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Information on EC 2.3.1.62 - 2-acylglycerophosphocholine O-acyltransferase
for references in articles please use BRENDA:EC2.3.1.62
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EC Tree 2 Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.62 2-acylglycerophosphocholine O-acyltransferase
The enzyme appears in viruses and cellular organisms
showSynonyms
2-acyl-glycerol-3-phosphorylcholine acyltransferase, 2-acylglycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 2, acyltransferase, AGPAT8, Alcat1, Lclat1, LPC acyltransferase, LPCAT1, LPLAT, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-acyl-glycerol-3-phosphorylcholine acyltransferase
2-acylglycerophosphocholine acyltransferase
acyltransferase
LPC acyltransferase
LPCAT1
LPLAT
lysophospholipid acyltransferase
additional information
2-acylglycerophosphocholine acyltransferase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine = CoA + phosphatidylcholine
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
64295-73-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphatidylcholine
CoA + 1,2-diacyl-sn-glycero-3-phosphatidylcholine
Substrates: -
Products: -
Products: -
?
arachidonoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
arachidonoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
gamma-linolenoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-gamma-linolenoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
linoleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
oleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
palmitoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linolenoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 2-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 2-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
stearoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linolenoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-oleoyl-sn-glycero-3-phosphatidylcholine
CoA + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine
Substrates: preferred substrate
Products: -
Products: -
?
stearoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
stearoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1,2-distearoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
oleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
Substrates: reaction of EC 2.3.1.23
Products: -
Products: -
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
Substrates: reaction of EC 2.3.1.23
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
palmitoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
stearoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
Substrates: development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn2 positions of palmitoyl-lysophosphatidylcholine (LPC). sn-1-palmitoyl LPC appears to have a slightly higher affinity for LPCAT1 than sn-2-palmitoyl LPC, while sn-2-palmitoyl LPC has a higher turnover rate
Products: -
Products: -
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additional information
?
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Substrates: LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
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additional information
?
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Substrates: LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
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additional information
?
-
Substrates: development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn2 positions of palmitoyl-LPC
Products: -
Products: -
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additional information
?
-
Substrates: development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn2 positions of palmitoyl-LPC
Products: -
Products: -
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additional information
?
-
Substrates: development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
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additional information
?
-
Substrates: development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphatidylcholine
CoA + 1,2-diacyl-sn-glycero-3-phosphatidylcholine
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
-
Substrates: reaction in phosphatidylcholine metabolism
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
acyl-CoA + 2-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
Substrates: -
Products: -
Products: -
?
additional information
?
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Substrates: LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
-
additional information
?
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Substrates: LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
Products: -
Products: -
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
palmitoyl-CoA
-
bovine serum albumin or boiled microsomal preparation restores activity
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
specific activities of microsomal preparations from cells grown at different temperatures
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene LPCAT1, functional recombinant expression in HEK-293 cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamada, K.; Okuyama, H.; Endo, Y.; Ikezawa, H.
Acyltransferase systems involved in phospholipid metabolism in Saccharomyces cerevisiae
Arch. Biochem. Biophys.
183
281-289
1977
Saccharomyces cerevisiae, Saccharomyces cerevisiae OC-2
brenda
Lands, W.E.M.; Hart, P.
Metabolism of glycerolipids. VI. Specificities of acyl-CoA: phospholipid acyltransferases
J. Biol. Chem.
240
1905-1911
1965
Bos taurus, Cavia porcellus, Rattus norvegicus, Sus scrofa
brenda
Holub, B.
The suitability of different acyl acceptors as substrates for the acyl-CoA: 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat liver microsomes
Biochim. Biophys. Acta
664
221-228
1981
Rattus norvegicus, Rattus norvegicus male Wistar
brenda
Yoshioka, S.; Kameyama, Y.; Nozawa, Y.
Mechanism for adaptive modification during cold acclimation of phospholipid acyl chain composition in Tetrahymena. II. Activities of 2-acyl-sn-glycerol-3-phosphorylcholine and 2-acyl-sn-glycerol-3-phosphorylethanolamine acyltransferases involving the reacylation
Biochim. Biophys. Acta
793
34-41
1984
Tetrahymena pyriformis, Tetrahymena pyriformis NT-1
brenda
Van den Bosch, H.; Van Golde, L.M.G.; Slotboom, A.J.; Van Deenen, L.L.M.
The acylation of isomeric monoacyl phosphatidylcholines
Biochim. Biophys. Acta
152
694-703
1968
Rattus norvegicus
brenda
Arthur, G.
Acylation of 2-acyl-glycerophosphocholine in guinea pig heart microsomal fractions
Biochem. J.
261
575-580
1989
Cavia porcellus
brenda
Kawana, H.; Kano, K.; Shindou, H.; Inoue, A.; Shimizu, T.; Aoki, J.
An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases
Biochim. Biophys. Acta
1864
1053-1060
2019
Homo sapiens (Q8NF37), Mus musculus (Q3TFD2), Mus musculus (Q3UN02)
brenda
EXTERNAL LINKS (specific for EC-Number 2.3.1.62)
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Release 2023.1 (January 2023)
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