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Information on EC 2.3.1.65 - bile acid-CoA:amino acid N-acyltransferase

for references in articles please use BRENDA:EC2.3.1.65

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IUBMB Comments

Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-β-alanine can act as substrates, but more slowly . The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase . Bile-acid—amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol . This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate—CoA ligase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
bile acid-coa:amino acid n-acyltransferase, bacat, bile acid coa:amino acid n-acyltransferase, bile acid coa amino acid n-acyltransferase, baatp1, bile acid coenzyme a-amino acid n-acyltransferase, bile acid coenzyme a:amino acid n-acyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
choloyl-CoA + glycine = CoA + glycocholate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acid biosynthesis, neutral pathway