Any feedback?
No. of entries
Information on EC 2.3.1.67 - 1-alkylglycerophosphocholine O-acetyltransferase
for references in articles please use BRENDA:EC2.3.1.67
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 2 Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.3.1.67
- paf-ah
-
acetylhydrolase
- paf-cpt
-
cholinephosphotransferase
- 1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine
- paf-acetylhydrolase
-
coa-independent
-
transacylase
-
dtt-insensitive
-
3hacetate
-
paf-synthesizing
- 1-o-alkyl-sn-glycero-3-phosphocholine
-
14carachidonic
-
phospholipase-a2
- medicine
- lppla2
- analysis
- drug development
Reaction Schemes
showSynonyms
lyso-paf-at, acetyl-coa:lyso-paf acetyltransferase, lyso-paf at, lyso-paf:acetyl-coa acetyltransferase, lyso-paf-acetyltransferase, acetyl-coa lyso-paf acetyltransferase, lyso-paf-act, lyso-pafat, lysopafat, lysopaf-at, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase
-
-
-
-
acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase
-
-
-
-
acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase
-
acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase
acetyl-CoA:lyso-PAF acetyltransferase
acetyl-CoA:lysoPAF acetyltransferase
acetyl-coenzyme A:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase
-
-
acetyltransferase, 1-alkyl-2-lysolecithin
-
-
-
-
acetyltransferase, 1-alkylglycerophosphocholine
-
-
-
-
acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase
-
-
-
-
blood platelet-activating factor acetyltransferase
-
-
-
-
LPCAT2
lyso-GPC:acetyl CoA acetyltransferase
-
-
-
-
lyso-PAF acetyltransferase
lyso-PAF acetyltransferase:LPC acyltransferase 1
lyso-PAF AT
lyso-PAFAT
lyso-platelet activating factor:acetyl-CoA acetyltransferase
-
-
-
-
lyso-platelet-activating factor acetyltransferase
lyso-platelet-activating factor:acetyl-CoA acetyltransferase
-
-
-
-
lysoPAF:acetyl CoA acetyltransferase
-
-
-
-
lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase
-
PAF acetyltransferase
-
-
-
-
platelet-activating factor acylhydrolase
-
-
-
-
platelet-activating factor-synthesizing enzyme
-
-
-
-
acetyl-CoA:lyso-PAF acetyltransferase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
Acyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
76773-96-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
acetyl-CoA + 1-acyl-sn-glycero-3-phosphate
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphate
CoA + 2-acetyl-1-alkyl-6-phosphate
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
?
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-6-phosphocholine
acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine
acetyl-CoA + acyl-lyso-glycero-3-phosphocholine
CoA + acetyl-acyl-glycero-3-phosphocholine
acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine
CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine
acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
acetyl-CoA + hexadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
acetyl-CoA + lyso-phosphatidylcholine
CoA + 2-acetyl-1-acylphosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-phosphatidylethanolamine
CoA + 2-acetyl-1-acyl-phosphatidylethanolamine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet activating factor
CoA + platelet activating factor
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
butyryl-CoA + 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
2-butyryl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
hexanoyl-CoA + 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
2-hexanoyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
CoA + 1-alkyl-2-oleoyl-glycero-3-phosphoethanolamine
-
Substrates: 10% of the activity observed in presence of acetyl-CoA
Products: -
Products: -
?
palmitoyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
CoA + acetyl-2-palmitoyl-glycero-3-phosphoethanolamine
-
Substrates: 5% of the activity observed in presence of acetyl-CoA
Products: -
Products: -
?
propionyl-CoA + alkyl-lyso-glycero-phosphocholine
CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
-
Substrates: lyso-PAF, lyso-platelet-activating factor
Products: PAF, platelet-activating factor
Products: PAF, platelet-activating factor
?
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
Substrates: lyso-PAF, lyso-platelet-activating factor
Products: PAF, platelet-activating factor
Products: PAF, platelet-activating factor
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: substrates are d31-16:0 LPC or d4-lyso-PAF
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: substrates are d31-16:0 LPC or d4-lyso-PAF
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
Substrates: 40% higher activity respect to the C18 analogue
Products: -
Products: -
?
acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-6-phosphocholine
-
Substrates: final step in remodelling pathway of PAF biosynthesis
Products: -
Products: -
?
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-6-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: rate reduced to 50%
Products: -
Products: -
?
acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: 12% of the activity observed in presence of alkyl-lyso-sn-glycero-phosphocholine
Products: -
Products: -
?
acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: rate of synthesis is 55% of the rate observed with the ether linked substrate
Products: -
Products: -
?
acetyl-CoA + acyl-lyso-glycero-3-phosphocholine
CoA + acetyl-acyl-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + acyl-lyso-glycero-3-phosphocholine
CoA + acetyl-acyl-glycero-3-phosphocholine
-
Substrates: worse substrate than alkyl-lyso-glycero-3-phosphocholine
Products: -
Products: -
?
acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine
CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine
CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine
-
Substrates: least enzyme activity
Products: -
Products: -
?
acetyl-CoA + alkyl-lyso-monomethylethanamine
?
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-lyso-N',N'-dimethylethanamine
?
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-lyso-N',N'-dimethylethanamine
?
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: alkyl-lyso-sn-glycero-3-phosphocholine is preferred to its saturated counterpart as substrate
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: the higher the degree of methylation of the nitrogen base, the lower the enzyme activity
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: the longer the acyl-CoA length, the smaller the values of apparent Km and Vmax
Products: -
Products: -
?
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: alkyl-lyso-sn-glycero-3-phosphocholine is preferred to its saturated counterpart as substrate
Products: -
Products: -
?
acetyl-CoA + hexadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + hexadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: intracellular redox state involved in regulating synthesis of platelet-activating factor (PAF)
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: metabolic processing of platelet-activating factor (PAF) in naive and experimental allergic encephalomyelitis (EAE) mice
Products: -
Products: -
?
acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
propionyl-CoA + alkyl-lyso-glycero-phosphocholine
CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
propionyl-CoA + alkyl-lyso-glycero-phosphocholine
CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is activated 1. by a second-order time course after stimulation with platelet-activating factor receptor, 2. by a minute-order time course after LPS stimulation in the MyD88-dependent and p38 MAPK-dependent pathway, and 3. by an hour-order time course after LPS-stimulation in the MyD88-independent and TRIF-independent pathway
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF
Products: -
Products: -
?
additional information
?
-
Substrates: LPCAT1 recognizes a wide range of acyl-CoAs as substrates, ranging from acetyl-CoA to palmitoyl-CoA
Products: -
Products: -
?
additional information
?
-
-
Substrates: LPCAT1 recognizes a wide range of acyl-CoAs as substrates, ranging from acetyl-CoA to palmitoyl-CoA
Products: -
Products: -
?
additional information
?
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
additional information
?
-
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
additional information
?
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-6-phosphocholine
-
Substrates: final step in remodelling pathway of PAF biosynthesis
Products: -
Products: -
?
acetyl-CoA + lyso-platelet activating factor
CoA + platelet activating factor
-
Substrates: -
Products: -
Products: -
?
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
-
Substrates: lyso-PAF, lyso-platelet-activating factor
Products: PAF, platelet-activating factor
Products: PAF, platelet-activating factor
?
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
Substrates: lyso-PAF, lyso-platelet-activating factor
Products: PAF, platelet-activating factor
Products: PAF, platelet-activating factor
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: -
Products: -
Products: -
?
acetyl-CoA + lyso-platelet-activating factor
platelet-activating factor + CoA
Substrates: -
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is activated 1. by a second-order time course after stimulation with platelet-activating factor receptor, 2. by a minute-order time course after LPS stimulation in the MyD88-dependent and p38 MAPK-dependent pathway, and 3. by an hour-order time course after LPS-stimulation in the MyD88-independent and TRIF-independent pathway
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF
Products: -
Products: -
?
additional information
?
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
additional information
?
-
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
additional information
?
-
Substrates: LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
selenium
-
as a consequence of Se deficiency increased phospholipase D activity and phosphatidic acid production contribute to enhanced enzyme activity, which results in an overall increase in platelet activating factor. The regulation of enzyme activity by Se may constitute an important control mechanism for the maintenance of levels of platelet activating factor in endothelial cells
Ca2+
-
activation reversed by addition of EGTA in excess of Ca2+, Ca2+ reduces the apparent Km for acetyl-CoA, maximum effect between 0.0001 and 0.01 mM, the action of Ca2+ seems to be independent of the presence of calmodulin or phosphorylation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
-
-
1-acyl-sn-glycero-3-phosphate
-
competitive inhibition for 1-alkyl-sn-glycero-3-phosphate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
-
irreversible inhibition dependent of both 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and enzyme concentration
1-O-alkyl-sn-glycero-3-phosphocholine
-
inhibition at high concentrations due to its detergent effect
2-methoxy-1,3,4-trihydroxy-5-methylbenzene
i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
i.e. Trolox, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
dihydrofumigatin
i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33
ebselen
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 7.7% and 26.6% in presence of glutathione
glutathione
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 18.9%
lopinavir-r
-
remaining activity in human mesangial cells: 76%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug
lysophosphatidylcholine
-
inhibition at high concentrations due to its detergent effect
MgATP2-
-
32% and 54% inhibition at 0.125 and 1 mM respectively in neuronal nuclear fraction
myricetin
-
suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 17%
N-acetylcysteine
reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
propan-2-yl 4-[3-chloro-4-(2-hydroxyanilino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl]benzoate
pyrrolidinecarbodithioic acid
i.e. PDTC, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells
resveratrol
-
0.157 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity
serine/threonine phosphatase
-
diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine
-
tenofovir-DF
-
remaining activity in human mesangial cells: 32%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug
Triton X-100
-
75 and 95% inhibition at 0.2 and 0.6 mM respectively due to detergent
tyrosol
-
0.048 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
-
derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide
3-chloro-1-(3-chloro-4-methoxyphenyl)-4-(2-methoxyphenoxy)-1H-pyrrole-2,5-dione
-
3-chloro-1-(3-chloro-4-methoxyphenyl)-4-(2-methoxyphenoxy)-1H-pyrrole-2,5-dione
-
3-chloro-1-(4,5-dichloro-2-methoxyphenyl)-4-(2-hydroxyanilino)-1H-pyrrole-2,5-dione
-
3-chloro-1-(4,5-dichloro-2-methoxyphenyl)-4-(2-hydroxyanilino)-1H-pyrrole-2,5-dione
-