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Information on EC 2.3.1.7 - carnitine O-acetyltransferase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P32796
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EC Tree
2.3.1.7 carnitine O-acetyltransferaseIUBMB Comments
Also acts on propanoyl-CoA and butanoyl-CoA (cf. EC 2.3.1.21 carnitine O-palmitoyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase).
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Word Map
- 2.3.1.7
- peroxisomal
- palmitoyltransferase
-
beta-oxidation
- acyl-coas
- l-carnitine
- acyltransferases
- clofibrate
- palmitoyl-coa
- acylcarnitine
- proliferators
-
hypolipidemic
-
octanoyltransferase
-
cyanide-insensitive
-
propionylation
- cardos
- acetyl-l-carnitine
- carbazole
-
carnitine-dependent
-
cronbach
-
alloy
-
1,9a-dioxygenase
- coash
-
peroxisome-associated
- palmitoylcarnitine
-
nafenopin
- bezafibrate
- ciprofibrate
- food industry
- analysis
- medicine
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
carnitine acetyltransferase, carat, carac, carnitine acetyl transferase, p-cat, carnitine o-acetyltransferase, h-cat, acetylcarnitine transferase, ct-cat, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetyl-CoA-carnitine O-acetyltransferase
-
-
-
-
acetylcarnitine transferase
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-
-
-
carnitine acetyl coenzyme A transferase
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-
-
-
carnitine acetylase
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-
-
-
carnitine acetyltransferase
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-
-
-
carnitine-acetyl-CoA transferase
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-
-
-
CATC
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:carnitine O-acetyltransferase
Also acts on propanoyl-CoA and butanoyl-CoA (cf. EC 2.3.1.21 carnitine O-palmitoyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase).
CAS REGISTRY NUMBER
COMMENTARY
9029-90-7
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
-
r
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
this reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix
-
-
r
additional information
?
-
-
carnitine acetyltransferases catalyse the reversible reaction between carnitine and acetyl-CoA to form acetylcarnitine and free CoA. This reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
additional information
?
-
carnitine acetyltransferases catalyse the reversible reaction between carnitine and acetyl-CoA to form acetylcarnitine and free CoA. This reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
additional information
?
-
-
CAT2 contributes to the response to oxidative stress
-
-
?
additional information
?
-
CAT2 contributes to the response to oxidative stress
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
this reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix
-
-
r
additional information
?
-
-
carnitine acetyltransferases catalyse the reversible reaction between carnitine and acetyl-CoA to form acetylcarnitine and free CoA. This reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
additional information
?
-
carnitine acetyltransferases catalyse the reversible reaction between carnitine and acetyl-CoA to form acetylcarnitine and free CoA. This reaction is important in transferring activated acetyl groups to the mitochondria and in regulating the acetyl-CoA/CoA pools within the cell
-
-
?
additional information
?
-
-
CAT2 contributes to the response to oxidative stress
-
-
?
additional information
?
-
CAT2 contributes to the response to oxidative stress
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpressing CAT2, which encodes the major mitochondrial and peroxisomal carnitine acetyltransferase, on the formation of esters and other flavour compounds during fermentation and overexpression of a modified CAT2 that results in a protein that localizes to the cytosol. The overexpression of both forms of CAT2 resulted in a reduction in ester concentrations, especially in ethyl acetate and isoamyl acetate
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
food industry
modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kispal, G.; Cseko, J.; Alkonyi, I.; Sandor, A.
Isolation and characterization of carnitine acetyltransferase from S. cerevisiae
Biochim. Biophys. Acta
1085
217-222
1991
Bos taurus, Saccharomyces cerevisiae, Candida tropicalis, Columba sp., Homo sapiens, Rattus norvegicus, Torulopsis bovina
Alhomida, A.S.
Inhibition studies of the carnitine acetyltransferase from skeletal muscle of the camel (Camelus dromedarius) by sulfhydryl reagents and metal ions
Biochem. Mol. Biol. Int.
39
923-931
1996
Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
Jernejc, K.; Legisa, M.
Purification and properties of carnitine acetyltransferase from citric acid producing Aspergillus niger
Appl. Biochem. Biotechnol.
60
151-158
1996
Aspergillus niger, Bos taurus, Saccharomyces cerevisiae, Cutaneotrichosporon curvatum, Candida tropicalis, Cyberlindnera jadinii, Columba sp., Homo sapiens, Lipomyces starkeyi, Mus musculus, Rattus norvegicus, Sus scrofa
Kawachi, H.; Atomi, H.; Ueda, M.; Hashimoto, N.; Kobayashi, K.; Yoshida, T.; Kamasawa, N.; Osumi, M.; Tanaka, A.
Individual expression of Candida tropicalis peroxisomal and mitochondrial carnitine acetyltransferase-encoding genes and subcellular localization of the products in Saccharomyces cerevisiae
J. Biochem.
120
731-735
1996
Saccharomyces cerevisiae, Candida tropicalis
Kawachi, H.; Atomi, H.; Ueda, M.; Tanaka, A.
Peroxisomal and mitochondrial carnitine acetyltransferases of the n-alkane-assimilating yeast Candida tropicalis. Analysis of gene structure and translation products
Eur. J. Biochem.
238
845-852
1996
Saccharomyces cerevisiae, Candida tropicalis, Columba sp., Homo sapiens
Brunner, S.; Kramar, K.; Denhardt, D.T.; Hofbauer, R.
Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression
Biochem. J.
322
403-410
1997
Saccharomyces cerevisiae, Columba sp., Homo sapiens, Mus musculus, Mus musculus (P47934), Sus scrofa, Mus musculus S3T3(ATCC CCL-92)
-
Cordente, A.G.; Swiegers, J.H.; Hegardt, F.G.; Pretorius, I.S.
Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae
FEMS Microbiol. Lett.
267
159-166
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32796)
EXTERNAL LINKS (specific for EC-Number 2.3.1.7)
Transporter Classification Database (TCDB): 4.C.2.1.1
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