenyl eicosanoate + CoA
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cis-11-eicosenol is the best acceptor
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-
?
eicosanoyl-CoA + cis-13-eicosenol
cis-13-eicosenyl eicosanoate + CoA
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-
-
-
?
eicosanoyl-CoA + cis-9-octadecenol
cis-9-octadecenyl eicosanoate + CoA
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-
-
-
?
eicosanoyl-CoA + docosanol
docosanyl eicosanoate + CoA
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low activity
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-
?
eicosanoyl-CoA + eicosanol
eicosanyl eicosanoate + CoA
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low activity
-
-
?
eicosanoyl-CoA + octadecanol
octadecanyl eicosanoate + CoA
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low activity
-
-
?
eicosapentaenoyl-CoA + hexadecan-1-ol
?
-
-
-
?
eicosapentaenoyl-CoA + hexadecanol
CoA + hexadecyl eicosapentaenoate
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-
-
?
eicosenoyl-CoA + hexadecanol
hexadecanyl eicosenate + CoA
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high activity
-
-
?
eicosenoyl-CoA + hexadecanol
hexadecyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + hexadecenol
hexadecenyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + linolenyl alcohol
linolenyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + linoleyl alcohol
linoleyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + octadecanol
octadecyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + ricinoleyl alcohol
ricinoleyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + tetracosanol
tetracosyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
eicosenoyl-CoA + tetracosenol
tetracosenyl eicosenoate + CoA
Marinobacter nauticus
-
-
-
?
erucyl-CoA + ricinoleyl alcohol
ricinoleyl erucoate + CoA
Marinobacter nauticus
-
-
-
?
hexadecanol + palmitoyl-CoA
hexadecyl palmitate + CoA
-
-
-
?
lauroyl-CoA + hexadecanol
hexadecanyl laurate + CoA
-
high activity
-
-
?
lauroyl-CoA + ricinoleyl alcohol
ricinoleyl laurate + CoA
Marinobacter nauticus
high activity
-
-
?
lino