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Information on EC 2.3.1.51 - 1-acylglycerol-3-phosphate O-acyltransferase
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EC Tree
2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferaseIUBMB Comments
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
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Word Map
- 2.3.1.51
- adipose
- triacylglycerols
- triglyceride
- lipodystrophy
- phospholipid
- acyl-coas
- lipase
- diacylglycerol
- droplet
- adipocytes
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berardinelli-seip
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lipolysis
- glycerolipids
- agpats
- glycerophospholipids
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chanarin-dorfman
- hypertriglyceridemia
- lysophospholipids
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seipin
- ichthyosis
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perilipins
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acanthosis
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ichthyosiform
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nigricans
- erythroderma
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identification-58
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kennedy
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acyl-acyl
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endophilins
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lipoatrophy
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acyl-coa-dependent
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
abhd5, agpat2, lpaat, lysophosphatidic acid acyltransferase, lpaat-beta, agpat1, 1-acylglycerol-3-phosphate o-acyltransferase, agpat3, lpa acyltransferase, agpat4, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-acyl-sn-glycero-3-phosphate acyltransferase
1-acyl-sn-glycerol 3-phosphate acyltransferase
1-acyl-sn-glycerol-3-phosphate acyltransferas
1-acyl-sn-glycerol-3-phosphate acyltransferase
1-acyl-sn-glycerol-3-phosphate O-acyltransferase
1-acylglycero-3-phosphate acyltransferase
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1-acylglycerol-3-phosphate acyltransferase
1-acylglycerol-3-phosphate-O-acyltransferase
1-acylglycerol-3-phosphate-O-acyltransferase isoform10/glycerol-3-phosphate acyltransferase isoform 3
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1-acylglycerolphosphate acyltransferase
1-acylglycerophosphate acyltransferase
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acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase
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acyltransferase, 1-acylglycerol phosphate
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AGPAT
AGPAT/PlsC
AGPAT1
AGPAT2
AGPAT3
AGPAT4
CGI-58/ABHD5
coenzyme A-dependent lysophosphatidic acid
CT775
CT_775
LPA acyltransferase
LPAAT
LPAAT3
LPAAT4
LPAATdelta
LPAT
LPCAT1
lysophosphatidic acid acyltansferase
lysophosphatidic acid acyltransferase
lysophosphatidic acid acyltransferase 3
lysophosphatidic acid ayltransferase
lysophosphatidic acid-acyltransferase
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lysophosphatidyl acyltransferase
lysophosphatidylcholine acyltransferase 1
lysophospholipid acyltransferase
PlsC
PlsC4
SlPlsC1
TM_1693
additional information
1-acyl-sn-glycero-3-phosphate acyltransferase
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1-acyl-sn-glycerol 3-phosphate acyltransferase
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1-acylglycerolphosphate acyltransferase
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lysophosphatidyl acyltransferase
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additional information
the enzyme belongs to the alpha/beta-hydrolase family
additional information
C4B4E7
the enzyme belongs to the 1-acylglycerol-3-phosphate O-acyltransferase, AGPAT, family
additional information
C4B4E7
the enzyme belongs to the 1-acylglycerol-3-phosphate O-acyltransferase, AGPAT, family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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PATHWAY SOURCE
PATHWAYS
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, , CDP-diacylglycerol biosynthesis, CDP-diacylglycerol biosynthesis, CDP-diacylglycerol biosynthesis, CDP-diacylglycerol biosynthesis, Glycerophospholipid metabolism, Glycerophospholipid metabolism, Glycerophospholipid metabolism, Glycerophospholipid metabolism, Glycerophospholipid metabolism, Glycerophospholipid metabolism, Glycerophospholipid metabolism
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
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CAS REGISTRY NUMBER
COMMENTARY
51901-16-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
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-
-
?
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
CoA + palmitoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
highest activity
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-
?
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
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-
-
?
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-lysophosphatidic acid
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-
-
?
1-oleoyl-sn-glycerol-3-phosphate + oleoyl-CoA
CoA + 1,2-oleoyl-sn-glycerol-3-phosphate
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-
-
-
?
1-oleoyl-sn-glycerol-3-phosphate + palmitoyl-CoA
CoA + 1-oleoyl-2-palmitoyl-sn-glycerol-3-phosphate
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-
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?
acyl-CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
acyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate
CoA + 1-lauroyl-2-acyl-sn-glycerol 3-phosphate
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assayed using coconut cDNA encoding a 299-amino acid protein with enzyme activity expressed in canola seeds
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?
acyl-CoA + 1-O-alkyl-sn-glycerol 3-phosphate
CoA + ?
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the activity is approximately half of that toward 1-acyl-sn-glycerol 3-phosphate
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?
acyl-CoA + 1-oleoyl-lysophosphatidylethanolamine
CoA + 1-oleoyl-2-acyl-lysophosphatidylethanolamine
acyl-CoA + 1-oleoyl-lysophosphatidylglycerol
CoA + 1-oleoyl-2-acyl-lysophosphatidylglycerol
low activity
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?
acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate
acyl-CoA + 1-palmitoleoyl-lysophosphatidic acid
CoA + 1-palmitoleoyl-2-acyl-lysophosphatidic acid
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-
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?
acyl-CoA + 1-palmitoyl-lysophosphatidic acid
CoA + 1-palmitoyl-2-acyl-lysophosphatidic acid
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?
acyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
acyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
ACP + 1,2-diacyl-sn-glycerol 3-phosphate
acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate
alpha-linolenoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-alpha-linolenoyl-lysophosphatidic acid
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-
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?
arachidonoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-arachidonoyl-lysophosphatidic acid
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?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
arachidonoyl-CoA + 1-arachidonoyl-2-lyso-sn-phosphatidylcholine
CoA + 1,2-diarachidonoyl-sn-phosphatidylcholine
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?
arachidonoyl-CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
CoA + 1,2-diarachidonoyl-sn-glycerol 3-phosphate
slight preference for 1-oleoyl lysophosphatidic acid over 1-palmitoyl, 1-stearoyl, or 1-arachidonoyl lysophosphatidic acid
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?
arachidonoyl-CoA + 1-octadecenyl-2-lysophosphatidylinositol
CoA + 1-octadecenyl-2-arachidonoylphosphatidylinositol
C4B4E7
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?
arachidonoyl-CoA + 1-oleoyl-2-lysophosphatidylcholine
CoA + 1-oleoyl-2-arachidonoylphosphatidylcholine
C4B4E7
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?
arachidonoyl-CoA + 1-oleoyl-glycerol-3-phosphate
1-oleoyl-2-arachidonoyl-glycerol-3-phosphate + CoA
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?
arachidonoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-arachidonoyl-sn-glycerol 3-phosphate
arachidonoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1-oleoyl-2-arachidonoylphosphatidylcholine
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?
arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylinositol
CoA + 1-palmitoyl-2-arachidonoylphosphatidylinositol
C4B4E7
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?
arachidonoyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycerol 3-phosphate
slight preference for 1-oleoyl lysophosphatidic acid over 1-palmitoyl, 1-stearoyl, or 1-arachidonoyl lysophosphatidic acid
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?
arachidonoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine
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?
arachidonoyl-CoA + 1-stearoyl-2-lysophosphatidic acid
CoA + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
C4B4E7
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?
arachidonoyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-stearoyl-sn-glycerol 3-phosphate
slight preference for 1-oleoyl lysophosphatidic acid over 1-palmitoyl, 1-stearoyl, or 1-arachidonoyl lysophosphatidic acid
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?
arachidonoyl-CoA + 1-stearoyl-sn-lysophosphatidylcholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphocholine
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?
arachidonoyl-CoA + oleoyl-lysophosphatidic acid
CoA + 2-arachidonoyl-1-oleoyl-sn-glycerol 3-phosphate
arachidoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-arachidoyl-lysophosphatidic acid
very low activity
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?
arachidoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidoyl-sn-glycerol 3-phosphate
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?
arachidoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 2-arachidoyl-1-oleoyl-sn-glycerol 3-phosphate
behenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-behenoyl-sn-glycerol 3-phosphate
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?
cis-11-eicosenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-cis-11 eicosenoyl-sn-glycerol 3-phosphate
docosahexaenoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate
C4B4E7
best substrates
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?
eicosapentaenoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-eicosapentaenoyl-lysophosphatidic acid
eicosapentaenoyl-CoA + oleoyl-lysophosphatidic acid
CoA + 2-eicosapentaenoyl-1-oleoyl-sn-glycerol 3-phosphate
eicosatetraenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-eicosatetraenoyl-sn-glycerol 3-phosphate
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?
erucoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-erucoyl-sn-glycerol 3-phosphate
erucoyl-CoA + 1-erucoyl-sn-glycerol-3-phosphate
CoA + 1,2-dierucoyl-sn-glycerol 3-phosphate
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?
gondoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-gondoyl-sn-glycerol 3-phosphate
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gondoyl-CoA is utilized less efficiently for the reaction than oleoyl-CoA
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?
heptadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-heptadecanoyl-sn-glycerol 3-phosphate
lauroyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-lauroyl-lysophosphatidic acid
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?
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
lauroyl-CoA + 1-lauroyl-sn-glycerol 3-phosphate
CoA + 1,2-dilauroyl-sn-glycerol 3-phosphate
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?
lauroyl-CoA + 1-oleoyl-2-lysophosphatidic acid
CoA + 2-lauroyl-1-oleoyl-sn-glycerol 3-phosphate
lignoceroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lignoceroyl-sn-glycerol 3-phosphate
linolenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linolenoyl-sn-glycerol 3-phosphate
linoleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-linoleoyl-lysophosphatidic acid
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
linoleoyl-CoA + oleoyl-lysophosphatidic acid
CoA + 2-linoleoyl-1-oleoyl-sn-glycerol 3-phosphate
the enzyme shows high specificity towards the unsaturated fatty acyl-CoAs, among which those having multiple cis-double bonds (linoleoyl-, arachidonoyl-, and eicosapentaenoyl-CoAs) are more preferred substrates. Saturated fatty acyl-CoAs, especially those with a carbon chain length of 14 or longer, serve as poor fatty acyl donors. The enzyme accepts lysophosphatidic acid having either unsaturated or saturated acyl chains. It shows little activity towards sn-glycerol 3-phosphate and lysophospholipids with head groups
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?
myristoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-myristoyl-lysophosphatidic acid
myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
myristoyl-CoA + 1-myristoyl-sn-glycerol 3-phosphate
CoA + 1,2-dimyristoyl-sn-glycerol 3-phosphate
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-
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?
myristoyl-CoA + 1-oleoyl-2-lysophosphatidic acid
CoA + 1-oleoyl-2-stearoyl-sn-glycerol 3-phosphate
the enzyme shows high specificity towards the unsaturated fatty acyl-CoAs, among which those having multiple cis-double bonds (linoleoyl-, arachidonoyl-, and eicosapentaenoyl-CoAs) are more preferred substrates. The enzyme accepts lysophosphatidic acid having either unsaturated or saturated acyl chains. It shows little activity towards sn-glycerol 3-phosphate and lysophospholipids with head groups
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?
myristoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-myristoyl-sn-glycerol 3-phosphate
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about 25% of the activity with oleoyl-CoA by AGPAT10/GPAT3
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?
myristoyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
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?
oleoyl-ACP + sn-1-oleoylglycerol 3-phosphate
ACP + sn-1,2-dioleoylglycerol 3-phosphate
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microsomal fractions from developing, transgenic seeds but not of untransformed plants
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?