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Disease on EC 2.3.1.48 - histone acetyltransferase and Organism(s) Homo sapiens and UniProt Accession Q8WYB5

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Circadian clock gene plays a key role on ovarian cycle and spontaneous abortion.
Genetic variation in the CLOCK gene is associated with idiopathic recurrent spontaneous abortion.
Rate of caffeine metabolism and risk of spontaneous abortion.
Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion.
Abscess
Acanthamoeba scleral abscess reoccurring after penetrating keratoplasty.
Innovative approach in the management of horse-shoe fistula-in-ano with K??ras?tra.
Accelerated Idioventricular Rhythm
A Novel Intronic Circular RNA Antagonizes Influenza Virus by Absorbing a microRNA That Degrades CREBBP and Accelerating IFN-? Production.
Acidosis
Extracellular Acidosis Promotes Metastatic Potency via Decrease of the BMAL1 Circadian Clock Gene in Breast Cancer.
Acquired Immunodeficiency Syndrome
Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.
Clock expires on case of an inmate sickened by AIDS drugs.
Diverse roles for MAPK signaling in circadian clocks.
Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins.
Legal clock starts at realization of harm, not AIDS diagnosis.
Light and circadian regulation of clock components aids flexible responses to environmental signals.
Reliability and reproducibility of several methods of arthroscopic assessment of femoral tunnel position during anterior cruciate ligament reconstruction.
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.
Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin ?(12)-PGJ(2) through Covalent Binding to Cys(1438).
The PAS/LOV protein VIVID controls temperature compensation of circadian clock phase and development in Neurospora crassa.
The pseudo-receiver domain of CikA regulates the cyanobacterial circadian input pathway.
Unravelling novel congeners from acetyllysine mimicking ligand targeting a lysine acetyltransferase PCAF bromodomain.
Acute Coronary Syndrome
Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression.
Acute Kidney Injury
Acute kidney injury due to COVID-19 and the circadian rhythm.
Acute Lung Injury
CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis.
Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury.
Adenocarcinoma
A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma.
Circadian gene expression and clinicopathologic correlates in pancreatic cancer.
Comprehensive analysis of histone modification-associated genes on differential gene expression and prognosis in gastric cancer.
Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A.
Expression pattern and prognostic value of circadian clock genes in pancreatic adenocarcinoma.
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas.
Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genes and susceptibility to gastric and colorectal adenocarcinoma.
KAT2A succinyltransferase activity-mediated 14-3-3? upregulation promotes ?-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells.
N-Acetyltransferase 2 (NAT2) genetic variation and the susceptibility to noncardiac gastric adenocarcinoma in Taiwan.
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Research on circadian clock genes in non-small-cell lung carcinoma.
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
The circadian clock is associated with prognosis and immune infiltration in stomach adenocarcinoma.
[The research the relationship between N-acetyltransferase 1 gene polymorphisms and genetic susceptibility to sporadic colorectal adenocarcinoma]
Adenocarcinoma of Lung
Circadian clock associates with tumor microenvironment in thoracic cancers.
Differences in Genomic Alterations Between Brain Metastases and Primary Tumors.
KAT2B is an immune infiltration-associated biomarker predicting prognosis and response to immunotherapy in non-small cell lung cancer.
Serum factor(s) from lung adenocarcinoma patients regulates the molecular clock expression.
Adenocarcinoma, Follicular
Circadian clock characteristics are altered in human thyroid malignant nodules.
Adenoma
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma.
Analysis of Secondary Phenotype Involving the Interactive Effect of the Secondary Phenotype and Genetic Variants on the Primary Disease.
Case-control study of candidate gene methylation and adenomatous polyp formation.
Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation.
Clock genes alterations and endocrine disorders.
Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians.
Expression of circadian clock genes in human colorectal adenoma and carcinoma.
Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism.
Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling.
Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
Melatonin Exerts Direct Inhibitory Actions on ACTH Responses in the Human Adrenal Gland.
N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies.
The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes.
Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.
Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.
Adenomatous Polyposis Coli
Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis.
E7386, a Selective Inhibitor of the Interaction between ?-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling.
Adrenal Insufficiency
Turning back the clock on adrenal insufficiency.
Agnosia
[Acalculia with clock agnosia in a patient with right cerebral hemisphere lesion and hidden lefthandedness]
Agranulocytosis
Dapsone-induced agranulocytosis - possible involvement of low activity N-acetyltransferase 2.
Genetic factors and risk of agranulocytosis from metamizol.
AIDS Dementia Complex
Epilepsy-associated neurocognitive disorders (EAND) in an onchocerciasis-endemic rural community in Cameroon: A population-based case-control study.
Alagille Syndrome
The vertebrate segmentation clock and its role in skeletal birth defects.
alcohol dehydrogenase deficiency
Ecogenetic and pharmacogenetic studies in Hungary.
Ecogenetic studies in Atacameño Indians.
Allesthesia
On the different mechanisms of spatial transpositions: a case of representational allochiria in clock drawing.
Spatial transpositions across tasks and response modalities: exploring representational allochiria.
Alopecia
The circadian clock and diseases of the skin.
Winding the clock back on female androgenetic alopecia.
alpha-Thalassemia
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alzheimer Disease
A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease.
A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment.
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease.
A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression(1,2,3).
A simple scoring system for clock drawing in patients with Alzheimer's disease.
A?-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer's disease.
Actigraphy for Assessing Light Effects on Sleep and Circadian Activity Rhythm in Alzheimer's Dementia: A Narrative Review.
Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease.
Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease.
Altered cell-matrix associated ADAM proteins in Alzheimer disease.
Amyloid-?-Induced Changes in Molecular Clock Properties and Cellular Bioenergetics.
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha.
Are serum lipid and lipoprotein levels related to dementia?
Attempt to Predict A/T/N-Based Alzheimer's Disease Cerebrospinal Fluid Biomarkers Using a Peripheral Blood DNA Methylation Clock.
Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease.
Broad spectrum assessment of psychopathology and adaptive functioning with the Older Adult Behavior Checklist: a validation and diagnostic discrimination study.
Can clock drawing differentiate Alzheimer's disease from other dementias?
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Central and peripheral circadian clocks and their role in Alzheimer's disease.
Changes in cortical activation during retrieval of clock time representations in patients with mild cognitive impairment and early Alzheimer's disease.
Changes over time in memory, processing speed and clock drawing tests help to discriminate between vascular cognitive impairment, mild cognitive impairment and Alzheimer's disease.
Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis.
Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.
Circadian Clock Gene Expression in Brain Regions of Alzheimer 's Disease Patients and Control Subjects.
Circadian clock gene polymorphisms and sleep--wake disturbance in Alzheimer disease.
Classifying Non-Dementia and Alzheimer's Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test.
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.
Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment.
Clock drawing and Alzheimer's disease.
Clock drawing and frontal lobe behavioral effects of memantine in Alzheimer's disease: a rater-blinded study.
Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
Clock drawing in Alzheimer's disease. A novel measure of dementia severity.
Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease.
Clock drawing performance in cognitively normal elderly.
Clock drawing test in elderly schizophrenia patients.
Clock drawing test in institutionalized patients with schizophrenia compared with Alzheimer's disease patients.
Clock drawing test in very mild Alzheimer's disease.
Clock drawing test ratings by dementia specialists: interrater reliability and diagnostic accuracy.
Clock drawing: analysis in a retirement community.
CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease.
Clock Test Deficits Are Associated With Semantic Memory Impairment in Alzheimer Disease.
Clock tests in depression, Alzheimer's disease, and elderly controls.
Clocking delirium: the value of the Clock Drawing Test with case illustrations.
Cognition in multiple system atrophy: a single-center cohort study.
Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study.
Cognitive function in UK community-dwelling African Caribbean elders: normative data for a test battery.
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.
Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly.
Comparing clock tests for dementia screening: naïve judgments vs formal systems--what is optimal?
Comparison of a clock drawing test in elderly schizophrenia and Alzheimer's disease patients: a preliminary study.
Comparisons of cognitive function and serum S-100B level between diabetic and non-diabetic patients after the implantation of carotid artery stent (CAS).
Cortical signature of clock drawing performance in Alzheimer's disease and mild cognitive impairment.
CREB-binding protein activation by presenilin 1 but not by its M146L mutant.
Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression.
Development of a Brief Cognitive Screen for Mild Cognitive Impairment and Neurocognitive Disorder.
Development of scoring criteria for the clock drawing task in Alzheimer's disease.
Diagnostic performance of a combination of Mini-Mental State Examination and Clock Drawing Test in detecting Alzheimer's disease.
Diagnostic Performance of Clock Drawing Test by CLOX in an Asian Chinese population.
Diagnostic value of digital clock drawing test in comparison with CERAD neuropsychological battery total score for discrimination of patients in the early course of Alzheimer's disease from healthy individuals.
Discrimination of dementia with lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test.
Discriminative capacity and construct validity of the Clock Drawing Test in Mild Cognitive Impairment and Alzheimer's disease.
Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction.
Does the Combination of the MMSE and Clock Drawing Test (Mini-Clock) Improve the Detection of Mild Alzheimer's Disease and Mild Cognitive Impairment?
Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease.
Early detection of Alzheimer's disease: a new working memory paradigm.
Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer's Disease.
Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.
Effects of Intermittent Theta Burst Stimulation on the Clock Drawing Test Performances in Patients with Alzheimer's Disease.
Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer's Disease Model.
Efficacy and safety of galantamine (reminyl) for dementia in patients with Parkinson's disease (an open controlled trial).
Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease.
Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep.
Executive Abilities as Reflected by Clock Hand Placement: Frontotemporal Dementia Versus Early-Onset Alzheimer Disease.
Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology.
Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population.
Functional neuroanatomical correlates of the executive clock drawing task (CLOX) performance in Alzheimer's disease: a FDG-PET study.
Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease.
Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease.
Improvement pattern in the clock drawing test in early Alzheimer's disease.
Increased Diagnostic Accuracy of Digital vs. Conventional Clock Drawing Test for Discrimination of Patients in the Early Course of Alzheimer's Disease from Cognitively Healthy Individuals.
Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.
Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.
Inhibition of casein kinase 1?/?improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects.
Intra-individual variability in Alzheimer's disease and cognitive aging: definitions, context, and effect sizes.
Lack of association between genetic polymorphism of circadian genes (PER2, PER3, CLOCK and OX2R) with late onset depression and Alzheimer's disease in a sample of a Brazilian population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).
Learning Classification Models of Cognitive Conditions from Subtle Behaviors in the Digital Clock Drawing Test.
Longitudinal analysis of clock drawing in Alzheimer's disease patients.
Machine Learning Analysis of Digital Clock Drawing Test Performance for Differential Classification of Mild Cognitive Impairment Subtypes Versus Alzheimer's Disease.
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.
MARIO Project: Validation and Evidence of Service Robots for Older People with Dementia.
Melatonin and brain inflammaging.
Metabolic alterations associated with impaired clock drawing in Lewy body dementia.
Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response.
Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
N-acetyltransferase (NAT2) genotype and susceptibility of sporadic Alzheimer's disease.
N-Acetyltransferase 2 gene polymorphism in a group of senile dementia patients in Shanghai suburb.
Neural correlates of impaired performance on the clock drawing test in Alzheimer's disease.
Neural Correlates of the Clock Drawing Test Performance in Alzheimer's Disease: A FDG-PET Study.
Neural correlates of the components of the clock drawing test.
Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients.
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.
Normative References for Graphomotor and Latency Digital Clock Drawing Metrics for Adults Age 55 and Older: Operationalizing the Production of a Normal Appearing Clock.
One-year Outcome of Shanghai Mild Cognitive Impairment Cohort Study.
p300 activation by Presenilin 1 but not by its M146L mutant.
Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study.
Performance on the clock drawing task correlates with FMRI response to a visuospatial task in Alzheimer's disease.
Physical Exercise with Multicomponent Cognitive Intervention for Older Adults with Alzheimer's Disease: A 6-Month Randomized Controlled Trial.
Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock".
Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease.
Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer's Disease in a Chinese Population.
Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain.
Qualitative analyses of clock drawings in Alzheimer's disease and vascular dementia.
Qualitative Features of Clock Drawings in Normal Aging and Alzheimer's Disease
Quantitative and qualitative analyses of clock drawing in frontotemporal dementia and Alzheimer's disease.
Quantitative and Qualitative Analyses of the Clock Drawing Test in Fall and Non-Fall Patients with Alzheimer's Disease.
Quantitative and qualitative analyses of the clock drawing test in mild cognitive impairment and Alzheimer disease: evaluation of a modified scoring system.
Real-world navigation in amnestic mild cognitive impairment: The relation to visuospatial memory and volume of hippocampal subregions.
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
Relationship between clock drawing test performance and regional cerebral blood flow in Alzheimer's disease: a single photon emission computed tomography study.
Relationships Between Behavioral Syndromes and Cognitive Domains in Alzheimer Disease: The Impact of Mood and Psychosis.
Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET.
Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition.
Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease.
Screening for Alzheimer's Disease Among Illiterate Elderly: Accuracy Analysis for Multiple Instruments.
Screening for Alzheimer's disease by clock drawing.
Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance.
Ten-point clock test sensitivity for Alzheimer's disease in patients with MMSE scores greater than 23.
Ten-Point Clock test: a correlation analysis with mini-mental state and proverb interpretation score in Alzheimer's disease.
The abbreviated form of the Brief Cognitive Battery in the diagnosis of dementia in Alzheimer's disease.
The accuracy of the Clock Drawing Test compared to that of standard screening tests for Alzheimer's disease: results from a study of Brazilian elderly with heterogeneous educational backgrounds.
The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes.
The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.
The characterization of biological rhythms in mild cognitive impairment.
The circadian clock in old Drosophila melanogaster.
The circadian rest-activity cycle in Korsakoff psychosis.
The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease.
The complex picture test in dementia.
The Effectiveness of Reality Orientation in the Treatment of Alzheimer's Disease.
The Effectiveness of Reality Orientation Therapy in the Treatment of Parkinson Disease Dementia.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
The four-point scoring system for the clock drawing test does not differentiate between Alzheimer's disease and vascular dementia.
The interlocking finger test in patients with Parkinson's disease and healthy subjects.
The minute hand phenomenon in the clock test of patients with early Alzheimer disease.
The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated With Susceptibility of Alzheimer Disease in Chinese Population.
The relevance of hippocampal subfield integrity and clock drawing test performance for the diagnosis of Alzheimer's disease and mild cognitive impairment.
The reversed clock drawing test phenomenon in Alzheimer's disease: A perfusion SPECT study.
The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer's Disease.
The role of circadian clock genes in mental disorders.
The role of NAT2 gene polymorphism in aetiology of the most frequent neurodegenerative diseases with dementia.
The short cognitive evaluation battery in cognitive disorders of the elderly--Italian version.
The six-item Clock Drawing Test - reliability and validity in mild Alzheimer's disease.
The Stick Design Test on the assessment of older adults with low formal education: evidences of construct, criterion-related and ecological validity.
The use of neuropsychological tests across Europe: the need for a consensus in the use of assessment tools for dementia.
The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer's type.
The validation of a mailed health survey for screening of dementia of the Alzheimer's type.
Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.
Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model.
TIP60 in aging and neurodegeneration.
Tracking cognitive functioning over time: ten-year longitudinal data from a community-based study.
Trajectories and risk factors of dementia progression: a memory clinic cohort followed up to 3 years from diagnosis.
Use of the clock drawing task in the diagnosis of mild and very mild Alzheimer's disease.
Use of the ten-point clock test to compare executive functioning across 24 months in patients with subcortical vascular dementia.
Validity and Clinical Utility of Different Clock Drawing Test Scoring Systems in Multiple Forms of Dementia.
Visual exploration behaviour during clock reading in Alzheimer's disease.
Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model.
[A proposal for application and scoring of the Clock Drawing Test in Alzheimer's disease]
[Asymptomatic encephalic calcifications in postsurgical hypoparathyroidism.]
[Clock drawing in dementia: its reliability and relation to the neuropsychological measures]
[Dysfunctions of biological clocks and their treatments]
[Effect of early acupuncture on cognitive function in patients with vascular dementia after cerebral infarction].
[Quantitative and qualitative analyses for characteristics of the clock drawing in Alzheimer's disease].
[Test scores as indicators of treatment efficacy in dementia caused by Alzheimer's disease in clinical practice].
Amnesia
The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.
[Amnesic stroke caused by hippocampal infarction]
Amnesia, Retrograde
Single-trace fragility theory of memory dynamics.
Amyloidosis
Patient outcomes in light chain (AL) amyloidosis: The clock is ticking from symptoms to diagnosis.
Amyotrophic Lateral Sclerosis
Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model.
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.
Racing against the clock: recognizing, differentiating, diagnosing, and referring the amyotrophic lateral sclerosis patient.
Anaphylaxis
Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction.
Disruption of the suprachiasmatic nucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice.
Anemia, Aplastic
Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia.
Anemia, Iron-Deficiency
[Polymorphism of xenobiotic detoxication genes in patients with iron deficiency anemia]
Aneurysm
Factors Predictive of Subretinal Fluid Resolution in Coats Disease: Analysis of 177 Eyes in 177 Patients at a Single Center.
Predictors of enucleation in Coats disease: analysis of 259 eyes of 259 patients at a single center.
Aneurysm, Dissecting
99-Case Study of Sporadic Aortic Dissection by Whole Exome Sequencing Indicated Novel Disease-Associated Genes and Variants in Chinese Population.
Angelman Syndrome
Genetic disorders associated with postnatal microcephaly.
Anus, Imperforate
EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74 patients.
Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.
Aortic Aneurysm
Aortic aneurysm: An underestimated serious finding in the EP300 mutation phenotypical spectrum.
Aortic Aneurysm, Abdominal
Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm.
The role of circadian clock gene BMAL1 in vascular proliferation.
Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy.
Aphakia
Current visual and anatomic outcomes of pneumatic retinopexy.
Aphasia
Education and cognitive function in Alzheimer's disease.
Apnea
Physiological changes in response to apnea impact the timing of motor representations: a preliminary study.
Prevalence of sleep apnea among Japanese industrial workers determined by a portable sleep monitoring system.
Apraxias
Assessment for apraxia in mild cognitive impairment and Alzheimer's dise.
Development of scoring criteria for the clock drawing task in Alzheimer's disease.
Factitious clock drawing adn constructional apraxia.
Neglect in elderly stroke patients: a comparison of five tests.
Relationship between clock and star drawing and the degree of hepatic encephalopathy.
The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease.
[Clock drawing test: qualitative and quantitative evaluation methods]
Arrhythmias, Cardiac
A 13.34?W Event-driven Patient-specific ANN Cardiac Arrhythmia Classifier for Wearable ECG Sensors.
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.
Circadian regulation of metabolism and healthspan in Drosophila.
Circadian rhythm. Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing.
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.
Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.
Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis.
Effect of reoxygenation on the electrical stability of the rat heart in vivo: a chronobiological study.
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.
PHYTOCLOCK 1 encoding a novel GARP protein essential for the Arabidopsis circadian clock.
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Prolonged QT intervals in mice with cardiomyocyte-specific deficiency of the molecular clock.
The Cardiomyocyte Molecular Clock, Regulation of Scn5a and Arrhythmia Susceptibility.
The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.
The Myb domain of LUX ARRHYTHMO in complex with DNA: expression, purification and crystallization.
The search for circadian rhythm pacemakers in the light of lesion experiments.
Transcriptomal dissection of soybean circadian rhythmicity in two geographically, phenotypically and genetically distinct cultivars.
Arteriosclerosis
Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.
Arthritis
Clock drawing: analysis in a retirement community.
Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.
Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis.
Regulatory T cells confer a circadian signature on inflammatory arthritis.
Resetting the clock on arthritis.
The circadian clock regulates inflammatory arthritis.
The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis.
Arthritis, Rheumatoid
Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene.
Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis.
DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP.
Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-?B acetylation in fibroblast-like synoviocyte MH7A cells.
Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1? and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation.
Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production.
Implications of transcriptional coactivator CREB binding protein complexes in rheumatoid arthritis.
Increased genotype frequency of N-acetyltransferase 2 slow acetylation in patients with rheumatoid arthritis.
Interactions between the genes that regulate the body clock and those that worsen rheumatoid arthritis.
Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis.
Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes.
N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis.
N-acetyltransferase-2 genotypes among patients with rheumatoid arthritis attending jordan university hospital.
Rheumatoid arthritis and the biological clock.
The influence of N-acetyltransferase 2 polymorphism on rheumatoid arthritis activity.
The role of the circadian clock in rheumatoid arthritis.
TNF-? induces expression of the circadian clock gene Bmal1 via dual calcium-dependent pathways in rheumatoid synovial cells.
TNF-? modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells.
Asthma
A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices.
Acetyl-CoA:lyso-platelet-activating factor acetyltransferase activity in neutrophils from asthmatic patients and normal subjects.
Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma.
Association between the N-acetylation genetic polymorphism and bronchial asthma.
Association of circadian clock TIMELESS variants and expression with asthma risk in children.
Asthma: Chronopharmacotherapy and the molecular clock.
Basophil degranulation in response to IgE ligation is controlled by a distinctive circadian clock in asthma.
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300.
Circadian asthma airway responses are gated by REV-ERB?.
Circadian rhythms in adaptive immunity.
Circadian rhythms in the CNS and peripheral clock disorders: function of clock genes: influence of medication for bronchial asthma on circadian gene.
Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma.
Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.
Histone deacetylase-2 and airway disease.
Knowledge and attitudes of American physicians and public about medical chronobiology and chronotherapeutics. Findings of two 1996 Gallup surveys.
Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules.
Molecular basis of chronic inflammation in lung diseases: new therapeutic approach.
N-acetyltransferase 2 (NAT2) polymorphism in patients with atopic asthma.
N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma.
N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.
Neuromedin U: physiology, pharmacology and therapeutic potential.
Novel insights from genetic and molecular characterization of the human clock.
Optimization of dosing schedule of daily inhalant dexamethasone to minimize phase shifting of clock gene expression rhythm in the lungs of the asthma mouse model.
Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis.
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.
The circadian clock and asthma.
The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.
The Role of the Body Clock in Asthma and COPD: Implication for Treatment.
[A new spacer, Babyhaler, for BDP inhalation therapy in severe infantile asthma]
[Roles of histone acetyltransferase and histone deacetylase in the pathogenesis of bronchial asthma].
Astigmatism
Assessment of a software guided system to reduce pre-existing astigmatism in cataract surgery.
Relaxing incisions. Corneal topography.
Astrocytoma
[Increased Egr-1 binding to promoter induced by histone hyperacetylation promotes gdnf gene transcription].
Ataxia
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways.
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
The double dealing of cyclin D1.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.
Regulation of TIP60 by ATF2 modulates ATM activation.
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
Tip60 in DNA damage response and growth control: many tricks in one HAT.
Tip60 is associated with resistance to X-ray irradiation in prostate cancer.
Atherosclerosis
Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho.
Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition.
Angiotensin II Suppresses Rev-erb? Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor ? Pathway.
Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice.
BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress.
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression.
Clock-Bmal1 mediates MMP9 induction in acrolein-promoted atherosclerosis associated with gut microbiota regulation.
Curing atherosclerosis should be the next major cardiovascular prevention goal.
Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice.
Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques.
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis.
Hyper nuclear acetylation (HNA) in proliferation, differentiation and apoptosis.
Impaired Cholesterol Metabolism and Enhanced Atherosclerosis in Clock Mutant Mice.
MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions.
Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NF-?B pathway.
P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.
Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract.
Rev-erb alpha gives a time cue to metabolism.
Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein E knockout mice.
The orphan nuclear receptor Rev-erbalpha: a transcriptional link between circadian rhythmicity and cardiometabolic disease.
The potential of chronopharmacology for treatment of atherosclerosis.
The role of circadian clock gene BMAL1 in vascular proliferation.
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Atrial Fibrillation
Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling.
Exercise-induced arterial hypertension - an independent factor for hypertrophy and a ticking clock for cardiac fatigue or atrial fibrillation in athletes?
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
Sinus node revisited.
The role of the calcium and the voltage clocks in sinoatrial node dysfunction.
Atrial Flutter
Progressive isthmus delay during atrial flutter ablation: the critical importance of isthmus spanning electrodes for distinguishing pseudoblock from block.
Autoimmune Diseases
Circadian clock genes as promising therapeutic targets for autoimmune diseases.
Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.
DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP.
Depression in Autoimmune Diseases.
Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
The Circadian Clock in Oral Health and Diseases.
The role of the circadian clock in rheumatoid arthritis.
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription.
TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation.
Bacteremia
Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization.
Bacterial Infections
A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy.
A Localized Pseudomonas syringae Infection Triggers Systemic Clock Responses in Arabidopsis.
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses.
Diel Variation in CC Chemokine Gene Expression in the Japanese Pufferfish Takifugu rubripes.
Barrett Esophagus
A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.
Correction: A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.
Behcet Syndrome
N-acetyltransferase 2 polymorphisms in patients with Behcet's disease.
beta-n-acetylhexosaminidase deficiency
A fluorimetric enzyme assay for the diagnosis of Sanfilippo disease C (MPS III C).
Bicuspid Aortic Valve Disease
Upregulated microRNA?330?3p promotes calcification in the bicuspid aortic valve via targeting CREBBP.
Blepharophimosis
De novo KAT6B Mutation Identified with Whole-Exome Sequencing in a Girl with Say-Barber/Biesecker/Young-Simpson Syndrome.
Further delineation of the KAT6B molecular and phenotypic spectrum.
KAT6B Genetic Variant Identified in a Short Stature Chinese Infant: A Report of Physical Growth in Clinical Spectrum of KAT6B-Related Disorders.
Blepharoptosis
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
Blindness
A switch from diurnal to nocturnal activity in S. ehrenbergi is accompanied by an uncoupling of light input and the circadian clock.
Are some melanomas caused by artificial light?
RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.
[Internal clock desynchronization, light and melatonin].
[Role of biological clock in human pathology]
[The circadian system in man: From the internal clock to melatonin secretion].
Blister
Bulla gouldiana period exhibits unique regulation at the mRNA and protein levels.
Evidence for a central role of transcription in the timing mechanism of a circadian clock.
Management of hypotony after glaucoma filtering surgery.
Bone Diseases, Metabolic
Identification of Differential Genes Expression Profiles and Pathways of Bone Marrow Mesenchymal Stem Cells of Adolescent Idiopathic Scoliosis Patients by Microarray and Integrated Gene Network Analysis.
Bone Resorption
Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.
Circadian Clock Regulates Bone Resorption in Mice.
Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.
Intestinal clock system regulates skeletal homeostasis.
Bowen's Disease
[Disseminated Bowen's disease 20 years after the handling of radioactive products in the clock manufacture]
Brachydactyly
Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders.
Bradycardia
New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²? cycling.
Pacemaker Gene Mutations, Bradycardia, Arrhythmias and the Coupled Clock Theory.
RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.
Brain Concussion
Executive clock drawing correlates with performance-based functional status in people with combat-related mild traumatic brain injury and comorbid posttraumatic stress disorder.
Brain Diseases
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
Relationship between clock and star drawing and the degree of hepatic encephalopathy.
The discovery of circadian clock genes and the use of similar strategies to discover unknown genes underlying complex behaviors and brain disorders.
Brain Edema
Subtle Cognitive Dysfunction in Resolving High Altitude Cerebral Edema Revealed by a Clock Drawing Test.
Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT.
Brain Infarction
Microbleeds and silent brain infarctions are differently associated with cognitive dysfunction in patients with advanced periventricular leukoaraiosis.
Brain Injuries
Monitoring anoxic depolarization at the bedside: A step closer to the 24th century.
The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia-ischemia brain injury.
The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats.
Brain Injuries, Traumatic
Clock drawing and mini-mental state examination in patients with traumatic brain injury.
Evaluation of Cognitive Functions in Traumatic Brain Injury Patients Using Mini Mental State Examination and Clock Drawing Test.
Neuroanatomical correlates of the clock drawing test in patients with traumatic brain injury.
Regulation of Circadian Clock Genes on Sleep Disorders in Traumatic Brain Injury Patients.
Revisiting the neuroanatomical correlates of the clock drawing test among persons with traumatic brain injury.
Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm.
THE MOLECULAR MECHANISMS AFFECTING N-ACETYLASPARTATE HOMEOSTASIS FOLLOWING EXPERIMENTAL GRADED TRAUMATIC BRAIN INJURY.
Brain Ischemia
Brain tissue sodium is a ticking clock telling time after arterial occlusion in rat focal cerebral ischemia.
Cyclic AMP response element binding protein (CREB) and CREB binding protein (CBP) in global cerebral ischemia.
Increased Neuronal Injury in Clock Gene Per-1 Deficient-Mice after Cerebral Ischemia.
Proton magnetic resonance spectroscopy as a time clock measurement device in cerebral ischemia.
The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia.
[Effects of Wulongdan on expression of pineal clock genes in rats with chronic cerebral ischemia].
Brain Neoplasms
Acetyl-coenzyme A: 1,4-diaminobutane N-acetyltransferase: activity in rat brain during development, in experimental brain tumours and in brains of fish of different metabolic activity.
Alterations to the circadian clock make brain tumours vulnerable.
Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours.
DNA methylation-based age estimation in pediatric healthy tissues and brain tumors.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Breast Neoplasms
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.
A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology.
A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.
A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression.
A novel deep autoencoder based survival analysis approach for microarray dataset.
Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer.
Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms.
Active smoking and secondhand smoke increase breast cancer risk: the report of the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk (2009).
Altered circadian genes expression in breast cancer tissue according to the clinical characteristics.
Analyses of BMAL1 and PER2 Oscillations in a Model of Breast Cancer Progression Reveal Changes With Malignancy.
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Arylamine N-acetyltransferase activities in human breast cancer tissues.
ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.
Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach.
Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence.
Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States).
Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work
BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.
Breast cancer and active and passive smoking: the role of the N-acetyltransferase 2 genotype.
Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms.
Breast cancer risk, nightwork, and circadian clock gene polymorphisms.
Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype.
Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotype.
Can Unknown Predisposition in Familial Breast Cancer be Family-Specific?
Cancer stem cell generation during epithelial-mesenchymal transition is temporally gated by intrinsic circadian clocks.
Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype.
CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells.
CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers.
Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen.
Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.
Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis.
Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk.
Circadian clock and breast cancer: a molecular link.
Circadian clock gene Per2 downregulation in non?small cell lung cancer is associated with tumour progression and metastasis.
Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms.
Circadian disruption and breast cancer: an epigenetic link?
Circadian disruption and breast cancer: from melatonin to clock genes.
Circadian gene variants and breast cancer.
Circadian Genes in Breast Cancer.
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
Circadian oscillations persist in low malignancy breast cancer cells.
CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses.
CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-?
Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population.
Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
Consumption of red and processed meat and breast cancer incidence: A systematic review and meta-analysis of prospective studies.
Correction to "High N-Acetyltransferase 1 5?-androstane-3?, Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 17?-Diol, or Dihydrotestosterone in Breast Cancer Cells".
Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.
Correlation of Expression of Human Arrest-Defective-1 (hARD1) Protein With Breast Cancer.
Correlation of expression of human arrest-defective-1 (hARD1) protein with breast cancer.
Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.
Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin.
Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3.
Digging Deeper into Breast Cancer Epigenetics: Insights from Chemical Inhibition of Histone Acetyltransferase TIP60 In Vitro.
DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.
Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm.
E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex.
Effects of tamoxifen on DNA adduct formation and arylamines N-acetyltransferase activity in human breast cancer cells.
Elevated GCN5 expression confers tamoxifen resistance by upregulating AIB1 expression in ER-positive breast cancer.
Entrainment of breast (cancer) epithelial cells detects distinct circadian oscillation patterns for clock and hormone receptor genes.
EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer.
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.
Epigenetic biomarker screening by FLIM-FRET for combination therapy in ER+ breast cancer.
Epigenetic impact of long-term shiftwork: pilot evidence from circadian genes and whole-genome methylation analysis.
Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol (E2)-activated expression of HBO1.
Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells.
Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.
Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors.
Extracellular Acidosis Promotes Metastatic Potency via Decrease of the BMAL1 Circadian Clock Gene in Breast Cancer.
Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation.
FOXA1 is a determinant of drug resistance in breast cancer cells.
Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast.
Function of GCN5 in the TGF-?1-induced epithelial-to-mesenchymal transition in breast cancer.
Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
Genetic variants in epigenetic genes and breast cancer risk.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
GSTM1 null genotype, red meat consumption and breast cancer risk (The Netherlands).
Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells.
Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases.
High levels of ?-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5
Highlight report: Role of the circadian clock system in breast cancer.
Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells.
Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.
Identification of a panel of MYC and Tip60 co-regulated genes functioning primarily in cell cycle and DNA replication.
Identification of an estrogen-regulated circadian mechanism necessary for breast acinar morphogenesis.
Identification of MYST3 as a novel epigenetic activator of ER? frequently amplified in breast cancer.
Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1).
Identification of valid reference genes for circadian gene-expression studies in human mammary epithelial cells.
Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo.
Implications of a peroxisome proliferator-activated receptor alpha (PPAR?) ligand clofibrate in breast cancer.
Improved lymphatic mapping technique for breast cancer.
Induction of the CLOCK gene by E2-ER? signaling promotes the proliferation of breast cancer cells.
Influence of night-shift and napping at work on urinary melatonin, 17-ß-estradiol and clock gene expression in pre-menopausal nurses.
Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels.
Inhibition of N-acetyltransferase 10 using remodelin attenuates doxorubicin resistance by reversing the epithelial-mesenchymal transition in breast cancer.
KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Kinetics of arylamine N-acetyltransferase in tissues from human breast cancer.
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
LINC01857 as an oncogene regulates CREB1 activation by interacting with CREBBP in breast cancer.
Loss of circadian clock gene expression is associated with tumor progression in breast cancer.
Master Regulators of Signaling Pathways: An Application to the Analysis of Gene Regulation in Breast Cancer.
Mechanisms of Breast Cancer in Shift Workers: DNA Methylation in Five Core Circadian Genes in Nurses Working Night Shifts.
Metagenomic characterization of KATs in human cancer and their association with clinic-pathological features.
Methylation-based biological age and breast cancer risk.
miR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300.
Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2.
Molecular mechanisms of melatonin anticancer effects.
Mutational landscape implicates epithelial-mesenchymal transition gene TGF-?2 mutations for uterine carcinosarcoma after adjuvant tamoxifen therapy for breast carcinoma.
MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer.
N-acetyltransferase (NAT2) polymorphism and breast cancer susceptibility: a lack of association in a case-control study of Turkish population.
N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk.
N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines.
N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer.
N-acetyltransferase 2 Genotype Modification of Active Cigarette Smoking on Breast Cancer Risk Among Hispanic and non-Hispanic White Women.
N-acetyltransferase 2 polymorphism and breast cancer risk with smoking: a case control study in Japanese women.
N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium.
N-acetyltransferase 2, exposure to aromatic and heterocyclic amines, and receptor-defined breast cancer.
NAT1*10 and NAT1*11 polymorphisms and breast cancer risk.
NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis.
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1?- and AP-1-mediated VEGFa transcription.
Night shift work and risk of breast cancer in women: the Generations Study cohort.
Night-shift work, circadian and melatonin pathway related genes and their interaction on breast cancer risk: evidence from a case-control study in Korean women.
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases.
Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin.
p33(ING1b) stimulates the transcriptional activity of the estrogen receptor alpha via its activation function (AF) 2 domain.
p33ING1b and estrogen receptor (ER) alpha.
PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair.
Peritumoural versus subareolar administration of technetium-99m nanocolloid for sentinel lymph node detection in breast cancer: preliminary results of a prospective intra-individual comparative study.
Pharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ER?) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast Cancer.
Polymorphisms in circadian genes, night work and breast cancer: results from the GENICA study.
Polymorphisms in Xenobiotic Metabolizing Genes, Intakes of Heterocyclic Amines and Red Meat, and Postmenopausal Breast Cancer.
Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias.
Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.
Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer.
Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.
Quantifying Tip60 (Kat5) stratifies breast cancer.
Race of the clock: reducing delay to curative breast cancer surgery.
Rational design and validation of a Tip60 histone acetyltransferase inhibitor.
Regulation of estrogen-mediated cell survival and proliferation by p160 coactivators.
Risk of breast cancer after night- and shift work: current evidence and ongoing studies in denmark.
Rotating-shift nurses after a day off: peripheral clock gene expression, urinary melatonin, and serum 17-?-estradiol levels.
Shift work, circadian gene variants and risk of breast cancer.
Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems.
Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.
Smoking (active and passive), N-acetyltransferase 2, and risk of breast cancer.
Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer.
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study.
The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16.
The association of polymorphic N-acetyltransferase (NAT2) with breast cancer risk.
The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day.
The clock gene Per2 links the circadian system to the estrogen receptor.
The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age.
The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ER? and enhances ER? target gene expression in breast cancer cells.
The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome.
The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.
The role of polymorphisms in circadian pathway genes in breast tumorigenesis.
Therapeutic Implications of Epigenetic Signaling in Breast Cancer.
Time will tell: Circadian clock dysregulation in triple negative breast cancer.
TIP60 Histone Acetyltransferase in Adipose Tissue: Possible Linkages with Breast Cancer Development?
TIP60 Inhibitor TH1834 Reduces Breast Cancer Progression in Xenografts in Mice.
TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.
TIP60-miR-22 axis as a prognostic marker of breast cancer progression.
TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.
TIP60: an actor in acetylation of H3K4 and tumor development in breast cancer.
Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells.
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.
Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world.
Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world.
[Association of genetic variantions of circadian clock genes and risk of breast cancer].
[hARD1 antiserum preparation and primary immunohistochemical analysis of hARD1 in tumor tissues]
[Molecular mechanism of inhibition of sodium butyrate on activation of tumor associated aromatase promoters]
[Night work as a possible risk factor for breast cancer in nurses. Correlation between the onset of tumors and alterations in blood melatonin levels]
[Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues]
[Shift work and breast cancer].
[The relationship between passive smoking, breast cancer risk and n-acetyltransferase 2 (NAT2)].
Bronchiolitis, Viral
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Burkitt Lymphoma
GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways.
Carcinogenesis
"US-JAPAN CONFERENCE: INFLAMMATION, DIABETES AND CANCER" held at the Beckman Research Institute of City of Hope, Duarte, CA, USA.
2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
A cybernetical model of the internal cellular clock.
A novel long noncoding RNA linc00460 upregulated by CBP/P300 promotes carcinogenesis in Esophageal Squamous Cell Carcinoma.
A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.
A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage.
A putative role for the aryl hydrocarbon receptor (AHR) gene in a patient with cyclical Cushing's disease.
Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics.
Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure.
Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9.
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma.
Altered expression of the clock gene machinery in kidney cancer patients.
Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors.
An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma.
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease.
Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation.
Artificial lighting in the industrialized world: circadian disruption and breast cancer.
Assays for Validating Histone Acetyltransferase Inhibitors.
Association of N-acetyltransferase polymorphism and environmental factors with bladder carcinogenesis. Study in a north German population.
c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.
c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level.
Cancer clocks in tumourigenesis: the p53 pathway and beyond.
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction.
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Chromatin Regulator SPEN/SHARP in X Inactivation and Disease.
Circadian biology: an unexpected invitee to new time zones.
Circadian clock and cancer: From a viewpoint of cellular differentiation.
Circadian clock and oral cancer.
Circadian clock associates with tumor microenvironment in thoracic cancers.
Circadian clock circuitry in colorectal cancer.
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma.
Circadian clock pathway genes associated with colorectal cancer risk and prognosis.
Circadian clock, carcinogenesis, chronochemotherapy connections.
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism.
Circadian clock: a regulator of the immunity in cancer.
Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124.
Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression.
Circadian regulation of c-MYC in mice.
Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock.
Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
Circadian rhythms and cancer.
Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa.
Clock at the Core of Cancer Development.
Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients.
Clock gene Per2 as a controller of liver carcinogenesis.
Clock genes and cancer.
CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses.
Correlation between deregulated expression of PER2 gene and degree of glioma malignancy.
Correlation between miRNAs and target genes in response to Campylobacter jejuni inoculation in chicken.
Correlation of Expression of Human Arrest-Defective-1 (hARD1) Protein With Breast Cancer.
Correlation of expression of human arrest-defective-1 (hARD1) protein with breast cancer.
CREBBP knockdown suppressed proliferation and promoted chemo-sensitivity via PERK-mediated unfolded protein response in ovarian cancer.
Critical cholangiocarcinogenesis control by cryptochrome clock genes.
Daily rhythm variations of the clock gene PER1 and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma.
Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia.
Deregulated Expression of the Clock Genes in Gliomas.
Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.
Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery.
Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II. In vivo studies.
Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.
Differential gene expression profiles of hepatocellular carcinomas associated or not with viral infection.
Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.
Disruption of the Molecular Circadian Clock and Cancer: An Epigenetic Link.
Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2.
Does "clock" matter in prostate cancer?
Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis.
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.
Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa.
Effects of light and food schedules on liver and tumor molecular clocks in mice.
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3pf.
Environmental factors promoting bladder cancer.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Epithelial proliferation and expression of the aromatic amine activation enzyme N-acetyltransferase in the prostate of postnatal rat.
Exciting History of Tip60 and Its Companions in Carcinogenesis Across the Heterochromatin Landscapes.
Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR.
Expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates with location of tumor differently.
Expression of clock-related genes in benign and malignant adrenal tumors.
Expression of N-acetyltransferase (NAT) in cultured human uroepithelial cells.
Expression of PER, CRY, and TIM genes for the pathological features of colorectal cancer patients.
Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors.
Expression pattern and prognostic value of circadian clock genes in pancreatic adenocarcinoma.
Extrahepatic expression of N-acetylator genotype in the inbred hamster.
Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300.
Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.
GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Genetic variation analysis in a Chinese Maffucci syndrome patient.
Glutathione S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in white, black and Asian smokers and nonsmokers.
Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors.
Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase.
High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5
Histone acetylation and chromatin signature in stem cell identity and cancer.
Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer.
Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development.
Histone acetyltransferases and deacetylases: molecular and clinical implications to gastrointestinal carcinogenesis.
Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors.
Histone deacetylation in epigenetics: an attractive target for anticancer therapy.
Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues.
Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo.
Impaired light detection of the circadian clock in a zebrafish melanoma model.
Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer.
Induction of the CBP transcriptional co-activator early during laryngeal carcinogenesis.
Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice.
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.
Is there a role for molecular prognostic factors in the clinical management of ductal carcinoma in situ (DCIS) of the breast?
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.
Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.
KAT2A succinyltransferase activity-mediated 14-3-3? upregulation promotes ?-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Light Pollution and Cancer.
LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.
Loss of cryptochrome reduces cancer risk in p53 mutant mice.
LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells.
Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis.
Metabolism of xenobiotics and chemical carcinogenesis.
Methods for In Vivo Functional Studies of Chromatin-Modifying Enzymes in Early Steps of Colon Carcinogenesis.
microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10.
MiR-596 activated by EP300 controls the tumorigenesis in epithelial ovarian cancer by declining BRD4 and KPNA4.
MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer.
Molecular dynamics simulations data of six compounds F3J-BRD4/CBP, EX1-BRD4/CBP, and E2T-BRD4/CBP.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Mutation analysis of EP300 in colon, breast and ovarian carcinomas.
Mutations in the circadian gene CLOCK in colorectal cancer.
Mutations truncating the EP300 acetylase in human cancers.
MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.
N-acetyltransferase activity--a susceptibility factor in human bladder carcinogenesis.
N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis.
N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population.
Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.
Oxysterols and Gastrointestinal Cancers Around the Clock.
p53 targets simian virus 40 large T antigen for acetylation by CBP.
Paclitaxel (taxol) inhibits the arylamine N-acetyltransferase activity and gene expression (mRNA NAT1) and 2-aminofluorene-DNA adduct formation in human bladder carcinoma cells (T24 and TSGH 8301).
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.
Period 2 mutation accelerates ApcMin/+ tumorigenesis.
Perspective: defects in cell cycle control and cancer.
PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer.
Potential role of garcinol as an anticancer agent.
Prognostic and Clinicopathological Significance of X-Box-Binding Protein 1 and N-Acetyltransferase 1 in Gallbladder Cancer.
Protein acetylation: more than chromatin modification to regulate transcription.
Ras-mediated deregulation of the circadian clock in cancer.
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.
Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus.
RNAi screening identifies HAT1 as a potential drug target in esophageal squamous cell carcinoma.
Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.
Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis.
RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking.
Sea-Blue Histiocytosis of Bone Marrow in a Patient with t(8;22) Acute Myeloid Leukemia.
SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.
Short-chain fatty acid inhibitors of histone deacetylases: promising anticancer therapeutics?
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 and the clock gene machinery in colorectal cancer.
Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27(Kip1) Accumulation.
Stopping the Clock with MYC.
Targeting Histone Modifications in Bone and Lung Metastatic Cancers.
Targeting Mybbp1a suppresses HCC progression via inhibiting IGF1/AKT pathway by CpG islands hypo-methylation dependent promotion of IGFBP5.
Targeting the SAGA and ATAC transcriptional coactivator complexes in MYC-driven cancers.
Tat-interactive Protein-60KDA (TIP60) Regulates the Tumorigenesis of Lung Cancer In Vitro.
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis.
The circadian clock and the hypoxic response pathway in kidney cancer.
The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma.
The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.
The circadian clock in cancer development and therapy.
The Circadian Clock in Skin: Implications for Adult Stem Cells, Tissue Regeneration, Cancer, Aging, and Immunity.
The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1?.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The Circadian Gene Clock Plays an Important Role in Cell Apoptosis and the DNA Damage Response In Vitro.
The circadian molecular clock creates epidermal stem cell heterogeneity.
The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.
The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.
The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma.
The clock proteins, aging, and tumorigenesis.
The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in A Zebrafish Xenograft Colon Cancer Model.
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis.
The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia.
The Impact of the Circadian Clock on Skin Physiology and Cancer Development.
The molecular basis of carcinogenesis: understanding the cell cycle clock.
The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.
The mutational landscape of adenoid cystic carcinoma.
The overexpression of MYST4 in human solid tumors is associated with increased aggressiveness and decreased overall survival.
The role of circadian clock genes in tumors.
The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.
Ticking time bombs: connections between circadian clocks and cancer.
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
TIP60 represses activation of endogenous retroviral elements.
TIP60: an actor in acetylation of H3K4 and tumor development in breast cancer.
Tip60: updates.
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.
Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer.
Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.
Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
[Circadian rhythm variation of the clock genes Per1 and cell cycle related genes in different stages of carcinogenesis of buccal mucosa in animal model].
[Circadian variation of clock gene Per2 and cancer-related clock-controlled genes in buccal mucosa carcinoma of golden hamster at different cancer stages].
[Identification of proteins interacting with the circadian clock protein PER1 in tumors using bacterial two-hybrid system technique].
[Role of clock proteins in skin carcinogenesis in 14-month-old SHR mice maintained under disrupted light regimen].
[The progress of studies on the relation between circadian rhythm disruption and cancer].
Carcinoma
A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL.
A novel long noncoding RNA linc00460 upregulated by CBP/P300 promotes carcinogenesis in Esophageal Squamous Cell Carcinoma.
A role for the clock period circadian regulator 2 gene in regulating the clock gene network in human oral squamous cell carcinoma cells.
A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.
Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma.
Altered expression of circadian clock genes in head and neck squamous cell carcinoma.
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus.
Association of N-acetyltransferase polymorphism and environmental factors with bladder carcinogenesis. Study in a north German population.
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma.
Circadian clock associates with tumor microenvironment in thoracic cancers.
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma.
Circadian clock gene Per2 plays an important role in cell proliferation, apoptosis and cell cycle progression in human oral squamous cell carcinoma.
Circadian clock is associated with tumor microenvironment in kidney renal clear cell carcinoma.
Circadian variability of pharmacokinetics of 5-fluorouracil and CLOCK T3111C genetic polymorphism in patients with esophageal carcinoma.
CREBBP mutation in human cutaneous squamous cell carcinoma.
Daily rhythm variations of the clock gene PER1 and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma.
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.
Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex.
Doxorubicin modulated clock genes and cytokines in macrophages extracted from tumor-bearing mice.
DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC).
Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing.
EBV MicroRNA BART16 Suppresses Type I IFN Signaling.
Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.
Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis.
Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma.
Evaluation of EP300, a histone acetyletransferase, in patients with epithelial ovarian carcinoma.
Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma.
Expression of circadian clock genes in human colorectal adenoma and carcinoma.
Expression of p300 and p300/CBP associated factor (PCAF) in actinic keratosis and squamous cell carcinoma of the skin.
Gene expression in poorly differentiated papillary thyroid carcinomas.
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer.
Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma.
Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa).
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide.
Human intestinal circadian clock: expression of clock genes in colonocytes lining the crypt.
Identification of the SOX2 interactome by BioID reveals EP300 as a mediator of SOX2-dependent squamous differentiation and lung squamous cell carcinoma growth.
Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo.
KAT2A succinyltransferase activity-mediated 14-3-3? upregulation promotes ?-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells.
KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma.
Landscape of genomic alterations in cervical carcinomas.
LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein.
Loss of circadian clock gene expression is associated with tumor progression in breast cancer.
Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway.
Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma.
MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion.
Mocetinostat for patients with previously treated, locally advanced/metastatic urothelial carcinoma and inactivating alterations of acetyltransferase genes.
Modelling with ANIMO: between fuzzy logic and differential equations.
Mutation analysis of EP300 in colon, breast and ovarian carcinomas.
N-acetyltransferase 2 gene polymorphism in patients with cervical cancer.
N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case-control studies.
N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma.
N-acetyltransferase phenotypes in bladder tumour patients with and without carcinoma in situ in selected site biopsies.
NAA10 promotes proliferation of renal cell carcinoma by upregulating UPK1B.
New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.
Novel o-Toluidine Metabolite in Rat Urine Associated with Urinary Bladder Carcinogenesis.
o-Anisidine Dimer, 2-Methoxy-N4-(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis.
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma.
Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines.
Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway.
Oxysterols and Gastrointestinal Cancers Around the Clock.
Paclitaxel (taxol) inhibits the arylamine N-acetyltransferase activity and gene expression (mRNA NAT1) and 2-aminofluorene-DNA adduct formation in human bladder carcinoma cells (T24 and TSGH 8301).
PER1 and CLOCK are potential circulating biomarkers for head and neck squamous cell carcinoma.
Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs.
Prevalence of high-risk human papillomavirus infection and cancer gene mutations in nonmalignant tonsils.
Research on circadian clock genes in non-small-cell lung carcinoma.
Seeking the driver in tumours with apparent normal molecular profile on comparative genomic hybridization and targeted gene panel sequencing: what is the added value of whole exome sequencing?
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60.
Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations.
Synchronous ovarian and endometrial carcinomas in a patient with rubinstein-taybi syndrome: a case report and literature review.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The circadian clock and the hypoxic response pathway in kidney cancer.
The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma.
The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.
The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma.
The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma.
The overexpression of MYST4 in human solid tumors is associated with increased aggressiveness and decreased overall survival.
The p300/CBP associated factor: is frequently downregulated in intestinal-type gastric carcinoma and constitutes a biomarker for clinical outcome.
Time-dependent effects of localized inflammation on peripheral clock gene expression in rats.
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Tip60-siRNA regulates ABCE1 acetylation to suppress lung cancer growth via activation of the apoptotic signaling pathway.
[Circadian rhythm variation of the clock genes Per1 and cell cycle related genes in different stages of carcinogenesis of buccal mucosa in animal model].
[Circadian variation of clock gene Per2 and cancer-related clock-controlled genes in buccal mucosa carcinoma of golden hamster at different cancer stages].
[Effect of clock gene PER1 knockdown on clock gene networks in human oral squamous cell carcinoma].
[Effects and mechanism of the circadian clock gene Per1 on the proliferation, apoptosis, cycle, and tumorigenicity in vivo of human oral squamous cell carcinoma].
[Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]
Carcinoma in Situ
N-acetyltransferase phenotypes in bladder tumour patients with and without carcinoma in situ in selected site biopsies.
Carcinoma, Adenoid Cystic
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer.
Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations.
Carcinoma, Embryonal
P19 Cells as a Model for Studying the Circadian Clock in Stem Cells before and after Cell Differentiation.
Carcinoma, Endometrioid
Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma.
The overexpression of MYST4 in human solid tumors is associated with increased aggressiveness and decreased overall survival.
Carcinoma, Hepatocellular
A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.
Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma.
Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells.
Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation.
Corrigendum to "Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells" [Canc. Lett. 469 (2020) 498-509].
Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver.
Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc.
Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines.
Diurnal expression of Thrombopoietin is regulated by Clock.
Dysregulation of metallothionein and circadian genes in human hepatocellular carcinoma.
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells.
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.
Escherichia coli Affects Expression of Circadian Clock Genes in Human Hepatoma Cells.
Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma.
Hepatocellular carcinoma: susceptibility markers.
High expression of N-acetyltransferase 10: a novel independent prognostic marker of worse outcome in patients with hepatocellular carcinoma.
Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression.
Histone acetyltransferase 1 promotes cells proliferation and induces cisplatin resistance in hepatocellular carcinoma.
Histone acetyltransferase activity in rat hepatomas.
Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling.
Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells.
Impact of N-acetyltransferase polymorphism (NAT2) in hepatocellular carcinoma (HCC)--an investigation in a department of surgical medicine.
Inaugural Article: A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades.
Joint effect of polymorphism in the N-acetyltransferase 2 gene and smoking on hepatocellular carcinoma.
Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells.
Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma.
miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells.
Myb-binding protein 1a augments AhR-dependent gene expression.
N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition.
N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study.
Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis.
P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy.
Polymorphism of the N-acetyltransferase 2 gene, red meat intake, and the susceptibility of hepatocellular carcinoma.
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.
Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.
Targeting Mybbp1a suppresses HCC progression via inhibiting IGF1/AKT pathway by CpG islands hypo-methylation dependent promotion of IGFBP5.
The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma.
The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth.
Time-dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and healthy liver of a transgenic mouse model.
Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition.
[Expression of PCAF in hepatocellular carcinoma and its clinical significance].
[Relationship between genetic polymorphisms of N-acetyltransferase and susceptibility to hepatocellular carcinoma]
Carcinoma, Intraductal, Noninfiltrating
Is there a role for molecular prognostic factors in the clinical management of ductal carcinoma in situ (DCIS) of the breast?
Carcinoma, Lewis Lung
Doxorubicin modulated clock genes and cytokines in macrophages extracted from tumor-bearing mice.
Carcinoma, Neuroendocrine
SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString).
Carcinoma, Non-Small-Cell Lung
A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL.
Cytotoxic Effects of 24-Methylenecyloartanyl Ferulate on A549 Nonsmall Cell Lung Cancer Cells through MYBBP1A Up-Regulation and AKT and Aurora B Kinase Inhibition.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.
KAT2B is an immune infiltration-associated biomarker predicting prognosis and response to immunotherapy in non-small cell lung cancer.
Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility.
Research on circadian clock genes in non-small-cell lung carcinoma.
Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines.
Carcinoma, Ovarian Epithelial
Clinicopathological significance of circadian rhythm-related gene expression levels in patients with epithelial ovarian cancer.
Evaluation of EP300, a histone acetyletransferase, in patients with epithelial ovarian carcinoma.
MiR-596 activated by EP300 controls the tumorigenesis in epithelial ovarian cancer by declining BRD4 and KPNA4.
Carcinoma, Papillary
Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.
Carcinoma, Renal Cell
Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma.
Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma.
Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer.
NAA10 promotes proliferation of renal cell carcinoma by upregulating UPK1B.
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma.
The circadian clock and the hypoxic response pathway in kidney cancer.
Carcinoma, Squamous Cell
Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma.
Altered expression of circadian clock genes in head and neck squamous cell carcinoma.
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Circadian clock associates with tumor microenvironment in thoracic cancers.
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma.
CREBBP mutation in human cutaneous squamous cell carcinoma.
Diallyl disulfide inhibits N-acetyltransferase activity and gene expression in human esophagus epidermoid carcinoma CE 81T/VGH cells.
EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.
Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis.
Expression of p300 and p300/CBP associated factor (PCAF) in actinic keratosis and squamous cell carcinoma of the skin.
Identification of the SOX2 interactome by BioID reveals EP300 as a mediator of SOX2-dependent squamous differentiation and lung squamous cell carcinoma growth.
Landscape of genomic alterations in cervical carcinomas.
N-acetyltransferase 2 gene polymorphism in patients with cervical cancer.
N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski).
Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
PER1 and CLOCK are potential circulating biomarkers for head and neck squamous cell carcinoma.
Prevalence of high-risk human papillomavirus infection and cancer gene mutations in nonmalignant tonsils.
Research on circadian clock genes in non-small-cell lung carcinoma.
Seeking the driver in tumours with apparent normal molecular profile on comparative genomic hybridization and targeted gene panel sequencing: what is the added value of whole exome sequencing?
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
[Effect and Regulatory Mechanism of Clock Gene Per1 on Biological Behaviors of Human Oral Squamous Carcinoma Cell].
Cardiomegaly
Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats.
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.
Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach.
Impact of epigenetics in the management of cardiovascular disease: a review.
Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice.
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.
The histone acetyltransferase MOF overexpression blunts cardiac hypertrophy by targeting ROS in mice.
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.
Cardiomyopathies
A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.
Female Clock?19/?19 Mice are Protected from the Development of Age-Dependent Cardiomyopathy.
N?-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.
Cardiomyopathy, Dilated
Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation.
Development of dilated cardiomyopathy in Bmal1-deficient mice.
Cardiomyopathy, Hypertrophic
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.
Cardiotoxicity
Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice.
The circadian clock protects against ionizing radiation-induced cardiotoxicity.
Cardiovascular Diseases
A molecular clock regulates angiopoietin-like protein 2 expression.
A Mouse Primary Hepatocyte Culture Model for Studies of Circadian Oscillation.
A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms.
Acetylation in cardiovascular diseases: Molecular mechanisms and clinical implications.
Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis.
Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet.
Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function.
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice.
Bmal1 Downregulation Worsens Critical Limb Ischemia by Promoting Inflammation and Impairing Angiogenesis.
Cardiovascular disease, chronopharmacotherapy, and the molecular clock.
Cardiovascular diseases: a therapeutic perspective around the clock.
Circadian angiogenesis.
Circadian clock and cardiovascular disease.
Circadian clock and vascular disease.
Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders?
Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research.
Circadian regulation of renal function.
Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases.
Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis.
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.
Circadian rhythms in cardiac gene expression.
Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases.
Circadian Rhythms, Exercise, and Cardiovascular Health.
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.
Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet.
Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice.
Diabetes and cardiovascular disease: related disorders created by disturbances in the endogenous clock.
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.
Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases.
Exploitation of host clock gene machinery by hepatitis viruses B and C.
Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort.
G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Identification of epigenetic factor KAT2B gene variants for possible roles in congenital heart diseases.
Influence of the cardiomyocyte circadian clock on cardiac physiology and pathophysiology.
Interactions between the circadian clock and metabolism: there are good times and bad times.
Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease.
Methods for monitoring the functional status of the circadian system in dietary surveys studies: application criteria and interpretation of results.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Molecular clocks, type 2 diabetes and cardiovascular disease.
Novel insights from genetic and molecular characterization of the human clock.
Old and New Roles and Evolving Complexities of Cardiovascular Clocks.
Period 2 is essential to maintain early endothelial progenitor cell function in vitro and angiogenesis after myocardial infarction in mice.
Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation.
Peripheral circadian clocks in the vasculature.
Possible contribution of chronobiology to cardiovascular health.
Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors.
Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Shift work modifies the circadian patterns of heart rate variability in nurses.
Social class and all-cause mortality in an urban population of North India.
Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury.
The Framingham Study, diabetes mellitus and cardiovascular disease: turning back the clock.
The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis.
The male biological clock is ticking: a review of the literature.
The mammalian circadian clock and its entrainment by stress and exercise.
The role of circadian clock gene BMAL1 in vascular proliferation.
The role of clock genes and circadian rhythm in the development of cardiovascular diseases.
The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response.
Thrombomodulin is a clock-controlled gene in vascular endothelial cells.
Tick-tock: is your cardiometabolic risk on the clock?
[Circadian CLOCK Gene Variants, Parameters of Arterial Stiffness and Blood Pressure Levels in Subjects Without Arterial Hypertension].
[Circadian rhythm and ischemic heart disease].
[Clock genes and circadian rhythm of blood pressure].
[Nocturia and the circadian rhythm].
[Research advances in relationship between biological clock and cardiovascular diseases].
Carotid Stenosis
CLOCK disruption aggravates carotid artery stenosis through endoplasmic reticulum stress-induced endothelial-mesenchymal transition.
Loss of CLOCK under high glucose upregulates ROCK1-mediated endothelial to mesenchymal transition and aggravates plaque vulnerability.
Cartilage Diseases
Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1.
Cataract
A cataract, 'a million cut' radial keratotomy, and Marfan syndrome February consultation #1.
Cataract in infants treated with argon laser photocoagulation for threshold retinopathy of prematurity.
Cognitive functions and normal tension glaucoma.
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.
Effectiveness and safety of combined cataract surgery and microhook ab interno trabeculotomy in Japanese eyes with glaucoma: report of an initial case series.
Femtosecond laser-assisted successful management of subluxated cataractous lens with vitreous in anterior chamber.
Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract.
Management of Severely Subluxated Cataracts Using Femtosecond Laser-Assisted Cataract Surgery.
Management of Traumatic Severely Subluxated Cataracts.
N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract.
Pneumatic retinopexy: a survey of current practice patterns among the vitreous society members.
Pupillary and iridovitreal block in pseudophakic eyes.
Catatonia
Refractory Catatonia Due to N-methyl-D-Aspartate Receptor Encephalitis Responsive to Electroconvulsive Therapy: The Clinical Use of the Clock Drawing Test.
Utility of the Clock Drawing Test in the Assessment of Catatonia.
Central Nervous System Diseases
Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells.
Cerebellar Ataxia
Psychometric properties of clock and pelvic drawings in Parkinson's disease: A validity and cross-sectional study.
Cerebral Hemorrhage
Race against the clock: overcoming challenges in the management of anticoagulant-associated intracerebral hemorrhage.
Cerebral Infarction
Cerebral infarction: tissue clock and reperfusion, brief overview.
Cerebral Small Vessel Diseases
Assessing Performance on Digital Clock Drawing Test in Aged Patients With Cerebral Small Vessel Disease.
Cerebrovascular Disorders
Diagnostic Performance of Clock Drawing Test by CLOX in an Asian Chinese population.
The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea.
Chagas Disease
Clock Gene
Clock Gene Timeless in the Chagas Disease Vector Triatoma infestans (Hemiptera: Reduviidae).
Nuclear rDNA-based molecular clock of the evolution of triatominae (Hemiptera: reduviidae), vectors of Chagas disease.
Phylogenetic multilocus codon models and molecular clocks reveal the monophyly of haematophagous reduviid bugs and their evolution at the formation of South America.
Chemical and Drug Induced Liver Injury
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Drug Hepatotoxicity: Environmental Factors.
Genetic and ethnic risk factors associated with drug hypersensitivity.
N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group.
NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis.
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
Susceptibility of N-acetyltransferase 2 slow acetylators to antituberculosis drug-induced liver injury: a meta-analysis.
Chickenpox
Rubinstein-Taybi syndrome and CREBBP c.201 202delTA mutation: a case presenting with varicella meningoencephalitis.
Chlamydia Infections
Effect of Time of Day of Infection on Chlamydia Infectivity and Pathogenesis.
Cholangiocarcinoma
Intrahepatic cholangiocarcinoma after Fontan procedure in an adult with visceral heterotaxy.
miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth.
Thyroid-Like Cholangiocarcinoma: Histopathological, Immunohistochemical, In-Situ Hybridization and Molecular Studies on an Uncommon Emerging Entity.
Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.
Cholangitis
Are primary biliary cirrhosis and autoimmune cholangitis reflective of the pendulum of a clock and therefore represent a 'phase' of the same disease?
Cholera
A recalibrated molecular clock and independent origins for the cholera pandemic clones.
Alpha 2-adrenergic regulation of arylalkylamine N-acetyltransferase in organ-cultured chick pineal gland: characterization with agonists and modulation of experimentally stimulated enzyme activity.
Arginine Vasopressin-Containing Neurons of the Suprachiasmatic Nucleus Project to CSF.
Cholestasis
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.
Deletion of clock gene Per2 exacerbates cholestatic liver injury and fibrosis in mice.
Cholestasis, Intrahepatic
Nuclear receptors, gestational metabolism and maternal metabolic disorders.
Chondrosarcoma
Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9.
Choroidal Effusions
Cyclodialysis ab interno as a surgical approach to intractable glaucoma.
Time to Unplanned Return to the Operating Room and Associated Risk Factors in Patients With Surgical Retinal Detachment Repair.
Chronic Kidney Disease-Mineral and Bone Disorder
Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder.
Chronic Periodontitis
Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?
Chronobiology Disorders
A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.
An impaired hepatic clock system effects lipid metabolism in rats with nephropathy.
Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock.
Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research.
Circadian rhythm sleep disorders.
D-Ser2-oxyntomodulin ameliorated A?31-35-induced circadian rhythm disorder in mice.
Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.
Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice.
From circadian clock gene expression to pathologies.
Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERB?/? pathway.
Modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiota and liver clock genes of circadian rhythm disorder mice model.
Molecular clock integration of brown adipose tissue formation and function.
Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.
Nimodipine potentiates the light-induced suppression of melatonin.
Non-invasive 40-Hz Light Flicker Ameliorates Alzheimer's-Associated Rhythm Disorder via Regulating Central Circadian Clock in Mice.
Nonlinear phenomena in models of the circadian clock.
Possible contribution of chronobiology to cardiovascular health.
Recent advances in modulators of circadian rhythms: an update and perspective.
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.
Sleeping sickness is a circadian disorder.
The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders.
[A role of nociceptin in the entrainment mechanism of the biological clock]
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses]
[Research progress of circadian rhythm].
Classical Swine Fever
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer.
Cleft Lip
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.
New diagram for cleft lip and palate description: the clock diagram.
NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population.
Variants in NAA15 cause pediatric hypertrophic cardiomyopathy.
Cleft Palate
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.
NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population.
Cluster Headache
A chronobiological study of melatonin, cortisol growth hormone and prolactin secretion in cluster headache.
A genetic CLOCK variant associated with cluster headache causing increased mRNA levels.
Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function.
Emerging relevance of circadian rhythms in headaches and neuropathic pain.
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study.
Investigation of the T3111C CLOCK gene polymorphism in cluster headache.
Lack of association between cluster headache and PER3 clock gene polymorphism.
Lack of association between the 3092 T-->C Clock gene polymorphism and cluster headache.
Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study.
Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.
Sleep-related headache and its management.
The biological clock in cluster headache: A review and hypothesis.
The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache.
The neurobiology of cluster headache.
Coinfection
Occurrence and reassortment of avian influenza A (H7N9) viruses derived from coinfected birds in China.
Colitis
An NF-?B-driven lncRNA orchestrates colitis and circadian clock.
C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome.
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine.
Circadian pharmacological effects of berberine on chronic colitis in mice: Role of the clock component Rev-erb?.
Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.
REV-ERB? integrates colon clock with experimental colitis through regulation of NF-?B/NLRP3 axis.
STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
Colitis, Ulcerative
An Inhibitor of Casein Kinase 1?/? (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation.
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.
Complex changes of circadian proteins expression in inflammatory bowel disease.
Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.
Importance of the Evaluation of N-Acetyltransferase Enzyme Activity Prior to 5-Aminosalicylic Acid Medication for Ulcerative Colitis.
N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis.
Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?
Colitis-Associated Neoplasms
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Coloboma
Combination of capsular tension ring and capsular tension segment for the management of lens coloboma >4 clock hours.
Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.
Colonic Neoplasms
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion.
Acetylation polymorphism and prevalence of colorectal adenomas.
Arylamine N-acetyltransferase: a possible promoter in Helicobacter pylori-related gastric carcinogenesis.
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation.
Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters.
Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice.
Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer.
Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs.
Hypermethylation of N-Acetyltransferase 1 Is a Prognostic Biomarker in Colon Adenocarcinoma.
Inhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfide.
Inhibition of Wnt/?-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.
Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer.
microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10.
Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.
N-Acetyltransferase 2 and glutathione s-transferase M1 in colon and rectal cancer cases from an industrialized area.
OVEREXPRESSION OF BOTH CLOCK AND BMAL1 INHIBITS ENTRY TO S PHASE IN HUMAN COLON CANCER CELLS.
Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
Peptide mimic isolated by autoantibody reveals human arrest defective 1 overexpression is associated with poor prognosis for colon cancer patients.
Polymorphic N-acetylation of 2-aminofluorene by cell-free colon extracts from inbred mice.
Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.
Research on circadian clock genes in common abdominal malignant tumors.
Role of acetylation in colorectal cancer.
Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems.
Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer.
The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes.
Transcriptional profiling of mRNA expression in the mouse distal colon.
XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.
[Molecular biological assessment of susceptibility to colorectal cancer]
Colorectal Neoplasms
5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer.
A meta-analysis of the relationship between NAT2 polymorphism and colorectal cancer susceptibility.
A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.
Absence of Association between N-Acetyltransferase 2 Acetylator Status and Colorectal Cancer Susceptibility: Based on Evidence from 40 Studies.
Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9.
Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes.
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma.
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors.
Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer.
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease.
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.
Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer.
Association of the clock genes polymorphisms with colorectal cancer susceptibility.
Bayesian analysis on meta-analysis of case-control studies accounting for within-study correlation.
BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5.
C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.
Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
Circadian clock circuitry in colorectal cancer.
Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.
Circadian clock pathway genes associated with colorectal cancer risk and prognosis.
Circadian gene hCLOCK contributes to progression of colorectal carcinoma and is directly regulated by tumor?suppressive microRNA?124.
Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients.
Clock genes: their role in colorectal cancer.
Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.
Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.
Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer.
Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer.
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
Deregulation of the circadian clock machinery: A novel biomarker for anti-angiogenic drug resistance in colorectal cancer.
Disruption of clock gene expression in human colorectal liver metastases.
Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer.
Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa.
Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue.
Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma.
Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR.
Expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates with location of tumor differently.
Expression of clock genes in patients with colorectal cancer.
Expression of core clock genes in colorectal tumour cells compared with normal mucosa; a systematic review of clinical trials.
Expression of HDAC1 and CBP/p300 in human colorectal carcinomas.
Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression.
Expression of PER, CRY, and TIM genes for the pathological features of colorectal cancer patients.
Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival.
Expressional and Mutational Analysis of CREBBP Gene in Gastric and Colorectal Cancers with Microsatellite Instability.
Frameshift mutations of tumor suppressor gene EP300 in gastric and colorectal cancers with high microsatellite instability.
Genetic polymorphisms of N-acetyltransferase 2 and colorectal cancer risk.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Glutathione S-transferase (GST) M1, T1, P1, N-acetyltransferase (NAT) 1 and 2 genetic polymorphisms and susceptibility to colorectal cancer.
GSK-3?-Regulated N-Acetyltransferase 10 Is Involved in Colorectal Cancer Invasion.
hClock gene expression in human colorectal carcinoma.
Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT.
Identification and meta-analysis of copy number variation-driven circadian clock genes for colorectal cancer.
Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.
Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.
MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.
Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status.
Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk.
Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
Metabolic genotypes and risk for colorectal cancer.
miR-6883 Family miRNAs Target CDK4/6 to Induce G
Mutations in the circadian gene CLOCK in colorectal cancer.
N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC).
N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer.
N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells.
N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?
N-acetyltransferase 2 gene polymorphism in patients with colorectal carcinoma.
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer.
N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions.
N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies.
N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review.
NAT2 knockdown inhibits the development of colorectal cancer and its clinical significance.
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and ?-Catenin Signaling.
Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer.
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.
Patient clock drawing and accuracy of self-report compared with chart review for colorectal cancer (CRC) screening.
PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS).
Period 2 mutation accelerates ApcMin/+ tumorigenesis.
Polymorphic N-acetylation of 2-aminofluorene by cell-free colon extracts from inbred mice.
Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.
Prognosis model of colorectal cancer patients based on NOTCH3, KMT2C, and CREBBP mutations.
Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands).
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.
Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas.
Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England.
Relationship between metabolic enzyme polymorphism and colorectal cancer.
Relationship between polymorphism of N-acetyltransferase gene and susceptibility to colorectal carcinoma in a Chinese population.
Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer.
Sex-dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial.
Sex-dependent regulation of estrogen receptor beta in human colorectal cancer tissue and its relationship with clock genes and VEGF-A expression.
SIRT1 and the clock gene machinery in colorectal cancer.
Targeting tumor vulnerabilities associated with loss of heterozygosity.
The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects.
The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.
The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes.
The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.
The TIP60 Complex Is a Conserved Coactivator of HIF1A.
TIP60 represses activation of endogenous retroviral elements.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer.
Wnt signaling inside the nucleus.
Colorectal Neoplasms, Hereditary Nonpolyposis
Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors.
N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC).
Coma
Cerebral perfusion alterations and cognitive decline in critically ill sepsis survivors.
Detecting delirium in patients with acute stroke: a systematic review of test accuracy.
Is the Glasgow Coma Scale Score in Children in the Emergency Department Lower During the Night?
[Circadian clock genes expression in peripheral blood mononuclear cells of comatose patients].
Communicable Diseases
For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.
Immunometabolism: Is it under the eye of the clock?
Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.
Communication Disorders
Validation of the Greek version of the Abbreviated Mental Test Score: Preliminary findings for cognitively impaired patients of different etiology.
Confusion
Cerebral perfusion alterations and cognitive decline in critically ill sepsis survivors.
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems.
The potential role of relatives in designing person-centred assistive technologies (innovative practice).
Validity of the confusion assessment method in detecting postoperative delirium in the elderly.
Congenital Abnormalities
Circadian Clock Regulation of Developmental Time in the Kidney.
Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.
Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1.
Sex Differences in Patients With CAM Deformities With Femoroacetabular Impingement: 3-Dimensional Computed Tomographic Quantification.
The male biological clock is ticking: a review of the literature.
The vertebrate segmentation clock and its role in skeletal birth defects.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.
Molecular clocks underlying vertebrate embryo segmentation: A 10-year-old hairy-go-round.
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Whole exome sequencing reveals de novo pathogenic variants in KAT6A as a cause of a neurodevelopmental disorder.
Connective Tissue Diseases
[Clinical evaluation of N-acetyltransferase activity in children with various forms of diffuse connective tissue diseases]
Corneal Edema
Rate and Localization of Graft Detachment in Descemet Membrane Endothelial Keratoplasty.
Corneal Neovascularization
Corneal melt in conjunctival intraepithelial neoplasia.
Nature and incidence of severe limbal stem cell deficiency in Australia and New Zealand.
Thalidomide prevents donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis.
[A synthetic peptide selected by bioinformatics inhibits mouse corneal neovascularization]
Corneal Ulcer
The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem.
Coronary Artery Disease
Does exercise training impact clock genes in patients with coronary artery disease and type 2 diabetes mellitus?
[Association of T3111C polymorphism in 3'-untranslated region of the CLOCK gene with the risk of essential arterial hypertension and coronary artery disease in the Russian population Karelia].
Coronary Disease
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
Chronic consumption of a low-fat diet improves cardiometabolic risk factors according to the CLOCK gene in patients with coronary heart disease.
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.
Cough
Circadian changes in effectiveness of corticosteroids in eight patients with allergic asthma.
COVID-19
A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care.
Acute kidney injury due to COVID-19 and the circadian rhythm.
An Early Pandemic Analysis of SARS-CoV-2 Population Structure and Dynamics in Arizona.
Are night shift workers at an increased risk for COVID-19?
Circadian Clock Genes: Targeting Innate Immunity for Antiviral Strategies Against COVID-19.
Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 Mpro for pharmacological interventions in COVID-19 pandemic.
Clock genes may drive seasonal variation in SARS-CoV-2 infectivity: are we due for a second wave of COVID-19 in the fall?
Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.
COVID-19 management in light of the circadian clock.
COVID-19: An overview for dermatologists.
Creating and implementing a COVID-19 recruitment Data Mart.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.
Identification of ACE2 modifiers by CRISPR screening.
Is There a Link between Orcadian Clock Protein PERIOD 3 (PER3) (rs57875989) Variant and the Severity of COVID-19 Infection?
Phylogenetic reconstruction of the initial stages of the spread of the SARS-CoV-2 virus in the Eurasian and American continents by analyzing genomic data.
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Strengths and Weaknesses of Docking Simulations in the SARS-CoV-2 Era: the Main Protease (Mpro) Case Study.
Telemedicine for Diabetes After the COVID-19 Pandemic: We Can't Put the Toothpaste Back in the Tube or Turn Back the Clock.
The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome.
The circadian clock gene Bmal1: Role in COVID-19 and periodontitis.
The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep.
Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.
World Tuberculosis Day 2021 Theme - 'The Clock is Ticking' - and the world is running out of time to deliver the United Nations General Assembly commitments to End TB due to the COVID-19 pandemic.
Craniosynostoses
A Novel Frameshift Mutation in KAT6A Is Associated with Pancraniosynostosis.
Cover Image, Volume 173A, Number 10, October 2017.
First case of pan-suture craniosynostosis due to de novo mosaic KAT6A mutation.
Lin-Gettig syndrome: Craniosynostosis expands the spectrum of the KAT6B related disorders.
Crohn Disease
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.
Complex changes of circadian proteins expression in inflammatory bowel disease.
Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.
Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?
Cushing Syndrome
A putative role for the aryl hydrocarbon receptor (AHR) gene in a patient with cyclical Cushing's disease.
Glucocorticoid-induced fingerprints on visceral adipose tissue transcriptome and epigenome.
MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing's syndrome.
Peripheral clock system circadian abnormalities in Cushing's disease.
Cyclodialysis Clefts
Direct cyclopexy for traumatic cyclodialysis with persisting hypotony. Report in 29 consecutive patients.
Magnetic resonance imaging of cyclodialysis clefts.
Placement of dual capsular tension rings for the combined management of traumatic cyclodialysis cleft and zonular dialysis.
Vitrectomy with Air Endotamponade for Traumatic Cyclodialysis.
Cystic Fibrosis
Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis.
Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients.
Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
Detection of human DNA mutations with nonradioactive, allele-specific oligonucleotide probes.
Dysregulation of Circadian Rhythm Gene Expression in Cystic Fibrosis Mice.
Interaction with CREB binding protein modulates the activities of Nrf2 and NF-?B in cystic fibrosis airway epithelial cells.
Cysts
An endogenous annual clock in the toxic marine dinoflagellate Gonyaulax tamarensis.
CONTROL OF GERMINATION OF ALEXANDRIUM TAMARENSE (DINOPHYCEAE) CYSTS FROM THE LOWER ST. LAWRENCE ESTUARY (CANADA)
Quantitative Analysis of CCL5 and ep300 in Periapical Inflammatory Lesions.
The clock face guide to peroneal intraneural ganglia: critical "times" and sites for accurate diagnosis.
[Acetylation phenotype in patients with periodic disease]
De Lange Syndrome
Exome sequencing identifies a novel EP300 frame shift mutation in a patient with features that overlap Cornelia de Lange syndrome.
Pathogenic variants in EP300 and ANKRD11 in patients with phenotypes overlapping Cornelia de Lange syndrome.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
[NIPBL gene mutations in two children with Cornelia de Lange syndrome].
Deaf-Blind Disorders
Usability of assistive listening devices by older adults with low vision.
Deafness
Hearing damage and deafness: a role for the circadian clock.
Death, Sudden, Cardiac
Circadian rhythm dynamics on multiscale entropy identifies autonomic dysfunction associated with risk of ventricular arrhythmias and near syncope in chronic kidney disease.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Research Progress on Pathological Fibrosis of Sinoatrial Node.
Dehydration
Biomimetic alcohol oxidations by an iron(III) porphyrin complex: relevance to cytochrome P-450 catalytic oxidation and involvement of the two-state radical rebound mechanism.
Extensive Transcriptome Changes During Natural Onset and Release of Vegetative Bud Dormancy in Populus.
Genome wide transcriptional profiling of acclimation to photoperiod in high-latitude accessions of Arabidopsis thaliana
Genome wide transcriptional profiling of acclimation to photoperiod in high-latitude accessions of Arabidopsis thaliana.
Interplay between circadian rhythm, time of the day and osmotic stress constraints in the regulation of the expression of a Solanum Double B-box gene.
The root-colonizing endophyte Pirifomospora indica confers drought tolerance in Arabidopsis by stimulating the expression of drought stress-related genes in leaves.
Delirium
A novel digital clock drawing test as a screening tool for perioperative neurocognitive disorders: A feasibility study.
A Simple Tool to Predict Development of Delirium After Elective Surgery.
A systematic review and meta-analysis of the accuracy of the clock drawing test (CDT) in the identification of delirium in older hospitalised patients.
Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?
Attention, vigilance and visuospatial function in hospitalized elderly medical patients: Relationship to neurocognitive diagnosis.
Clocking delirium: the value of the Clock Drawing Test with case illustrations.
Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery.
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Environmental risk factors for delirium in hospitalized older people.
Functional connectivity of the circadian clock and neural substrates of sleep-wake disturbance in delirium.
Incidence and risk factors of acute delirium in older patients with hip fracture in Siriraj Hospital.
Monitoring cognitive disturbance in delirium with the ten-point clock test.
Preoperative risk factors for postoperative delirium (POD) after urological surgery in the elderly.
Preoperative risk factors of postoperative delirium after transurethral prostatectomy for benign prostatic hyperplasia.
Prevalence and risk factors of postoperative delirium in patients undergoing open heart surgery in northwest of iran.
Prevalence of delirium among patients at a cancer ward: Clinical risk factors and prediction by bedside cognitive tests.
Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery--a randomized controlled trial.
The clock drawing test is a poor screening tool for postoperative delirium and cognitive dysfunction after aortic repair.
The performance of the Clock Drawing Test in elderly medical inpatients: does it have utility in the identification of delirium?
The utility of the clock drawing test in detection of delirium in elderly hospitalised patients.
The utility of the ten-point clock test as a screen for cognitive impairment in general hospital patients.
Treatment of delirium in older adults with quetiapine.
Underdiagnosis of delirium on admission and prediction of patients who will develop delirium during their inpatient stay: a pilot study.
Validity of the confusion assessment method in detecting postoperative delirium in the elderly.
[Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit].
Dementia
"Clockness" in the detection of dementia: a semantic-conceptual effect.
2 clock tests had high accuracy and naïve raters had acceptable accuracy for detecting dementia.
A comparison of alternative approaches to the scoring of clock drawing.
A comparison of five clock scoring methods using ROC (receiver operating characteristic) curve analysis.
A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved.
A new approach for the quantitative evaluation of the clock drawing test: preliminary results on subjects with Parkinson's disease.
A pilot study for circadian gene disturbance in dementia patients.
A quick dementia screening tool for primary care physicians.
A quick test of cognitive speed (AQT): usefulness in dementia evaluations in primary care.
A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia.
A reduced scoring system for the Clock Drawing Test using a population-based sample.
A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans.
Accuracy of the clock drawing test for detecting dementia in a multicultural sample of elderly Australian patients.
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
An analysis of the cognitive items of the movement disorders society checklist for the diagnosis of dementia in patients with Parkinson's disease.
An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test.
An evaluation of dementia screening in the primary care setting.
Are our norms "normal"? A 4-year follow-up study of a biracial sample of rural elders with low education.
Assessment of Dementia in Individuals with Dual Sensory Loss: Application of a Tactile Test Battery.
Association of the Qualitative Clock Drawing Test with Progression to Dementia in Non-Demented Older Adults.
Attention, vigilance and visuospatial function in hospitalized elderly medical patients: Relationship to neurocognitive diagnosis.
Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease.
Brief cognitive screening instruments: an update.
Brief Tests such as the Clock Drawing Test or Cognistat Can Be Useful Predictors of Conversion from MCI to Dementia in the Clinical Assessment of Outpatients.
Broad spectrum assessment of psychopathology and adaptive functioning with the Older Adult Behavior Checklist: a validation and diagnostic discrimination study.
Can clock drawing differentiate Alzheimer's disease from other dementias?
Can clock drawing test help to differentiate between dementia of the Alzheimer's type and vascular dementia? A preliminary study.
Can visuospatial measures improve the diagnosis of Alzheimer's disease?
Characteristics of clock drawing test (CDT) errors by the dementia type: quantitative and qualitative analyses.
Characteristics of patients assessed for cognitive decline in primary healthcare, compared to patients assessed in specialist healthcare.
Classifying Non-Dementia and Alzheimer's Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test.
Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment.
Clock completion: an objective screening test for dementia.
Clock drawing as a screen for impaired driving in aging and dementia: is it worth the time?
Clock drawing as an assessment tool for dementia.
Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
Clock drawing in Alzheimer's disease. A novel measure of dementia severity.
Clock drawing in schizophrenia.
Clock Drawing in the Montreal Cognitive Assessment: Recommendations for Dementia Assessment.
Clock drawing performance in cognitively normal elderly.
Clock drawing test (CDT) and activities of daily living (ADL) questionnaire as a short screening test for dementia in Thai population.
Clock Drawing Test - screening utility for mild cognitive impairment according to different scoring systems: results of the Leipzig Longitudinal Study of the Aged (LEILA 75+).
Clock Drawing Test in acute stroke and its relationship with long-term functional and cognitive outcomes.
Clock drawing test in elderly individuals with different education levels: correlation with clinical dementia rating.
Clock drawing test in mild and moderate dementia of the Alzheimer's type: a comparative and correlation study.
Clock drawing test in mild cognitive impairment: quantitative analysis of four scoring methods and qualitative analysis.
Clock drawing test in screening for Alzheimer's dementia and mild cognitive impairment in clinical practice.
Clock drawing test in very mild Alzheimer's disease.
Clock drawing test ratings by dementia specialists: interrater reliability and diagnostic accuracy.
Clock Drawing Test-Modified and Integrated Approach (CDT-MIA): description and preliminary examination of its validity and reliability in dementia patients referred to a specialized psychogeriatric setting.
Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia.
Clock drawing test: correlation with linear measurements of CT studies in demented patients.
Clock drawing test: is it useful for dementia screening in patients having Parkinson disease with and without depression?
Clock drawing, clock copying, and physical abilities in geriatric rehabilitation.
Clock drawing, clock reading, clock setting, and judgment of clock faces in elderly people with dementia and depression.
CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease.
Clock Test Deficits Related to the Global Cognitive State in Alzheimer's and Parkinson's Disease.
Clock tests in depression, Alzheimer's disease, and elderly controls.
Cluster analysis of cognitive performance in a sample of patients with Parkinson's disease.
Codex (Cognitive Disorders Examination) Decision Tree Modified for the Detection of Dementia and MCI.
Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population.
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.
Cognitive impairment in 873 patients with idiopathic Parkinson's disease. Results from the German Study on Epidemiology of Parkinson's Disease with Dementia (GEPAD).
Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD.
Cognitive screening in Parkinson's disease: Comparison of the Parkinson Neuropsychometric Dementia Assessment (PANDA) with 3 other short scales.
Cognitive Screening Tool for Geriatrics: A Retrospective Observational Study on the Correlation of the Scores in 30-Point Clock Face Test and MMSE.
Cognitive stimulation for older people with Alzheimer's disease performed by the caregiver.
Combination of the Clock Drawing Test with the Physical Phenotype of Frailty for the Prediction of Mortality and Other Adverse Outcomes in Older Community Dwellers without Dementia.
Comparing clock tests for dementia screening: naïve judgments vs formal systems--what is optimal?
Comparison of the clock test and a questionnaire-based test for screening for cognitive impairment in Nigerians.
Comparisons of cognitive function and serum S-100B level between diabetic and non-diabetic patients after the implantation of carotid artery stent (CAS).
Computer-Based Driving in Dementia Decision Tool With Mail Support: Cluster Randomized Controlled Trial.
Correlation of MMSE, SKT and clock test scores in patients with mild and moderate dementia.
Cortical activation during clock reading as a quadratic function of dementia state.
Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type.
Decreased cognitive functioning in patients with advanced oral squamous cell carcinoma.
Dementia in Hungary: General practitioners' routines and perspectives regarding early recognition.
Diabetes and cognitive outcomes in a nationally representative sample: the National Health and Aging Trends Study.
Diagnostic accuracy of the clock drawing test: the relevance of "time setting'' in screening for dementia.
Diagnostic Accuracy of the Overlapping Infinity Loops, Wire Cube, and Clock Drawing Tests for Cognitive Impairment in Mild Cognitive Impairment and Dementia.
Diagnostic accuracy of the Phototest for cognitive impairment and dementia in Argentina.
Diagnostic Performance of Clock Drawing Test by CLOX in an Asian Chinese population.
Diagnostic value of digital clock drawing test in comparison with CERAD neuropsychological battery total score for discrimination of patients in the early course of Alzheimer's disease from healthy individuals.
Discrimination of dementia with lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test.
Do Lesions Involving the Cortical Cholinergic Pathways Help or Hinder Efficacy of Donepezil in Patients with Alzheimer's Disease?
Do vascular lesions and related risk factors influence responsiveness to donepezil chloride in patients with Alzheimer's disease?
Does the Clock Drawing Test Predict Dementia? Results of the Leipzig Longitudinal Study of the Aged (LEILA 75+).
Early identification of dementia: predictive validity of the clock test.
Effect of education on the clock-drawing dementia screen in non-demented elderly persons.
Effects of education, literacy, and dementia on the Clock Drawing Test performance.
Effects of Exercise on Cognition: The Finnish Alzheimer Disease Exercise Trial: A Randomized, Controlled Trial.
Estimation of diagnostic performance of dementia screening tests: Mini-Mental State Examination, Mini-Cog, Clock Drawing test and Ascertain Dementia 8 questionnaire.
Examining Cognitive Status of Elderly Iranians: Farsi Version of the Modified Mini-Mental State Examination.
Factors affecting the results of the clock drawing test in elderly patients hospitalized for physical rehabilitation.
Frailty, with or without Cognitive Impairment, is a Strong Predictor of Recurrent Falls in a US Population-Representative Sample of Older Adults.
Handgrip Strength Predicts Longitudinal Changes in Clock Drawing Test Performance. An Observational Study in a Sample of Older Non-Demented Adults.
Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study.
Hierarchical Development of Frailty and Cognitive Impairment: Clues into Etiological Pathways.
Impacting dementia and cognitive loss with innovative strategies: mechanistic target of rapamycin, clock genes, circular non-coding ribonucleic acids, and Rho/Rock.
Increased Diagnostic Accuracy of Digital vs. Conventional Clock Drawing Test for Discrimination of Patients in the Early Course of Alzheimer's Disease from Cognitively Healthy Individuals.
Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer's disease.
Is the Clock Drawing Test a screening tool for the diagnosis of mild cognitive impairment? A systematic review.
Is the clock drawing test appropriate for screening for mild cognitive impairment?--Results of the German study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe).
Learning Classification Models of Cognitive Conditions from Subtle Behaviors in the Digital Clock Drawing Test.
Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests.
Longitudinal association between diabetes and cognitive decline: The National Health and Aging Trends Study.
Longitudinal changes in clock drawing test (CDT) performance according to dementia subtypes and severity.
Loss of functional capacity in elderly individuals with Alzheimer disease.
MARIO Project: Validation and Evidence of Service Robots for Older People with Dementia.
Metabolic alterations associated with impaired clock drawing in Lewy body dementia.
Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.
Neuropsychiatric symptoms and executive function impairments in Alzheimer's disease and vascular dementia: The role of subcortical circuits.
Neuropsychological assesment of psychogeriatric patients with limited education.
Neuropsychological Profile and Dementia Symptom Recognition in Help-Seekers in a Community Early-Detection Program in Hong Kong.
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.
Normal peripheral circadian phase in the old-old with abnormal circadian behavior.
Normative performance on the executive clock drawing task in a multi-ethnic bilingual cohort: a project FRONTIER study.
Normative References for Graphomotor and Latency Digital Clock Drawing Metrics for Adults Age 55 and Older: Operationalizing the Production of a Normal Appearing Clock.
Nothing to complain about? Residents' and relatives' views on a "good life" and ethical challenges in nursing homes.
Performance of three clock scoring systems across different ranges of dementia severity.
Poorer clock draw test scores are associated with greater functional impairment in peripheral artery disease: the Walking and Leg Circulation Study II.
Prevalence of Dementia and Mild Cognitive Impairment in a Rural Area of Sivas, Turkey.
Prospective and retrospective memory in mild Alzheimer's disease.
Psychometric properties of Clock Drawing Test and MMSE or Short Performance Test (SKT) in dementia screening in a memory clinic population.
Qualitative analyses of clock drawings in Alzheimer's disease and vascular dementia.
Quantitative and qualitative analyses of clock drawing in frontotemporal dementia and Alzheimer's disease.
Quantitative and Qualitative Analyses of the Clock Drawing Test in Fall and Non-Fall Patients with Alzheimer's Disease.
Quantitative and qualitative analyses of the clock drawing test in mild cognitive impairment and Alzheimer disease: evaluation of a modified scoring system.
Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function.
Relation between the clock drawing test (CDT) and structural changes of brain in dementia.
Relationships Between Behavioral Syndromes and Cognitive Domains in Alzheimer Disease: The Impact of Mood and Psychosis.
Reliability, validity, and diagnostic accuracy of Parkinson's Disease-Cognitive Rating Scale in Iranian patients with idiopathic Parkinson's disease.
Rouleau version of the Clock Drawing Test: age- and education-adjusted normative data from a wide Italian sample.
Scoring clock tests for dementia screening: a comparison of two scoring methods.
Screening for dementia and investigating its causes.
Screening for dementia in community-based memory clinics.
Screening for Dementia in Older Adults: Comparison of Mini-Mental State Examination, Mini-Cog, Clock Drawing Test and AD8.
Screening for dementia of the alzheimer type in the community: the utility of the Clock Drawing Test.
Screening of dementia in Chinese elderly adults by the clock drawing test and the time and change test.
Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group.
Sensitivity and specificity of the Clock Drawing Test, incorporating Rouleau scoring system, as a screening instrument for questionable and mild dementia: scale development.
Shedding a Light on Phototherapy Studies with People having Dementia: A Critical Review of the Methodology from a Light Perspective.
Sleep difficulties, incident dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study.
Staphylococcus aureus carriage in care homes: identification of risk factors, including the role of dementia.
Tai Chi and the Protection of Cognitive Ability: A Systematic Review of Prospective Studies in Healthy Adults.
Ten-Point Clock Test: a correlation analysis with other neuropsychological tests in dementia.
The abbreviated form of the Brief Cognitive Battery in the diagnosis of dementia in Alzheimer's disease.
The accuracy of the Clock Drawing Test compared to that of standard screening tests for Alzheimer's disease: results from a study of Brazilian elderly with heterogeneous educational backgrounds.
The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes.
The characterization of biological rhythms in mild cognitive impairment.
The clock drawing test and questionable dementia: reliability and validity.
The clock drawing test as a screening tool in mild cognitive impairment and very mild dementia: a new brief method of scoring and normative data in the elderly.
The Clock Drawing Test for dementia of the Alzheimer's type: A comparison of three scoring methods in a memory disorders clinic.
The clock drawing test in primary care: sensitivity in dementia detection and specificity against normal and depressed elderly.
The clock drawing test is a poor screen for very mild dementia.
The clock drawing test is a poor screening tool for postoperative delirium and cognitive dysfunction after aortic repair.
The Clock Drawing Test versus Mini-mental Status Examination as a Screening Tool for Dementia: A Clinical Comparison.
The clock drawing test, mortality, incident cardiovascular events and dementia.
The Clock Drawing Test: A Reasonable Instrument to Assess Probable Dementia in Primary Care?
The Clock Drawing Test: A review of its accuracy in screening for dementia.
The clock drawing test: A systematic review and meta-analysis of diagnostic accuracy.
The Clock Drawing Test: performance among elderly with low educational level.
The Clock Drawing Test: Performance differences between the free-drawn and incomplete-copy versions in patients with MCI and dementia.
The Clock Drawing Test: utility for dementia detection in multiethnic elders.
The clock is ticking on dementia care excuses.
The Clock Reading Test: validation of an instrument for the diagnosis of dementia and disorders of visuo-spatial cognition.
The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease.
The complex picture test in dementia.
The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.
The four-point scoring system for the clock drawing test does not differentiate between Alzheimer's disease and vascular dementia.
The Gesture Imitation in Alzheimer's Disease Dementia and Amnestic Mild Cognitive Impairment.
The Impact of Routine Cognitive Screening by Using the Clock Drawing Task in the Evaluation of Elderly Patients in the Emergency Department.
The interlocking finger test in patients with Parkinson's disease and healthy subjects.
The Mini-Cog versus the Mini-Mental State Examination and the Clock Drawing Test in daily clinical practice: screening value in a German Memory Clinic.
The Mini-Cog, Clock Drawing Test, and the Mini-Mental State Examination in a German Memory Clinic: specificity of separation dementia from depression.
The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies.
The Rapid Cognitive Screen (RCS): A Point-of-Care Screening for Dementia and Mild Cognitive Impairment.
The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition.
The role of circadian clock genes in mental disorders.
The sensitivity and specificity of subjective memory complaints and the subjective memory rating scale, deterioration cognitive observee, mini-mental state examination, six-item screener and clock drawing test in dementia screening.
The ten point clock test: a quick screen and grading method for cognitive impairment in medical and surgical patients.
The Times They Are a-Changin': Clock Drawing and Prediction of Dementia.
The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer's type.
The use of the mini-mental state examination and the clock-drawing test for dementia in a tertiary hospital.
The utility of the ten-point clock test as a screen for cognitive impairment in general hospital patients.
The validation of a mailed health survey for screening of dementia of the Alzheimer's type.
The value of the clock drawing test and the mini-mental state examination for identifying vascular cognitive impairment no dementia.
Time that tells: critical clock-drawing errors for dementia screening.
Trajectories and risk factors of dementia progression: a memory clinic cohort followed up to 3 years from diagnosis.
Usefulness of the Clock Drawing Test as a Cognitive Screening Instrument for Mild Cognitive Impairment and Mild Dementia: an Evaluation Using Three Scoring Systems.
Validation of a Spanish translation of the CLOX for use in Hispanic samples: the Hispanic EPESE study.
Validation of the Greek version of the Abbreviated Mental Test Score: Preliminary findings for cognitively impaired patients of different etiology.
Validity and Clinical Utility of Different Clock Drawing Test Scoring Systems in Multiple Forms of Dementia.
Validity of clock drawing test (CDT), scoring by Chula clock-drawing scoring system (CCSS) in screening dementia among Thai elderly in community.
Visual exploration behaviour during clock reading in Alzheimer's disease.
Visual spatial abilities and fall risk: an assessment tool for individuals with dementia.
Visuospatial Dysfunction May Be a Key in the Differentiation between Alzheimer's Disease and Subcortical Cognitive Impairment in Moderate to Severe Stages.
Which factors are associated with global cognitive impairment in Wilson's disease?
Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.
[A proposal for application and scoring of the Clock Drawing Test in Alzheimer's disease]
[Assessment of dementia]
[Asymptomatic encephalic calcifications in postsurgical hypoparathyroidism.]
[Automobile driving capacity in dementia].
[Clock drawing in dementia: its reliability and relation to the neuropsychological measures]
[Early clinical signs of dementia in the elderly]
[Efficacy of actovegin in the treatment of elderly patients with vascular mild cognitive impairment].
[Light therapy can restore a disturbed sleep/wake rhythm in dementia: but what is the basis of its efficacy?]
[Memantine (akatinol) therapy of cognitive impairment in Parkinson's disease complicated by dementia]
[Performance of cognitive brief test in elderly patients with dementia in advanced stage living in an urban community of Lima, Peru].
[Psychometric diagnosis of dementia in clinical gerontopsychiatry practice]
[The clock test: a simple method to assess dementia]
[The diagnostic value of drawing a clock in geriatrics]
[The photo test]
[Validation of the clock drawing test - Manos´ version - as a screening test for detection of dementia in older persons of Lima, Peru].
Dementia, Vascular
Are serum lipid and lipoprotein levels related to dementia?
Can clock drawing differentiate Alzheimer's disease from other dementias?
Can clock drawing test help to differentiate between dementia of the Alzheimer's type and vascular dementia? A preliminary study.
Classifying Non-Dementia and Alzheimer's Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test.
Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
Clock drawing test: correlation with linear measurements of CT studies in demented patients.
Cognitive Screening Tool for Geriatrics: A Retrospective Observational Study on the Correlation of the Scores in 30-Point Clock Face Test and MMSE.
Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population.
Diagnostic Performance of Clock Drawing Test by CLOX in an Asian Chinese population.
Evil and elder abuse: intersections of Paul Ricoeur's and Simone Weil's perspectives on evil with one abused older woman's narrative.
Qualitative analyses of clock drawings in Alzheimer's disease and vascular dementia.
Ten-Point Clock Test: a correlation analysis with other neuropsychological tests in dementia.
The complex picture test in dementia.
The four-point scoring system for the clock drawing test does not differentiate between Alzheimer's disease and vascular dementia.
The segmented clock: a typical pattern in vascular dementia.
Use of the ten-point clock test to compare executive functioning across 24 months in patients with subcortical vascular dementia.
Demyelinating Diseases
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Dengue
Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera:Culicidae).
Dengue virus replicons: Production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity.
Evolution, dispersal and replacement of American genotype dengue type 2 viruses in India (1956-2005): selection pressure and molecular clock analyses.
Extensive circadian and light regulation of the transcriptome in the malaria mosquito Anopheles gambiae.
Inferring the rate and time-scale of dengue virus evolution.
Molecular characterization and genotype shift of dengue virus strains between 2001 and 2014 in Guangzhou.
Phylogenetic and Molecular Clock Analysis of Dengue Serotype 1 and 3 from New Delhi, India.
[Phylogenetic analysis of envelope gene of dengue virus serotype 2 in Guangzhou, 2001-2015].
Dental Caries
Sugar Clock: A Primordial Approach to Prevent Dental Caries.
Dermatitis
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.
Effects of Genetic Polymorphisms of N-Acetyltransferase on Trichloroethylene-Induced Hypersensitivity Dermatitis among Exposed Workers.
Dermatitis, Allergic Contact
Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis.
Dermatitis, Atopic
N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects.
The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice.
Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice.
Dermatitis, Contact
Biological clock dysfunction exacerbates contact hypersensitivity in mice.
Dermatitis, Phototoxic
Effects and mechanisms of action of light-emitting diodes on the human retina and internal clock.
Dermoid Cyst
Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients.
Diabetes Insipidus
Molecular clock is involved in predictive circadian adjustment of renal function.
Diabetes Mellitus
Are Type 2 Diabetes Mellitus and Depression Part of a Common Clock Genes Network?
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus.
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.
Clock genes alterations and endocrine disorders.
Clock Genes, Metabolism, and Cardiovascular Risk.
Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report.
Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways.
Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus.
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Evidence for a dysfunction and disease-promoting role of the circadian clock in the diabetic retina.
Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.
Glucocorticoids use in kidney transplant setting.
Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus.
Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis.
N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population.
N-acetyltransferase 2 polymorphism in patients with diabetes mellitus.
N-acetyltransferase-2 genotypes among Jordanian patients with diabetes mellitus.
Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus.
Regulation of core clock genes in human islets.
Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury.
Synergistic Effect of Feeding Time and Diet on Hepatic Steatosis and Gene Expression in Male Wistar Rats.
The Framingham Study, diabetes mellitus and cardiovascular disease: turning back the clock.
[Nocturia and the circadian rhythm].
[PHENOTYPIC POLYMORPHISM OF N-ACETYLTRANSFERASE 2 IN PATIENTS WITH DIABETES MELLITUS].
[Role of circadian rhythms and cellular clock in aging-related diseases].
Diabetes Mellitus, Type 1
Clinical studies. Trying to reset the clock on type 1 diabetes.
Clock Gene Expression in the Liver of Streptozotocin-induced and Spontaneous Type 1 Diabetic Rats.
The clock is ticking: Parental stress around emerging adulthood for adolescents with type 1 diabetes.
Diabetes Mellitus, Type 2
"Diabetes of the elderly" and type 2 diabetes in younger patients: possible role of the biological clock.
A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms.
A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.
A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.
Are Type 2 Diabetes Mellitus and Depression Part of a Common Clock Genes Network?
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
Astrocyte Clocks and Glucose Homeostasis.
At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?: Circadian Clock and Microbiota: Potential Egffect on Growth Hormone and Sexual Development.
Autonomous and self-sustained circadian oscillators displayed in human islet cells.
Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes.
Chronomedicine and type 2 diabetes: shining some light on melatonin.
Circadian clock gene expression is impaired in gestational diabetes mellitus.
Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus.
Circadian Rhythms and Mitochondria: Connecting the Dots.
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.
Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.
Clock genes alterations and endocrine disorders.
Comment on Jakubowicz et al. Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial. Diabetes Care 2019;42:2171-2180.
Common genetic variation in circadian clock genes are associated with cardiovascular risk factors in an African American and Hispanic/Latino cohort.
Complex disease interventions from a network model for type 2 diabetes.
Computational modeling and analysis of the impacts of sleep deprivation on glucose stimulated insulin secretion.
Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus.
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American.
Diet-induced insulin resistance state disturbs brain clock processes and alters tuning of clock outputs in the Sand rat, Psammomys obesus.
Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals.
Does exercise training impact clock genes in patients with coronary artery disease and type 2 diabetes mellitus?
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?
Enhanced effect of daytime restricted feeding on the circadian rhythm of streptozotocin-induced type 2 diabetic rats.
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.
Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus.
Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial.
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue.
Loss of arginine vasopressin- and vasoactive intestinal polypeptide-containing neurons and glial cells in the suprachiasmatic nucleus of individuals with type 2 diabetes.
Mice deficient in cryptochrome 1 (cry1 (-/-)) exhibit resistance to obesity induced by a high-fat diet.
Molecular clocks, type 2 diabetes and cardiovascular disease.
N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population.
Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Pro-inflammatory Cytokine Interleukin 1? Disrupts ? cell Circadian Clock Function and Regulation of Insulin Secretion.
Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial.
Regulation of core clock genes in human islets.
Response to Comment on Jakubowicz et al. Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial. Diabetes Care 2019;42:2171-2180.
Role of High Energy Breakfast "Big Breakfast Diet" in Clock Gene Regulation of Postprandial Hyperglycemia and Weight Loss in Type 2 Diabetes.
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.
Should we listen to our clock to prevent type 2 diabetes mellitus?
Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.
Synergistic Effect of Feeding Time and Diet on Hepatic Steatosis and Gene Expression in Male Wistar Rats.
The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus.
Time zones of pancreatic islet metabolism.
Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.
Timing of food intake during simulated night shift impacts glucose metabolism: A controlled study.
[Circadian clock disruption and diabetes mellitus].
[PHENOTYPIC POLYMORPHISM OF N-ACETYLTRANSFERASE 2 IN PATIENTS WITH DIABETES MELLITUS].
[Role of circadian rhythms and cellular clock in aging-related diseases].
[The role of biological clock in glucose homeostasis].
Diabetes, Gestational
Circadian clock gene expression is impaired in gestational diabetes mellitus.
Nuclear receptors, gestational metabolism and maternal metabolic disorders.
Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels.
Diabetic Nephropathies
Circadian Clock Genes in Diabetic Kidney Disease (DKD).
Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB.
Epigenetic memory in kidney diseases.
The N-acetyltransferase (NAT) gene: an early risk marker for diabetic nephropathy in Japanese type 2 diabetic patients?
Diabetic Retinopathy
Changes in the daily rhythm of lipid metabolism in the diabetic retina.
Clock genes and behavioral responses to light are altered in a mouse model of diabetic retinopathy.
Diabetic retinopathy alters light-induced clock gene expression and dopamine levels in the mouse retina.
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
Evidence for a dysfunction and disease-promoting role of the circadian clock in the diabetic retina.
Tumor Necrosis Factor Alpha (TNF-?) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina.
DiGeorge Syndrome
MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome.
Diphtheria
Negative selection with the Diphtheria toxin A fragment gene improves frequency of Cre-mediated cassette exchange in ES cells.
Diplopia
[The relation of the motion velocity of the real image to the velocity of illusory image in diplopia studied by the clock method]
Disorders of Excessive Somnolence
3111T/C clock gene polymorphism is not associated with sleep disturbances in untreated depressed patients.
Circadian clock genes and circadian phenotypes in patients with myocardial infarction.
Circadian rhythms in narcolepsy: studies on a 90 minute day.
Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.
Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness.
How does diurnal intermittent fasting impact sleep, daytime sleepiness, and markers of the biological clock? Current insights.
Selective effects of CPAP on sleep apnoea-associated manifestations.
[Sleep problems in occupational health].
[Sleep quality and daytime sleepiness in schizophrenia spectrum disorders during antipsychotic treatment]
Diverticular Diseases
No need to watch the clock: persistence during laparoscopic sigmoidectomy for diverticular disease.
Down Syndrome
Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy.
Drug Eruptions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Drug Hypersensitivity
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.
Drug Resistant Epilepsy
Sleep, Circadian Rhythms, and Epilepsy.
Drug-Related Side Effects and Adverse Reactions
Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil.
Discordance between N-acetyltransferase 2 phenotype and genotype in a population of Hmong subjects.
Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues.
Improving the reporting of adverse drug reactions in the hospital setting.
Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid.
N-acetyltransferase polymorphism among northern Sudanese.
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
TaqMan real time-polymerase chain reaction methods for determination of nucleotide polymorphisms in human N-acetyltransferase-1 (NAT1) and -2 (NAT2).
[Sleep quality and daytime sleepiness in schizophrenia spectrum disorders during antipsychotic treatment]
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Duodenal Ulcer
Seasonality in duodenal ulcer disease: possible relationship with circannually cycling neurons enclosed in the biological clock.
Dwarfism
Running on time: the role of circadian clocks in the musculoskeletal system.
Dyscalculia
[Acalculia with clock agnosia in a patient with right cerebral hemisphere lesion and hidden lefthandedness]
Dyskinesias
Effects of histone acetyltransferase inhibitors on L-DOPA-induced dyskinesia in a murine model of Parkinson's disease.
Dyslexia
Clock drawing in developmental dyslexia.
Representational neglect for words as revealed by bisection tasks.
Time-based prospective memory in adults with developmental dyslexia.
Dyslipidemias
Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2.
Circadian Rhythms in Diet-Induced Obesity.
Common genetic variation in circadian clock genes are associated with cardiovascular risk factors in an African American and Hispanic/Latino cohort.
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation.
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.
Rev-erb alpha gives a time cue to metabolism.
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.
Dysostoses
Altered Cogs of the Clock: Insights into the Embryonic Etiology of Spondylocostal Dysostosis.
The long and short of it: Somite formation in mice.
The vertebrate segmentation clock and its role in skeletal birth defects.
When body segmentation goes wrong.
Dysplastic Nevus Syndrome
Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival.
Dyspnea
Circadian changes in effectiveness of corticosteroids in eight patients with allergic asthma.
Dyssomnias
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Ectropion
Iris Nevus Growth into Melanoma: Analysis of 1611 Consecutive Eyes: The ABCDEF Guide.
Melanoma of the eye: Revealing hidden secrets, one at a time.
Elephantiasis, Filarial
Exploring factors affecting quality implementation of lymphatic filariasis mass drug administration in Bole and Central Gonja Districts in Northern Ghana.
Encephalitis
Refractory Catatonia Due to N-methyl-D-Aspartate Receptor Encephalitis Responsive to Electroconvulsive Therapy: The Clinical Use of the Clock Drawing Test.
Encephalomyelitis
IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis.
Enchondromatosis
Genetic variation analysis in a Chinese Maffucci syndrome patient.
Endocrine System Diseases
Clock genes alterations and endocrine disorders.
Endometrial Neoplasms
Genetic Variants in ER Cofactor Genes and Endometrial Cancer Risk.
Histone acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ER? stability.
Endometriosis
Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population.
MicroRNA-regulated pathways associated with endometriosis.
NAT2 gene polymorphisms and endometriosis risk: A PRISMA-compliant meta-analysis.
Endotoxemia
Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response.
Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats.
Enteritis
Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.
Enuresis
Nocturnal enuresis.
Primary nocturnal enuresis: a new approach to conditioning treatment.
Epilepsies, Partial
Focal Epilepsy and the Clock Gene.
How to assess circadian rhythm in humans: a review of literature.
Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy.
Epilepsy
16p13 microduplication without CREBBP involvement: Moving toward a phenotype delineation.
A single generalized seizure alters the amplitude, but not phase, of the circadian activity rhythm of the hamster.
Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Bidirectional relationships of sleep and epilepsy in adults with epilepsy.
CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development.
Chronobiology of epilepsy: diagnostic and therapeutic implications of chrono-epileptology.
Circadian rhythms: interactions with seizures and epilepsy.
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats.
Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy.
Dysregulation of REV-ERB? impairs GABAergic function and promotes epileptic seizures in preclinical models.
Epilepsy Occurrence and Circadian Rhythm: A Bibliometrics Study and Visualization Analysis via CiteSpace.
Genetic diagnoses in epilepsy: The impact of dynamic exome analysis in a pediatric cohort.
Genotype-phenotype correlations in Rubinstein-Taybi syndrome.
Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy.
Molecular regulation of brain metabolism underlying circadian epilepsy.
Moving the clock on comprehensive post-surgical outcome assessment in specific etiological categories of epilepsy.
Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in KAT6A.
PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.
Recording human electrocorticographic (ECoG) signals for neuroscientific research and real-time functional cortical mapping.
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.
Stopping the Clock on Seizures!
Sudden unexpected death in epilepsy: Trying to reset the clock on diabetes.
The circadian rhythm and its interaction with human epilepsy: A review of literature.
The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy.
Uncovering the Pharmacological Mechanism of Chaibei Zhixian Decoction on Epilepsy by Network Pharmacology Analysis.
[Activity of polymorphic N-acetyltransferase in epilepsy]
Epilepsy, Frontal Lobe
Bidirectional relationships of sleep and epilepsy in adults with epilepsy.
Epilepsy, Temporal Lobe
Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.
Epstein-Barr Virus Infections
Intranuclear localization of the transcription coadaptor CBP/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and -5 in B lymphocytes.
Erectile Dysfunction
The image of the heart and the synergic principle in psychoanalysis (psychosynergy). II. Three dreams of the disguised heart-image. III. The disguised image of the heart in a case of severe sexual impotence and talent inhibition; the case of the clock chimer (paroxysmal auricular tachycardia in father and son).
The male biological clock is ticking: a review of the literature.
Erythema
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
Erythema Multiforme
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Esophageal Neoplasms
Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery.
Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population.
Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes.
Circadian variability of pharmacokinetics of 5-fluorouracil and CLOCK T3111C genetic polymorphism in patients with esophageal carcinoma.
Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer.
N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis.
N-acetyltransferase 2 polymorphisms and risk of esophageal cancer in a Chinese population.
Esophageal Squamous Cell Carcinoma
A novel long noncoding RNA linc00460 upregulated by CBP/P300 promotes carcinogenesis in Esophageal Squamous Cell Carcinoma.
Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma.
Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex.
LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein.
Esophagitis, Peptic
Changes in Clock Genes Expression in Esophagus in Rat Reflux Esophagitis.
Essential Hypertension
Association of insulin resistance with polymorphic variants of Clock and Bmal1 genes: A case-control study.
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.
Essential Tremor
When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock.
Exanthema
"The clock is ticking": the timely management of a painful skin rash in a seventy-year-old woman.
Exostoses
A novel truncating variant within exon 7 of KAT6B associated with features of both Say-Barber-Bieseker-Young-Simpson syndrome and genitopatellar syndrome: Further evidence of a continuum in the clinical spectrum of KAT6B-related disorders.
Extensively Drug-Resistant Tuberculosis
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
Eye Diseases
Circadian organization of the mammalian retina: from gene regulation to physiology and diseases.
Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium.
Evolution of visual sensory system in cichlid fishes from crater lake Barombi Mbo in Cameroon.
Fanconi Anemia
Tip60 Is Required for DNA Interstrand Cross-link Repair in the Fanconi Anemia Pathway.
Fatigue Syndrome, Chronic
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Sleep-wake behavior in chronic fatigue syndrome.
Fatty Liver
Circadian Clock and Liver Cancer.
Circadian Clock Control of Liver Metabolic Functions.
Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease.
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Clock Genes, Metabolism, and Cardiovascular Risk.
Different expressions of clock genes in fatty liver induced by high-sucrose and high-fat diets.
Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis.
Dysregulation of intercellular signaling by MOF deletion leads to liver injury.
Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice.
MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice.
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.
Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease.
Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes.
Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model.
The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis.
The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
Tick-Tock Hedgehog-Mutual crosstalk with liver circadian clock promotes liver steatosis.
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.
[Circadian clock and non-alcoholic fatty liver disease].
Fatty Liver, Alcoholic
Effect of chronic ethanol exposure on the liver of Clock-mutant mice.
Femoracetabular Impingement
Clinical Outcomes of Hip Arthroscopy for Hip Labrum Calcification in Young and Middle-Aged Patients.
Fetal Alcohol Spectrum Disorders
Epigenetic Clock Analysis in Children With Fetal Alcohol Spectrum Disorder.
[Effects of ethanol on the development of circadian time keeping system]
Fibromyalgia
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Validity and reliability of the clock drawing test as a screening tool for cognitive impairment in patients with fibromyalgia.
Fibrosarcoma
Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.
The kruppel-like protein gli-similar 3 (glis3) functions as a key regulator of insulin transcription.
Food Hypersensitivity
Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.
Food allergy in a child with de novo KAT6A mutation.
Genotype of N-acetyltransferase 2 (NAT2) polymorphism in children with immunoglobulin E-mediated food allergy.
Fragile X Syndrome
Circadian biology and sleep in monogenic neurological disorders and its potential application in drug discovery.
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Frontotemporal Dementia
Executive Abilities as Reflected by Clock Hand Placement: Frontotemporal Dementia Versus Early-Onset Alzheimer Disease.
Quantitative and qualitative analyses of clock drawing in frontotemporal dementia and Alzheimer's disease.
Gait Apraxia
Falls associated with dementia: how can you tell?
Gallbladder Neoplasms
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Prognostic and Clinicopathological Significance of X-Box-Binding Protein 1 and N-Acetyltransferase 1 in Gallbladder Cancer.
Ganglion Cysts
Melatonin and 5-methoxytryptophol (5-ML) in nervous and/or neurosensory structures of a gastropod mollusc (Helix aspersa maxima): synthesis and diurnal rhythms.
Gastroesophageal Reflux
Changes in Clock Genes Expression in Esophagus in Rat Reflux Esophagitis.
Gastrointestinal Diseases
Disruption of Circadian Rhythms and Gut Motility: An Overview of Underlying Mechanisms and Associated Pathologies.
Gastrointestinal Neoplasms
Oxysterols and Gastrointestinal Cancers Around the Clock.
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.
[Preoperative cognitive function in very old patients : Influence on the complication rate and length of hospitalization].
Gastrointestinal Stromal Tumors
An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells.
Genetic Diseases, Inborn
A Comprehensive, High-Resolution Map of a Gene's Fitness Landscape.
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.
A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase Naa10S37P mutant.
An individual with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and additional features expands the phenotype associated with mutations in KAT6B.
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip.
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.
De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy.
Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.
NAA10 p.(D10G) and NAA10 p.(L11R) Variants Hamper Formation of the NatA N-Terminal Acetyltransferase Complex.
NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy.
Severe syndromic ID and skewed X-inactivation in a girl with NAA10 dysfunction and a novel heterozygous de novo NAA10 p.(His16Pro) variant - a case report.
The Biological Clock and the Molecular Basis of Lysosomal Storage Diseases.
Genital Diseases, Female
Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System.
Giardiasis
Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia.
Gilbert Disease
The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine.
Glaucoma
Chronotyping glaucoma patients with the Munich ChronoType Questionnaire: A case-control study.
Circadian Regulation of IOP Rhythm by Dual Pathways of Glucocorticoids and the Sympathetic Nervous System.
Cognitive functions and normal tension glaucoma.
Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, I: correlation analysis in glaucoma.
Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study.
Comparison of Scanning Laser Polarimetry and Optical Coherence Tomography in Preperimetric Glaucoma.
Correlation between retinal nerve fibre layer thickness and retinal sensitivity.
Development of a Nanofabricated Sensor for Monitoring Intraocular Pressure via Ocular Tissue Strain.
Early Glaucoma Discrimination Index.
Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal.
N-acetyltransferase activity and melatonin level in the eyes of glaucomatous chickens.
Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography.
Plasma melatonin rhythm lost in preglaucomatous chicks.
Pupillary and iridovitreal block in pseudophakic eyes.
Reproducibility of peripapillary retinal nerve fibre layer thickness measurements with spectral domain optical coherence tomography in normal and glaucomatous eyes.
Utility of CLOCK CHART binocular edition for self-checking the binocular visual field in patients with glaucoma.
[Diurnal variation of intraocular pressure in low tension glaucoma]
Glaucoma, Angle-Closure
Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma.
Visual results and complications following posterior iris-fixated posterior chamber lenses at penetrating keratoplasty.
Glaucoma, Open-Angle
Comparison between pilocarpine and timolol on diurnal pressures in open-angle glaucoma.
Glioblastoma
Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy.
Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124.
Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint.
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Models of Epigenetic Age Capture Patterns of DNA Methylation in Glioma Associated with Molecular Subtype, Survival, and Recurrence.
Proliferative Glioblastoma Cancer Cells Exhibit Persisting Temporal Control of Metabolism and Display Differential Temporal Drug Susceptibility in Chemotherapy.
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.
The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Glioma
A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage.
Aberrant rhythmic expression of
Association of Circadian Clock Gene Expression with Glioma Tumor Microenvironment and Patient Survival.
Cancer stem cell generation during epithelial-mesenchymal transition is temporally gated by intrinsic circadian clocks.
Circadian Alterations in a Murine Model of Hypothalamic Glioma.
Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation.
Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124.
Circadian properties of cancer stem cells in glioma cell cultures and tumorspheres.
Circadian rhythm generation in a glioma cell line.
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis.
Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.
Correlation between deregulated expression of PER2 gene and degree of glioma malignancy.
Deregulated expression of cry1 and cry2 in human gliomas.
Deregulated Expression of the Clock Genes in Gliomas.
Deregulated expression of the Per1 and Per2 in human gliomas.
Effects of caffeine on cell viability and activity of histone deacetylase 1 and histone acetyltransferase in glioma cells.
EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.
Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.
Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway.
Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas.
Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.
IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87?MG cells.
Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain.
Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.
Insights About Circadian Clock and Molecular Pathogenesis in Gliomas.
LncRNA UCA1 facilitated cell growth and invasion through the miR-206/CLOCK axis in glioma.
Microglial Exosome miR-7239-3p Promotes Glioma Progression by Regulating Circadian Genes.
Models of Epigenetic Age Capture Patterns of DNA Methylation in Glioma Associated with Molecular Subtype, Survival, and Recurrence.
MYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells.
Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).
Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway.
Temperature-amplitude coupling for stable biological rhythms at different temperatures.
The analysis of deregulated expression and methylation of the PER2 genes in gliomas.
The Circadian Gene Clock Plays an Important Role in Cell Apoptosis and the DNA Damage Response In Vitro.
Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
[The Mechanism Study on Histone Acetylation Activating Glioblastoma-derived Neurotrophic Factor Transcription].
Glomerulonephritis, Membranous
Membranous nephropathy, hydrocarbon exposure and genetic variants of hydrocarbon detoxification.
Glucose Intolerance
An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice.
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Female Clock?19/?19 Mice are Protected from the Development of Age-Dependent Cardiomyopathy.
Glucocorticoids use in kidney transplant setting.
Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances ?-Cell Function and Protects Against Obesity-Induced Glucose Intolerance.
Influence of Age on Clock Gene Expression in Peripheral Blood Cells of Healthy Women.
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.
miRNA-10a-5p Alleviates Insulin Resistance and Maintains Diurnal Patterns of Triglycerides and Gut Microbiota in High-Fat Diet-Fed Mice.
Pancreatic ? cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high fat diet on inflammation and metabolism.
The Singapore impaired glucose tolerance follow-up study: does the ticking clock go backward as well as forward?
Glucose Metabolism Disorders
Capsaicin Ameliorates the Redox Imbalance and Glucose Metabolism Disorder in an Insulin-Resistance Model via Circadian Clock-Related Mechanisms.
Goldenhar Syndrome
Methods and Challenges in a Cohort Study of Infants and Toddlers With Craniofacial Microsomia: The Clock Study.
Granuloma
Quantitative Analysis of CCL5 and ep300 in Periapical Inflammatory Lesions.
Granulomatosis with Polyangiitis
Dysregulation of histone deacetylase and histone acetyltransferase in development of Wegener's granulomatosis.
Graves Disease
Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves' disease but not to Hashimoto's thyroiditis.
Hallucinations
Prevalence of psychiatric symptoms and mental disorders detected in primary care in an elderly Spanish population. The PSICOTARD Study: preliminary findings.
Hashimoto Disease
Analysis of expression of different histone deacetylases in autoimmune thyroid disease.
Head and Neck Neoplasms
Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery.
N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer.
PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.
Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck.
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.
Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective.
The Circadian Clock in Oral Health and Diseases.
[Chronobiological considerations for the management of human head and neck cancer]
Headache Disorders
Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function.
Lack of association between the 3092 T-->C Clock gene polymorphism and cluster headache.
[Headache].
Headache Disorders, Primary
Other primary headaches.
Sleep-related headache and its management.
[Headache].
Hearing Loss
Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment.
Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study.
No association between apolipoprotein E or N-acetyltransferase 2 gene polymorphisms and age-related hearing loss.
Sleep Disturbance and Altered Expression of Circadian Clock Genes in Patients With Sudden Sensorineural Hearing Loss.
Usability of assistive listening devices by older adults with low vision.
Hearing Loss, Noise-Induced
A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population.
Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss.
Hearing Loss, Sensorineural
Novel Causative Variants in DYRK1A, KARS, and KAT6A Associated with Intellectual Disability and Additional Phenotypic Features.
Sleep Disturbance and Altered Expression of Circadian Clock Genes in Patients With Sudden Sensorineural Hearing Loss.
Heart Arrest
Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest.
Defibrillator and dispatch center clock synchronization is essential for time-sensitive treatment of cardiac arrest.
Risk factors and outcomes of in-hospital cardiac arrest following pediatric heart operations of varying complexity.
Heart Defects, Congenital
16p13 microduplication without CREBBP involvement: Moving toward a phenotype delineation.
Identification of epigenetic factor KAT2B gene variants for possible roles in congenital heart diseases.
Partial microduplication in the histone acetyltransferase complex member KANSL1 is associated with congenital heart defects in 22q11.2 microdeletion syndrome patients.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Diseases
A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine.
A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.
Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
Circadian heart rate and blood pressure variability considered for research and patient care.
Corticosteroids and circadian rhythms in the cardiovascular system.
Female Clock?19/?19 Mice are Protected from the Development of Age-Dependent Cardiomyopathy.
Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.
Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1.
The cardiomyocyte circadian clock: emerging roles in health and disease.
The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Restores Cardiomyocyte Contractility in a Rat Model of Early Diabetes.
Heart Failure
A Natural p300-Specific Histone Acetyltransferase Inhibitor, Curcumin, in Addition to Angiotensin-Converting Enzyme Inhibitor, Exerts Beneficial Effects on Left Ventricular Systolic Function After Myocardial Infarction in Rats.
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
A Structured Measurement of Highly Synchronous Real-Time Ballistocardiography Signal Data of Heart Failure Patients.
Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan.
Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.
Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis.
Application of curcumin to heart failure therapy by targeting transcriptional pathway in cardiomyocytes.
Ca clock malfunction in a Canine Model of Pacing-Induced Heart Failure.
Correlation of gene expression and clinical parameters identifies a set of genes reflecting LV systolic dysfunction and morphological alterations.
Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats.
Is the Clock Drawing Test useful in the screening assessment of aged patients with chronic heart failure?
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
Older people with heart failure and general practitioners - temporal reference frameworks and implications for practice.
Optimal dose-setting study of curcumin for improvement of left ventricular systolic function after myocardial infarction in rats.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Sinus node revisited.
The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock?19/?19 Mice With Implications for Circadian Medicine.
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
Down-regulation of EBAF in the heart with ventricular septal defects and its regulation by histone acetyltransferase p300 and transcription factors smad2 and cited2.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hematologic Neoplasms
Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.
CBP/p300 acetyltransferase activity in hematologic malignancies.
Clock genes and cancer development in particular in endocrine tissues.
Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments.
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
FGFR1 and KAT6A rearrangements in patients with hematological malignancies and chromosome 8p11 abnormalities: biological and clinical features.
Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues.
Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Mice heterozygous for CREB binding protein are hypersensitive to ?-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.
[Advances of Researches on the Role of Histone Modification in Hematological Neoplasms].
Hemianopsia
Clock drawing in acute stroke.
Neglect in elderly stroke patients: a comparison of five tests.
Hemochromatosis
Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?
Hemorrhagic Fever, Crimean
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011.
Hemorrhagic Stroke
The Clock Drawing Test as a predictor of cognitive decline in non-demented stroke patients.
Hemorrhoids
Management of internal hemorrhoids by Kshara karma: An educational case report.
[Hemorrhoidal disease and the concomitant changes in the rectosigmoid]
Hepatic Encephalopathy
Relationship between clock and star drawing and the degree of hepatic encephalopathy.
The role of astrocytes in generating circadian rhythmicity in health and disease.
Hepatic Insufficiency
Chronotypology and melatonin alterations in minimal hepatic encephalopathy.
Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy.
Hepatitis
Antituberculosis drug-induced hepatitis: risk factors, prevention and management.
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine.
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Exploitation of host clock gene machinery by hepatitis viruses B and C.
Genetic predisposition to drug-induced hepatotoxicity.
Hepatocellular carcinoma.
Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation.
Hepatitis A
Genotype I hepatitis A virus introduction in Italy: Bayesian phylogenetic analysis to date different epidemics.
Hepatitis B
Case studies in orthotopic liver transplantation for hepatitis B: a panel discussion.
Exploitation of host clock gene machinery by hepatitis viruses B and C.
Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma.
Molecular epidemiology of health care-associated transmission of hepatitis B and C viruses.
N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study.
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma.
Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome.
Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.
TIP60 Complex Inhibits Hepatitis B Virus Transcription.
Hepatitis C
Analysis of the overdispersed clock in the short-term evolution of hepatitis C virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak.
Hepatitis C virus evolutionary patterns studied through analysis of full-genome sequences.
Inaugural Article: A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades.
MicroRNA-10a Impairs Liver Metabolism in Hepatitis C Virus-Related Cirrhosis Through Deregulation of the Circadian Clock Gene Brain and Muscle Aryl Hydrocarbon Receptor Nuclear Translocator-Like 1.
Molecular analysis of hepatitis C virus infection in Bulgarian injecting drug users.
Molecular epidemiology of health care-associated transmission of hepatitis B and C viruses.
Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgrounds.
Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock.
Hepatitis C, Chronic
Effects of multiple-dose pegylated interferon alfa-2b on the activity of drug-metabolizing enzymes in persons with chronic hepatitis C.
The impact of chronic hepatitis C infection on the circadian clock and sleep.
Hepatitis, Chronic
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Herpes Simplex
A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells.
Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity.
Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.
Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of ?-Hemoglobinopathies.
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.
Systemic Immunosuppression in High-Risk Penetrating Keratoplasty: A Systematic Review.
The Histone Acetyltransferase CLOCK Is an Essential Component of the Herpes Simplex Virus 1 Transcriptome That Includes TFIID, ICP4, ICP27, and ICP22.
Herpes Zoster
Diurnal rhythmicity of the canonical clock genes Per1, Per2 and Bmal1 in the rat adrenal gland is unaltered after hypophysectomy.
QUASIMODO, a Novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock.
Hirschsprung Disease
Rubinstein-Taybi syndrome and Hirschsprung disease in a patient harboring an intragenic deletion of the CREBBP gene.
histone acetyltransferase deficiency
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.
Circadian Dysfunction and Obesity: Is Leptin the Missing Link?
CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma.
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females.
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.
Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency.
Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis.
Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition.
Rubinstein-Taybi syndrome and CREBBP c.201 202delTA mutation: a case presenting with varicella meningoencephalitis.
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration.
The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells.
The circadian rhythm controls telomeres and telomerase activity.
The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells.
The N-end rule pathway enzyme Naa10 supports epiblast specification in mouse embryonic stem cells by modulating FGF/MAPK.
Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency.
[Treatment of discoid lupus erythematosus with sulfasalazine: 11 cases]
HIV Infections
An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection.
Basic science and pathogenesis of ageing with HIV: potential mechanisms and biomarkers.
HIV-1 Infection Accelerates Age According to the Epigenetic Clock.
Incident infection in high-priority HIV molecular transmission clusters in the United States.
Validation of molecular clock inferred HIV infection ages: Evidence for accurate estimation of infection dates.
Hodgkin Disease
Chidamide and decitabine can synergistically induce apoptosis of Hodgkin lymphoma cells by up-regulating the expression of PU.1 and KLF4.
JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte rich large B-cell lymphoma.
Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study.
The reciprocal interplay between TNF? and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells.
Huntington Disease
Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease.
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research.
Base rates of "10 to 11" clocks in Alzheimer's and Parkinson's disease.
Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse.
Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.
Epigenetic Changes and Its Intervention in Age-Related Neurodegenerative Diseases.
Huntingtin protein: A new option for fixing the Huntington's disease countdown clock.
Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.
Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
Partial Depletion of CREB-Binding Protein Reduces Life Expectancy in a Mouse Model of Huntington Disease.
Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease.
Polyglutamine disease: acetyltransferases awry.
Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease.
Screening for cognitive dysfunction in Huntington's disease with the clock drawing test.
Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's disease.
Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington's disease.
Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease.
The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice.
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
Hydrocephalus
Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.
Hyperacusis
Identification of a Circadian Clock in the Inferior Colliculus and Its Dysregulation by Noise Exposure.
Hyperaldosteronism
Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice.
Hyperalgesia
Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure.
Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.
Hyperandrogenism
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Hypercholesterolemia
Cholesterol diet enhances daily rhythm of Pai-1 mRNA in the mouse liver.
Hypercholesterolemia Among Premature Infarcts: Time to Start the Clock of Familial Hypercholesterolemia Assessment.
Hyperglycemia
A renal genetic risk score (GRS) is associated with kidney dysfunction in people with type 2 diabetes.
Characterization, localization and temporal expression of crustacean hyperglycemic hormone (CHH) in the behaviorally rhythmic peracarid crustaceans, Eurydice pulchra (Leach) and Talitrus saltator (Montagu).
Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.
DNA Methylation of Five Core Circadian Genes Jointly Contributes to Glucose Metabolism: A Gene-Set Analysis in Monozygotic Twins.
Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5.
Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ?-cells.
Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycemic conditions.
miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300.
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Novel putative mechanisms to link circadian clocks to healthy aging.
Obesity and metabolic syndrome in circadian Clock mutant mice.
PAX6 mutation alters circadian rhythm and ? cell function in mice without affecting glucose tolerance.
Role of High Energy Breakfast "Big Breakfast Diet" in Clock Gene Regulation of Postprandial Hyperglycemia and Weight Loss in Type 2 Diabetes.
Hyperhomocysteinemia
Aging-like circadian disturbances in folate-deficient mice.
Chronopharmacological targeting of Rev-erb? by puerarin alleviates hyperhomocysteinemia in mice.
[The role of homocysteine levels in the pathogenesis of cognitive disorders in patients with chronic cerebral ischemia]
Hyperinsulinism
Functional CLOCK Is Not Essentially Associated with Metabolic Disruption Caused by Sleep Phase Feeding in Mice.
Hyperinsulinism in an individual with an EP300 variant of Rubinstein-Taybi syndrome.
Metabolic syndrome and cancer: "The common soil hypothesis".
Hyperlipidemias
Circadian rhythms in the CNS and peripheral clock disorders: the circadian clock and hyperlipidemia.
Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice.
Novel putative mechanisms to link circadian clocks to healthy aging.
Obesity and metabolic syndrome in circadian Clock mutant mice.
Proxisome proliferator-activated receptor-? mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.
[Hyperlipidemia and peroxisome proliferator-activated receptor (PPAR)--regulation of the PPARalpha gene by CLOCK: BMAL1]
Hyperparathyroidism
Changing landscape of the treatment of hyperparathyroidism related to end-stage renal disease-can we turn the clock backward?
Hyperparathyroidism, Secondary
A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder.
Hyperpigmentation
Bilateral Annular Isolated Choroidal Melanocytosis.
Hyperprolactinemia
A review of dopamine agonist therapy in type 2 diabetes and effects on cardio-metabolic parameters.
Effects of the short-acting benzodiazepine triazolam, taken at bedtime, on circadian and sleep-related hormonal profiles in normal men.
Hypersensitivity
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity.
A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo.
Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.
Arylamine N-acetyltransferase (NAT2) gene mutations in children with allergic diseases.
Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle.
Circadian asthma airway responses are gated by REV-ERB?.
Circadian regulation of allergic reactions by the mast cell clock in mice.
Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy.
Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.
Clockwork allergy: How the circadian clock underpins allergic reactions.
Controlling the peripheral clock might be a new treatment strategy in allergy and immunology.
Crosstalk Among Circadian Rhythm, Obesity and Allergy.
Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.
Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation.
Effects of Genetic Polymorphisms of N-Acetyltransferase on Trichloroethylene-Induced Hypersensitivity Dermatitis among Exposed Workers.
Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.
Genotype and phenotype of N-acetyltransferase 2 (NAT2) polymorphism in patients with contact allergy.
Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity.
IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock.
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.
Interacting proteins Rtt109 and Vps75 affect the efficiency of non-homologous end-joining in Saccharomyces cerevisiae.
Lentinan Inhibited the Activation of Th2 Cells in Allergic Mice by Reducing the Amplitude of Changes in Biological Rhythm.
Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers.
Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity.
N-acetyltransferase 1 and 2 polymorphisms in para-substituted arylamine-induced contact allergy.
Role of the Histone Acetyltransferase Rtt109 in Development and Pathogenicity of the Rice Blast Fungus.
Targeting histone-acetyltransferase Tip60 inhibits intestinal allergy.
Temporal establishment of neural cell identity in vivo and in vitro.
The Circadian Clock Drives Mast Cell Functions in Allergic Reactions.
The circadian clock functions as a potent regulator of allergic reaction.
The circadian clock is functional in eosinophils and mast cells.
The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins.
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Xenobiotic metabolism in the fourth dimension: PARtners in time.
[Epigenetic regulation of abiotic stress response in plants to improve the stress tolerance].
Hypertension
About-half-weekly (circasemiseptan) component of the endothelin-1 (ET-1) chronome and vascular disease risk.
Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.
Aldosterone and cardiovascular disease.
Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet.
Altered expression of norepinephrine transporter participate in hypertension and depression through regulated TNF-? and IL-6.
Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients.
Blood pressure AsSAuLTed by the circadian clock.
Circadian clock and vascular disease.
Circadian clock-deficient mice as a tool for exploring disease etiology.
Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs: is dosing in the evening better than in the morning?
Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.
Clock genes in hypertension: novel insights from rodent models.
Common genetic variation in circadian clock genes are associated with cardiovascular risk factors in an African American and Hispanic/Latino cohort.
Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension.
DOCP-Salt Treatment Leads to Non-dipping Hypertension in Per1 Knockout Mice.
Downregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study.
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort.
Exercise-induced arterial hypertension - an independent factor for hypertrophy and a ticking clock for cardiac fatigue or atrial fibrillation in athletes?
Expression of circadian rhythm genes CLOCK, BMAL1, and PER1 in buccal epithelial cells of patients with essential arterial hypertension in dependence on polymorphic variants of CLOCK and BMAL1 genes.
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
Gene-gene interaction between serotonin transporter (SLC6A4) and clock modulates the risk of metabolic syndrome in rotating shiftworkers.
High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring.
Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis.
Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice.
Hypertension: A Disease That Strikes Around the Clock.
Hypertension: do we need to consider the biological clock in drug dosing?
Hypertension: Tick, tock goes the renal circadian clock.
Identification of Clock Genes Related to Hypertension in Kidney From Spontaneously Hypertensive Rats.
Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Lysine Acetyltransferases CBP and p300 Attenuate Transcriptional Activity of the Mineralocorticoid Receptor through its Acetylation.
MicroRNAs: a potential interface between the circadian clock and human health.
mTOR Signaling and Entrainment of the Mammalian Circadian Clock.
Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock.
OS 33-09 ASSOCIATION OF CLOCK GENE POLYMORPHISM WITH INSULIN RESISTANCE IN HYPERTENSION: A CASE-CONTROL STUDY.
Osler's maneuver, pseudohypertension, and true hypertension in the elderly.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Pressed for time: the circadian clock and hypertension.
Renal Na Handling Defect Associated with PER1-Dependent Non-Dipping Hypertension In Male Mice.
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Social class and all-cause mortality in an urban population of North India.
The Circadian Clock in the Regulation of Renal Rhythms.
The circadian system and the balance of the autonomic nervous system.
The clock is ticking: the case for achieving more rapid control of hypertension.
The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition.
Thousands of blood pressure and heart rate measurements at fixed clock hours may mislead.
Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus.
[Association of T3111C polymorphism in 3'-untranslated region of the CLOCK gene with the risk of essential arterial hypertension and coronary artery disease in the Russian population Karelia].
[Circadian rhythm abnormality and hypertension].
[Clock genes and circadian rhythm of blood pressure].
[Nocturia and the circadian rhythm].
[Selection of psychoemotional load test for the diagnosis of hypertension]
[The role of clock genes involved with a hypertension development].
Hypertension, Portal
Correlation Between NAT2 Gene Polymorphism and Cirrhotic Portal Hypertension in the Chinese Population.
Hyperthyroidism
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Interconnection between circadian clocks and thyroid function.
Repercussions of hypo and hyperthyroidism on the heart circadian clock.
[Acetylation phenotype and the changes in selected indicators of calcium-phosphate metabolism in patients with hyperthyroidism treated with propranolol]
Hypertriglyceridemia
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Hyphema
Iris Nevus Growth into Melanoma: Analysis of 1611 Consecutive Eyes: The ABCDEF Guide.
Scleral and corneal laceration with iris prolapse caused by an eagle claw.
Hypoglycemia
American College of Physicians diabetes guidelines attempt to turn back the clock, conflating good HbA1c with hypoglycemia.
Physiological significance of a peripheral tissue circadian clock.
Hypophosphatemia
Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.
Hypotension
Case studies in orthotopic liver transplantation for hepatitis B: a panel discussion.
Circadian rhythm in hypotensive effect of sodium nitroprusside in rats and its relevance to sympathetic nervous activity.
Conventional and ambulatory blood pressure measurement in older patients with isolated systolic hypertension:second progress report on the ambulatory blood pressure monitoring project in the Syst-Eur trial.
Hypothalamic Neoplasms
Circadian Alterations in a Murine Model of Hypothalamic Glioma.
Hypothyroidism
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Effects of inhibition of thyroid function and of cold on melatonin synthesis and porphyrin content in the Harderian glands of male Syrian hamsters, Mesocricetus auratus.
Interconnection between circadian clocks and thyroid function.
[Effect of experimental hypothyroidism on N-acetyltransferase activity in the rat liver]
Hypoventilation
Effect of reoxygenation on the electrical stability of the rat heart in vivo: a chronobiological study.
Hypoxia, Brain
Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy.
Hypoxia-Ischemia, Brain
Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy.
Idiopathic Hypersomnia
Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.
Idiopathic Pulmonary Fibrosis
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.
Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo.
Illusions
Auditory chronostasis: hanging on the telephone.
How a clock can change your pain? The illusion of duration and pain perception.
Human time perception and its illusions.
Internal clock processes and the filled-duration illusion.
Motion illusions in optical art presented for long durations are temporally distorted.
Neural Repetition Suppression Modulates Time Perception: Evidence From Electrophysiology and Pupillometry.
On the relation between body ownership and sense of agency: A link at the level of sensory-related signals.
Shared processing of perception and imagery of music in decomposed EEG.
Spatio-temporal contingency of saccade-induced chronostasis.
Temporal data representation, normalization, extraction, and reasoning: A review from clinical domain.
The master clock illusion.
The perception of empty and filled time intervals by rats.
Ticks per thought or thoughts per tick? A selective review of time perception with hints on future research.
Voluntary action expands perceived duration of its sensory consequence.
Immune System Diseases
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.
Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.
Infections
A Localized Pseudomonas syringae Infection Triggers Systemic Clock Responses in Arabidopsis.
A matter of time: study of circadian clocks and their role in inflammation.
Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus.
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Analysis of the overdispersed clock in the short-term evolution of hepatitis C virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak.
Antibiotic Treatment for Febrile Urinary Tract Infection: The Clock Is Ticking.
Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses.
Bayesian skyline plot inference of the Toscana virus epidemic: a decline in the effective number of infections over the last 30 years.
Bmal1 integrates mitochondrial metabolism and macrophage activation.
Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity.
Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer's Disease?
Characterisation of a SAT-1 outbreak of foot-and-mouth disease in captive African buffalo (Syncerus caffer): clinical symptoms, genetic characterisation and phylogenetic comparison of outbreak isolates.
Circadian clock components Bmal1 and Clock1 regulate tlr9 gene expression in the Japanese medaka (Oryzias latipes).
Circadian clock regulates the host response to Salmonella.
Circadian nature of immune function.
Circadian regulation in the ability of Drosophila to combat pathogenic infections.
Circadian regulation of plant immunity to pathogens.
Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic.
Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.
Control of IRF-3 activation by phosphorylation.
Creating and implementing a COVID-19 recruitment Data Mart.
Crosstalk between the circadian clock and innate immunity in Arabidopsis.
Crystal structure of the aminoglycosides N-acetyltransferase Eis2 from Mycobacterium abscessus.
Current methods for diagnosis of human coronaviruses: pros and cons.
Defence responses of Arabidopsis thaliana to infection by Pseudomonas syringae are regulated by the circadian clock.
Differential control of pre-invasive and post-invasive antibacterial defense by the Arabidopsis circadian clock.
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
Drug Hepatotoxicity: Environmental Factors.
Dysregulation of photic induction of Fos-related protein in the biological clock during experimental trypanosomiasis.
Earlier treatment initiation is associated with a decreased number of HIV-1 subtype A1 transmissions in Greece.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation.
Effect of Time of Day of Infection on Chlamydia Infectivity and Pathogenesis.
Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV.
Epigenetic reader BRD4 supports mycobacterial pathogenesis by co-modulating host lipophagy and angiogenesis.
Episodic sexual transmission of HIV revealed by molecular phylodynamics.
Evidence for a new contiguous gene syndrome, the chromosome 16p13.3 deletion syndrome alias severe Rubinstein-Taybi syndrome.
Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus.
Experimental infection of gnotobiotic piglets with Escherichia coli strains positive for EAST1 and AIDA.
Foodborne illness in the elderly.
From trypanosomes to the nervous system, from molecules to behavior: a survey, on the occasion of the 90th anniversary of Castellani's discovery of the parasites in sleeping sickness.
Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus.
Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-?B Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP.
Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway.
Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.
HIV-1 Infection Accelerates Age According to the Epigenetic Clock.
Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.
Hydrophobin CmHYD1 Is Involved in Conidiation, Infection and Primordium Formation, and Regulated by GATA Transcription Factor CmAreA in Edible Fungus, Cordyceps militaris.
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.
Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.
Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells.
Interplay between Microbes and the Circadian Clock.
Jasmonate signalling drives time-of-day differences in susceptibility of Arabidopsis to the fungal pathogen Botrytis cinerea.
Lights, Rhythms, Infection: The Role of Light and the Circadian Clock in Determining the Outcome of Plant-Pathogen Interactions.
Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection.
Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates.
Lysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp.
Microbes in the Era of Circadian Medicine.
Modulation of allostery by protein intrinsic disorder.
Molecular clock of HIV-1 envelope genes under early immune selection.
MYO1F regulates antifungal immunity by regulating acetylation of microtubules.
N-acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus.
Nighttime activities and peripheral clock oscillations depend on Wolbachia endosymbionts in flies.
NPR1 and Redox Rhythmx: Connections, between Circadian Clock and Plant Immunity.
Nuclear receptor REV-ERB? mediates circadian sensitivity to mortality in murine vesicular stomatitis virus-induced encephalitis.
Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels.
Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods.
Promoter-Targeted Histone Acetylation of Chromatinized Parvoviral Genome Is Essential for the Progress of Infection.
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.
Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins.
Safety issues associated with dietary management in patients with hepatic glycogen storage disease.
Seasonally variant gene expression in full-term human placenta.
Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.
Sleep and timekeeping changes, and dysregulation of the biological clock in experimental trypanosomiasis.
Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish.
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System.
Sleeping sickness is a circadian disorder.
Spread times of hepatitis C virus estimated by the molecular clock differ among Japan, the United States and Egypt in reflection of their distinct socioeconomic backgrounds.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics.
The circadian clock and diseases of the skin.
The Circadian Clock and Viral Infections.
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.
The circadian clock in immune cells controls the magnitude of Leishmania parasite infection.
The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock.
The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.
The circadian system of Trypanosoma cruzi-infected mice.
The effect of Wolbachia on diapause, fecundity, and clock gene expression in Trichogramma brassicae (Hymenoptera: Trichogrammatidae).
The Effects of Anti-retroviral Therapy on Epigenetic Age Acceleration Observed in HIV-1-infected Adults.
The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population.
The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9.
The human cytomegalovirus 86-kilodalton major immediate-early protein interacts physically and functionally with histone acetyltransferase P/CAF.
The impact of chronic hepatitis C infection on the circadian clock and sleep.
The innate immune cell response to bacterial infection in larval zebrafish is light-regulated.
The International Dimension of the U.S. HIV Transmission Network and Onward Transmission of HIV Recently Imported into the United States.
The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells.
The rise of superbugs. Dangerous infections that are resistant to antibiotics are spreading and growing stronger, with dire consequences. Medical experts say it's a mess of our own making--and the clock is ticking on when and how we must solve it. The first in a three-part series.
The Ticking CLOCK of HSV-2 Pathology.
Tick Tock: Circadian Regulation of Plant Innate Immunity.
TIP60 Complex Inhibits Hepatitis B Virus Transcription.
Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock.
Transcriptomic response to parasite infection in Nile tilapia (Oreochromis niloticus) depends on rearing density.
Vaccination as a preventative measure contributing to immune fitness.
Validation of molecular clock inferred HIV infection ages: Evidence for accurate estimation of infection dates.
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.
What is the basis of transmissible spongiform encephalopathy induced neurodegeneration and can it be repaired?
Infertility
Association of CLOCK gene variants with semen quality in idiopathic infertile Han-Chinese males.
Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling.
Circadian rhythms and reproduction.
Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle.
Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice.
Involvement of the luteinizing hormone surge in the regulation of ovary and oviduct clock gene expression in mice.
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period.
Regulation of reproduction by the circadian rhythms.
Rethinking the biological clock: eleventh-hour moms, miracle moms and meanings of age-related infertility.
Space and Time in the Obsessive-Compulsive Phenomenon.
Sterility assurance. Clock is ticking to replace STERIS SS1 units--are hospitals ready? Interview by Jeff Ferenc.
The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge.
Variants of the CLOCK gene affect the risk of idiopathic male infertility in the Han-Chinese population.
Infertility, Male
Bovine Circadian Locomotor Output Cycles Kaput (CLOCK) and Clusterin (CLU) mRNA Quantitation in Ejaculated Crossbred Bull Spermatozoa.
Genetic Variation in Circadian Rhythm Genes CLOCK and ARNTL as Risk Factor for Male Infertility.
Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility.
The male biological clock is ticking: a review of the literature.
The role of circadian rhythm in male reproduction.
Variants of the CLOCK gene affect the risk of idiopathic male infertility in the Han-Chinese population.
[Single nucleotide polymorphisms of the N-acetyltransferase 2 gene not correlated with male infertility].
Inflammatory Bowel Diseases
Association Study of a Polymorphism in Clock Gene PERIOD3 and Risk of Inflammatory Bowel Disease.
Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Clock Gene Disruption is an Initial Manifestation of Inflammatory Bowel Disease.
Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.
Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.
N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease.
Neonatal Exposures and Risk of Inflammatory Bowel Disease: When Does the Clock Start Ticking?
STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
The Role of N-Acetyltransferase 2 Polymorphism in the Etiopathogenesis of Inflammatory Bowel Disease.
Influenza, Human
A Novel Intronic Circular RNA Antagonizes Influenza Virus by Absorbing a microRNA That Degrades CREBBP and Accelerating IFN-? Production.
Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock.
Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway.
Influenza A virus nucleoprotein is acetylated by histone acetyltransferases, PCAF and GCN5.
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.
Influenza viruses and the evolution of avian influenza virus H5N1.
Local and relaxed clocks: the best of both worlds.
Molecular clock of viral evolution, and the neutral theory.
Novel non-parametric models to estimate evolutionary rates and divergence times from heterochronous sequence data.
Insulin Resistance
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-? Pathway Activity in Mice.
Association of insulin resistance with polymorphic variants of Clock and Bmal1 genes: A case-control study.
Associations of Plasma BACE1 Level and BACE1 C786G Gene Polymorphism with Cognitive Functions in Patients with Type 2 Diabetes: A Cross- Sectional Study.
Astrocyte Clocks and Glucose Homeostasis.
Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome.
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.
Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice.
Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events.
Chronic circadian shift leads to adipose tissue inflammation and fibrosis.
Circadian clocks and insulin resistance.
Circadian misalignment disturbs the skeletal muscle lipidome in healthy young men.
Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.
Circadian Rhythms in Diet-Induced Obesity.
Circadian rhythms, metabolism, and insulin sensitivity: transcriptional networks in animal models.
Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology.
Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues.
CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice.
Clock Genes, Inflammation and the Immune System-Implications for Diabetes, Obesity and Neurodegenerative Diseases.
CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1.
Cortisol Circadian Rhythm and Insulin Resistance in Muscle: Effect of Dosing and Timing of Hydrocortisone Exposure on Insulin Sensitivity in Synchronized Muscle Cells.
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Diabetes and atherothrombosis: The circadian rhythm and role of melatonin in vascular protection.
Diet-induced insulin resistance state disturbs brain clock processes and alters tuning of clock outputs in the Sand rat, Psammomys obesus.
Diurnal Regulation of Peripheral Glucose Metabolism: Potential Effects of Exercise Timing.
Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.
Effect of sleep deprivation on the human metabolome.
EGCG Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1.
Evidence-based practice use of quick-release bromocriptine across the natural history of type 2 diabetes mellitus.
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.
Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster.
Hypothalamic control of energy metabolism via the autonomic nervous system.
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.
Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.
Insulin under the influence of light.
Is exercise a viable therapeutic intervention to mitigate mitochondrial dysfunction and insulin resistance induced by sleep loss?
Keeping a 'watch-full' eye on metabolic disease.
Later chronotype is associated with higher hemoglobin A1c in prediabetes patients.
Light therapy for better mood and insulin sensitivity in patients with major depression and type 2 diabetes: a randomised, double-blind, parallel-arm trial.
Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver.
Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation.
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis.
Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.
Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.
Night-restricted feeding improves locomotor activity rhythm and modulates nutrient utilization to accelerate growth in rabbits.
Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes.
Novel association between the nonsynonymous A803G polymorphism of the N-acetyltransferase 2 gene and impaired glucose homeostasis in obese children and adolescents.
Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.
OS 33-09 ASSOCIATION OF CLOCK GENE POLYMORPHISM WITH INSULIN RESISTANCE IN HYPERTENSION: A CASE-CONTROL STUDY.
Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview.
Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction.
Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and A? Accumulation in Alzheimer's Disease.
Retinoic acid-related orphan receptor ? (ROR?): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity.
Rev-erb alpha gives a time cue to metabolism.
REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity.
Role of High Energy Breakfast "Big Breakfast Diet" in Clock Gene Regulation of Postprandial Hyperglycemia and Weight Loss in Type 2 Diabetes.
Rosiglitazone reverses high fat diet-induced changes in BMAL1 function in muscle, fat, and liver tissue in mice.
Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high fat diet on inflammation and metabolism.
Suprachiasmatic nucleus neuropeptides and their control of endogenous glucose production.
The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance.
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism.
The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity.
Thyroid Cancer and Circadian Clock Disruption.
Ticking for Metabolic Health: The Skeletal-Muscle Clocks.
TRPV1 participates in the activation of clock molecular machinery in the brown adipose tissue in response to light-dark cycle.
Insulinoma
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4{alpha}, and CBP.
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Intellectual Disability
A Novel De Novo Frameshift Mutation in KAT6A Identified by Whole Exome Sequencing.
A Novel Frameshift Mutation in KAT6A Is Associated with Pancraniosynostosis.
A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly.
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.
A novel truncating variant within exon 7 of KAT6B associated with features of both Say-Barber-Bieseker-Young-Simpson syndrome and genitopatellar syndrome: Further evidence of a continuum in the clinical spectrum of KAT6B-related disorders.
Analysis of mutations within the intron20 splice donor site of CREBBP in patients with and without classical RSTS.
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.
Clinical Manifestations in a Girl with NAA10-Related Syndrome and Genotype-Phenotype Correlation in Females.
Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report.
Confirmation of a new phenotype in an individual with a variant in the last part of exon 30 of CREBBP.
Confirmation of EP300 gene mutations as a rare cause of Rubinstein-Taybi syndrome.
De novo mutations in the SET nuclear proto-oncogene, encoding a component of the inhibitor of histone acetyltransferases (INHAT) complex in patients with nonsyndromic intellectual disability.
Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features.
Duplication 16p13.3 and the CREBBP gene: confirmation of the phenotype.
Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency.
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Further delineation of the KAT6B molecular and phenotypic spectrum.
Generation of the Rubinstein-Taybi syndrome type 2 patient-derived induced pluripotent stem cell line (IAIi001-A) carrying the EP300 exon 23 stop mutation c.3829A?>?T, p.(Lys1277*).
Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G>T, p.(Gly1479*) and c.3474G>A, p.(Trp1158*) and missense c.4627G>T, p.(Asp1543Tyr) mutations.
Genetic and clinical heterogeneity in Korean patients with Rubinstein-Taybi syndrome.
Identifying the KAT6B Mutation via Diagnostic Exome Sequencing to Diagnose Say-Barber-Biesecker-Young-Simpson Syndrome in Three Generations of a Family.
Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders.
iPSC-derived neurons of CREBBP- and EP300-mutated Rubinstein-Taybi syndrome patients show morphological alterations and hypoexcitability.
Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.
Knowledge of results and learning to tell the time in an adult male with an intellectual disability: a single-subject research design.
Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.
MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease.
Mutations in Histone Acetylase Modifier BRPF1 Cause an Autosomal-Dominant Form of Intellectual Disability with Associated Ptosis.
NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report.
NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.
NAA10-related syndrome.
Novel Causative Variants in DYRK1A, KARS, and KAT6A Associated with Intellectual Disability and Additional Phenotypic Features.
Ocular Findings in a Patient With KAT6A Mutation.
Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in KAT6A.
Perthes disease: A new finding in Floating-Harbor syndrome.
Rubinstein-Taybi syndrome with epidermal nevus: a case report.
Severe syndromic ID and skewed X-inactivation in a girl with NAA10 dysfunction and a novel heterozygous de novo NAA10 p.(His16Pro) variant - a case report.
Sleep, Behavior, and Adaptive Function in KAT6A Syndrome.
Spectrum of CREBBP mutations in Indian patients with Rubinstein-Taybi syndrome.
Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Three brothers with a nonsense mutation in KAT6A caused by parental germline mosaicism.
Transcriptome Analysis of iPSC-Derived Neurons from Rubinstein-Taybi Patients Reveals Deficits in Neuronal Differentiation.
Variants in NAA15 cause pediatric hypertrophic cardiomyopathy.
Intervertebral Disc Degeneration
The circadian rhythm in intervertebral disc degeneration: an autophagy connection.
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intestinal Volvulus
Putrescine N-acetyltransferase in Onchocerca volvulus and Ascaris suum, an enzyme which is involved in polyamine degradation and release of N-acetylputrescine.
Intracranial Hemorrhages
Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein.
Iron Deficiencies
Comprehensive mapping of abiotic stress inputs into the soybean circadian clock.
Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit.
Ischemic Stroke
Caring for stroke survivors: baseline and 1-year determinants of caregiver burden.
Circadian rhythms of melatonin, cortisol, and clock gene expression in the hyperacute phase of wake-up stroke: study design and measurement.
Collateral status as the fifth dimension: warping the time clock for endovascular treatment in acute ischaemic stroke.
Daylight saving time and the incidence of thrombolysis to treat acute ischemic stroke.
Does b1000-b0 Mismatch Challenge Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery Mismatch in Stroke?
Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction.
Particulate Air Pollution, Clock Gene Methylation, and Stroke: Effects on Stroke Severity and Disability.
The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep.
Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT.
We are on the clock: MRI as a surrogate marker of lesion age in acute ischemic stroke.
[Transient ischemic attacks and prolonged reversible ischemic neurologic deficit. Diagnosis, differential diagnosis and treatment]
[Treatment of acute ischemic stroke: tissue clock and reperfusion].
Jet Lag Syndrome
A Looser Clock to Cure Jet Lag.
Accelerating recovery from jet lag: prediction from a multi-oscillator model and its experimental confirmation in model animals.
Adrenal glucocorticoids as a target for jet lag therapies.
Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag.
Amplitude Effects Allow Short Jet Lags and Large Seasonal Phase Shifts in Minimal Clock Models.
Arginine vasopressin signaling in the suprachiasmatic nucleus on the resilience of circadian clock to jet lag.
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Chronic jet lag impairs startle-induced locomotion in Drosophila.
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Chronotype and stability of spontaneous locomotor activity rhythm in BMAL1-deficient mice.
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Circadian clocks and insulin resistance.
Circadian clocks: genes, sleep, and cognition.
Circadian disruption and remedial interventions: effects and interventions for jet lag for athletic peak performance.
Circadian Dysfunction and Obesity: Is Leptin the Missing Link?
Circadian Dysfunction Induces Leptin Resistance in Mice.
Circadian rhythmicity and the pharmacologic management of insomnia.
Circadian rhythms of micturition during jet lag.
Critical cholangiocarcinogenesis control by cryptochrome clock genes.
Critical phase shifts slow down circadian clock recovery: implications for jet lag.
Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag.
Disorders of the sleep-wake cycle in adults.
Disruption of adolescents' circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk behaviors.
Dysregulation of inflammatory responses by chronic circadian disruption.
Effect of BRAND's Essence of Chicken on the resetting process of circadian clocks in rats subjected to experimental jet lag.
Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions.
Effect of regular and irregular stimulation cycles of dexamethasone on circadian clock in NIH3T3 cells.
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice.
Effects of light and food schedules on liver and tumor molecular clocks in mice.
Effects of melatonin on vertebrate circadian systems.
Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition.
Even a stopped clock tells the right time twice a day: circadian timekeeping in Drosophila.
Evening and night exposure to screens of media devices and its association with subjectively perceived sleep: Should "light hygiene" be given more attention?
Feeding and circadian clocks.
From circadian clock mechanism to sleep disorders and jet lag: Insights from a computational approach.
How jet lag impairs Major League Baseball performance.
Identifying some determinants of "jet lag" and its symptoms: a study of athletes and other travellers.
Insomnia, biological clock, and the bedtime decision: an economic perspective.
Jet lag and shift work sleep disorders: how to help reset the internal clock.
Jet lag: trends and coping strategies.
Keeping time with the human genome.
Light and biological rhythms.
Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag.
Managing jet lag: Some of the problems and possible new solutions.
Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease.
Metabolic jet lag when the fat clock is out of sync.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Modeling and analysis of the impacts of jet lag on circadian rhythm and its role in tumor growth.
Modeling the circadian clock: from molecular mechanism to physiological disorders.
Molecular analysis of sleep: wake cycles in Drosophila.
Novel insights from genetic and molecular characterization of the human clock.
Optimal adjustment of the human circadian clock in the real world.
Phenotyping Circadian Rhythms in Mice.
Rapid phase adjustment of melatonin and core body temperature rhythms following a 6-h advance of the light/dark cycle in the horse.
Shift work, jet lag, and female reproduction.
Sleep, circadian rhythm, and gut microbiota.
The bird circadian clock: insights from a computational model.
The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer.
The Circadian System: A Regulatory Feedback Network of Periphery and Brain.
The effect of L-carnosine on the circadian resetting of clock genes in the heart of rats.
Transgenic rats expressing dominant negative BMAL1 showed circadian clock amplitude reduction and rapid recovery from jet lag.
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.
Treatment of Circadian Rhythm Sleep-Wake Disorders.
[Circadian clock disruption and diabetes mellitus].
[Developments of chronobiology abroad]
[Molecular and Neural Mechanisms for the Robustness of the Circadian Clock].
Joint Diseases
Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice.
Running on time: the role of circadian clocks in the musculoskeletal system.
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Keratitis
Insect wing tarsal foreign body causing conjunctival granuloma and marginal keratitis.
Keratosis, Actinic
Expression of p300 and p300/CBP associated factor (PCAF) in actinic keratosis and squamous cell carcinoma of the skin.
Kidney Diseases
Circadian Clock Genes in Diabetic Kidney Disease (DKD).
Glucocorticoids use in kidney transplant setting.
Mechanism of circadian regulation of the NRF2/ARE pathway in renal ischemia-reperfusion.
Predicted Effect of Circadian Clock Modulation of NHE3 of a Proximal Tubule Cell on Sodium Transport.
Kidney Failure, Chronic
Diastolic dysfunction in end-stage renal disease patient: what the ticking clock has told us?
IMMUNOGENETIC AND PHARMACOCHEMICAL CHARACTERIZATION OF THE ABO SYSTEM GLYCOPROTEIN PROPERTIES AS CRITERIA OF INDIVIDUAL SENSITIVITY TO ANTITUMOR AGENT BORTEZOMIB IN THE PLASMA CELL MYELOMA PATIENTS.
Kidney Neoplasms
Altered expression of the clock gene machinery in kidney cancer patients.
c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.
Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer.
Research on circadian clock genes in common abdominal malignant tumors.
The circadian clock and the hypoxic response pathway in kidney cancer.
The role of vascular clamping during robot-assisted partial nephrectomy for localized renal cancer: rationale and design of the CLOCK randomized phase III study.
Laminopathies
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
Language Development Disorders
A Novel Frameshift Mutation in KAT6A Is Associated with Pancraniosynostosis.
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Ocular Findings in a Patient With KAT6A Mutation.
Three brothers with a nonsense mutation in KAT6A caused by parental germline mosaicism.
Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.
Laryngeal Neoplasms
N-acetyltransferase phenotype of patients with cancer of the larynx.
Laryngomalacia
A Say-Barber-Biesecker-Young-Simpson variant of Ohdo syndrome with a KAT6B 10-base pair palindromic duplication: A recurrent mutation causing a severe phenotype mixed with genitopatellar syndrome.
Latex Hypersensitivity
Latex allergy sufferers--the clock is ticking.
Learning Disabilities
Novel insights from genetic and molecular characterization of the human clock.
Leiomyoma
Leiomyoma with KAT6B-KANSL1 fusion: case report of a rapidly enlarging uterine mass in a postmenopausal woman.
Ovarian steroid hormones modulate the expression of progesterone receptors and histone acetylation patterns in uterine leiomyoma cells.
Leiomyosarcoma
Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1.
Leishmaniasis, Visceral
The biological clock of an hematophagous insect: locomotor activity rhythms, circadian expression and downregulation after a blood meal.
Lens Subluxation
Assessment of the safety and efficacy of primary retropupillary fixation of iris-claw intraocular lenses in children with large lens subluxations.
Evaluation of functional outcome and stability of sutureless scleral tunnel fixated IOLs in children with ectopia lentis.
Leukemia
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma.
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.
Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement.
An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.
BCR-ABL1 kinase facilitates localization of acetylated histones 3 and 4 on DNA double-strand breaks.
Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells.
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.
Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
BRD1-Mediated Acetylation Promotes Integrin ?V Gene Expression Via Interaction with Sulfatide.
Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.
Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.
Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression.
Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain.
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.
CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.
Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.
Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands.
Detection of differential mitotic cell age in bone marrow CD34(+) cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Disease-related potential of mutations in transcriptional cofactors CREB-binding protein and p300 in leukemias.
Disruption of Core Circadian Clock Genes Reduces Leukemia Growth.
Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells.
Effects of berberine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adduct formation in human leukemia cells.
Epigenetic mechanisms in acute myeloid leukemia.
Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play.
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation.
Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.
Genetic predisposition and treatment-related leukemia.
Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil.
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.
Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.
Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.
Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol.
Hypoxia Selects for a Quiescent, CML Stem/Leukemia Initiating- Like Population Dependent on CBP/Catenin Transcription.
Identification and mapping of human histone acetylation modifier gene homologues.
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.
In silico evidence of signaling pathways of notch mediated networks in leukemia.
Inhibition of PCAF by Anacardic Acid Derivative Leads to Apoptosis and Breaks Resistance to DNA Damage in BCR-ABL-Expressing Cells.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells.
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells.
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
miR-143-3p represses leukemia cell proliferation by inhibiting KAT6A expression.
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.
Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.
Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.
MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.
MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease.
MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.
MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
MOZ is essential for maintenance of hematopoietic stem cells.
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).
moz regulates Hox expression and pharyngeal segmental identity in zebrafish.
Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.
MYST family histone acetyltransferases take center stage in stem cells and development.
N-ACETYLTRANSFERASE 2 POLYMORPHISMS AND SUSCEPTIBILITY TO INFANT LEUKEMIA WITH MATERNAL EXPOSURE TO DIPYRONE DURING PREGNANCY.
N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells.
New KAT6 inhibitors induce senescence and arrest cancer growth.
New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias.
Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins.
Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
Peptidomimetic blockade of MYB in acute myeloid leukemia.
Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction.
Prepaying the entropic cost for allosteric regulation in KIX.
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor.
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells.
Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11).
Recognition of Histone H3K14 Acylation by MORF.
Reconstitution of active and stoichiometric multisubunit lysine acetyltransferase complexes in insect cells.
Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ.
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein.
Revisiting allostery in CREB-binding protein (CBP) using residue-based interaction energy.
Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis.
Sea-Blue Histiocytosis of Bone Marrow in a Patient with t(8;22) Acute Myeloid Leukemia.
Secondary acute monocytic leukemia with a translocation t(8;16)(p11;p13): case report and review of the literature.
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein.
Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia.
Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.
The allosteric communication pathways in KIX domain of CBP.
The DAC system and associations with acute leukemias and myelodysplastic syndromes.
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.
The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia.
The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting.
The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13).
The mixed lineage leukemia 4 (MLL4) methyltransferase complex is involved in transforming growth factor beta (TGF-?)-activated gene transcription.
The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase.
The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body.
Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia.
Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein.
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.
Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia.
Viral and cellular factors that target the promyelocytic leukemia oncogenic domains strongly activate a glucocorticoid-responsive promoter.
Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells.
[Expression and Mechanism of KAT2A and CDK4/CDK6 in Children with Acute Leukemia].
[Reverse correlation between natural resistance of mice to transplanted leukemia EL-4 and rectal temperature]
Leukemia, Erythroblastic, Acute
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.
Leukemia, Lymphocytic, Chronic, B-Cell
Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia.
Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Leukemia, Monocytic, Acute
Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement.
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation.
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).
New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Altered expression of circadian clock genes in human chronic myeloid leukemia.
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3.
Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia.
Leukemia, Myeloid
Acetylation of lysine564 adjacent to the CTBP-binding motif in EVI1 is crucial for transcriptional activation of GATA2.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil.
Peptidomimetic blockade of MYB in acute myeloid leukemia.
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein.
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.
[Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays]
Leukemia, Myeloid, Acute
A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb.
Acute myeloid leukemia with erythrophagocytosis indicative of KAT6A rearrangement.
Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.
Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.
Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development.
Chromosome 8p11.2 translocations: prevalence, FISH analysis for FGFR1 and MYST3, and clinicopathologic correlates in a consecutive cohort of 13 cases from a single institution.
CITED2 affects leukemic cell survival by interfering with p53 activation.
Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer.
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells.
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.
MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters.
MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
MOZ is essential for maintenance of hematopoietic stem cells.
MOZ regulates B cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.
NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma.
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein.
t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia.
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia.
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13).
The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase.
The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease.
Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia.
Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.
Whole exome sequencing reveals de novo pathogenic variants in KAT6A as a cause of a neurodevelopmental disorder.
Leukemia, Myelomonocytic, Juvenile
CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.
Leukemia, T-Cell
Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitors.
Activator-dependent p300 acetylation of chromatin in vitro: enhancement of transcription by disruption of repressive nucleosome-nucleosome interactions.
Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation.
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.
c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein.
Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.
Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.
Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter.
p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300.
The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein.
The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.
The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression.
Leukemia-Lymphoma, Adult T-Cell
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Leukocytosis
Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats.
Leukoplakia, Oral
Association between polymorphisms at N-acetyltransferase 1 (NAT1) & risk of oral leukoplakia & cancer.
Lewy Body Disease
Metabolic alterations associated with impaired clock drawing in Lewy body dementia.
Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.
Lipid Metabolism Disorders
Does a high-fat diet affect the circadian clock, or is it the other way around? A systematic review.
Effects of altered photoperiod on circadian clock and lipid metabolism in rats.
Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.
Lipodystrophy
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.
Lipoma
Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.
Liposarcoma
Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.
Promoter-associated noncoding RNA from the CCND1 promoter.
Liver Cirrhosis
Disruption of the diurnal rhythm of plasma melatonin in cirrhosis.
Effect of L-carnitine upon ammonia tolerance test in cirrhotic patients.
Loss of clock gene mPer2 promotes liver fibrosis induced by carbon tetrachloride.
p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis.
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
[Changes in the 24-hour rhythm of plasma melatonin in patients with liver cirrhosis--relation to sleep architecture]
Liver Cirrhosis, Alcoholic
Polymorphism of N-acetyltransferase 2 Gene and the Susceptibility to Alcoholic Liver Cirrhosis: Interaction With Smoking.
Liver Cirrhosis, Biliary
Are primary biliary cirrhosis and autoimmune cholangitis reflective of the pendulum of a clock and therefore represent a 'phase' of the same disease?
Liver Diseases
3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.
Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver.
Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation.
Circadian Clock and Liver Cancer.
Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease.
Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes.
Circadian rhythms in liver physiology and liver diseases.
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease.
Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis.
Diurnal rhythm of follicle-stimulating hormone is associated with nonalcoholic fatty liver disease in a Chinese elderly population.
Emerging role of circadian clock disruption in alcohol-induced liver disease.
First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors.
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.
Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease.
Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
Nonalcoholic fatty liver disease in CLOCK mutant mice.
Polymorphism of N-acetyltransferase 2 Gene and the Susceptibility to Alcoholic Liver Cirrhosis: Interaction With Smoking.
Prediction of chronic liver diseases on the basis of the N-acetyltransferase 2 phenotype.
Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases.
Relationship between clock and star drawing and the degree of hepatic encephalopathy.
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.
Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model.
The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis.
The hepatic BMAL1/AKT/Lipogenesis axis protects against alcoholic liver disease via promoting PPAR? pathway.
The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
The role of astrocytes in generating circadian rhythmicity in health and disease.
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.
Liver Diseases, Alcoholic
N-acetyltransferase 2 polymorphism is not related to the risk of advanced alcoholic liver disease.
Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock.
Liver Failure, Acute
Pyruvate dehydrogenase complex and lactate dehydrogenase as targets for therapy of acute liver failure.
Liver Neoplasms
A Role for the Biological Clock in Liver Cancer.
Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.
Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China?
Circadian Clock and Liver Cancer.
Circadian clock gene expression regulates cancer cell growth through glutaminase.
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepatoma 7288CTC Warburg Effect and Progression.
Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells.
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Low Tension Glaucoma
Cognitive functions and normal tension glaucoma.
[Diurnal variation of intraocular pressure in low tension glaucoma]
Lung Diseases
A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices.
Bringing the cellular clock into understanding lung disease: it's time, period!
Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury.
It's about time: clocks in the developing lung.
Redox regulation of circadian molecular clock in chronic airway diseases.
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.
Lung Injury
Ammonia exposure causes lung injuries and disturbs pulmonary circadian clock gene network in a pig study.
Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury.
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway.
Lung Neoplasms
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL.
A pilot study testing the genetic polymorphism of N-acetyltransferase 2 as a risk factor in lung cancer.
Association between CLOCK, PER3 and CCRN4L with non?small cell lung cancer in Brazilian patients.
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis.
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.
C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.
Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats.
Circadian clock gene Per2 downregulation in non?small cell lung cancer is associated with tumour progression and metastasis.
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation.
Clock time and embodied time experienced by patients with inoperable lung cancer.
Correlation between acetylation phenotype and genotype in Chinese women.
CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition.
Curcumin inhibited the arylamines N-acetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells (A549).
Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.
Cytotoxic Effects of 24-Methylenecyloartanyl Ferulate on A549 Nonsmall Cell Lung Cancer Cells through MYBBP1A Up-Regulation and AKT and Aurora B Kinase Inhibition.
DDIT3 and KAT2A regulate TNFRSF10A and TNFRSF10B expression in endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells.
Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk.
Effect of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549.
Epigallocatechin?3?gallate inhibits self?renewal ability of lung cancer stem?like cells through inhibition of CLOCK.
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Glutathione S-transferase mu1 and N-acetyltransferase 2 genetic polymorphisms and exposure to tobacco smoke in nonsmoking and smoking lung cancer patients and population controls.
Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer.
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.
hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers.
Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation.
Identification of the SOX2 interactome by BioID reveals EP300 as a mediator of SOX2-dependent squamous differentiation and lung squamous cell carcinoma growth.
Impact of bromodomain-containing protein 4 (BRD4) and intestine-specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity.
KAT2B is an immune infiltration-associated biomarker predicting prognosis and response to immunotherapy in non-small cell lung cancer.
KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.
Lung Cancer Resets the Liver's Metabolic Clock.
N-acetylation polymorphism in patients with lung cancer and its association with p53 gene mutation.
N-Acetyltransferase 2 (NAT2) gene polymorphism and exposure to smoking in lung cancer of Chinese males.
N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients.
N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.
NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.
Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer.
Novel genetic variants in HDAC2 and PPARGC1A of the CREB-binding protein pathway predict survival of non-small-cell lung cancer.
Nuclear Localization Is Not Required for Tip60 Tumor Suppressor Activity in Breast and Lung Cancer Cells.
Paclitaxel (taxol) inhibits the arylamine N-acetyltransferase activity and gene expression (mRNA NAT1) and 2-aminofluorene-DNA adduct formation in human bladder carcinoma cells (T24 and TSGH 8301).
Period 3, a tumor suppressor in non-small cell lung cancer, is silenced by hypermethylation.
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation.
Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility.
Research on circadian clock genes in non-small-cell lung carcinoma.
Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe.
Snail acetylation by histone acetyltransferase p300 in lung cancer.
SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString).
Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines.
Tat-interactive Protein-60KDA (TIP60) Regulates the Tumorigenesis of Lung Cancer In Vitro.
The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase.
The protein acetyltransferase ARD1: a novel cancer drug target?
Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Tip60-siRNA regulates ABCE1 acetylation to suppress lung cancer growth via activation of the apoptotic signaling pathway.
Whole-exome sequencing to identify novel somatic mutations in squamous cell lung cancers.
[hARD1 antiserum preparation and primary immunohistochemical analysis of hARD1 in tumor tissues]
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
[Phenotypic changes in acetylation in tumor patients]
[Polymorphism in the N-acetyltransferase 2 gene in patients with lung cancer. Short communication].
[Role of gene polymorphisms of phase II of xenobiotic biotransformation from glutathione-S-transferase and N-acetyltransferase families in susceptibility to lung cancer among Mayak workers].
Lupus Erythematosus, Systemic
Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus.
Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus.
Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese population.
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells.
Lymphatic Metastasis
EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.
Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma.
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases.
Lymphoma
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
Activity of N-acetyltransferase in patients with malignant lymphomas.
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Case Report: Multiple Chromosomal Translocations Including Novel CIITA-CREBBP Fusion and Mutations in a Follicular Lymphoma.
CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.
Clinical efficacy and molecular biomarkers in a phase II study of tucidinostat plus R-CHOP in elderly patients with newly diagnosed diffuse large B-cell lymphoma.
Clonal evolution in diffuse large B-cell lymphoma with central nervous system recurrence.
Correction: The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP.
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice.
CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP.
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.
GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways.
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.
Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.
Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation.
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort.
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas.
Scoring a HAT-Trick against Lymphoma.
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
The double dealing of cyclin D1.
The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP.
The reciprocal interplay between TNF? and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells.
Tip60 is a cell-type-specific transcriptional regulator.
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma.
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Lymphoma, B-Cell
A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity.
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
Bone Metastasis in Advanced Breast Cancer: Analysis of Gene Expression Microarray.
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Case Report: Multiple Chromosomal Translocations Including Novel CIITA-CREBBP Fusion and Mutations in a Follicular Lymphoma.
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma.
CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma.
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice.
Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies.
Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP.
Epigenetic alterations in hematopoietic malignancies.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.
Genetic polymorphism and transcriptional regulation of CREBBP gene in patient with diffuse large B-cell lymphoma.
Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.
Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.
Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.
JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte rich large B-cell lymphoma.
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort.
Reverse translational strategies for developing animal models of bipolar disorder.
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones.
Stress-induced cell-cycle activation in tip60 haploinsufficient adult cardiomyocytes.
Targeted next generation sequencing reveals high mutation frequency of CREBBP, BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and /or BCL6 rearrangements.
TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma.
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma.
Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma.
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Lymphoma, Follicular
Case Report: Multiple Chromosomal Translocations Including Novel CIITA-CREBBP Fusion and Mutations in a Follicular Lymphoma.
CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma.
Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice.
Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.
Follicular lymphoma: are we ready for a risk-adapted approach?
Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry.
Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation.
Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma.
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Lymphoma, Large B-Cell, Diffuse
A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity.
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma.
Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice.
Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies.
Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.
EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.
Genetic polymorphism and transcriptional regulation of CREBBP gene in patient with diffuse large B-cell lymphoma.
Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.
Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.
Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort.
Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones.
TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma.
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma.
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma.
Association of NAT and GST polymorphisms with non-Hodgkin's lymphoma: a population-based case-control study.
Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma.
Meat intake and risk of non-Hodgkin lymphoma.
Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author response.
Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.
[N-acetyltransferase activity during growth of the transplantable Pliss lymphosarcoma and during pregnancy in rats]
Lysosomal Storage Diseases
Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.
The Biological Clock and the Molecular Basis of Lysosomal Storage Diseases.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Machado-Joseph Disease
Pathology of CAG repeat diseases.
Magnesium Deficiency
Early transcriptomic changes induced by magnesium deficiency in Arabidopsis thaliana reveal the alteration of circadian clock gene expression in roots and the triggering of abscisic acid-responsive genes.
Malaria
A molecular clock for malaria parasites.
A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum.
Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species.
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Extensive circadian and light regulation of the transcriptome in the malaria mosquito Anopheles gambiae.
How can we determine the molecular clock of malaria parasites?
Investigating associations between biting time in the malaria vector Anopheles arabiensis Patton and single nucleotide polymorphisms in circadian clock genes: support for sub-structure among An. arabiensis in the Kilombero valley of Tanzania.
Sleeping sickness is a circadian disorder.
The clock of the malaria parasite.
The malaria parasite has an intrinsic clock.
The MYST Family Histone Acetyltransferase Regulates Gene Expression and Cell Cycle in Malaria Parasite Plasmodium falciparum.
Malnutrition
Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A-deficient rats.
Long-Lasting Effect of Perinatal Exposure to L-tryptophan on Circadian Clock of Primary Cell Lines Established from Male Offspring Born from Mothers Fed on Dietary Protein Restriction.
Nutritional screening of patients at a memory clinic - association between patients' and their relatives' self-reports.
Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism.
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice.
The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults.
Malocclusion
Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion.
Molecular motor MYO1C, acetyltransferase KAT6B and osteogenetic transcription factor RUNX2 expression in human masseter muscle contributes to development of malocclusion.
Mania
An important role for Cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.
An inhibitor of casein kinase 1 ?/? partially normalizes the manic-like behaviors of the Clock?19 mouse.
Behavioral and pharmacological assessment of a potential new mouse model for mania.
Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function.
Circadian Rhythm Hypotheses of Mixed Features, Antidepressant Treatment Resistance, and Manic Switching in Bipolar Disorder.
Clock genes at the heart of depression.
Disruption of the circadian timing systems: molecular mechanisms in mood disorders.
Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism.
Further evidence for Clock?19 mice as a model for bipolar disorder mania using cross-species tests of exploration and sensorimotor gating.
Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.
Mania-like behavior induced by disruption of CLOCK.
Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours.
Specific Role of VTA Dopamine Neuronal Firing Rates and Morphology in the Reversal of Anxiety-Related, but not Depression-Related Behavior in the Clock?19 Mouse Model of Mania.
The Mood Stabilizer Valproic Acid Opposes the Effects of Dopamine on Circadian Rhythms.
Marfan Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Massive Hepatic Necrosis
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine.
Measles
Global spatiotemporal transmission dynamics of measles virus clade D genotypes in the context of the measles elimination goal 2020 in India.
Measles virus and rinderpest virus divergence dated to the sixth century BCE.
Medulloblastoma
Identification of Hub Genes in Pediatric Medulloblastoma by Multiple-Microarray Analysis.
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation.
The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
Melanoma
A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma.
Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors.
Analysis of Genetic Alterations in Cutaneous Malignant Melanomas Unveils Unique Loco-Regional Variations and Novel Predictors of Metastatic Potential.
Are some melanomas caused by artificial light?
Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma.
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells.
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.
Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2).
Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma.
Expression of the circadian clock genes clock and period1 in human skin.
Factors associated with elevated intraocular pressure in eyes with iris melanoma.
Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.
Humoral immune response against melanoma antigens induced by vaccination with cytokine gene-modified autologous tumor cells.
Impaired light detection of the circadian clock in a zebrafish melanoma model.
Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma.
Iris Nevus Growth into Melanoma: Analysis of 1611 Consecutive Eyes: The ABCDEF Guide.
L-Theanine inhibits melanoma cell growth and migration via regulating expression of the clock gene BMAL1.
Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R.
Management of conjunctival and corneal melanoma with surgical excision, amniotic membrane allograft, and topical chemotherapy.
Melanopsin, a Canonical Light Receptor, Mediates Thermal Activation of Clock Genes.
MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.
Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.
Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage.
Primary acquired melanosis of the conjunctiva: experience with 311 eyes.
Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture.
Ras-ERK1/2 signaling promotes the development of uveal melanoma by downregulating H3K14ac.
Regulation of TIP60 by ATF2 modulates ATM activation.
Ring melanoma of the anterior chamber angle: a report of fourteen cases.
Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival.
Running for time: circadian rhythms and melanoma.
Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells.
Stage-specific prognostic biomarkers in melanoma.
Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP.
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models.
The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
VCAM-1-, ELAM-1-, and ICAM-1-independent adhesion of melanoma cells to cultured human dermal microvascular endothelial cells.
Melanoma, Experimental
Enhancing circadian clock function in cancer cells inhibits tumor growth.
Melanosis
Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture.
Memory Disorders
A neuropsychological approach to time estimation.
CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.
CREB binding protein is required for both short-term and long-term memory formation.
Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease.
Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.
Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
The Clock Drawing Test for dementia of the Alzheimer's type: A comparison of three scoring methods in a memory disorders clinic.
Time perception depends on accurate clock mechanisms as well as unimpaired attention and memory processes.
Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.
Meningioma
The CREB-binding protein inhibitor ICG-001: a promising therapeutic strategy in sporadic meningioma with NF2 mutations.
Meningitis, Bacterial
Therapy of community-acquired acute bacterial meningitis: the clock is running.
Meningoencephalitis
Rubinstein-Taybi syndrome and CREBBP c.201 202delTA mutation: a case presenting with varicella meningoencephalitis.
Mental Retardation, X-Linked
A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression(1,2,3).
Mesenteric Ischemia
Mesenteric ischemia.
Mesothelioma
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.
Mesothelioma, Malignant
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.
Metabolic Diseases
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude.
A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.
A role for circadian clock in metabolic disease.
A time to fast, a time to feast: the crosstalk between metabolism and the circadian clock.
Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts.
AMP-activated protein kinase as a key molecular link between metabolism and clockwork.
An Endocrinologist's Guide to the Clock.
Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock.
Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock.
Bile acids Metabolism and Circadian Rhythms.
Central and peripheral clocks in cardiovascular and metabolic function.
Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night.
Chronomedicine and type 2 diabetes: shining some light on melatonin.
Circadian Clock Control of Liver Metabolic Functions.
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
Circadian metabolic regulation through crosstalk between casein kinase 1? and transcriptional coactivator PGC-1?.
Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks.
Circadian rhythms and bile acid homeostasis: a comprehensive review.
Circadian rhythms and exercise - re-setting the clock in metabolic disease.
Circadian Rhythms and Mitochondria: Connecting the Dots.
Circadian rhythms, insulin action, and glucose homeostasis.
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.
Clock Genes and Metabolic Disease.
Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.
Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms.
Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks.
Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis.
Host-Microbiota Interaction and Intestinal Epithelial Functions under Circadian Control: Implications in Colitis and Metabolic Disorders.
Identification of small molecule activators of cryptochrome.
Mathematical modeling informs the impact of changes in circadian rhythms and meal patterns on insulin secretion.
Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
New Horizons: Circadian control of metabolism offers novel insight into the cause and treatment of metabolic diseases.
Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes.
Nutrition in the spotlight: metabolic effects of environmental light.
Off the Clock: From Circadian Disruption to Metabolic Disease.
Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology.
Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian cClock of mice subjected to chronic jet-lag.
Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis.
The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erb? and indirectly via Cebpb/(C/ebp?) in zebrafish.
The circadian epigenome: how metabolism talks to chromatin remodeling.
The circadian timing system: a recent addition in the physiological mechanisms underlying pathological and aging processes.
The cost of circadian desynchrony: Evidence, insights and open questions.
The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
The molecular clock as a metabolic rheostat.
The role of the molecular circadian clock in human energy homeostasis.
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Time-restricted feeding regulates molecular mechanisms with involvement of circadian rhythm to prevent metabolic diseases.
Visceral adiposity and expression of clock genes in peripheral blood mononuclear cells: A pilot study.
Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model.
White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies.
Working Around the Clock: Circadian rhythms and skeletal muscle.
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.
[Sleep/wake cycle, circadian disruption and the development of obesity].
Metabolic Syndrome
"Diabetes of the elderly" and type 2 diabetes in younger patients: possible role of the biological clock.
A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.
Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome.
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome.
Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events.
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level.
Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems.
Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction.
Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock.
Circadian clock desynchronisation and metabolic syndrome.
Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver.
Circadian genes and insulin exocytosis.
Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters.
Circadian rhythms of glucocorticoid hormone actions in target tissues: potential clinical implications.
CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease.
CLOCK Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids.
Clock genes are implicated in the human metabolic syndrome.
Clock Genes, Metabolism, and Cardiovascular Risk.
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids.
CLOCK, PER2 and BMAL1 DNA methylation: association with obesity and metabolic syndrome characteristics and monounsaturated fat intake.
Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus.
CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome.
Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet.
Diabetes and cardiovascular disease: related disorders created by disturbances in the endogenous clock.
Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Effects of altered photoperiod on circadian clock and lipid metabolism in rats.
Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis.
Effects of circadian restricted feeding on parameters of metabolic syndrome among healthy subjects.
EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock.
Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats.
Exploitation of host clock gene machinery by hepatitis viruses B and C.
Expression pattern of clock under acute phase-delay of the light/dark cycle in the chicken pineal model.
Gene-gene interaction between serotonin transporter (SLC6A4) and clock modulates the risk of metabolic syndrome in rotating shiftworkers.
High-fat feeding exerts minimal effects on rhythmic mRNA expression of clock genes in mouse peripheral tissues.
Hydrogen sulfide regulates circadian-clock genes in C2C12 myotubes and the muscle of high-fat-diet-fed mice.
Influence of menopause on adipose tissue clock gene genotype and its relationship with metabolic syndrome in morbidly obese women.
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects.
Keep time, stay healthy.
Metabolic syndrome and cancer: "The common soil hypothesis".
Mice deficient in cryptochrome 1 (cry1 (-/-)) exhibit resistance to obesity induced by a high-fat diet.
Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome.
Molecular basis of chronopharmaceutics.
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
Obesity and metabolic syndrome in circadian Clock mutant mice.
Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes.
PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Retinoic acid-related orphan receptors ? and ?: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity.
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.
Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome.
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.
Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-?.
The circadian clock component PERIOD2: From molecular to cerebral functions.
The circadian system and the balance of the autonomic nervous system.
The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
The human circadian metabolome.
The Metabolic Syndrome Predicts Longitudinal Changes in Clock Drawing Test Performance in Older Nondemented Hypertensive Individuals.
The molecular clock as a metabolic rheostat.
The Role of Circadian Rhythms in the Hypertension of Diabetes Mellitus and the Metabolic Syndrome.
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases.
When the Clock stops ticking, metabolic syndrome explodes.
[Alteration of biological rhythms causes metabolic diseases and obesity].
[Molecular and genetic aspects of interactions of the circadian clock and the energy-producing substrate metabolism in mammals].
[Regulation of adipose functions by molecular clocks]
Metrorrhagia
Enzyme activity dot blots: a rapid and convenient assay for acetyltransferase or protein kinase activity immobilized on nitrocellulose.
Microcephaly
A KAT6A variant in a family with autosomal dominantly inherited microcephaly and developmental delay.
A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly.
De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay.
Food allergy in a child with de novo KAT6A mutation.
Interstitial 16p13.3 microduplication: case report and critical review of genotype-phenotype correlation.
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Novel Causative Variants in DYRK1A, KARS, and KAT6A Associated with Intellectual Disability and Additional Phenotypic Features.
Two patients with EP300 mutations and facial dysmorphism different from the classic Rubinstein-Taybi syndrome.
Microphthalmos
A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome.
CBP/p300 as a co-factor for the Microphthalmia transcription factor.
NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.
NAA10 polyadenylation signal variants cause syndromic microphthalmia.
Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.
Migraine Disorders
Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment.
Financial Stress Interacts With CLOCK Gene to Affect Migraine.
Solving the mystery of human sleep schedules one mutation at a time.
Triptans attenuate circadian responses to light.
Mitochondrial Diseases
Mitochondrial DNA mutations in disease and aging.
Mouth Neoplasms
Association study of NAT2 gene polymorphism and risk of oral cancer in Southern Punjab, Pakistan.
Circadian clock and oral cancer.
Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer.
Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation.
Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention.
Temporal patterns of lipid peroxidation product formation and antioxidants activity in oral cancer patients.
Movement Disorders
Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in KAT6A.
The Development of the Social Functioning Scale for Patients with Parkinson's Disease.
Mucopolysaccharidoses
An acetylated 120-kDa lysosomal transmembrane protein is absent from mucopolysaccharidosis IIIC fibroblasts: a candidate molecule for MPS IIIC.
Characterization of the biosynthesis, processing and kinetic mechanism of action of the enzyme deficient in mucopolysaccharidosis IIIC.
Crosstalk between 2 organelles: Lysosomal storage of heparan sulfate causes mitochondrial defects and neuronal death in mucopolysaccharidosis III type C.
Functional analysis of the HGSNAT gene in patients with mucopolysaccharidosis IIIC (Sanfilippo C Syndrome).
Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles.
Molecular characterization of a large group of Mucopolysaccharidosis type IIIC patients reveals the evolutionary history of the disease.
Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome).
Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.
Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase (HGSNAT) gene.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidosis III
Crosstalk between 2 organelles: Lysosomal storage of heparan sulfate causes mitochondrial defects and neuronal death in mucopolysaccharidosis III type C.
Molecular characterization of a large group of Mucopolysaccharidosis type IIIC patients reveals the evolutionary history of the disease.
Molecular characterization of MPS IIIA, MPS IIIB and MPS IIIC in Tunisian patients.
Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome). Mutation in brief #959. Online.
Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model.
Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.
Sanfilippo syndrome type C: assay for acetyl-CoA: alpha-glucosaminide N-acetyltransferase in leukocytes for detection of homozygous and heterozygous individuals.
Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase (HGSNAT) gene.
Sanfilippo type C disease: clinical findings in four patients with a new variant of mucopolysaccharidosis III.
Multiple Myeloma
Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases.
Multiple Sclerosis
Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis.
Circadian rhythms in adaptive immunity.
Genetic and epigenetic control on clock genes in multiple sclerosis.
Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients.
Importance of magnesium depletion with hypofunction of the biological clock in the pathophysiology of headhaches with photophobia, sudden infant death and some clinical forms of multiple sclerosis.
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
Screening for early cognitive impairment in multiple sclerosis patients using the clock drawing test.
The incubation period of multiple sclerosis.
Multiple System Atrophy
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Suprachiasmatic nucleus in a patient with multiple system atrophy with abnormal circadian rhythm of arginine-vasopressin secretion into plasma.
Muscle Hypotonia
Features of KAT6B-related disorders in a patient with 10q22.1q22.3 deletion.
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Food allergy in a child with de novo KAT6A mutation.
Further delineation of the KAT6B molecular and phenotypic spectrum.
Muscle Weakness
Quadriceps muscle weakness and atrophy are associated with a differential Epigenetic Profile in Advanced COPD.
Muscular Atrophy
Atypical expression of circadian clock genes in denervated mouse skeletal muscle.
Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Disruptions to the Limb Muscle Core Molecular Clock Coincide with Changes in Mitochondrial Quality Control following Androgen Depletion.
Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
Muscular Diseases
Circadian clock regulation of skeletal muscle growth and repair.
Deep RNA profiling identified clock and molecular clock genes as pathophysiological signatures in collagen VI myopathy.
Muscular Dystrophies
Satellite cells and training in the elderly.
The clock regulator Bmal1 protects against muscular dystrophy.
Muscular Dystrophy, Facioscapulohumeral
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Musculoskeletal Pain
Tramadol in musculoskeletal pain--a survey.
Mycoses
Cross-species interference of gene expression.
Myelodysplastic Syndromes
Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments.
Detection of differential mitotic cell age in bone marrow CD34(+) cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Identification and characterization of ASXL3 gene in silico.
Mice heterozygous for CREB binding protein are hypersensitive to ?-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.
The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene.
Myeloproliferative Disorders
More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders.
Myocardial Infarction
A Natural p300-Specific Histone Acetyltransferase Inhibitor, Curcumin, in Addition to Angiotensin-Converting Enzyme Inhibitor, Exerts Beneficial Effects on Left Ventricular Systolic Function After Myocardial Infarction in Rats.
A New Time Clock for ST-Segment Elevation Myocardial Infarction.
A rhythm method for better health. Being aware of your body clock could help protect you from a heart attack or stroke and let you time your medications for when they'll do the most good.
Acute myocardial infarction. The clock is ticking...
Age- and Gender-related Disparities in Primary Percutaneous Coronary Interventions for Acute ST-segment elevation Myocardial Infarction.
Association of daylight saving time transitions with incidence and in-hospital mortality of myocardial infarction in Finland.
Brain-heart connection and the risk of heart attack.
Circadian clock genes and circadian phenotypes in patients with myocardial infarction.
Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus.
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine.
Circadian variation of blood pressure and the vascular response to asynchronous stress.
Circadian variations of infarct size in acute myocardial infarction.
Comparison of results of percutaneous coronary interventions in patients with ST-segment elevation myocardial infarction during routine working hours or off-hours.
Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice.
Exploring Epigenetic Age in Response to Intensive Relaxing Training: A Pilot Study to Slow Down Biological Age.
Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo.
Knowledge and attitudes of American physicians and public about medical chronobiology and chronotherapeutics. Findings of two 1996 Gallup surveys.
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Modification of the circadian rhythm of onset of acute myocardial infarction by long-term antianginal treatment.
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
Period 2 is essential to maintain early endothelial progenitor cell function in vitro and angiogenesis after myocardial infarction in mice.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein E knockout mice.
Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility.
The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction.
The self-employed and the self-driven: two coronary-prone subpopulations from the Zeist study.
Time Is Like a Clock in My Heart: Implications for Stem Cell Delivery after Myocardial Infarction.
Time to Reperfusion in ST-Segment Elevation Acute Myocardial Infarction: When Does the Clock Start?
[Interventional treatment of acute myocardial infarct]
Myocardial Ischemia
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Myocarditis
Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice.
Myoclonic Epilepsies, Progressive
Pathology of CAG repeat diseases.
Myoclonic Epilepsy, Juvenile
PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.
Myopia
Altered ocular parameters from circadian clock gene disruptions.
Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia.
Characteristics of sixty myopic eyes with pre-laser in situ keratomileusis retinal examination and post-laser in situ keratomileusis retinal lesions.
Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms.
Pneumatic retinopexy: a survey of current practice patterns among the vitreous society members.
Retinal nerve fiber layer measurements in myopia: An optical coherence tomography study.
Time to Unplanned Return to the Operating Room and Associated Risk Factors in Patients With Surgical Retinal Detachment Repair.
Narcolepsy
Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients.
Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker.
Nasopharyngeal Carcinoma
Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.
The circadian clock gene PER2 enhances chemotherapeutic efficacy in nasopharyngeal carcinoma when combined with a targeted nanosystem.
The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1?.
Nasopharyngeal Neoplasms
Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells.
Neoplasm Metastasis
A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.
Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma.
An insight into metastasis: Random or evolving paradigms?
Angiopoietin-like protein 4 is a chromatin-bound protein that enhances mammosphere formation in vitro and experimental triple-negative breast cancer brain and liver metastases in vivo.
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.
ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.
Circadian clock gene Per2 downregulation in non?small cell lung cancer is associated with tumour progression and metastasis.
Circadian regulation of cancer cell and tumor microenvironment crosstalk.
Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.
Disruption of clock gene expression in human colorectal liver metastases.
Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer.
Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review.
EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.
EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas.
FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner.
Identification of a novel microRNA profile including miR-106b, miR-17, miR-20b, miR-18a and miR-93 in the metastasis of nasopharyngeal carcinoma.
Identification of genetic mutations related to invasion and metastasis of acral melanoma via whole-exome sequencing.
Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression.
Impact of bromodomain-containing protein 4 (BRD4) and intestine-specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity.
Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein.
Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma.
Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1? interaction with p300.
Molecular mechanisms of melatonin anticancer effects.
N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines.
NAA10 as a New Prognostic Marker for Cancer Progression.
NAT1 promotes osteolytic metastasis in luminal breast cancer by regulating the bone metastatic niche via NF-?B/IL-1B signaling pathway.
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1?- and AP-1-mediated VEGFa transcription.
Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma.
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases.
PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition.
Perspectives on the Role of Histone Modification in Breast Cancer Progression and the Advanced Technological Tools to Study Epigenetic Determinants of Metastasis.
Primary limbal stem cell transplantation in the surgical management of extensive ocular surface squamous neoplasia involving the limbus.
Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival.
Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer.
Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.
Targeting Histone Modifications in Bone and Lung Metastatic Cancers.
The circadian clock and hypoxia in tumor cell de-differentiation and metastasis.
The Clock Is Ticking: Countdown to Metastases.
TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.
Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.
Tip60-dependent acetylation of KDM2B promotes osteosarcoma carcinogenesis.
Transcriptional control of cancer metastasis.
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma.
[Phenotypic changes in acetylation in tumor patients]
Neoplasms
"Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases.
"US-JAPAN CONFERENCE: INFLAMMATION, DIABETES AND CANCER" held at the Beckman Research Institute of City of Hope, Duarte, CA, USA.
'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility.
2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins.
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
?-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line.
A bivalent role of TIP60 histone acetyl transferase in human cancer.
A circadian clock transcription model for the personalization of cancer chronotherapy.
A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets.
A connection between MAPK pathways and circadian clocks.
A contact Nd:YAG laser to resect large ciliary body and choroidal tumors.
A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine.
A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation.
A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb.
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.
A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo.
A molecular clock regulates angiopoietin-like protein 2 expression.
A new international framework for palliative care.
A New RING Tossed into an Old HAT.
A new timepiece: an epigenetic mitotic clock.
A Nobel-Winning Scientist: Aziz Sancar and the Impact of his Work on the Molecular Pathology of Neoplastic Diseases.
A novel low-cost method for assessing intra-urban variation in night time light and applications to public health.
A novel mutation lacking the bromodomain of the transcriptional coactivator p300 in the SiHa cervical carcinoma cell line.
A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration.
A pilot study of nasal fentanyl for patient controlled treatment of cancer pain.
A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma.
A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer.
A review of oral transmucosal fentanyl citrate: potent, rapid and noninvasive opioid analgesia.
A rhythmic placenta? Circadian variation, clock genes and placental function.
A Role for the Biological Clock in Liver Cancer.
A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.
A Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models.
A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.
A Time Bomb for Leukemia.
A Time for MYC: Metabolism and Therapy.
A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.
A transcriptional response to Wnt protein in human embryonic carcinoma cells.
Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis.
Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics.
Acetylation control of the retinoblastoma tumour-suppressor protein.
Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer.
Acetylation of beta-catenin by CREB-binding protein (CBP).
Acetylation of proteins as novel target for antitumor therapy: review article.
Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.
Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9.
Activity of N-acetyltransferase in patients with malignant lymphomas.
Acute systemic inflammation transiently synchronizes clock gene expression in equine peripheral blood.
Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain.
Adenosine A(2A) Receptor and TNF-? Regulate the Circadian Machinery of the Human Monocytic THP-1 Cells.
Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy.
Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes.
Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence.
ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition.
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy.
Altered circadian genes expression in breast cancer tissue according to the clinical characteristics.
Altered Circadian Rhythms and Breast Cancer: From the Human to the Molecular Level.
Altered expression of circadian clock genes in head and neck squamous cell carcinoma.
Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors.
Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery.
Altered Stra13 and Dec2 circadian gene expression in hypoxic cells.
Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load.
An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.
An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells.
An Optimal Time for Treatment-Predicting Circadian Time by Machine Learning and Mathematical Modelling.
An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer.
An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of south Indians.
Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer.
Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.
Analysis of incomplete excisions of basal-cell carcinomas after breadloaf microscopy compared with 3D-microscopy: a prospective randomized and blinded study.
Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review.
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease.
Analysis of the p300/CBP-Associated Factor (PCAF) gene in astrocytic tumors.
And-1 is required for the stability of histone acetyltransferase Gcn5.
Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells.
Anticancer potential of emodin.
Aptamer-mediated rolling circle amplification for label-free and sensitive detection of histone acetyltransferase activity.
ARNTL2 knockdown suppressed the invasion and migration of colon carcinoma: decreased SMOC2-EMT expression through inactivation of PI3K/AKT pathway.
Aromatic DNA adducts in coke-oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes.
Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation.
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Arylamine N-acetyltransferase activities in human breast cancer tissues.
Arylamine N-acetyltransferase activity and 2 aminofluorene-DNA adducts formation in rat glial tumor cells.
ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.
Assays for Validating Histone Acetyltransferase Inhibitors.
Association between CLOCK, PER3 and CCRN4L with non?small cell lung cancer in Brazilian patients.
Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence.
Association between polymorphisms at N-acetyltransferase 1 (NAT1) & risk of oral leukoplakia & cancer.
Association of Circadian Clock Gene Expression with Glioma Tumor Microenvironment and Patient Survival.
Association of Slow Acetylation Profile of NAT2 with Breast and Gastric Cancer Risk in Brazil.
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.
Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma.
Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation.
Autophagic degradation of the circadian clock regulator promotes ferroptosis.
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells.
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Bilateral ocular surface squamous neoplasia with bilateral periocular basal cell carcinoma in a case of xeroderma pigmentosum.
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.
Biological functions of the ING family tumor suppressors.
Biology of the Radio- and Chemo-Responsiveness in HPV Malignancies.
BMAL1 Knockdown Leans Epithelial-Mesenchymal Balance toward Epithelial Properties and Decreases the Chemoresistance of Colon Carcinoma Cells.
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways.
Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development.
Bypassing the Requirement for an Essential MYST Acetyltransferase.
c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.
c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level.
Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase.
Cancer and the Circadian Clock.
Cancer and the circadian clock: has the time finally come?
Cancer clocks in tumourigenesis: the p53 pathway and beyond.
Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing.
Cancer pain management: newer perspectives on opioids and episodic pain.
Cancer stem cell generation during epithelial-mesenchymal transition is temporally gated by intrinsic circadian clocks.
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
Cancer: Reset your circadian clock.
Cancers with wrong HATs: the impact of acetylation.
Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation.
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NF?B-dependent pathway.
Cation-? interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity.
CBP/p300 acetyltransferase activity in hematologic malignancies.
CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers.
CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration.
Cell "circadian" cycle: new role for mammalian core clock genes.
Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
Cellular distribution of N-acetyltransferase activity in the rat small intestine.
Changes of telomerase and telomere lengths in paired normal and cancer tissues of breast.
Characterization of a recurrent t(1;2)(p36;p24) in human uterine leiomyoma.
Characterization of hampin/MSL1 as a node in the nuclear interactome.
Characterization of Histone Deacetylase Mechanisms in Cancer Development.
Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma.
Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.
Chemotherapy-related cognitive impairment in patients with breast cancer based on MRS and DTI analysis.
Chidamide and decitabine can synergistically induce apoptosis of Hodgkin lymphoma cells by up-regulating the expression of PU.1 and KLF4.
Cholecystokinin attenuates radiation-induced lung cancer cell apoptosis by modulating p53 gene transcription.
Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats.
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level.
Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems.
Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction.
Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock.
Chronotherapy and the molecular clock: Clinical implications in oncology.
Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases.
Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma.
Circadian alteration in neurobiology during 30 days of abstinence in heroin users.
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
Circadian angiogenesis.
Circadian clock and cancer therapy: an unexpected journey.
Circadian clock and cancer: From a viewpoint of cellular differentiation.
Circadian clock and oral cancer.
Circadian clock associates with tumor microenvironment in thoracic cancers.
Circadian clock circuitry in colorectal cancer.
Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells.
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index.
Circadian clock disruptions and the risk of cancer.
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma.
Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.
Circadian clock gene expression regulates cancer cell growth through glutaminase.
Circadian clock gene Per2 downregulation in non?small cell lung cancer is associated with tumour progression and metastasis.
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation.
Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation.
Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders?
Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.
Circadian clock is associated with tumor microenvironment in kidney renal clear cell carcinoma.
Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms.
Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Circadian clock synchrony and chronotherapy opportunities in cancer treatment.
Circadian clock, cancer and lipid metabolism.
Circadian clock, cancer, and chemotherapy.
Circadian clock, carcinogenesis, chronochemotherapy connections.
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism.
Circadian clock-deficient mice as a tool for exploring disease etiology.
Circadian clock: a regulator of the immunity in cancer.
Circadian clock: Time for novel anticancer strategies?
Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism.
Circadian clocks and tumor biology: what is to learn from human skin biopsies?
Circadian Clocks and UPR: New Twists as the Story Unfolds.
Circadian clocks, epigenetics, and cancer.
Circadian clocks: from stem cells to tissue homeostasis and regeneration.
Circadian disruption accelerates liver carcinogenesis in mice.
Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?
Circadian disruption in experimental cancer processes.
Circadian disruption in lung cancer.
Circadian disruption induced by tumor development in a murine model of melanoma.
Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation.
Circadian disruption, Per3, and human cytokine secretion.
Circadian disruption, sleep loss, and prostate cancer risk: a systematic review of epidemiologic studies.
Circadian effects in cancer-relevant psychoneuroendocrine and immune pathways.
Circadian expression of clock- and tumor suppressor genes in human oral mucosa.
Circadian gene expression and clinicopathologic correlates in pancreatic cancer.
Circadian Genes in Breast Cancer.
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
Circadian modulation of proteasome activities and removal of carbonylated proteins.
Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.
Circadian molecular clocks and cancer.
Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes.
Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies.
Circadian regulation of c-MYC in mice.
Circadian regulation of cancer cell and tumor microenvironment crosstalk.
Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock.
Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment.
Circadian rhythm and its role in malignancy.
Circadian Rhythm Disruption Promotes Lung Tumorigenesis.
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Circadian rhythm of tumor promotion in the two-stage model of mouse tumorigenesis.
Circadian rhythms of factors involved in luteal regression are modified in p55 tumour necrosis factor receptor (TNFRp55)-deficient mice.
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.
Circadian time-dependent tumor suppressor function of period genes.
Circadian timing in cancer treatments.
Circadian transcription profile of mouse breast cancer under light-dark and dark-dark conditions.
Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa.
CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis.
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines.
CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells.
Clock at the Core of Cancer Development.
Clock dial integrated positioning combined with single utility port video-assisted thoracoscopic surgery: a new localization method for lung tumors.
Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients.
Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.
Clock gene Per2 as a controller of liver carcinogenesis.
Clock genes and cancer development in particular in endocrine tissues.
Clock genes and cancer.
CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses.
CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-?
Clocking cancer: the circadian clock as a target in cancer therapy.
Clocking delirium: the value of the Clock Drawing Test with case illustrations.
Clocks, cancer, and chronochemotherapy.
Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation.
Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.
Combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest.
Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.
Combined analysis of polymorphisms of the tumor necrosis factor-alpha and interleukin-10 promoter regions and polymorphic xenobiotic metabolizing enzymes in psoriasis.
Combined hamartoma of the retina and retinal pigment epithelium in 77 consecutive patients visual outcome based on macular versus extramacular tumor location.
Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734.
Concomitant Simple Limbal Epithelial Transplantation After Surgical Excision of Ocular Surface Squamous Neoplasia.
Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.
Connecting cellular metabolism to circadian clocks.
Consistency of observations from echograms made centrally in the Collaborative Ocular Melanoma Study COMS Report No. 13.
Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.
Construction of a plasmid for overexpression of human circadian gene period2 and its biological activity in osteosarcoma cells.
Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1? protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.
Control of gene expression and the cell cycle.
Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase.
Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress.
Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.
Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer.
Correlation between acetylation phenotype and genotype in Chinese women.
Correlation between deregulated expression of PER2 gene and degree of glioma malignancy.
Correlation of an epigenetic mitotic clock with cancer risk.
Correlation of Inflammation in Frozen Sections With Site of Nonmelanoma Skin Cancer.
Corrigendum: Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist.
Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth.
CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma.
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.
CREBBP gene mutations are frequently detected in in situ follicular neoplasia.
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
CREBBP knockdown suppressed proliferation and promoted chemo-sensitivity via PERK-mediated unfolded protein response in ovarian cancer.
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition.
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Cross-talk between the circadian clock and the cell cycle in cancer.
Cross-talks between circadian timing system and cell division cycle determine cancer biology and therapeutics.
Cry 1 Regulates the Clock Gene Network and Promotes Proliferation and Migration Via the Akt/P53/P21 Pathway in Human Osteosarcoma Cells.
Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.
Curcumin as a regulator of epigenetic events.
Curcumin decreases the DNA adduct formation, arylamines N-acetyltransferase activity and gene expression in human colon tumor cells (colo 205).
Curcumin is an inhibitor of p300 histone acetylatransferase.
Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells.
Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/?-catenin pathway.
Current development of CBP/p300 inhibitors in the last decade.
Current Status of Research on the Period Family of Clock Genes in the Occurrence and Development of Cancer.
Custom-designed plaque radiotherapy for nonresectable iris melanoma in 38 patients: tumor control and ocular complications.
CVID-Associated Tumors: Czech Nationwide Study Focused on Epidemiology, Immunology, and Genetic Background in a Cohort of Patients With CVID.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications.
Daily coordination of cancer growth and circadian clock gene expression.
Daily rhythm variations of the clock gene PER1 and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma.
Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.
Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver.
DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression.
Deciphering the Binding Mode and Mechanistic Insights of Pentadecylidenemalonate (1b) as Activator of Histone Acetyltransferase PCAF.
Decreased circadian component Bmal1 predicts tumor progression and poor prognosis in human pancreatic ductal adenocarcinoma.
Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas.
Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.
Defining the molecular pathology of pancreatic body and tail adenocarcinoma.
Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality.
Deregulated expression of cry1 and cry2 in human gliomas.
Deregulated Expression of the Clock Genes in Gliomas.
Deregulated expression of the Per1 and Per2 in human gliomas.
Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.
Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes.
Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery.
Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II. In vivo studies.
Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).
Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.
Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway.
Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection.
Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies.
Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells.
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Development of transgenic minipigs with expression of antimorphic human cryptochrome 1.
Diallyl disulfide inhibits N-acetyltransferase activity and gene expression in human esophagus epidermoid carcinoma CE 81T/VGH cells.
Dietary agents as histone deacetylase inhibitors.
Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.
Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention.
Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A.
Differential expression of selected histone modifier genes in human solid cancers.
Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia.
Diffuse iris melanoma: a report of 25 cases.
DIFFUSE PERIPAPILLARY CHOROIDAL MELANOMA THAT EVOLVED FROM A SMALL PRESUMED CHOROIDAL NEVUS SUCCESSFULLY TREATED WITH GAMMA KNIFE RADIOTHERAPY.
Directional divergence of Ep300 duplicates in teleosts and its implications.
Discordance between N-acetyltransferase 2 phenotype and genotype in a population of Hmong subjects.
Discovery and characterization of NK13650s, naturally occurring p300-selective histone acetyltransferase inhibitors.
Discovery and mechanism of natural products as modulators of histone acetylation.
Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Discovery of a Potent and Selective Covalent p300/CBP Inhibitor.
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.
Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.
Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes.
Disruption of circadian clockwork in in vivo reprogramming-induced mouse kidney tumors.
Disruption of circadian coordination accelerates malignant growth in mice.
Disruption of circadian coordination and malignant growth.
Disruption of clock gene expression in human colorectal liver metastases.
Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.
Disruption of the Molecular Circadian Clock and Cancer: An Epigenetic Link.
Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2.
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.
Diverse roles of arrest defective 1 in cancer development.
DMM Outstanding Paper Prize 2019 winner: Alessandro Bailetti.
DNA Methylation in Epidermal Differentiation, Aging, and Cancer.
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.
DNA methylation loss in late-replicating domains is linked to mitotic cell division.
Double recording system of Period1 gene expression rhythm in the olfactory bulb and liver in freely moving mouse.
Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm.
Down regulation of the interleukin-8 promoter by human papillomavirus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF.
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer.
Downregulation of CREB-binding protein expression sensitizes endothelial cells to serum-deprived apoptosis: important role of nitric oxide.
Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis.
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers.
E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.
E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60.
E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain.
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) or 2-amino-3,8- dimethylimidazo- [4,5-f] quinoxaline (MeIQx).
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Effect of the Interaction Between Cadmium Exposure and CLOCK Gene Polymorphisms on Thyroid Cancer: a Case-Control Study in China.
Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review.
Effects and mechanisms of action of light-emitting diodes on the human retina and internal clock.
Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice.
Effects of chronic jet lag on tumor progression in mice.
Effects of light and food schedules on liver and tumor molecular clocks in mice.
Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity.
Effects of the butylated hydroxyanisole and butylated hydroxytoluene on the DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumor cells.
Efficient AuPd@GO-based electrochemical nanoprobe for sensitive detection of histone acetylase activity and its inhibitor.
Elevated mPer1 gene expression in tumor stroma imaged through bioluminescence.
ELF magnetic fields: animal studies, mechanisms of action.
Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer.
Endogenous synthesis of peptidoglycan in eukaryotic cells; a novel concept involving its essential role in cell division, tumor formation and the biological clock.
Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells.
Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity.
Enhancing circadian clock function in cancer cells inhibits tumor growth.
Entrainment of peripheral clock genes by cortisol.
Enzyme kinetics and inhibition of histone acetyltransferase KAT8.
EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients.
EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas.
Epigenetic Age Acceleration of Stomach Adenocarcinoma Associated With Tumor Stemness Features, Immunoactivation, and Favorable Prognosis.
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort.
Epigenetic Aging: More Than Just a Clock When It Comes to Cancer.
Epigenetic Basis of Circadian Rhythm Disruption in Cancer.
Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma.
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Epigenetic regulation of active Chinese herbal components for cancer prevention and treatment: A follow-up review.
Epigenetics provides a new generation of oncogenes and tumour-suppressor genes.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Escaping Circadian Regulation: An Emerging Hallmark of Cancer?
Establishment and Verification of a Bagged-Trees-Based Model for Prediction of Sentinel Lymph Node Metastasis for Early Breast Cancer Patients.
Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia.
Evaluation of multidrug cancer chronotherapy based on cell cycle model under influences of circadian clock.
Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.
Evidence for widespread dysregulation of circadian clock progression in human cancer.
Evidence that human blastomere cleavage is under unique cell cycle control.
Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes.
EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.
Exploitation of host clock gene machinery by hepatitis viruses B and C.
Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist.
Exploring the link between chronobiology and drug delivery: effects on cancer therapy.
Exploring the role of circadian clock gene and association with cancer pathophysiology.
Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma.
Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue.
Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes.
Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR.
Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer.
Expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates with location of tumor differently.
Expression of core clock genes in colorectal tumour cells compared with normal mucosa; a systematic review of clinical trials.
Expression of HDAC1 and CBP/p300 in human colorectal carcinomas.
Expression of histone acetylases p300 and PCAF in pediatric astrocytomas.
Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression.
Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.
Expression of PCAF, p300 and Gcn5 and more highly acetylated histone H4 in pediatric tumors.
Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma.
Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors.
Expression pattern and prognostic value of circadian clock genes in pancreatic adenocarcinoma.
Extrahepatic expression of the N-acetylation polymorphism toward arylamine carcinogens in tumor target organs of an inbred rat model.
Eye-wall resection.
Factors associated with the mammalian RNA polymerase II holoenzyme.
Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation.
Feasibility of quantifying the effects of epoetin alfa therapy on cognitive function in women with breast cancer undergoing adjuvant or neoadjuvant chemotherapy.
Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention.
FOXA1 is a determinant of drug resistance in breast cancer cells.
Frameshift mutations of tumor suppressor gene EP300 in gastric and colorectal cancers with high microsatellite instability.
From circadian clock gene expression to pathologies.
Functional analysis of HBO1 in tumor development and inhibitor screening.
Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.
Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.
Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.
Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.
Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1.
Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis.
Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.
G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Gaps in the Use of Long-Acting Opioids Within Intervals of Consecutive Days Among Cancer Outpatients Using Electronic Pill Caps.
Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining.
Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug.
GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.
Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.
Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
Genetic and clinical heterogeneity in Korean patients with Rubinstein-Taybi syndrome.
Genetic factors in contact allergy--review and future goals.
Genetic polymorphism and cancer risk.
Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias.
Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer.
Genetic polymorphism of N-acetyltransferase and glutathione S-transferase related to neoplasm of genitourinary system. Minireview.
Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population.
Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.
Genetic regulation of N-acetyltransferase in target organs of arylamine tumors: homologous expression in human and hamster bladder and colon.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Genome-wide somatic copy number alteration analysis and database construction for cervical cancer.
Genomic alterations in advanced gastric cancer endoscopic biopsy samples using targeted next-generation sequencing.
Genomic analysis for the prediction of prognosis in small-bowel cancer.
Genomic characterization for familial cases with urothelial carcinoma.
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.
Genotypes of glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer.
Genotyping of the polymorphic N-acetyltransferase (NAT2) and loss of heterozygosity in bladder cancer patients.
Giant Ocular Surface Squamous Neoplasia Wrapping Whole Cornea.
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men.
Glucocorticoids use in kidney transplant setting.
Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes.
Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking.
Haematological cancer: Turning the clock back on clonal evolution.
Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase.
Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics.
Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells.
Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype.
Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma.
High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints.
Highly aggressive undifferentiated small round blue cell tumor of foot with unique SMARCA1, KAT6A and NAV3 mutations.
Histological control of tumor surgical margins with three-dimensional histology.
Histone acetylation and disease.
Histone acetylation-mediated regulation of genes in leukaemic cells.
Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide.
Histone acetyltransferase Hbo1 destabilizes estrogen receptor ? by ubiquitination and modulates proliferation of breast cancers.
Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers.
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.
Histone acetyltransferase inhibitors and preclinical studies.
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation.
Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation.
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy.
Histone Acetyltransferases in Cancer: Guardians or Hazards?
Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials.
Histone deacetylase inhibitors induce the expression of tumor suppressor genes Per1 and Per2 in human gastric cancer cells.
Histone deacetylase inhibitors: a new wave of molecular targeted anticancer agents.
Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review).
Histone deacetylase inhibitors: biology and mechanism of action.
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.
Host circadian clock as a control point in tumor progression.
Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis.
How to tell time: advances in decoding circadian phase from omics snapshots.
Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription.
Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.
Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology.
Hyper nuclear acetylation (HNA) in proliferation, differentiation and apoptosis.
Hypermethylation of N-Acetyltransferase 1 Is a Prognostic Biomarker in Colon Adenocarcinoma.
Hypothesis: coffee consumption, N-acetyltransferase phenotype, and cancer.
Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma.
Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin.
Identification and meta-analysis of copy number variation-driven circadian clock genes for colorectal cancer.
Identification of a panel of MYC and Tip60 co-regulated genes functioning primarily in cell cycle and DNA replication.
Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis.
Identification of MYST3 as a novel epigenetic activator of ER? frequently amplified in breast cancer.
Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
Identification of prognostic molecular biomarkers in 157 HPV-positive and HPV-negative squamous cell carcinomas of the oropharynx.
Identification of valid reference genes for circadian gene-expression studies in human mammary epithelial cells.
IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87?MG cells.
Immune profiles in primary squamous cell carcinoma of the head and neck.
Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo.
Immunoregulatory role of melatonin in cancer.
Impact of bromodomain-containing protein 4 (BRD4) and intestine-specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity.
Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain.
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
Impaired light detection of the circadian clock in a zebrafish melanoma model.
Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.
Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative.
Improved lymphatic mapping technique for breast cancer.
Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.
Improvement of sensitivity to platinum compound with siRNA knockdown of upregulated genes in platinum complex-resistant ovarian cancer cells in vitro.
Improvements in Algorithms for Phenotype Inference: The NAT2 Example.
In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation.
In silico quest of selective naphthyl-based CREBBP bromodomain inhibitor.
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.
Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid.
Incompatibility of the circadian protein BMAL1 and HNF4? in hepatocellular carcinoma.
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
Induction of apoptosis by telomere 3' overhang-specific DNA.
Induction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor.
Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8(+) T Cells and Histone Acetyltransferases.
Induction of transcription through the p300 CRD1 motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent.
Influence of heredity on human sensitivity to environmental chemicals.
Influence of the extracellular matrix on cell-intrinsic circadian clocks.
ING1b-inducible microRNA203 inhibits cell proliferation.
ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells.
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.
Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.
Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo.
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.
Inhibition of histone deacetylases in melanoma-a perspective from bench to bedside.
Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells.
Inhibition of N-acetyltransferase 10 using remodelin attenuates doxorubicin resistance by reversing the epithelial-mesenchymal transition in breast cancer.
Inhibition of N-acetyltransferase activity and DNA-2-aminofluorene adducts by glycyrrhizic acid in human colon tumour cells.
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity.
Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines.
Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells.
Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice.
Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Inhibitory effects of the mitogen-activated protein kinase kinase inhibitor CI-1040 on the proliferation and tumor growth of thyroid cancer cells with BRAF or RAS mutations.
Insights About Circadian Clock and Molecular Pathogenesis in Gliomas.
Insights into interaction mechanism of inhibitors E3T, E3H and E3B with CREB binding protein by using molecular dynamics simulations and MM-GBSA calculations.
Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer.
Interactions between endocrine and circadian systems.
Interferon Alfa 2b for Ocular Surface Squamous Neoplasia: Factors Influencing the Treatment Response.
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects.
Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling.
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.
Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management.
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.
Inverse correlation between Naa10p and Pirh2 expression and the combined prognostic value in oral squamous cell carcinoma patients.
Involvement of RFX1 protein in the regulation of the human proliferating cell nuclear antigen promoter.
Iris melanoma: risk factors for metastasis in 169 consecutive patients.
Iris Nevus Growth into Melanoma: Analysis of 1611 Consecutive Eyes: The ABCDEF Guide.
Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia.
Is light-at-night a health risk factor or a health risk predictor?
Isolated cardiac recurrence of acute lymphoblastic leukemia characterized by t(11;19) two years after unrelated allogeneic bone marrow transplantation.
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.
KAT2A coupled with the ?-KGDH complex acts as a histone H3 succinyltransferase.
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
KAT2B is an immune infiltration-associated biomarker predicting prognosis and response to immunotherapy in non-small cell lung cancer.
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2.
KAT5 and KAT6B are in positive regulation on cell proliferation of prostate cancer through PI3K-AKT signaling.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma.
KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer.
KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.
Ketoprofen-inhibited N-acetyltransferase activity and gene expression in human colon tumor cells.
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Knockdown of MIR9?3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR?498 via EP300.
Knockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3.
Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland.
Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.
Life expectancy for a class of life distributions having the "setting the clock back to zero" property.
Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations.
Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention.
Liver-Targeting Class I Selective Histone Deacetylase Inhibitors Potently Suppress Hepatocellular Tumor Growth as Standalone Agents.
Long-term outcomes after enucleation or plaque brachytherapy of choroidal melanomas touching the optic disc.
Loss of circadian clock gene expression is associated with tumor progression in breast cancer.
Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy.
Loss of cryptochrome reduces cancer risk in p53 mutant mice.
Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer.
Loss of p300 accelerates MDS-associated leukemogenesis.
Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway.
Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer.
Low circadian clock genes expression in cancers: A meta-analysis of its association with clinicopathological features and prognosis.
Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma.
Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-Small Cell Lung Cancer via Promotion of E2F1, Cyclin D1 and Cyclin E1 Expression.
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.
MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.
Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Mammalian circadian biology: elucidating genome-wide levels of temporal organization.
Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice.
Mapping the Interactions of the p53 Transactivation Domain with the KIX Domain of CBP (dagger).
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules.
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.
Melatonin: clinical relevance.
Melatonin: resetting the clock of cancer progression?
Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1? interaction with p300.
Metabolic rivalry: circadian homeostasis and tumorigenesis.
Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer.
Metabolic syndrome and cancer: "The common soil hypothesis".
Metabolism and cancer: the circadian clock connection.
Metachronous carcinogenesis of superficial esophagus squamous cell carcinoma after endoscopic submucosal dissection: incidence and risk stratification during long-term observation.
Metagenomic characterization of KATs in human cancer and their association with clinic-pathological features.
Methods for monitoring the functional status of the circadian system in dietary surveys studies: application criteria and interpretation of results.
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
Mice heterozygous for CREB binding protein are hypersensitive to ?-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.
Micro-incision, trans-iridal aspiration cutter biopsy for ciliary body tumours.
Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors.
MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms.
MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancer.
MicroRNAs: a potential interface between the circadian clock and human health.
Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress.
MiR-206-mediated dynamic mechanism of the mammalian circadian clock.
miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth.
miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.
MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.
Mocetinostat for patients with previously treated, locally advanced/metastatic urothelial carcinoma and inactivating alterations of acetyltransferase genes.
Modeling and analysis of the impacts of jet lag on circadian rhythm and its role in tumor growth.
Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing.
Modeling the circadian clock: from molecular mechanism to physiological disorders.
Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer.
Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.
Modulation of nuclear receptor function by chromatin modifying factor TIP60.
Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.
Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: a possible mechanism of chemotherapy-induced circadian rhythm disturbances.
Molecular analysis of encapsulated papillary carcinoma of the breast with and without invasion.
Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay.
Molecular basis of chronopharmaceutics.
Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3.
Molecular connections between circadian rhythm and genome maintenance pathways.
Molecular epidemiology of breast cancer: a review.
Molecular Links between the Circadian Clock and the Cell Cycle.
Molecular mechanisms of melatonin anticancer effects.
Molecular overlap of fly circadian rhythms and human pancreatic cancer.
Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.
Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease.
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Multi-omics analysis of the prognosis and therapeutic significance of circadian clock in ovarian cancer.
Multiple Machine Learning Based-Chemoinformatics Models for Identification of Histone Acetyl Transferase Inhibitors.
Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours.
Mutation analysis of EP300 in colon, breast and ovarian carcinomas.
Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors.
Mutational dynamics in human tumors confirm the neutral intrinsic instability of the mitochondrial D-loop poly-cytidine repeat.
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Mutations in the circadian gene CLOCK in colorectal cancer.
Mutations truncating the EP300 acetylase in human cancers.
Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
Myc and mRNA capping: Revised manuscript with changes in green.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer.
MYST family histone acetyltransferases take center stage in stem cells and development.
MYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells.
Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.
N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients.
N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer.
N-acetyltransferase (NAT2) polymorphism and breast cancer susceptibility: a lack of association in a case-control study of Turkish population.
N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer.
N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.
N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?
N-acetyltransferase 2 gene polymorphisms are associated with susceptibility to cancer: a meta-analysis.
N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.
N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case-control studies.
N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions.
N-acetyltransferase 2 influences cancer prevalence in hMLH1/hMSH2 mutation carriers.
N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis.
N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk.
N-acetyltransferase activity as a possible criterion in prognosing the anti-tumor effect of cyclophosphamide.
N-acetyltransferase phenotype of patients with cancer of the larynx.
N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population.
N-acetyltransferase polymorphism among northern Sudanese.
N-Acetyltransferase polymorphism and human cancer risk.
N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies.
NAA10 as a New Prognostic Marker for Cancer Progression.
NAA10 promotes proliferation of renal cell carcinoma by upregulating UPK1B.
NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis.
NAT10 upregulation indicates a poor prognosis in acute myeloid leukemia.
NAT2 polymorphism and lung cancer risk: A meta-analysis.
NAT2, XRCC1 and hOGG1 polymorphisms, cigarette smoking, alcohol consumption and risk of upper aerodigestive tract cancer.
Naturally occurring small molecule compounds that target histone deacetylases and their potential applications in cancer therapy.
Near-infrared-traceable DNA nano-hydrolase: specific eradication of telomeric G-overhang in vivo.
NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma.
Neurogenetics of Drosophila circadian clock: expect the unexpected.
Neuromedin U: physiology, pharmacology and therapeutic potential.
New KAT6 inhibitors induce senescence and arrest cancer growth.
New modification of transurethral incision of the prostate in surgical treatment of bladder outlet obstruction: prospective study.
New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.
New sublines of Chinese hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferases or Salmonella typhimurium O-acetyltransferase: comparison of the sensitivities to nitroarenes and aromatic amines using the in vitro micronucleus test.
Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A.
No Barrett's-No Cancer: A Proposed New Paradigm for Prevention of Esophageal Adenocarcinoma.
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.
Nonhistone targets of KAT2A and KAT2B implicated in cancer biology 1.
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Novel insights from genetic and molecular characterization of the human clock.
NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A.
Nr1d1, an important circadian pathway regulatory gene, is suppressed by cigarette smoke in murine lungs.
Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.
Nuclear Localization Is Not Required for Tip60 Tumor Suppressor Activity in Breast and Lung Cancer Cells.
Nuclear receptors, their coactivators and modulation of transcription.
Nuclear thyroid hormone receptors in C3H/HeN mouse mammary glands and spontaneous tumors.
Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany.
Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene.
Ocular surface reconstruction using amniotic membrane following excision of conjunctival and limbal tumors.
Ocular surface squamous neoplasia: analysis based on the 8th American Joint Committee on Cancer classification.
Of Tangerines, Asparagus, and Nonprotein Biomolecules.
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma.
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases.
Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1.
Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor.
Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin.
Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.
Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer.
Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway.
P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma.
p21 and CK2 interaction-mediated HDAC2 phosphorylation modulates KLF4 acetylation to regulate bladder cancer cell proliferation.
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts.
p300 promotes differentiation of Th17 cells via positive regulation of the nuclear transcription factor ROR?t in acute respiratory distress syndrome.
p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells.
P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance.
p33(ING1b) stimulates the transcriptional activity of the estrogen receptor alpha via its activation function (AF) 2 domain.
p33ING1b and estrogen receptor (ER) alpha.
p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation.
p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300.
Paclitaxel inhibits N-acetyltransferase activity and gene expression in human stomach tumor cells (SC-M1).
Paeonol promotion of DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumour cells.
Palliative care afterhours: a review of a phone support service.
Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion.
Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma.
PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes.
Patterns of tumor initiation in choroidal melanoma.
PCAF inhibits hepatocellular carcinoma metastasis by inhibition of epithelial-mesenchymal transition by targeting Gli-1.
PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition.
PER1 and CLOCK are potential circulating biomarkers for head and neck squamous cell carcinoma.
PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex.
PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy.
Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction.
PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/??catenin signaling pathway.
Per2 participates in AKT-mediated drug resistance in A549/DDP lung adenocarcinoma cells.
PER2 regulation of mammary gland development.
Period 3, a tumor suppressor in non-small cell lung cancer, is silenced by hypermethylation.
Period Family of Clock Genes as Novel Predictors of Survival in Human Cancer: A Systematic Review and Meta-Analysis.
Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-alpha.
Peritumoural versus subareolar administration of technetium-99m nanocolloid for sentinel lymph node detection in breast cancer: preliminary results of a prospective intra-individual comparative study.
PERK links the clock and protein stress in cancer.
Perspectives on the Role of Histone Modification in Breast Cancer Progression and the Advanced Technological Tools to Study Epigenetic Determinants of Metastasis.
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.
Pharmacogenetic phenotyping and genotyping. Present status and future potential.
Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan.
Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells.
Pharmacological treatment of cancer pain.
Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.
Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure.
Phylogenetics of Cancer crabs (Crustacea: Decapoda: Brachyura).
PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.
PIWIL1 suppresses circadian rhythms through GSK3?-induced phosphorylation and degradation of CLOCK and BMAL1 in cancer cells.
PML regulates PER2 nuclear localization and circadian function.
PML3 Orchestrates the Nuclear Dynamics and Function of TIP60.
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae.
Polyamine-mediated regulation of protein acetylation in murine skin and tumors.
Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
Polymorphism of N-acetyltransferase 2 Gene and the Susceptibility to Alcoholic Liver Cirrhosis: Interaction With Smoking.
Poor clock management and cancer.
Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.
Posttranscriptional regulation of PER1 underlies the oncogenic function of IRE?.
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses.
Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation.
Preservation of circadian rhythms by the protein folding chaperone, BiP.
Prevalence of delirium among patients at a cancer ward: Clinical risk factors and prediction by bedside cognitive tests.
PRMT5 and Tip60 Modify FOXP3 Function in Tumor Immunity.
Prognostic and Clinicopathological Significance of X-Box-Binding Protein 1 and N-Acetyltransferase 1 in Gallbladder Cancer.
Prognostic relevance of Period1 (Per1) and Period2 (Per2) expression in human gastric cancer.
Prognostic role of upregulated P300 expression in human cancers: A clinical study of synovial sarcoma and a meta-analysis.
Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.
Proliferative Glioblastoma Cancer Cells Exhibit Persisting Temporal Control of Metabolism and Display Differential Temporal Drug Susceptibility in Chemotherapy.
Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.
Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation.
Protein acetylation: more than chromatin modification to regulate transcription.
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Proton beam radiotherapy of iris melanoma.
Psychological aspect of cancer: From stressor to cancer progression.
PTOV1 antagonizes MED25 in RAR transcriptional activation.
Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution.
Quantifying Tip60 (Kat5) stratifies breast cancer.
Radiation biology and oncology in the genomic era.
Ras-mediated deregulation of the circadian clock in cancer.
Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck.
Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors.
Recent insights into mammalian circadian rhythms.
Recognition of Histone H3K14 Acylation by MORF.
Regulated DNA methylation and the circadian clock: implications in cancer.
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.
Regulation of CBP and Tip60 coordinates histone acetylation at local and global levels during Ras-induced transformation.
Regulation of estrogen-mediated cell survival and proliferation by p160 coactivators.
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.
Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300.
Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).
Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300.
Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation.
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer.
Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer.
Research on circadian clock genes in common abdominal malignant tumors.
Research on circadian clock genes in non-small-cell lung carcinoma.
Research on the circadian clock gene HNF4a in different malignant tumors.
Research progress on circadian clock genes in common abdominal malignant tumors.
Restoration of the molecular clock is tumor suppressive in neuroblastoma.
Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf.
REV-ERB Agonists Block Autophagy in Cancer Cells.
Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus.
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer.
Rewiring of Lactate-Interleukin-1? Autoregulatory Loop with Clock-Bmal1: a Feed-Forward Circuit in Glioma.
Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells.
Ring melanoma of the ciliary body: report on twenty-three patients.
Risks on N-acetyltransferase 2 and bladder cancer: a meta-analysis.
RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.
RNAi screening identifies KAT8 as a key molecule important for cancer cell survival.
Role of histone acetyltransferase inhibitors in cancer therapy.
Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.
Role of m6A methyltransferase component VIRMA in multiple human cancers (Review).
Role of the histone acetyl transferase Tip60 in the p53 pathway.
Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival.
Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.
Ruthenium plaque radiation therapy for iris and iridociliary melanomas.
RVBs Are Required for Assembling a Functional TIP60 Complex.
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Scientific and ethical aspects of genetic screening of workers for cancer risk: the case of the N-acetyltransferase phenotype.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells.
Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer.
Shift work, circadian gene variants and risk of breast cancer.
Signaling Pathways of the ING Proteins in Apoptosis.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms.
Sirtuin-dependent clock control: new advances in metabolism, aging and cancer.
Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates.
Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs.
Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells.
Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes.
Spatiotemporal chromatin dynamics - A tell tale of circadian epigenetic gene regulation.
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy.
Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations.
Stabilization of ADAM9 by N-?-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer.
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Stopping the Clock with MYC.
Stress-induced cell-cycle activation in tip60 haploinsufficient adult cardiomyocytes.
Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization.
Structural and expression analysis of the porcine FUS2 gene.
Structure and function of MYST1 histone acetyltransferase in the interactome of animal cells.
Structure based identification and biological evaluation of novel and potent inhibitors of PCAF catalytic domain.
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
Structure of the p53 transactivation domain in complex with the nuclear coactivator binding domain of CBP.
Structure of Thermoplasma volcanium Ard1 belongs to N-acetyltransferase family member suggesting multiple ligand binding modes with acetyl coenzyme A and coenzyme A.
Structure-based identification of drug-like inhibitors of p300 histone acetyltransferase.
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor-a case report and review of literature.
Successful implementation of genomically based treatment of chemotherapy refractory peripheral T-cell lymphoma (PTCL).
SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma.
Suppression of tumor growth through disruption of hypoxia-inducible transcription.
Surgical treatment of epibulbar melanocytomas by complete excision and homologous corneoscleral grafting in dogs: 11 cases.
Synchronous ovarian and endometrial carcinomas in a patient with rubinstein-taybi syndrome: a case report and literature review.
Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer.
Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions.
Targeted Proteomic Analyses of Histone H4 Acetylation Changes Associated with Homologous-Recombination-Deficient High-Grade Serous Ovarian Carcinomas.
Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies.
Targeting cancer using KAT inhibitors to mimic lethal knockouts.
Targeting Histone Acetyltransferase MOZ/KAT6A as a New Avenue for Hematological Tumor Therapy.
Targeting Histone Modifications in Bone and Lung Metastatic Cancers.
Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small molecule inhibitor of p300/CBP.
Targeting NAT10 Induces Apoptosis Associated With Enhancing Endoplasmic Reticulum Stress in Acute Myeloid Leukemia Cells.
Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin ?(12)-PGJ(2) through Covalent Binding to Cys(1438).
Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.
Tat-interactive Protein-60KDA (TIP60) Regulates the Tumorigenesis of Lung Cancer In Vitro.
Telomerase activity and telomere lengths in various cell lines: changes of telomerase activity can be another method for chemosensitivity evaluation.
Telomerase in cutaneous carcinogenesis.
Telomerase inhibitors as anticancer therapy.
Telomeres, p53 and cellular senescence.
Temporal regulation of tumor growth in nocturnal mammals: In vivo studies and chemotherapeutical potential.
TGF-? induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.
The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
The biological clock that measures the mitotic life-span of mouse embryo fibroblasts continues to function in the presence of simian virus 40 large tumor antigen.
The cancer cell and the cell cycle clock.
The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The circadian clock and cell cycle: interconnected biological circuits.
The circadian clock and hypoxia in tumor cell de-differentiation and metastasis.
The circadian clock and tumor suppression by Mammalian period genes.
The circadian clock component PERIOD2: From molecular to cerebral functions.
The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway.
The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day.
The circadian clock gene PER2 enhances chemotherapeutic efficacy in nasopharyngeal carcinoma when combined with a targeted nanosystem.
The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma.
The circadian clock gene period extends healthspan in aging Drosophila melanogaster.
The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.
The circadian clock in cancer development and therapy.
The Circadian Clock in Oral Health and Diseases.
The Circadian Clock in Skin: Implications for Adult Stem Cells, Tissue Regeneration, Cancer, Aging, and Immunity.
The circadian clock protects against acute radiation-induced dermatitis.
The circadian clock protects against ionizing radiation-induced cardiotoxicity.
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The circadian clock: pacemaker and tumour suppressor.
The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells.
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells.
The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.
The circadian timing system: a recent addition in the physiological mechanisms underlying pathological and aging processes.
The circular RNome of primary breast cancer.
The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.
The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma.
The cost of circadian desynchrony: Evidence, insights and open questions.
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
The days and nights of cancer cells.
The diagnosis, management, and role of hematopoietic stem cell transplantation in aggressive peripheral T-cell neoplasms.
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.
The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines.
The emerging link between cancer, metabolism, and circadian rhythms.
The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.
The fission yeast inhibitor of growth (ING) protein PNG1P functions in response to DNA damage.
The focal treatment of retinoblastoma with emphasis on xenon arc photocoagulation.
The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric carcinoma cells.
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer.
The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway.
The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma.
The human circadian metabolome.
The impact of CBP expression in estrogen receptor-positive breast cancer.
The impact of HIF1? on the Per2 circadian rhythm in renal cancer cell lines.
The Impact of the Circadian Clock on Skin Physiology and Cancer Development.
The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.
The important tumor suppressor role of PER1 in regulating the cyclin-CDK-CKI network in SCC15 human oral squamous cell carcinoma cells.
The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway.
The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes.
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology.
The ladder and the clock: cancer pain and public policy at the end of the twentieth century.
The Mammalian circadian clock gene per2 modulates cell death in response to oxidative stress.
The molecular basis of carcinogenesis: understanding the cell cycle clock.
The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.
The molecular mechanisms associated with PIN7, a protein-protein interaction network of seven pleiotropic proteins.
The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target.
The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary.
The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy.
The MYST family of histone acetyltransferases and their intimate links to cancer.
The overexpression of MYST4 in human solid tumors is associated with increased aggressiveness and decreased overall survival.
The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.
The prognostic capacities of CBP and p300 in locally advanced rectal cancer.
The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome.
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.
The protein acetyltransferase ARD1: a novel cancer drug target?
The putative tumour suppressor Fus-2 is an N-acetyltransferase.
The reciprocal interplay between TNF? and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells.
The regulation of circadian clock by tumor necrosis factor alpha.
The role of circadian clock genes in tumors.
The role of genetically-based metabolic polymorphisms in human cancer: an ecological study of bladder cancer and N-acetyltransferase in 23 populations.
The role of p300 in the tumor progression of oral squamous cell carcinoma.
The role of polymorphisms in circadian pathway genes in breast tumorigenesis.
The role of telomeres in the ageing of human skin.
The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics.
The safety profile of vorinostat (suberoylanilide hydroxamic acid) in hematologic malignancies: A review of clinical studies.
The search for preoperative biomarkers for thyroid carcinoma: application of the thyroid circadian clock properties.
The Stress Responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating Tip60 and p53.
The Time for Chronotherapy in Radiation Oncology.
The tumor circadian clock: a new target for cancer therapy?
The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region.
The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.
The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation.
The tumour suppressing role of the circadian clock.
The twilight zone between health and sickness: a qualitative exploration with asymptomatic BRCA1 and 2 mutation carriers.
The Ubiquitin-Proteasome Pathway and Epigenetic Modifications in Cancer.
The WTX Tumor Suppressor Enhances p53 Acetylation by CBP/p300.
Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.
Thyroid Cancer and Circadian Clock Disruption.
Ticking time bombs: connections between circadian clocks and cancer.
Time to fight: targeting the circadian clock molecular machinery in cancer therapy.
Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus.
TIMELESS Promotes Tumor Progression by Enhancing Macrophages Recruitment in Ovarian Cancer.
Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies.
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells.
TIP60 as a potential marker for the malignancy of gastric cancer.
Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.
Tip60 in DNA damage response and growth control: many tricks in one HAT.
TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.
TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.
Tip60 Protein Isoforms and Altered Function in Skin and Tumors that Overexpress Ornithine Decarboxylase.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
TIP60 represses activation of endogenous retroviral elements.
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.
Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT.
Tip60-dependent acetylation of KDM2B promotes osteosarcoma carcinogenesis.
TIP60-miR-22 axis as a prognostic marker of breast cancer progression.
Tip60-siRNA regulates ABCE1 acetylation to suppress lung cancer growth via activation of the apoptotic signaling pathway.
TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.
TIP60: an actor in acetylation of H3K4 and tumor development in breast cancer.
Tip60: Main Functions and Its Inhibitors.
Tip60: updates.
Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.
Tissue-Specific Dissociation of Diurnal Transcriptome Rhythms During Sleep Restriction in Mice.
TNF induced inhibition of
TNF-? induces expression of the circadian clock gene Bmal1 via dual calcium-dependent pathways in rheumatoid synovial cells.
TNF-? modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells.
Tobacco habituated and non-habituated subjects exhibit different mutational spectrums in head and neck squamous cell carcinoma.
Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma.
Toppling the HAT to Treat Lethal Prostate Cancer.
Tossing monkey wrenches into the clock: new ways of treating cancer.
TPPII, MYBBP1A and CDK2 form a protein-protein interaction network.
Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases.
Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma.
Transcriptional control of cancer metastasis.
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.
Transdermal Opioids for Cancer Pain Management.
Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.
Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.
TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells.
Tumor necrosis factor and transforming growth factor ? regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.
Tumor suppression by the Mammalian period genes.
Tumor suppressor role of genes involved in circadian clock control.
Tumor-targeting pH/redox dual-responsive nanosystem epigenetically reverses cancer drug resistance by co-delivering doxorubicin and GCN5 siRNA.
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.
Twist1 Is a TNF-Inducible Inhibitor of Clock Mediated Activation of Period Genes.
Understanding Histone Deacetylases in the Cancer Development and Treatment: An Epigenetic Perspective of Cancer Chemotherapy.
Unravelling novel congeners from acetyllysine mimicking ligand targeting a lysine acetyltransferase PCAF bromodomain.
Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition.
Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia.
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.
Use of Intravitreal Bevacizumab for the Treatment of Secondary Glaucoma Due to Metastatic Iris Tumor.
Use of the Freund Clock Drawing Test within the Mini-Cog as a screening tool for cognitive impairment in elderly patients with or without cancer.
Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.
Utilization of a Transanal TME Platform to Enable a Distal TME Dissection En Bloc with Presacral Fascia and Pelvic Sidewall with Intraoperative Radiotherapy Delivery in a Locally Advanced Rectal Cancer: Advanced Application of taTME.
Uveal tumour resection.
Validation of the Freund Clock Drawing Test as a screening tool to detect cognitive dysfunction in elderly cancer patients undergoing comprehensive geriatric assessment.
Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells.
Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.
Vitamin C inhibited DNA adduct formation and arylamine N-acetyltransferase activity and gene expression in rat glial tumor cells.
Vulvar Squamous Cell Carcinoma: Comprehensive Genomic Profiling of HPV+ Versus HPV- Forms Reveals Distinct Sets of Potentially Actionable Molecular Targets.
Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.
When the band begins to play: histone acetylation caught in the crossfire of gene control.
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.
Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms.
ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module.
[A Case of Anal Canal Adenocarcinoma Locally Controlled by Rectal Amputation after Chemoradiotherapy].
[Activity of coenzyme A and N-acetyltransferase during tumor growth]
[Blastomogenic action of low concentrations of nitrosodimethylamine, dimethylamine and nitrogen dioxide]
[Cell cycle clock and its dysregulation in bronchopulmonary cancers]
[Circadian variation of clock gene Per2 and cancer-related clock-controlled genes in buccal mucosa carcinoma of golden hamster at different cancer stages].
[Cisplatin sensitivity transcriptional factor and mitochondrial DNA maintenance protein]
[Clinical relevance of acetylator phenotyping in 196 urothelial tumor patients]
[Determination of the N-acetyltransferase phenotype in urothelial cancer patients and healthy controls]
[Diagnosis and Therapy of Iris Lesions].
[Dysfunctions of biological clocks and their treatments]
[Effect and Regulatory Mechanism of Clock Gene Per1 on Biological Behaviors of Human Oral Squamous Carcinoma Cell].
[Effect of a chalone-containing preparation from Ehrlich ascites tumor on DNA synthesis and cell division in the tumor in relation to the time of day]
[Elevated expression of CLOCK is associated with poor prognosis in hepatocellular carcinoma].
[Genes and enzymes of the xenobiotic-metabolizing system in cancer pathology]
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility]
[Genetics of contact allergy].
[Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer]
[hARD1 antiserum preparation and primary immunohistochemical analysis of hARD1 in tumor tissues]
[Identification of proteins interacting with the circadian clock protein PER1 in tumors using bacterial two-hybrid system technique].
[Interactions between clock gene mutation, circadian phenotype and tumor growth in mice]
[Light-induced disruption of the circadian clock and risk of malignant tumors in laboratory animals: state of the problem].
[Pain relief around the clock is a right of the cancer patient. Coordination of oncological and pharmaceutical methods makes it possible]
[Patient-controlled analgesia with subcutaneous opoids for out-patients with severe tumour pain.]
[Phenotypic changes in acetylation in tumor patients]
[Production of anti-recombinant human arrest defective 1 protein (hARD1) monoclonal antibodies for assaying human breast cancer tissues]
[Role of circadian rhythms and cellular clock in aging cancer development].
[Role of clock proteins in skin carcinogenesis in 14-month-old SHR mice maintained under disrupted light regimen].
[Type of acetylation in children with Hodgkin's disease]
[WHO step II-clinical reality or a didactic instrument?]
Neoplasms, Radiation-Induced
Circadian clock, carcinogenesis, chronochemotherapy connections.
Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.
Neoplasms, Squamous Cell
Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer.
N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk.
Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck.
Neoplastic Cells, Circulating
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.
Nephritis
The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis.
Nephrotic Syndrome
A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.
Urinary sodium excretion in patients with nephrotic syndrome, and its circadian variation.
Nervous System Diseases
At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?: Circadian Clock and Microbiota: Potential Egffect on Growth Hormone and Sexual Development.
Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools.
Current understanding of the circadian clock and the clinical implications for neurological disorders.
Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.
Early Cognitive Impairment: Role of Clock Drawing Test.
Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.
Learning Classification Models of Cognitive Conditions from Subtle Behaviors in the Digital Clock Drawing Test.
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders.
The biological clock: Future of neurological disorders therapy.
The cost of circadian desynchrony: Evidence, insights and open questions.
Watching the clock and hitting the snooze button: Introduction to the special issue on circadian rhythms and sleep in neurological disorders.
Neuralgia
Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model.
Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.
Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain.
Epigenetic modification of BDNF mediates neuropathic pain via miR-30a-3p/EP300 axis in CCI rats.
p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI).
Transdermal Opioids for Cancer Pain Management.
Neurobehavioral Manifestations
A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia.
Gene expression meta-analysis reveals the up-regulation of CREB1 and CREBBP in Brodmann Area 10 of patients with schizophrenia.
Neuroblastoma
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease.
CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A.
CREB-Binding Protein Regulates Ku70 Acetylation in Response to Ionization Radiation in Neuroblastoma.
Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo.
Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction.
Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1.
Restoration of the molecular clock is tumor suppressive in neuroblastoma.
Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells.
Neurodegenerative Diseases
"Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases.
Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein.
An acetylated 120-kDa lysosomal transmembrane protein is absent from mucopolysaccharidosis IIIC fibroblasts: a candidate molecule for MPS IIIC.
ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.
Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease.
Cell clocks and neuronal networks: neuron ticking and synchronization in aging and aging-related neurodegenerative disease.
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.
Central and peripheral circadian clocks and their role in Alzheimer's disease.
Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools.
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Circadian Clock Genes Are Essential for Normal Adult Neurogenesis, Differentiation, and Fate Determination.
Circadian clocks and neurodegenerative diseases: time to aggregate?
Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity.
Circadian regulation of astrocyte function: implications for Alzheimer's disease.
Clock Genes, Inflammation and the Immune System-Implications for Diabetes, Obesity and Neurodegenerative Diseases.
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.
Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction.
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.
Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.
Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology.
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.
Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock.
Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation.
Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases.
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.
Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Neurodegeneration-associated FUS is a novel regulator of circadian gene expression.
Neurogenetics of Drosophila circadian clock: expect the unexpected.
Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors.
PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment. A 10-year follow-up study.
Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance.
The Molecular Clock and Neurodegenerative Disease: A Stressful Time.
The role of astrocytes in generating circadian rhythmicity in health and disease.
The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.
Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model.
Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.
Variation in the CBP gene involved in epigenetic control associates with cognitive function.
[Role of circadian rhythms and cellular clock in aging-related diseases].
Neuroendocrine Tumors
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition.
Neurofibromatoses
Coffin-Siris syndrome with café-au-lait spots, obesity and hyperinsulinism caused by a mutation in the ARID1B gene.
Neurofibromatosis 1
A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Neurofibrosarcoma
Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase.
Neuroinflammatory Diseases
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis.
Circadian clock protein Rev-erb? regulates neuroinflammation.
Gallic acid, a histone acetyltransferase inhibitor, suppresses ?-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation.
Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats.
Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer's Disease Mouse Model.
NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons.
Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats.
Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation.
The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression.
The clock-controlled chemokine contributes to neuroinflammation-induced depression.
The Effect of Rev-erb? Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia.
The Molecular Clock and Neurodegenerative Disease: A Stressful Time.
Neuromuscular Diseases
Complex disease interventions from a network model for type 2 diabetes.
Nevus
Iris Nevus Growth into Melanoma: Analysis of 1611 Consecutive Eyes: The ABCDEF Guide.
Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival.
[Diagnosis and Therapy of Iris Lesions].
Nocturnal Enuresis
Chronobiology of micturition: putative role of the circadian clock.
The pathophysiology of monosymptomatic nocturnal enuresis with special emphasis on the circadian rhythm of renal physiology.
Voiding dysfunction in the orthotopic neobladder.
Non-alcoholic Fatty Liver Disease
3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.
Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD.
Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.
Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation.
Circadian Clock Control of Liver Metabolic Functions.
Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease.
Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease.
Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease.
Diurnal rhythm of follicle-stimulating hormone is associated with nonalcoholic fatty liver disease in a Chinese elderly population.
Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity.
Nonalcoholic fatty liver disease in CLOCK mutant mice.
Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview.
Perturbation of the circadian clock and pathogenesis of NAFLD.
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.
Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model.
The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis.
The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.
[Circadian clock and non-alcoholic fatty liver disease].
Non-ST Elevated Myocardial Infarction
Abnormal circadian rhythms are associated with plaque instability in acute coronary syndrome patients.
Obesity
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
A molecular clock regulates angiopoietin-like protein 2 expression.
A Mouse Primary Hepatocyte Culture Model for Studies of Circadian Oscillation.
A rhythmic placenta? Circadian variation, clock genes and placental function.
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.
A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.
Adipocyte NR1D1 dictates adipose tissue expansion during obesity.
AKT and TOR signaling set the pace of the circadian pacemaker.
Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts.
Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome.
AMP-activated protein kinase as a key molecular link between metabolism and clockwork.
Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B.
Are Gut Microbes Responsible for Post-dieting Weight Rebound?
Association between genetic variants of the clock gene and obesity and sleep duration.
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
Associations between REV-ERB?, sleep duration and body mass index in European adolescents.
Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men.
At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?: Circadian Clock and Microbiota: Potential Egffect on Growth Hormone and Sexual Development.
Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue.
Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice.
Body weight, metabolism and clock genes.
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice.
Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity.
Characterization of peripheral circadian clocks in adipose tissues.
Chronic circadian shift leads to adipose tissue inflammation and fibrosis.
Chronic consumption of dietary proanthocyanidins modulates peripheral clocks in healthy and obese rats.
Chronobiology and obesity.
Chronomedicine and type 2 diabetes: shining some light on melatonin.
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health.
Circadian angiogenesis.
Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation.
Circadian clock gene expression is impaired in gestational diabetes mellitus.
Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study.
Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.
Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders?
Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
Circadian clock-deficient mice as a tool for exploring disease etiology.
Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.
Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of ?-Cell Failure and Diabetes in Male Rats.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Circadian gene methylation profiles are associated with obesity, metabolic disturbances and carbohydrate intake.
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.
Circadian Rhythms and Obesity in Mammals.
Circadian rhythms and obesity: Timekeeping governs lipid metabolism.
Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet.
Circadian Rhythms in Diet-Induced Obesity.
Circadian rhythms in liver physiology and liver diseases.
Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte.
Circadian rhythms of glucocorticoid hormone actions in target tissues: potential clinical implications.
Circadian Rhythms of the Hypothalamus: From Function to Physiology.
Circadian rhythms, food timing and obesity.
Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.
Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein-Taybi Syndrome kids with high frequency of polydactyly.
CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.
CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet.
CLOCK Gene Variants Associate with Sleep Duration in Two Independent Populations.
Clock genes and body composition in patients with schizophrenia under treatment with antipsychotic drugs.
Clock genes as a link between addiction and obesity.
Clock Genes, Inflammation and the Immune System-Implications for Diabetes, Obesity and Neurodegenerative Diseases.
Clock Genes, Metabolism, and Cardiovascular Risk.
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids.
CLOCK, PER2 and BMAL1 DNA methylation: association with obesity and metabolic syndrome characteristics and monounsaturated fat intake.
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Common genetic variation in circadian clock genes are associated with cardiovascular risk factors in an African American and Hispanic/Latino cohort.
Common variants of ARID1A and KAT2B are associated with obesity in Indian adolescents.
Coordination of the transcriptome and metabolome by the circadian clock.
Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus.
Crosstalk Among Circadian Rhythm, Obesity and Allergy.
Daily Rhythm of Fractal Cardiac Dynamics Links to Weight Loss Resistance: Interaction with CLOCK 3111T/C Genetic Variant.
Diabetes and cardiovascular disease: related disorders created by disturbances in the endogenous clock.
Diet-Induced Obesity Alters the Circadian Expression of Clock Genes in Mouse Gustatory Papillae.
Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner.
Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.
Disrupted daily light-dark cycles induce physical inactivity and enhance weight gain in mice depending on dietary fat intake.
Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice.
Disrupted light-dark cycle induces obesity with hyperglycemia in genetically intact animals.
Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals.
Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.
Double recording system of Period1 gene expression rhythm in the olfactory bulb and liver in freely moving mouse.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice.
Effect of sleep deprivation on the human metabolome.
Effects of altered photoperiod on circadian clock and lipid metabolism in rats.
Effects of circadian restricted feeding on parameters of metabolic syndrome among healthy subjects.
Effects of PM Exposure on the Methylation of Clock Genes in a Population of Subjects with Overweight or Obesity.
Enhanced food-anticipatory circadian rhythms in the genetically obese Zucker rat.
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.
Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.
Expression of clock genes in human subcutaneous and visceral adipose tissues.
Food for thought: hormonal, experiential, and neural influences on feeding and obesity.
Functional CLOCK Is Not Essentially Associated with Metabolic Disruption Caused by Sleep Phase Feeding in Mice.
G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Gene-by-environment interactions of the CLOCK, PEMT, and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children.
Genetic association of the PERIOD3 (PER3) Clock gene with extreme obesity.
Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity.
Genetics of Sleep and Insights into Its Relationship with Obesity.
Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks.
Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice.
High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster.
High-fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver.
High-fat feeding exerts minimal effects on rhythmic mRNA expression of clock genes in mouse peripheral tissues.
Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis.
Impact of circadian misalignment on energy metabolism during simulated nightshift work.
Impact of Clock Gene Bmal1 Deficiency on Nutritionally Induced Obesity in Mice.
Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances ?-Cell Function and Protects Against Obesity-Induced Glucose Intolerance.
Influence of Age on Clock Gene Expression in Peripheral Blood Cells of Healthy Women.
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.
Influence of the core circadian gene "Clock" on obesity and leptin resistance in mice.
Interactions between endocrine and circadian systems.
Interactions between metabolism and circadian clocks: reciprocal disturbances.
Intermittent Fasting Does Not Uniformly Impact Genes Involved in Circadian Regulation in Women with Obesity.
Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects.
Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index.
Keeping Up With the Clock: Circadian Disruption and Obesity Risk.
Leptin Normalizes Photic Synchronization in Male ob/ob Mice, via Indirect Effects on the Suprachiasmatic Nucleus.
Light rhythm and diet differently influence facets of the metabolic syndrome in WOKW rats.
Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring.
Metabolic syndrome and cancer: "The common soil hypothesis".
Metabolism and Circadian Rhythms--Implications for Obesity.
Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.
Methods for monitoring the functional status of the circadian system in dietary surveys studies: application criteria and interpretation of results.
Methylation on the Circadian Gene BMAL1 Is Associated with the Effects of a Weight Loss Intervention on Serum Lipid Levels.
Mice deficient in cryptochrome 1 (cry1 (-/-)) exhibit resistance to obesity induced by a high-fat diet.
miRNA-10a-5p Alleviates Insulin Resistance and Maintains Diurnal Patterns of Triglycerides and Gut Microbiota in High-Fat Diet-Fed Mice.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Molecular clocks, type 2 diabetes and cardiovascular disease.
Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device.
mTOR Signaling and Entrainment of the Mammalian Circadian Clock.
Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.
Nonhomeostatic control of human appetite and physical activity in regulation of energy balance.
Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.
Nutrition, movement and sleep behaviours: their interactions in pathways to obesity and cardiometabolic diseases.
Obesity alters circadian expressions of molecular clock genes in the brainstem.
Obesity alters the expression profile of clock genes in peripheral blood mononuclear cells.
Obesity alters the peripheral circadian clock in the aorta and microcirculation.
Obesity and metabolic syndrome in circadian Clock mutant mice.
Obesity and pharmacologic control of the body clock.
Obesity and shift work: chronobiological aspects.
Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.
Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Obesity: Obesity turns the hepatic epigenetic clock forward.
Off the Clock: From Circadian Disruption to Metabolic Disease.
Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1.
Out of synch: Clock mutation causes obesity in mice.
Paraventricular hypothalamus mediates diurnal rhythm of metabolism.
Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism.
Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes.
Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project.
Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders.
Polymorphic Appetite Effects on Waist Circumference Depend on rs3749474 CLOCK Gene Variant.
Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism.
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways.
Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian cClock of mice subjected to chronic jet-lag.
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice.
Regulation of the clock gene expression in human adipose tissue by weight loss.
Reprogramming of the circadian clock by nutritional challenge.
Restoration of circadian corticosterone rhythm in ventromedial hypothalamic lesioned rats.
Rev-erb alpha gives a time cue to metabolism.
Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates.
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.
Seasonal differences in clock gene expression levels in buccal epithelial cells of obese men: a pilot study.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease.
Serum asprosin levels and bariatric surgery outcomes in obese adults.
Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.
Sleep and circadian rhythms: key components in the regulation of energy metabolism.
Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations.
Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren.
Sugar sensor genes in the murine gastrointestinal tract display a cephalocaudal axis of expression and a diurnal rhythm.
Synergistic Effect of Feeding Time and Diet on Hepatic Steatosis and Gene Expression in Male Wistar Rats.
Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.
Targeting of the circadian clock via CK1?/? to improve glucose homeostasis in obesity.
The chronobiology, etiology and pathophysiology of obesity.
The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erb? and indirectly via Cebpb/(C/ebp?) in zebrafish.
The circadian clock, metabolism and obesity.
The circadian system and the balance of the autonomic nervous system.
The clock diet: a practical nutritional guide to manage obesity through chrononutrition.
The clock gene Rev-erb? regulates pancreatic ?-cell function: modulation by leptin and high-fat diet.
The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway.
The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?
The expanding phenotypes of cohesinopathies: one ring to rule them all!
The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice.
The mammalian circadian clock and its entrainment by stress and exercise.
The molecular clock as a metabolic rheostat.
The nuclear receptor REV-ERB? is required for the daily balance of carbohydrate and lipid metabolism.
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism.
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus.
Timed high-fat diet resets circadian metabolism and prevents obesity.
Timing of food intake and obesity: A novel association.
Timing of Meals: When is as Critical as What and How Much.
Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.
Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice.
Validation of RUNX1 as a potential target for treating circadian clock-induced obesity through preventing migration of group 3 innate lymphoid cells into intestine.
Variants in Circadian Rhythm Gene Cry1 Interacts with Healthy Dietary Pattern for Serum Leptin Levels: a Cross-sectional Study.
Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model.
White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies.
[Alteration of biological rhythms causes metabolic diseases and obesity].
[Chrono-nutrition and chrono-exercise].
[Circadian clock disruption and diabetes mellitus].
[Modifying effect of physical activity on genetic predisposition to obesity].
[Molecular and genetic aspects of interactions of the circadian clock and the energy-producing substrate metabolism in mammals].
[Sleep/wake cycle, circadian disruption and the development of obesity].
[The role of biological clock in glucose homeostasis].
Obesity, Abdominal
Associations of polymorphisms in circadian genes with abdominal obesity in Chinese adult population.
Effects of circadian restricted feeding on parameters of metabolic syndrome among healthy subjects.
Visceral adiposity and expression of clock genes in peripheral blood mononuclear cells: A pilot study.
Obesity, Maternal
High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring.
Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver.
Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring.
Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.
Obesity-induced changes in hepatic and placental clock gene networks in rat pregnancy.
Obesity, Morbid
Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity.
Obstetric Labor, Premature
Premature labor. Resetting pregnancy's clock.
Optic Nerve Diseases
Comparison of the intraocular pressure-lowering effect of latanoprost and timolol in patients with chronic angle closure glaucoma: a preliminary study.
Optic Nerve Hypoplasia
Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice.
Orthomyxoviridae Infections
Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus.
Osteoarthritis
Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes.
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NF?B-dependent pathway.
Chondrocyte clocks make cartilage time-sensitive material.
Chronoeffectiveness of indomethacin in four patients suffering from an evolutive osteoarthritis of hip or knee.
Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis.
Clock mutant promotes osteoarthritis by inhibiting the acetylation of NF?B.
HDACi and Nrf2: not from alpha to omega but from acetylation to OA.
Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients.
Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage.
IL-1? induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-?B signalling pathways.
Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes.
Osteoarthritis: Chondrocyte clock maintains cartilage tissue.
Per2 attenuates LPS-induced chondrocyte injury through the PTEN/PI3K/Akt signalling pathway.
Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis.
The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis.
The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis.
The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?
Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.
Osteoarthritis, Knee
Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study.
Osteomyelitis
[The history of the radiation damage in occupations].
Osteophyte
What is the tolerated width of periacetabular osteophytes to avoid impingement in cementless THA?: a three-dimensional simulation study.
Osteoporosis
Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management.
Can Alarming Improve Compliance with Weekly Bisphosphonate in Patients with Osteoporosis?
Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis.
Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis.
Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?
Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur.
The Role of the Molecular Clock in Skeletal Muscle and What It Is Teaching Us About Muscle-Bone Crosstalk.
Osteosarcoma
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
A molecular clock regulates angiopoietin-like protein 2 expression.
Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells.
Cry 1 Regulates the Clock Gene Network and Promotes Proliferation and Migration Via the Akt/P53/P21 Pathway in Human Osteosarcoma Cells.
Cryptochrome 2 (CRY2) Suppresses Proliferation and Migration and Regulates Clock Gene Network in Osteosarcoma Cells.
Effects of caffeine on the human circadian clock in vivo and in vitro.
FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner.
General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.
Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation.
Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.
MicroRNA-377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1-mediated Wnt axis.
MicroRNA-489 suppresses osteosarcoma invasion, migration and epithelial-to-mesenchymal transition by directly targeting NAA10.
N-?-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas.
Oncogenic and Circadian Effects of Small Molecules Directly and Indirectly Targeting the Core Circadian Clock.
The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells.
The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies.
The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma.
Tip60-dependent acetylation of KDM2B promotes osteosarcoma carcinogenesis.
Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.
Ovarian Neoplasms
A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first.
Association between circadian gene CLOCK and cisplatin resistance in ovarian cancer cells: A preliminary study.
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Circadian Gene CLOCK Affects Drug-Resistant Gene Expression and Cell Proliferation in Ovarian Cancer SKOV3/DDP Cell Lines Through Autophagy.
Clinicopathological significance of circadian rhythm-related gene expression levels in patients with epithelial ovarian cancer.
CREBBP knockdown suppressed proliferation and promoted chemo-sensitivity via PERK-mediated unfolded protein response in ovarian cancer.
Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Ginsenoside Rb1 inhibits hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells by regulating microRNA-25.
HBO1 directs histone H4 specific acetylation, potentiating mechano-transductionpathways and membrane elasticity in ovarian cancer cells.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Multi-omics analysis of the prognosis and therapeutic significance of circadian clock in ovarian cancer.
Mutation analysis of EP300 in colon, breast and ovarian carcinomas.
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
The circadian rhythm and core gene Period2 regulate the chemotherapy effect and multidrug resistance of ovarian cancer through the PI3K signaling pathway.
The overexpression of MYST4 in human solid tumors is associated with increased aggressiveness and decreased overall survival.
Overnutrition
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.
Overweight
A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.
CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study.
CLOCK, PER2 and BMAL1 DNA methylation: association with obesity and metabolic syndrome characteristics and monounsaturated fat intake.
Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Effects of PM Exposure on the Methylation of Clock Genes in a Population of Subjects with Overweight or Obesity.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population).
Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren.
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.
Visceral adiposity and expression of clock genes in peripheral blood mononuclear cells: A pilot study.
[Health problems due to night shift work and jetlag]
Pancreatic Diseases
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Pancreatic Neoplasms
Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis.
Circadian Genes as Therapeutic Targets in Pancreatic Cancer.
Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin.
Deciphering microRNA targets in pancreatic cancer using miRComb R package.
Defining the molecular pathology of pancreatic body and tail adenocarcinoma.
FBP1 binds to the bromodomain of BRD4 to inhibit pancreatic cancer progression.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors.
Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.
Molecular overlap of fly circadian rhythms and human pancreatic cancer.
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.
P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer.
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Research progress on circadian clock genes in common abdominal malignant tumors.
The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer.
The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway.
The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth.
Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression.
Pancreatitis
PENTOXIFYLLINE PREVENTS LOSS OF PP2A PHOSPHATASE ACTIVITY AND RECRUITMENT OF HISTONE ACETYLTRANSFERASES TO PRO-INFLAMMATORY GENES IN ACUTE PANCREATITIS.
The clock and acute pancreatitis.
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Pancytopenia
Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis.
Papilledema
Optical Coherence Tomography as an Adjunctive Tool for Diagnosing Papilledema in Young Patients.
Variability Within Optic Nerve Optical Coherence Tomography Measurements Distinguishes Papilledema From Pseudopapilledema.
Papilloma
A Protein Array Screen for KSHV LANA Interactors Links LANA to TIP60, PP2A activity and Telomere Shortening.
Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis.
Papillomavirus Infections
Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors.
Paralysis
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Paraplegia
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.
Parasitic Diseases
Circadian rhythms in adaptive immunity.
The circadian clock in immune cells controls the magnitude of Leishmania parasite infection.
Parkinson Disease
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease.
A neuropsychological approach to time estimation.
A new approach for the quantitative evaluation of the clock drawing test: preliminary results on subjects with Parkinson's disease.
A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.
Acetylator genotype for N-acetyltransferase 2 and Parkinson's disease.
Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease.
Association of slow acetylator genotype of N-acetyltransferase 2 with Parkinson's disease in south Indian population.
Can clock drawing differentiate Alzheimer's disease from other dementias?
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease.
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back.
CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson's Disease.
Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
Clock drawing test: is it useful for dementia screening in patients having Parkinson disease with and without depression?
CLOCK rs1801260 Polymorphism is Associated with Susceptibility to Parkinson's Disease in a Chinese Population.
Clock Test Deficits Related to the Global Cognitive State in Alzheimer's and Parkinson's Disease.
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.
Decomposition of warning effects in Parkinson's disease.
Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.
Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients.
Discrimination of dementia with lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test.
Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson's Disease.
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.
Does the Clock Tick Slower or Faster in Parkinson's Disease? - Insights Gained From the Synchronized Tapping Task.
Early impairment of cognitive functions in Parkinson's disease.
Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease.
Effects of histone acetyltransferase inhibitors on L-DOPA-induced dyskinesia in a murine model of Parkinson's disease.
Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease.
Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models.
Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease.
Freezing of gait and executive functions in patients with Parkinson's disease.
Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Genetics and Parkinson's disease.
Integration of motor imagery and physical practice in group treatment applied to subjects with Parkinson's disease.
Learning Classification Models of Cognitive Conditions from Subtle Behaviors in the Digital Clock Drawing Test.
Menopause accelerates biological aging.
Modeling prior information of common genetic variants improves gene discovery for neuroticism.
Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease.
N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish population.
Parkinson's Disease Cognitive Phenotypes Show Unique Clock Drawing Features when Measured with Digital Technology.
Parkinson's disease patients showed delayed awareness of motor intention.
Performance at the clock drawing test of individuals affected by Parkinson's disease and healthy subjects: a retrospective study.
Physiotherapy versus physiotherapy plus cognitive training on cognition and quality of life in Parkinson´s disease: randomized clinical trial.
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
Promoter methylation analysis of seven clock genes in Parkinson's disease.
Psychometric properties of clock and pelvic drawings in Parkinson's disease: A validity and cross-sectional study.
Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients.
Quantitative digital clock drawing test as a sensitive tool to detect subtle cognitive impairments in early stage Parkinson's disease.
Reliability, validity, and diagnostic accuracy of Parkinson's Disease-Cognitive Rating Scale in Iranian patients with idiopathic Parkinson's disease.
Reversal of visuospatial deficit on the Clock Drawing Test in Parkinson's disease by treatment with weak electromagnetic fields.
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease.
Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned rats.
The central clock in patients with Parkinson disease.
The complex picture test in dementia.
The Development of the Social Functioning Scale for Patients with Parkinson's Disease.
The interlocking finger test in patients with Parkinson's disease and healthy subjects.
The role of NAT2 gene polymorphism in aetiology of the most frequent neurodegenerative diseases with dementia.
Time Distortion in Parkinsonism.
Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2.
Treatment of Neurodegeneration: Integrating Photobiomodulation and Neurofeedback in Alzheimer's Dementia and Parkinson's: A Review.
Turning Back the Clock in Parkinson's Disease: Practical Recommendations for Managing Diurnal Symptom Worsening.
[Memantine (akatinol) therapy of cognitive impairment in Parkinson's disease complicated by dementia]
[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease]
[The role of N-acetyltransferase polymorphism in the pathogenesis of Parkinson's disease]
Parkinsonian Disorders
Time Distortion in Parkinsonism.
Pediatric Obesity
Disruption of the circadian rhythms and its relationship with pediatric obesity.
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children.
Pellagra
Isoniazid-induced pellagra and the N-acetyltransferase gene genotype.
Perceptual Disorders
Around the clock surveillance: simple graphic disturbance in patients with hemispatial neglect carries implications for the clock drawing task.
Periapical Granuloma
Quantitative Analysis of CCL5 and ep300 in Periapical Inflammatory Lesions.
Periodontal Diseases
Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase (NAT2).
Polymorphism of the N-acetyltransferase (NAT2), smoking and the potential risk of periodontal disease.
Periodontitis
The circadian clock gene Bmal1: Role in COVID-19 and periodontitis.
[K (lysine) acetyltransferase 2A affects the osteogenic differentiation of periodontal ligament stem cells through the canonical Wnt pathway].
Peripheral Arterial Disease
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease.
Poorer clock draw test scores are associated with greater functional impairment in peripheral artery disease: the Walking and Leg Circulation Study II.
Peripheral Nerve Injuries
Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.
Peritonitis
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine.
Pheochromocytoma
Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock.
Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma.
Photophobia
A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.
Altered Light Sensitivity of Circadian Clock in Shank3+/- Mouse.
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock in Drosophila melanogaster.
Development of the Astyanax mexicanus circadian clock and non-visual light responses.
Development of the light sensitivity of the clock genes Period1 and Period2, and immediate-early gene c-fos within the rat suprachiasmatic nucleus.
Development of the Molecular Circadian Clock and Its Light Sensitivity in Drosophila Melanogaster.
Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.
Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock?
Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates.
Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats.
Fly cryptochrome and the visual system.
Human Melatonin and Alerting Response to Blue-Enriched Light Depend on a Polymorphism in the Clock Gene PER3.
Importance of magnesium depletion with hypofunction of the biological clock in the pathophysiology of headhaches with photophobia, sudden infant death and some clinical forms of multiple sclerosis.
Individual differences in light sensitivity affect sleep and circadian rhythms.
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
Modeling the photoperiodic entrainment of the plant circadian clock.
Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila.
Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.
Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions.
Reduced light sensitivity of the circadian clock in a hypopigmented mouse mutant.
Response of the human circadian system to millisecond flashes of light.
Seasonality and light phase-resetting in the mammalian circadian rhythm.
The ability to entrain to long photoperiods differs between 3 Drosophila melanogaster wild-type strains and is modified by twilight simulation.
The avian pineal gland.
The Compound Eye Possesses a Self-Sustaining Circadian Oscillator in the Cricket Gryllus bimaculatus.
The effect of neuropeptides from Limulus on its circadian rhythm in retinal sensitivity.
The Role of Light Sensitivity and Intrinsic Circadian Period in Predicting Individual Circadian Timing.
White Collar-1, a circadian blue light photoreceptor, binding to the frequency promoter.
Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity.
Zebrafish circadian clocks: cells that see light.
Piebaldism
Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.
Pituitary ACTH Hypersecretion
MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing's syndrome.
Peripheral clock system circadian abnormalities in Cushing's disease.
Pituitary Neoplasms
Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells.
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition.
Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG).
Plague
Genome and Evolution of Yersinia pestis.
Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis.
Pneumococcal Infections
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Pneumonia
A local circadian clock calls time on lung inflammation.
Abnormal histone acetylase and deacetylase expression and function in lung inflammation.
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Circadian clock component REV-ERB? controls homeostatic regulation of pulmonary inflammation.
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.
Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury.
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.
Molecular clock REV-ERB? regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition.
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
The nuclear receptor and clock gene REV-ERB? regulates cigarette smoke-induced lung inflammation.
Pneumonia, Pneumococcal
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Pneumonia, Pneumocystis
Pneumocystis jirovecii Rtt109, a novel drug target for Pneumocystis pneumonia in immunosuppressed humans.
Polycystic Ovary Syndrome
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome.
Circadian Rhythms Within the Female HPG Axis: From Physiology to Etiology.
Polydactyly
Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein-Taybi Syndrome kids with high frequency of polydactyly.
Polyendocrinopathies, Autoimmune
Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions.
Polyuria
Suprachiasmatic nucleus in a patient with multiple system atrophy with abnormal circadian rhythm of arginine-vasopressin secretion into plasma.
Terminology, epidemiology, etiology, and pathophysiology of nocturia.
The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.
The pathophysiology of monosymptomatic nocturnal enuresis with special emphasis on the circadian rhythm of renal physiology.
Porcine Reproductive and Respiratory Syndrome
A G-Box-Like Motif Is Necessary for Transcriptional Regulation by Circadian Pseudo-Response Regulators in Arabidopsis.
A molecular clock dates the common ancestor of European-type porcine reproductive and respiratory syndrome virus at more than 10 years before the emergence of disease.
BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes.
Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the porcine reproductive and respiratory syndrome virus nsp1? subunit.
Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells.
Pseudo-Response Regulators (PRRs) or True Oscillator Components (TOCs).
Roles of Circadian Clock in Developmental Controls and Stress Responses in Arabidopsis: Exploring a Link for Three Components of Clock Function in Arabidopsis
Porphyrias
Relationship between N-acetyltransferase (NAT) activity and liver protoporphyrin level in experimental porphyria.
Prader-Willi Syndrome
Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein-Taybi Syndrome kids with high frequency of polydactyly.
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Pre-Eclampsia
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies.
Biological rhythms and preeclampsia.
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene.
Early- and late-onset preeclampsia and the DNA methylation of circadian clock and clock-controlled genes in placental and newborn tissues.
Effective Aspirin Treatment of Women at Risk for Preeclampsia Delays the Metabolic Clock of Gestation.
N-acetyl-transferase phenotype and risk for preeclampsia.
Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Beating the Clock in T-cell Acute Lymphoblastic Leukemia.
CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia.
CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.
Detection of a Cryptic EP300/ZNF384 Gene Fusion by Chromosomal Microarray and Next-Generation Sequencing Studies in a Pediatric Patient with B-Lymphoblastic Leukemia.
Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint.
KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia.
MSH2 deletion with CREBBP and KRAS mutations in pediatric high-hyperdiploid acute lymphoblastic leukemia.
Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.
N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia.
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells.
The Leukemia-Driving Fusion Protein TCF3-HLF Is Regulated by EP300.
Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.
Prediabetic State
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.
Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content.
Neuropathy in prediabetes: does the clock start ticking early?
Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction: The Maastricht Study.
[Early consequent blood pressure lowering is the goal. The "blood vessel clock ticks" in prediabetic state]
Pregnancy Complications
Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels.
Pregnancy Around the Clock.
Premature Birth
Early- and late-onset preeclampsia and the DNA methylation of circadian clock and clock-controlled genes in placental and newborn tissues.
Low CLOCK and CRY2 in 2nd trimester human maternal blood and risk of preterm birth: A nested case-control study.
Revisiting the placental clock: Early corticotrophin-releasing hormone rise in recurrent preterm birth.
The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth.
Presbycusis
N-acetyltransferase 2 gene polymorphism and presbycusis.
Pressure Ulcer
Marjolin's Ulcer Complicating a Pressure Sore: The Clock is Ticking.
Practical nursing: turning clock system to prevent pressure sores.
Primary Myelofibrosis
More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders.
Progeria
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.
Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients.
Speeding up the clock: The past, present and future of progeria.
Prognathism
Genetic Factors Involved in Mandibular Prognathism.
Prolactinoma
A review of dopamine agonist therapy in type 2 diabetes and effects on cardio-metabolic parameters.
Prostatic Hyperplasia
Kinetics of acetyl coenzyme A: arylamine N-acetyltransferase from rapid and slow acetylator human benign prostatic hyperplasia tissues.
Prostatic Neoplasms
A differential expression network method identifies ankylosing spondylitis-related genes.
A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins.
A role for the clock gene per1 in prostate cancer.
Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells.
Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells.
All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes.
Androgen axis in prostate cancer.
Androgen receptor signalling in prostate cancer: the functional consequences of acetylation.
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Circadian clock genes and risk of fatal prostate cancer.
Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences.
Circadian genes and risk of prostate cancer: Findings from the EPICAP study.
CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease.
Clock genes and cancer development in particular in endocrine tissues.
Coactivator MYST1 Regulates NF-?B and AR Functions during Proliferation of Prostate Cancer Cells.
Current development of CBP/p300 inhibitors in the last decade.
DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis.
Does "clock" matter in prostate cancer?
Expression and function of androgen receptor coactivators in prostate cancer.
Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development.
Extrahepatic expression of the N-acetylation polymorphism toward arylamine carcinogens in tumor target organs of an inbred rat model.
Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population.
Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.
High copy number variations, particular transcription factors, and low immunity contribute to the stemness of prostate cancer cells.
In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation.
ING3 promotes prostate cancer growth by activating the androgen receptor.
Isoform-Specific Lysine Methylation of ROR?2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression.
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
KAT5 and KAT6B are in positive regulation on cell proliferation of prostate cancer through PI3K-AKT signaling.
KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.
Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland.
Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours.
Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells.
Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer.
miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.
MYC-Mediated Ribosomal Gene Expression Sensitizes Enzalutamide-resistant Prostate Cancer Cells to EP300/CREBBP Inhibitors.
N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.
N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium.
NAA10 as a New Prognostic Marker for Cancer Progression.
No association between variant N-acetyltransferase genes, cigarette smoking and Prostate Cancer susceptibility among men of African descent.
p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis.
p300 is up-regulated by docetaxel and is a target in chemoresistant prostate cancer.
p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6.
p300/CBP-associated factor promotes autophagic degradation of ?-catenin through acetylation and decreases prostate cancer tumorigenicity.
p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells.
Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.
Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor.
Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.
Regulation of TIP60 by ATF2 modulates ATM activation.
Role of 11C-choline positron emission tomography in prostate cancer recurrence--potential for delayed cure or just resetting the clock of the disease?
Screening for prostate cancer. Why can't the clock be turned back?
Social Jetlag and Prostate Cancer Incidence in Alberta's Tomorrow Project: A Prospective Cohort Study.
Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.
The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.
Therapeutic targeting of the CBP/p300 bromodomain blocks the growth of castration-resistant prostate cancer.
Tip60 is associated with resistance to X-ray irradiation in prostate cancer.
Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus.
TNF-? regulates diabetic macrophage function through the histone acetyltransferase MOF.
Toppling the HAT to Treat Lethal Prostate Cancer.
Variation in N-acetyltransferase 2 (NAT2), smoking and risk of prostate cancer in the Slovak population.
Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer.
[hARD1 antiserum preparation and primary immunohistochemical analysis of hARD1 in tumor tissues]
Prostatitis
Preoperative risk factors of postoperative delirium after transurethral prostatectomy for benign prostatic hyperplasia.
Protein Deficiency
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice.
Proteinuria
Circadian glomerular function: from physiology to molecular and therapeutical aspects.
Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.
The association between shift work and chronic kidney disease in manual labor workers using data from the Korea National Health and Nutrition Examination Survey (KNHANES 2011-2014).
Pseudorabies
Pseudorabies virus glycoprotein gE suppresses interferon-? production via CREB-binding protein degradation.
Psittacosis
Comparative Analysis of Chlamydia psittaci Genomes Reveals the Recent Emergence of a Pathogenic Lineage with a Broad Host Range.
Psoriasis
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.
Combined analysis of polymorphisms of the tumor necrosis factor-alpha and interleukin-10 promoter regions and polymorphic xenobiotic metabolizing enzymes in psoriasis.
The Circadian Clock in Skin: Implications for Adult Stem Cells, Tissue Regeneration, Cancer, Aging, and Immunity.
The Impact of Ramadan Fasting on the Reduction of PASI Score, in Moderate-To-Severe Psoriatic Patients: A Real-Life Multicenter Study.
[Molecular Mechanism of KLF4 Up-regulating Keratin 17 Expression in Keratinocytes].
Psychogenic Nonepileptic Seizures
Seizures by the clock: Temporal patterns of psychogenic nonepileptic seizures.
Psychomotor Agitation
Variation in candidate genes CLOCK and ADCYAP1 does not consistently predict differences in migratory behavior in the songbird genus Junco.
Pulmonary Disease, Chronic Obstructive
A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices.
CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration.
Cognitive dysfunction in severe chronic obstructive pulmonary disease (COPD) with or without Long-Term Oxygen Therapy (LTOT).
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.
Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease?
Epigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease.
Expression of CREB-binding protein and peroxisome proliferator-activated receptor gamma during formoterol or formoterol and corticosteroid therapy of chronic obstructive pulmonary disease.
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.
Quadriceps muscle weakness and atrophy are associated with a differential Epigenetic Profile in Advanced COPD.
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.
The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
The Role of the Body Clock in Asthma and COPD: Implication for Treatment.
Tiotropium Increases PPAR? and Decreases CREB in Cells Isolated from Induced Sputum of COPD Patients.
[Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
Pulmonary Embolism
Acute pulmonary embolism: comparison and integration of perfusion lung scintigraphy with multislice spiral CT.
Pulmonary Fibrosis
Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo.
Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity.
The circadian clock protein REVERB? inhibits pulmonary fibrosis development.
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Q Fever
Early sex-specific modulation of the molecular clock in trauma.
Overexpression of the Per2 gene in male patients with acute Q fever.
Quadriplegia
Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation.
Rabies
A reassessment of the evolutionary timescale of bat rabies viruses based upon glycoprotein gene sequences.
Evolutionary history of African mongoose rabies.
Radiation Fibrosis Syndrome
Protective effect of ?-lipoic acid against radiation-induced fibrosis in mice.
Radicular Cyst
Quantitative Analysis of CCL5 and ep300 in Periapical Inflammatory Lesions.
Radiodermatitis
The circadian clock protects against acute radiation-induced dermatitis.
Rectal Neoplasms
Longer Intervals from Neoadjuvant Therapy to Rectal Cancer Surgery: The Clock is Ticking….
N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area.
N-Acetyltransferase 2 and glutathione s-transferase M1 in colon and rectal cancer cases from an industrialized area.
Refractive Errors
Circadian rhythms, refractive development, and myopia.
Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms.
Visual Image Quality Impacts Circadian Rhythm-Related Gene Expression in Retina and in Choroid: A Potential Mechanism for Ametropias.
REM Sleep Behavior Disorder
Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder.
Renal Insufficiency
An observational study on disturbed peripheral circadian rhythms in hemodialysis patients.
Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report.
Renal Insufficiency, Chronic
A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder.
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level.
Chronopharmacological strategies focused on chrono-drug discovery.
Testicular dysfunction in experimental chronic renal insufficiency: a deficiency of nocturnal pineal N-acetyltransferase activity.
The association between shift work and chronic kidney disease in manual labor workers using data from the Korea National Health and Nutrition Examination Survey (KNHANES 2011-2014).
The Circadian Clock in the Regulation of Renal Rhythms.
The Vascular Circadian Clock in Chronic Kidney Disease.
Reperfusion Injury
Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy.
Restless Legs Syndrome
Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia.
Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders.
Retinal Degeneration
Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein.
Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina.
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish.
The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration.
Retinal Detachment
Additional indications for a temporary balloon buckle.
Analysis of risk factors for the outcome of primary retinal reattachment surgery in phakic and pseudophakic eyes.
Anatomic Success of Scleral Buckling for Rhegmatogenous Retinal Detachment - A Retrospective Study of 524 Cases.
Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction.
Combined Pars Plana Vitrectomy and Segmental Scleral Buckle for Rhegmatogenous Retinal Detachment with Inferior Retinal Breaks.
Comparison of 1000-Centistoke versus 5000-Centistoke Silicone Oil in Complex Retinal Detachment Surgery.
Correlation of Clinical Outcomes with Quantitative Polymerase Chain Reaction DNA Copy Number in Patients with Acute Retinal Necrosis.
Expanded indications for pneumatic retinopexy.
Features associated with surgical outcome in patients with stages 4 and 5 retinopathy of prematurity.
Functional outcome and prognostic factors in 304 eyes managed by retinectomy.
Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy.
Pneumatic retinopexy for the repair of retinal detachments: a comprehensive review (1986-2007).
Pneumatic retinopexy for the treatment of giant retinal dialyses.
Pneumatic retinopexy perfluoroethane (C2F6) in the treatment of rhegmatogenous retinal detachment.
Predictors of enucleation in Coats disease: analysis of 259 eyes of 259 patients at a single center.
Repair of retinal detachments with temporary balloon buckling.
Retinal detachment and convexity intracranial meningioma: an uncommon association.
Retinal features predictive of progressive stage 4 retinopathy of prematurity.
SCLERAL BUCKLING FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT USING A NONCONTACT WIDE-ANGLE VIEWING SYSTEM WITH A CANNULA-BASED 27-G CHANDELIER ENDOILLUMINATOR.
Severe proliferative vitreoretinopathy and retinal detachment. I. Initial clinical findings.
STRICT POSTURING WITH OR WITHOUT BILATERAL PATCHING FOR POSTERIOR VITREOUS DETACHMENT-RELATED VITREOUS HEMORRHAGE.
The treatment of bullous rhegmatogenous retinal detachment.
TRAUMATIC RETINAL DETACHMENT CAUSED BY NERF GUN SHOT IN A PEDIATRIC PATIENT.
Visual prognosis of Coats' disease.
[Screening for retinal detachment using wide-field retinal imaging.]
Retinal Diseases
An allosteric peptide inhibitor of HIF-1? regulates hypoxia-induced retinal neovascularization.
Physiology of circadian entrainment.
Retinal vascular manifestations of obstructive sleep apnea.
Retinal Perforations
Additional indications for a temporary balloon buckle.
Anatomic, Visual and Financial Outcomes for Traditional and Nontraditional Primary Pneumatic Retinopexy for Retinal Detachment.
Combined Pars Plana Vitrectomy and Segmental Scleral Buckle for Rhegmatogenous Retinal Detachment with Inferior Retinal Breaks.
Giant retinal tears.
Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy.
Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment in Pseudophakia.
Pneumatic retinopexy for the repair of retinal detachments: a comprehensive review (1986-2007).
Pneumatic retinopexy for the treatment of giant retinal dialyses.
Pneumatic retinopexy perfluoroethane (C2F6) in the treatment of rhegmatogenous retinal detachment.
Pneumatic retinopexy versus scleral buckling: a randomised controlled trial.
Primary vitrectomy with Densiron-68 for rhegmatogenous retinal detachment.
Retinal detachment and convexity intracranial meningioma: an uncommon association.
Rhegmatogenous Retinal Detachment after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor.
Sandwich Technique with Anterior Silicone Oil and Posterior Perfluorocarbon Liquid for Intraoperative Retinal Stabilization in Eyes with Large Retinal Breaks.
Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR Study): recruitment list evaluation. Study report no. 2.
SEQUENTIAL PNEUMATIC RETINOPEXIES FOR THE TREATMENT OF PRIMARY INFERIOR RHEGMATOGENOUS RETINAL DETACHMENTS WITH INFERIOR BREAKS: The Double-Bubble Approach.
Severe proliferative vitreoretinopathy and retinal detachment. I. Initial clinical findings.
Standardized echography (ultrasonography) for the detection and characterization of retinal detachment.
Submacular perfluorocarbon liquid: long-term follow-up.
Success and complications of pneumatic retinopexy.
The Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT).
The Safety and Efficacy of Adjustable Postoperative Position after Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment.
The treatment of bullous rhegmatogenous retinal detachment.
Time to Unplanned Return to the Operating Room and Associated Risk Factors in Patients With Surgical Retinal Detachment Repair.
Vision-Related Functioning in Patients Undergoing Pneumatic Retinopexy vs Vitrectomy for Primary Rhegmatogenous Retinal Detachment: A Post Hoc Exploratory Analysis of the PIVOT Randomized Clinical Trial.
[Giant retinal tears treated with lens sparing, bimanual 23 g vitrectomy without scleral buckle].
Retinitis
Correlation of Clinical Outcomes with Quantitative Polymerase Chain Reaction DNA Copy Number in Patients with Acute Retinal Necrosis.
The utility of entoptic perimetry as a screening test for cytomegalovirus retinitis.
Retinitis Pigmentosa
RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.
Retinoblastoma
Acetylation control of the retinoblastoma tumour-suppressor protein.
AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Cell cycle-mediated regulation of smooth muscle alpha-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors.
Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells.
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.
Human papillomavirus type 16 E7 protein increases acetylation of histone H3 in human foreskin keratinocytes.
Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.
Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP.
Modulation of allostery by protein intrinsic disorder.
N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells.
Regulation of CBP and Tip60 coordinates histone acetylation at local and global levels during Ras-induced transformation.
Requirement of an E1A-sensitive coactivator for long-range transactivation by the beta-globin locus control region.
Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation.
The double dealing of cyclin D1.
Retinopathy of Prematurity
Diode laser photocoagulation for retinopathy of prematurity.
Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity.
Limiting applications of cryotherapy for severe retinopathy of prematurity.
Long-term results of cryotherapy for active stages of retinopathy of prematurity.
Neovascularization grading methods in a rat model of retinopathy of prematurity.
Retrognathia
Two patients with EP300 mutations and facial dysmorphism different from the classic Rubinstein-Taybi syndrome.
Rett Syndrome
Circadian biology and sleep in monogenic neurological disorders and its potential application in drug discovery.
Rheumatic Diseases
Glucocorticoid receptor: implications for rheumatic diseases.
Rhinitis
Dose-dependent effects of budesonide aqueous nasal spray on symptoms in a daily nasal allergen challenge model.
Rhinitis, Allergic
Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle.
Glucocorticoids Reset the Nasal Circadian Clock in Mice.
Period2 gene regulates diurnal changes of nasal symptoms in an allergic rhinitis mouse model.
[Principle of biological clock and its regulation on allergic rhinitis].
Rhinitis, Allergic, Seasonal
Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
Rinderpest
Measles virus and rinderpest virus divergence dated to the sixth century BCE.
ring-type e3 ubiquitin transferase deficiency
Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis.
Rubella
Emergence and continuous evolution of genotype 1E rubella viruses in China.
Rubinstein-Taybi Syndrome
A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.
A case of Rubinstein-Taybi Syndrome with a CREB-binding protein gene mutation.
A case with Rubinstein-Taybi syndrome: A novel frameshift mutation in the CREBBP gene.
A Novel CREBBP in-Frame Deletion Variant in a Chinese Girl with Atypical Rubinstein-Taybi Syndrome Phenotypes.
A novel EP300 mutation associated with Rubinstein-Taybi syndrome type 2 presenting as combined immunodeficiency.
A novel mutation c.4003 G>C in the CREBBP gene in an adult female with Rubinstein-Taybi syndrome presenting with subtle dysmorphic features.
A submicroscopic deletion involving part of the CREBBP gene detected by array-CGH in a patient with Rubinstein-Taybi syndrome.
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.
Benign and malignant tumors in Rubinstein-Taybi syndrome.
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Case Report: Low-Level Maternal Mosaicism of a Novel CREBBP Variant Causes Recurrent Rubinstein-Taybi Syndrome in Two Siblings of a Chinese Family.
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.
CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development.
Characterization of 14 novel deletions underlying Rubinstein-Taybi syndrome: an update of the CREBBP deletion repertoire.
Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish.
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.
Chromosome 16p13.3 Contiguous Gene Deletion Syndrome including the SLX4, DNASE1, TRAP1, and CREBBP Genes Presenting as a Relatively Mild Rubinstein-Taybi Syndrome Phenotype: A Case Report of a Saudi Boy.
Clinical and molecular characterization of Rubinstein-Taybi syndrome patients carrying distinct novel mutations of the EP300 gene.
Clinical exome sequencing identifies novel CREBBP variants in 18 Chinese Rubinstein-Taybi Syndrome kids with high frequency of polydactyly.
Coffin-Siris syndrome with café-au-lait spots, obesity and hyperinsulinism caused by a mutation in the ARID1B gene.
Comprehensive screening of CREB-binding protein gene mutations among patients with Rubinstein-Taybi syndrome using denaturing high-performance liquid chromatography.
Confirmation of a new phenotype in an individual with a variant in the last part of exon 30 of CREBBP.
Confirmation of EP300 gene mutations as a rare cause of Rubinstein-Taybi syndrome.
CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene.
CREBBP and EP300 mutational spectrum and clinical presentations in a cohort of Swedish patients with Rubinstein-Taybi syndrome.
CREBBP gene mutation in an infant with Rubinstein-Taybi syndrome.
CREBBP mutations in individuals without Rubinstein-Taybi syndrome phenotype.
CREBBP Re-arrangements affect protein function and lead to aberrant neuronal differentiation.
Cryptic microdeletion of the CREBBP gene from t(1;16) (p36.2;p13.3) as a novel genetic defect causing Rubinstein-Taybi syndrome.
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome.
Disruption of the CREBBP gene and decreased expression of CREB, NF?B p65, c-JUN, c-FOS, BCL2 and c-MYC suggest immune dysregulation.
DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS.
Duplication 16p13.3 and the CREBBP gene: confirmation of the phenotype.
Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognizable syndrome.
Epigenetic factors in intellectual disability: the Rubinstein-Taybi syndrome as a paradigm of neurodevelopmental disorder with epigenetic origin.
Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.
Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.
Expanding the phenotype associated to KMT2A variants: overlapping clinical signs between Wiedemann-Steiner and Rubinstein-Taybi syndromes.
Expanding the phenotypic spectrum in EP300-related Rubinstein-Taybi syndrome.
Fetal phenotype of Rubinstein-Taybi syndrome caused by CREBBP mutations.
First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene.
First case report of inherited Rubinstein-Taybi syndrome associated with a novel EP300 variant.
Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.
Fluorescein angiography findings in a case of Rubinstein-Taybi syndrome.
Further case of Rubinstein-Taybi syndrome due to a deletion in EP300.
Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.
Generation of the Rubinstein-Taybi syndrome type 2 patient-derived induced pluripotent stem cell line (IAIi001-A) carrying the EP300 exon 23 stop mutation c.3829A?>?T, p.(Lys1277*).
Generation of three iPSC lines (IAIi002, IAIi004, IAIi003) from Rubinstein-Taybi syndrome 1 patients carrying CREBBP non sense c.4435G>T, p.(Gly1479*) and c.3474G>A, p.(Trp1158*) and missense c.4627G>T, p.(Asp1543Tyr) mutations.
Genes for RNA-binding proteins involved in neural-specific functions and diseases are downregulated in Rubinstein-Taybi iNeurons.
Genetic heterogeneity in Rubinstein-Taybi syndrome: delineation of the phenotype of the first patients carrying mutations in EP300.
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.
Genome-wide sequencing expands the phenotypic spectrum of EP300 variants.
Genotype-phenotype specificity in Menke-Hennekam syndrome caused by missense variants in exon 30 or 31 of CREBBP.
High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints.
Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients.
Hyperinsulinism in an individual with an EP300 variant of Rubinstein-Taybi syndrome.
Identification of a novel de novo mutation of CREBBP in a patient with Rubinstein-Taybi syndrome by targeted next-generation sequencing: a case report.
Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.
Insights into genotype-phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein-Taybi syndrome patients.
Insights into the Role of the Microbiota and of Short-Chain Fatty Acids in Rubinstein-Taybi Syndrome.
Interstitial 16p13.3 microduplication: case report and critical review of genotype-phenotype correlation.
Interstitial duplication of 22q13.2 in a girl with short stature, impaired speech and language, and dysmorphism.
Introduction of a de novo Creb-binding protein gene mutation in sperm to produce a Rubinstein-Taybi syndrome model using inbred C57BL/6 mice.
iPSC-derived neurons of CREBBP- and EP300-mutated Rubinstein-Taybi syndrome patients show morphological alterations and hypoexcitability.
Letter to the Editor: A Novel Mutation in the CREBBP Gene of a Korean Girl with Rubinstein-Taybi syndrome.
Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome.
Molecular studies in 10 cases of Rubinstein-Taybi syndrome, including a mild variant showing a missense mutation in codon 1175 of CREBBP.
Multiplex ligation-dependent probe amplification detection of an unknown large deletion of the CREB-binding protein gene in a patient with Rubinstein-Taybi Syndrome.
Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.
Mutations in CREBBP and EP300 genes affect DNA repair of oxidative damage in Rubinstein-Taybi syndrome cells.
Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome.
Novel Findings in Floating-Harbor Syndrome and a Mini-Review of the Literature.
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Perthes disease: A new finding in Floating-Harbor syndrome.
Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Rubinstein Taybi Syndrome in an Indian Child due to EP300 Gene Mutation.
Rubinstein Taybi Syndrome in an Indian Child due to EP300 Gene Mutation: Correspondence.
Rubinstein-Taybi syndrome and CREBBP c.201 202delTA mutation: a case presenting with varicella meningoencephalitis.
Rubinstein-Taybi syndrome and Hirschsprung disease in a patient harboring an intragenic deletion of the CREBBP gene.
Rubinstein-Taybi syndrome associated with Chiari type I malformation caused by a large 16p13.3 microdeletion: a contiguous gene syndrome?
Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.
Rubinstein-Taybi syndrome in diverse populations.
Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma.
Rubinstein-Taybi syndrome with epidermal nevus: a case report.
Rubinstein-Taybi syndrome with multiple pilomatricomas: The first case diagnosed by CREBBP mutation analysis.
Rubinstein-Taybi syndrome with normal FISH result and CREBBP gene analysis: a case report.
Rubinstein-Taybi Syndrome: spectrum of CREBBP mutations in Italian patients.
Screening for partial deletions in the CREBBP gene in Rubinstein-Taybi syndrome patients using multiplex PCR/liquid chromatography.
Screening of a large Rubinstein-Taybi cohort identified many novel variants and emphasizes the importance of the CREBBP histone acetyltransferase domain.
Secondary hemophagocytic lymphohystiocytosis in a Rubinstein Taybi syndrome patient.
Simulations suggest pharmacological methods for rescuing long-term potentiation.
Spectrum of CREBBP gene dosage anomalies in Rubinstein-Taybi syndrome patients.
Spectrum of CREBBP mutations in Indian patients with Rubinstein-Taybi syndrome.
Testing and improving experimental parameters for the use of low molecular weight targets in array-CGH experiments.
Tissue-specific mosaicism in a patient with Rubinstein-Taybi syndrome and CREBBP exon 1 duplication.
To learn better, keep the HAT on.
Transcriptome Analysis of iPSC-Derived Neurons from Rubinstein-Taybi Patients Reveals Deficits in Neuronal Differentiation.
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage.
Two patients with EP300 mutations and facial dysmorphism different from the classic Rubinstein-Taybi syndrome.
Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndrome.
Whole Exome Sequencing for a Patient with Rubinstein-Taybi Syndrome Reveals de Novo Variants besides an Overt CREBBP Mutation.
[Clinical features of Rubinstein-Taybi syndrome and novel mutation in the CREBBP gene: an analysis of one case].
Salmonella Infections
Involvement of TIP60 acetyltransferase in intracellular Salmonella replication.
Sarcoma
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.
Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.
Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA.
EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function.
Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.
Investigation on the genomic characterization of uterine sarcoma for rAd-p53 combined with chemotherapy treatment.
[Change in acetylation activity in 7,12-dimethylbenz(alpha)-anthracene induction]
Sarcoma 180
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.
Sarcoma 37
N-acetyltransferase activity as a possible criterion in prognosing the anti-tumor effect of cyclophosphamide.
Sarcoma, Clear Cell
EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function.
Sarcopenia
Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression.
Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction.
Circadian clock regulation of skeletal muscle growth and repair.
Inactivation of the intrinsic muscle clock does not cause sarcopenia.
Re-Setting the Circadian Clock Using Exercise against Sarcopenia.
The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia.
The Role of the Molecular Clock in Skeletal Muscle and What It Is Teaching Us About Muscle-Bone Crosstalk.
Schistosomiasis
The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays.
Scoliosis
Breathe in and straighten your back: hypoxia, notch, and scoliosis.
Identical twin sisters with Rubinstein-Taybi syndrome associated with Chiari malformations and syrinx.
Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging.
What are you synching about? Emerging complexity of Notch signaling in the segmentation clock.
Scotoma
Modified astigmatism dial diagram for locating eccentric fixation in patients with central scotoma.
Seizures
A fully-asynchronous low-power implantable seizure detector for self-triggering treatment.
A single generalized seizure alters the amplitude, but not phase, of the circadian activity rhythm of the hamster.
Acute and Chronic Electroconvulsive Seizures (ECS) Differentially Regulate the Expression of Epigenetic Machinery in the Adult Rat Hippocampus.
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Bidirectional relationships of sleep and epilepsy in adults with epilepsy.
Bimodal ultradian seizure periodicity in human mesial temporal lobe epilepsy.
Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy.
Circadian rhythm and epilepsy.
Circadian rhythms: interactions with seizures and epilepsy.
Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest.
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Experiences of spiritual visitation and impregnation: potential induction by frequency-modulated transients from an adjacent clock.
How to assess circadian rhythm in humans: a review of literature.
Identification of a Circadian Clock in the Inferior Colliculus and Its Dysregulation by Noise Exposure.
Improvement of an automated neonatal seizure detector using a post-processing technique.
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
Magnetic stimulation in the treatment of partial seizures.
Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy.
N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.
Neurotrophins, growth-factor-regulated genes and the control of energy balance.
Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in KAT6A.
PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.
Seizures by the clock: Temporal patterns of psychogenic nonepileptic seizures.
Seizures on hearing the alarm clock.
Sleep-wake patterns of seizures in children with lesional epilepsy.
Stopping the Clock on Seizures!
The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy.
Weighted performance metrics for automatic neonatal seizure detection using multi-scored EEG data.
[Indication for mobile 8-channel long-term EEG]
Sepsis
Association of postnatal dexamethasone use and fungal sepsis in the development of severe retinopathy of prematurity and progression to laser therapy in extremely low-birth-weight infants.
Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation.
Circadian rhythms in septic shock patients.
CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis.
Daily Changes in The Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin.
Day-night variation in heart rate variability changes induced by endotoxaemia in healthy volunteers.
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Diurnal variation in endotoxin-induced mortality in mice: correlation with proinflammatory factors.
Melatonin, clock genes and mitochondria in sepsis.
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins.
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.
Uncoupling of peripheral and master clock gene rhythms by reversed feeding leads to an exacerbated inflammatory response after polymicrobial sepsis in mice.
Severe Acute Respiratory Syndrome
Current methods for diagnosis of human coronaviruses: pros and cons.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Shock, Cardiogenic
Arterial Lactate Assessment in Cardiogenic Shock: It Is High Time to Beat the Clock.
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
Shock, Septic
Bioinformatics Analysis of Gene Expression Profiles for Risk Prediction in Patients with Septic Shock.
Circadian rhythms in septic shock patients.
Pediatric Septic Shock in the Emergency Department: Can We Set the Alarm Clock a Little Forward?
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
The role of the calcium and the voltage clocks in sinoatrial node dysfunction.
Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction.
Silicosis
Matrix stiffness regulates ?-TAT1-mediated acetylation of ?-tubulin and promotes silica-induced epithelial-mesenchymal transition via DNA damage.
Skin Diseases
?-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis.
The circadian clock and diseases of the skin.
Skin Neoplasms
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.
Ras-mediated deregulation of the circadian clock in cancer.
Running for time: circadian rhythms and melanoma.
The circadian clock and diseases of the skin.
The Circadian Clock in Skin: Implications for Adult Stem Cells, Tissue Regeneration, Cancer, Aging, and Immunity.
Sleep Apnea Syndromes
Circadian rhythms in blood pressure, heart rate, hormones, and on polysomnographic parameters in severe obstructive sleep apnea syndrome patients: effect of continuous positive airway pressure.
Clock gene expression is altered in veterans with sleep apnea.
Sleep Apnea, Obstructive
Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea.
Circadian Biology in Obstructive Sleep Apnea.
Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research.
Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea.
Relationship between HIF-1 and Circadian Clock Proteins in Obstructive Sleep Apnea Patients-Preliminary Study.
Sleep disruptions and bone health: what do we know so far?
The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea.
Sleep Arousal Disorders
Circadian clock-deficient mice as a tool for exploring disease etiology.
Sleep Deprivation
A mathematical model of homeostatic regulation of sleep-wake cycles by hypocretin/orexin.
A role for cryptochromes in sleep regulation.
Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.
Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption.
Caffeine increases light responsiveness of the mouse circadian pacemaker.
Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons.
Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.
Circadian clock resetting by sleep deprivation without exercise in Syrian hamsters: dark pulses revisited.
Circadian clock resetting by sleep deprivation without exercise in the Syrian hamster.
Circadian genes, rhythms and the biology of mood disorders.
Circadian rhythm in plasma noradrenaline of healthy sleep-deprived subjects.
Circadian rhythms and depression: Human psychopathology and animal models.
Classifying Vulnerability to Sleep Deprivation Using Resting-State Functional MRI Graph Theory Metrics.
Computational modeling and analysis of the impacts of sleep deprivation on glucose stimulated insulin secretion.
Daily rhythms in locomotor circuits in Drosophila involve PDF.
Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation.
Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans.
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.
Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster.
Higher Number of Night Shifts Associates with Good Perception of Work Capacity and Optimal Lung Function but Correlates with Increased Oxidative Damage and Telomere Attrition.
Identification of Genes Associated With Resilience/Vulnerability to Sleep Deprivation and Starvation in Drosophila.
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
Impact of COVID-19 social-distancing on sleep timing and duration during a university semester.
In Vivo Imaging of the Central and Peripheral Effects of Sleep Deprivation and Suprachiasmatic Nuclei Lesion on PERIOD-2 Protein in Mice.
Lithium acts to modulate abnormalities at behavioral, cellular and molecular levels in sleep deprivation induced mania-like behavior.
Long term effects of sleep deprivation on the mammalian circadian pacemaker.
Managing jet lag: Some of the problems and possible new solutions.
Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms.
Mutual influence of sleep and circadian clocks on physiology and cognition.
New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.
Overexpression of circadian clock protein cryptochrome (CRY) 1 alleviates sleep deprivation-induced vascular inflammation in a mouse model.
Sensorimotor and executive function slowing in anesthesiology residents after overnight shifts.
Seven days' around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes.
Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila.
Shift work, jet lag, and female reproduction.
Shift work: coping with the biological clock.
Shift work: health, performance and safety problems, traditional countermeasures, and innovative management strategies to reduce circadian misalignment.
Sleep and circadian rhythm disruption and recognition memory in schizophrenia.
Sleep deprivation and caffeine treatment potentiate photic resetting of the master circadian clock in a diurnal rodent.
Sleep deprivation and endothelial function: reconciling seminal evidence with recent perspectives.
Sleep deprivation as a method of chronotherapy in the treatment of depression.
Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains.
Sleep Deprivation Influences Circadian Gene Expression in the Lateral Habenula.
Sleep deprivation influences diurnal variation of human time perception with prefrontal activity change: a functional near-infrared spectroscopy study.
Sleep Disturbance Induces Increased Cholesterol Level by NR1D1 Mediated CYP7A1 Inhibition.
Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?
Sleep insufficiency, sleep health problems and performance in high school students.
Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency.
Stress response genes protect against lethal effects of sleep deprivation in Drosophila.
The cholinergic forebrain arousal system acts directly on the circadian pacemaker.
The circadian basis of mood disorders: recent developments and treatment implications.
The circadian clock mutation alters sleep homeostasis in the mouse.
The Circadian System: A Regulatory Feedback Network of Periphery and Brain.
The effect of chronotherapy on depressive symptoms. Evidence-based practice.
The effect of partial sleep deprivation on computer-based measures of fitness to drive.
The fatigued anesthesiologist: A threat to patient safety?
The impact of sleep deprivation and nighttime light exposure on clock gene expression in humans.
The role of circadian rhythms in Obstructive Sleep Apnea symptoms and novel targets for treatment.
The wake maintenance zone shows task dependent changes in cognitive function following one night without sleep.
Ultradian rhythms in pituitary and adrenal hormones: their relations to sleep.
Why are living things sensitive to weak magnetic fields?
Work Habit-Related Sleep Debt; Insights From Factor Identification Analysis of Actigraphy Data.
[Sleep problems in occupational health].
Sleep Disorders, Circadian Rhythm
A circadian rhythm sleep disorder: melatonin resets the biological clock.
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light.
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.
Association study of a variable-number tandem repeat polymorphism in the clock gene PERIOD3 and Chronotype in Norwegian university students.
Chronobiological disorders: current and prevalent conditions.
Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review.
Circadian rhythm sleep disorders (CRSD).
Circadian rhythm sleep disorders and phototherapy.
Circadian rhythm sleep disorders.
Circadian rhythmicity and the pharmacologic management of insomnia.
Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes.
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome.
Clock polymorphisms and circadian rhythms phenotypes in a sample of the Brazilian population.
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.
Diagnosis of circadian rhythm sleep disorders.
Disorders of the sleep-wake cycle in adults.
Estimation methods for human circadian phase by use of peripheral tissues.
Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders.
Familial advanced sleep phase syndrome.
From circadian clock mechanism to sleep disorders and jet lag: Insights from a computational approach.
Genetics of the sleep-wake cycle and its disorders.
Jet lag and shift work sleep disorders: how to help reset the internal clock.
Metabolic dysfunction and circadian rhythm abnormalities in adolescents with sleep disturbance.
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
Modeling of a human circadian mutation yields insights into clock regulation by PER2.
Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms.
Mutation screening of the human Clock gene in circadian rhythm sleep disorders.
New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists.
Novel insights from genetic and molecular characterization of the human clock.
Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome.
PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.
Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects.
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.
The effect of light on the human circadian pacemaker.
Therapeutics for Circadian Rhythm Sleep Disorders.
Timing of sleep and its relationship with the endogenous melatonin rhythm.
Total sleep deprivation study in delayed sleep-phase syndrome.
When the body clock goes wrong: delayed sleep phase syndrome.
[Advanced sleep phase syndrome (ASPS) and delayed sleep phase syndrome (DSPS)]
[Circadian rhythm sleep disorders]
[Delayed wakefulness-sleep rhythm syndrome and melatonin. Synthesis of existing studies]
[Diagnosis and comorbidities of Circadian Rhythm Sleep Disorders].
[Functional polymorphisms in clock genes and circadian rhythm sleep disorders]
Sleep Disorders, Intrinsic
Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.
Sleep Initiation and Maintenance Disorders
3111T/C Clock Gene Polymorphism in Women with Insomnia.
3111T/C clock gene polymorphism is not associated with sleep disturbances in untreated depressed patients.
A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock.
Advances in the pharmacological management of non-24-h sleep-wake disorder.
Applying the quarter-hour rule: can people with insomnia accurately estimate 15-min periods during the sleep-onset phase?
Association of 3111T/C Polymorphism of the Clock Gene with Circadian Rhythm of Melatonin in Menopausal Women with Insomnia.
Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia.
Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.
Circadian Phase and Phase Angle Disorders in Primary Insomnia.
Circadian rhythm sleep disorders and phototherapy.
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome.
Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients.
CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients.
Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.
Digital CBT Reduces Insomnia Symptoms Round the Clock.
Disorders of the sleep-wake cycle in adults.
Disruption of the circadian system by environmental factors: Effects of hypoxia, magnetic fields and general anesthetics agents.
Disruption of the circadian timing systems: molecular mechanisms in mood disorders.
Effects of CLOCK gene variants and early stress on hopelessness and suicide in bipolar depression.
Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection.
Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.
Genetics of the sleep-wake cycle and its disorders.
Human CRY1 variants associate with attention deficit/hyperactivity disorder.
Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism.
Insomnia, biological clock, and the bedtime decision: an economic perspective.
Insomnia: a ticking clock for depression?
Lipid peroxidation depends on the clock 3111T/C gene polymorphism in menopausal women with Insomnia.
Manipulation of a central circadian clock regulating behavioral and endocrine rhythms with a short-acting benzodiazepine used in the treatment of insomnia.
Mechanisms underlying the association between insomnia, anxiety, and depression in adolescence: Implications for behavioral sleep interventions.
Methylphenidate modifies the motion of the circadian clock.
Psychiatric aspects of jet lag: review and hypothesis.
Racial/Ethnic Differences in the Longitudinal Effects of Fear of Falling on Falls.
Sleep Disturbance and Altered Expression of Circadian Clock Genes in Patients With Sudden Sensorineural Hearing Loss.
Sleep: important considerations in management of pain.
Sleeping with the enemy: clock monitoring in the maintenance of insomnia.
The association between shift work and possible obstructive sleep apnea: a systematic review and meta-analysis.
The clock as a focus of selective attention in those with primary insomnia: an experimental study using a modified Posner paradigm.
The effect of circadian preferences on insomnia severity and depressive symptoms via sleep hygiene in older adults with depression and healthy controls.
The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.
The human circadian system in normal and disordered sleep.
The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 ?-cells.
The perspective of management of sleep disorders in Japan.
Trait anxiety and sleep-onset insomnia: evaluation of treatment using anxiety management training.
[Diagnosis and comorbidities of Circadian Rhythm Sleep Disorders].
[Sleep quality and daytime sleepiness in schizophrenia spectrum disorders during antipsychotic treatment]
Sleep Wake Disorders
A circadian rhythm sleep disorder: melatonin resets the biological clock.
A circadian sleep disorder reveals a complex clock.
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy.
Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock.
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.
Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia.
Association study of a variable-number tandem repeat polymorphism in the clock gene PERIOD3 and Chronotype in Norwegian university students.
Challenges in synthetically designing mammalian circadian clocks.
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level.
Chronobiological disorders: current and prevalent conditions.
Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders?
Circadian clocks and metabolism.
Circadian disruption induced by tumor development in a murine model of melanoma.
Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters.
Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review.
Circadian rhythm sleep disorders (CRSD).
Circadian rhythm sleep disorders and phototherapy.
Circadian rhythm sleep disorders.
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.
Circadian rhythms and depression: Human psychopathology and animal models.
Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes.
Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.
CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson's Disease.
Clock desynchronisation: why and how?
Clock gene expression is altered in veterans with sleep apnea.
Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism.
Cyclic alternating pattern in polysomnography: what is it and what does it mean?
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.
Diagnosis of circadian rhythm sleep disorders.
Disruption of the circadian system by environmental factors: Effects of hypoxia, magnetic fields and general anesthetics agents.
Dose response curve for the phase-shifting effect of triazolam on the mammalian circadian clock.
Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease.
Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish.
Effects of melatonin on vertebrate circadian systems.
Effects of Occupational Stress and Circadian CLOCK Gene Polymorphism on Sleep Quality of Oil Workers in Xinjiang, China.
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Estimation methods for human circadian phase by use of peripheral tissues.
Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders.
Familial advanced sleep phase syndrome.
From circadian clock mechanism to sleep disorders and jet lag: Insights from a computational approach.
Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
Human clock genes.
Impact of circadian disruption on health; SIRT1 and Telomeres.
Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans.
Jet lag and shift work sleep disorders: how to help reset the internal clock.
Keeping time with the human genome.
Light exposure in the natural environment: relevance to mood and sleep disorders.
Light therapy for better mood and insulin sensitivity in patients with major depression and type 2 diabetes: a randomised, double-blind, parallel-arm trial.
Metabolic dysfunction and circadian rhythm abnormalities in adolescents with sleep disturbance.
Mutation screening of the human Clock gene in circadian rhythm sleep disorders.
New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists.
Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters.
PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.
Regulation of Circadian Clock Genes on Sleep Disorders in Traumatic Brain Injury Patients.
Relationship between Mental Health, the CLOCK Gene, and Sleep Quality in Surgical Nurses: A Cross-Sectional Study.
Review: Identification and Management of Circadian Rhythm Sleep Disorders as a Transdiagnostic Feature in Child and Adolescent Psychiatry.
Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders.
Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
Shift work disorder: overview and diagnosis.
Sleep Disorders in the Older Adult: A Mini-Review.
Some implications of melatonin use in chronopharmacology of insomnia.
Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations.
Terminology, epidemiology, etiology, and pathophysiology of nocturia.
The Association of Sleep Disorders, Obesity and Sleep-Related Hypoxia with Cancer.
The brain's master circadian clock: implications and opportunities for therapy of sleep disorders.
The circadian clock and pathology of the ageing brain.
The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.
The effect of light on the human circadian pacemaker.
The etiology of delayed sleep phase disorder.
The human circadian system in normal and disordered sleep.
The perspective of management of sleep disorders in Japan.
The search for circadian clock and sleep genes.
Therapeutics for Circadian Rhythm Sleep Disorders.
Timing of sleep and its relationship with the endogenous melatonin rhythm.
Treatment of Circadian Rhythm Sleep-Wake Disorders.
Update of sleep alterations in depression.
[Advanced sleep phase syndrome (ASPS) and delayed sleep phase syndrome (DSPS)]
[Circadian rhythm sleep disorders]
[Diagnosis and comorbidities of Circadian Rhythm Sleep Disorders].
[Functional polymorphisms in clock genes and circadian rhythm sleep disorders]
[Internal clock desynchronization, light and melatonin].
Small Cell Lung Carcinoma
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition.
DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC).
KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.
Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation.
SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString).
Smith-Magenis Syndrome
Alteration of the circadian clock in children with Smith-Magenis syndrome.
Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome.
Phase advance of circadian rhythms in Smith-Magenis syndrome: a case study in an adult man.
Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity.
Sotos Syndrome
Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1.
Specific Language Disorder
De novo KAT6B mutation, Say-Barber-Biesecker-Young-Simpson syndrome, and specific language impairment.
Spina Bifida Occulta
EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74 patients.
Spinal Cord Injuries
Elevated Serum Melatonin under Constant Darkness Enhances Neural Repair in Spinal Cord Injury through Regulation of Circadian Clock Proteins Expression.
Spinal Dysraphism
Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use.
Spinocerebellar Ataxias
Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.
Histone acetylation, acetyltransferases, and ataxia-alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders.
Partial Loss of Tip60 Slows Midstage Neurodegeneration in a Spinocerebellar Ataxia Type 1 (SCA1) Mouse Model.
Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity.
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Spondylitis, Ankylosing
Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism.
Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production.
Squamous Cell Carcinoma of Head and Neck
A role for the clock period circadian regulator 2 gene in regulating the clock gene network in human oral squamous cell carcinoma cells.
Altered expression of circadian clock genes in head and neck squamous cell carcinoma.
Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma.
Circadian clock gene Per2 plays an important role in cell proliferation, apoptosis and cell cycle progression in human oral squamous cell carcinoma.
Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma.
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway.
Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines.
Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway.
PER1 and CLOCK are potential circulating biomarkers for head and neck squamous cell carcinoma.
Prevalence of high-risk human papillomavirus infection and cancer gene mutations in nonmalignant tonsils.
RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers.
The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma.
The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.
The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
[Effect of clock gene PER1 knockdown on clock gene networks in human oral squamous cell carcinoma].
[Effects and mechanism of the circadian clock gene Per1 on the proliferation, apoptosis, cycle, and tumorigenicity in vivo of human oral squamous cell carcinoma].
ST Elevation Myocardial Infarction
Abnormal circadian rhythms are associated with plaque instability in acute coronary syndrome patients.
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
The Patient's Alarm Clock in STEMI.
Working Against the Clock: A Model for Rural STEMI Triage.
Starvation
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.
BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.
Clock and cycle limit starvation-induced sleep loss in Drosophila.
Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding.
Costs of Clock-Environment Misalignment in Individual Cyanobacterial Cells.
Effects of fasting and re-feeding on the expression of dec1, per1, and other clock-related genes.
Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation.
Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster.
Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.
Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock.
Response of the circadian clock and diel starch turnover to one day of low light or low CO2.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior.
The Influence of Short-term Fasting on Muscle Growth and Fiber Hypotrophy Regulated by the Rhythmic Expression of Clock Genes and Myogenic Factors in Nile Tilapia.
The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila.
The small G protein RAS2 is involved in the metabolic compensation of the circadian clock in the circadian model Neurospora crassa.
Time to grow: circadian regulation of growth and metabolism in photosynthetic organisms.
Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.
[Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics--CYP2E1 substrates in rats]
Status Epilepticus
Histone modifications in kainate-induced status epilepticus.
Histone modifications in status epilepticus induced by kainate.
Stevens-Johnson Syndrome
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Stillbirth
[Stillbirth: Better to improve the care than to put the clock back]
Stomach Neoplasms
A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma.
Adenovirus vector-mediated upregulation of spermidine /spermine N-acetyltransferase impairs human gastric cancer growth in vitro and in vivo.
Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery.
Combining multi-dimensional data to identify key genes and pathways in gastric cancer.
Deregulated expression of circadian clock genes in gastric cancer.
E7386, a Selective Inhibitor of the Interaction between ?-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling.
Effects of dietary factors and the NAT2 acetylator status on gastric cancer in Koreans.
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Genotypes of glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer.
High-Expression HBO1 Predicts Poor Prognosis in Gastric Cancer.
Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines.
Histone Deacetylases (HDACs) in gastric cancer: An update of their emerging prognostic and therapeutic role.
lncRNA GCAWKR Promotes Gastric Cancer Development by Scaffolding the Chromatin Modification Factors WDR5 and KAT2A.
LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.
MicroRNA-4513 Promotes Gastric Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Targeting KAT6B.
N-acetyltransferase 2 status and gastric cancer risk: a meta-analysis.
NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations.
Nuclear Localization Is Not Required for Tip60 Tumor Suppressor Activity in Breast and Lung Cancer Cells.
Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms.
Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer.
The p300/CBP associated factor: is frequently downregulated in intestinal-type gastric carcinoma and constitutes a biomarker for clinical outcome.
TIP60 as a potential marker for the malignancy of gastric cancer.
[Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer]
Stomatitis
A scoring system for the assessment of oral mucositis in daily nursing practice.
Strabismus
Ocular Findings in a Patient With KAT6A Mutation.
Stroke
A rhythm method for better health. Being aware of your body clock could help protect you from a heart attack or stroke and let you time your medications for when they'll do the most good.
Abrupt shift of the pattern of diurnal variation in stroke onset with daylight saving time transitions.
Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making?
Benefit of thrombolysis for stroke is maintained around the clock: results from the SITS-EAST Registry.
Caring for stroke survivors: baseline and 1-year determinants of caregiver burden.
Challenges in Acute Ischemic Stroke Clinical Trials.
Circadian variation of blood pressure and the vascular response to asynchronous stress.
Clinical usefulness of the clock drawing test applying rasch analysis in predicting of cognitive impairment.
Clock drawing from the occupational therapy adult perceptual screening test: its correlation with demographic and clinical factors in the stroke population.
Clock drawing in acute stroke.
Clock drawing in children with perinatal stroke.
Clock Drawing Performance Slows for Older Adults After Total Knee Replacement Surgery.
Clock drawing task, mini-mental state examination and cognitive-functional independence measure: relation to functional outcome of stroke patients.
Clock Drawing Test in acute stroke and its relationship with long-term functional and cognitive outcomes.
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.
Cognitive and connectome properties detectable through individual differences in graphomotor organization.
Daylight saving time and the incidence of thrombolysis to treat acute ischemic stroke.
Detecting delirium in patients with acute stroke: a systematic review of test accuracy.
Development of regional programs to speed treatment of stroke.
Diabetes and cognitive outcomes in a nationally representative sample: the National Health and Aging Trends Study.
Discovery and Longitudinal Evaluation of Candidate Biomarkers for Ischaemic Stroke by Mass Spectrometry-Based Proteomics.
Disruptions of Circadian Rhythms and Thrombolytic Therapy During Ischemic Stroke Intervention.
DNA methylation predicts stroke outcome better: The epigenetic clock is ticking.
Does b1000-b0 Mismatch Challenge Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery Mismatch in Stroke?
Effect of Electroacupuncture on Neurological Deficit and Activity of Clock and Bmal1 in Cerebral Ischemic Rats.
Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice.
Effects of a Feedback-Demanding Stroke Clock on Acute Stroke Management: A Randomized Study.
Epigenetic Alterations Induced by Photothrombotic Stroke in the Rat Cerebral Cortex: Deacetylation of Histone h3, Upregulation of Histone Deacetylases and Histone Acetyltransferases.
Free thyroxine, brain frailty and clock drawing test performance in patients with acute minor stroke or transient ischaemic attack.
Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study.
Implications of Circadian Rhythm in Stroke Occurrence: Certainties and Possibilities.
Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction.
Increased Diagnostic Accuracy of Digital vs. Conventional Clock Drawing Test for Discrimination of Patients in the Early Course of Alzheimer's Disease from Cognitively Healthy Individuals.
Interrater reliability of three clock drawing test scoring systems.
Long-term health-related quality of life after decompressive hemicraniectomy in stroke patients with life-threatening space-occupying brain edema.
Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct.
Measurement properties of the CLOX Executive Clock Drawing Task in an inpatient stroke rehabilitation setting.
Multidirectional transpositions suggesting pathologic approach behavior after frontal stroke.
Normative References for Graphomotor and Latency Digital Clock Drawing Metrics for Adults Age 55 and Older: Operationalizing the Production of a Normal Appearing Clock.
Obesity and lowered cognitive performance in a canadian first nations population.
Off-hour admission and impact on neurological outcome in endovascular treatment for acute ischemic stroke.
Parkinson's Disease Cognitive Phenotypes Show Unique Clock Drawing Features when Measured with Digital Technology.
Particulate Air Pollution, Clock Gene Methylation, and Stroke: Effects on Stroke Severity and Disability.
Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery.
Patterns of Admission and Outcomes for Patients with Intracranial Hemorrhage in Catalonia, Spain.
Prevention or cure of acute stroke: the clock is ticking away.
Quantitative and qualitative performance of stroke versus normal elderly on six clock drawing systems.
Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal.
Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein E knockout mice.
Screening for cognitive deficits after stroke: a comparison of three screening tools.
Stroke of the clock: 'time is brain' when treating stroke patients.
Strokes happen round the clock, but why is stroke care worse on weekends and overnight?
The Clock Drawing Test as a predictor of cognitive decline in non-demented stroke patients.
The Expression and Localization of Histone Acetyltransferases HAT1 and PCAF in Neurons and Astrocytes of the Photothrombotic Stroke-Induced Penumbra in the Rat Brain Cortex.
The gated gait of the processive molecular motor, myosin V.
The psychometric properties of the clock drawing test in South Korea.
The Standardization of the Clock Drawing Test (CDT) for People with Stroke Using Rasch Analysis.
Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.
Thrombolysis beyond the guidelines: two treatments in one subject within 90 hours based on a modified magnetic resonance imaging brain clock concept.
Time to Target Stroke: Examining the Circadian System in Stroke.
Use of calcium channel blockers in acute ischemic cerebrovascular disease.
[Nocturia and the circadian rhythm].
[THE RELATIONSHIP BETWEEN SERUM AND LIQUOR IL-1?, IL-6, TNF?, IL-10 LEVELS AND CLINICAL, COGNITIVE AND FUNCTIONAL CHARACTERISTICS IN ACUTE ISCHEMIC STROKE].
[Transient ischemic attacks and prolonged reversible ischemic neurologic deficit. Diagnosis, differential diagnosis and treatment]
Sudden Unexpected Death in Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Sudden unexpected death in epilepsy: Trying to reset the clock on diabetes.
Sunburn
The circadian clock and diseases of the skin.
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
Supranuclear Palsy, Progressive
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Syncope
Auditory stimuli as a major cause of syncope in a patient with idiopathic long QT syndrome.
Syndactyly
Mosaic CREBBP mutation causes overlapping clinical features of Rubinstein-Taybi and Filippi syndromes.
Synovitis
Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis.
Synucleinopathies
Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder.
Tachycardia
The image of the heart and the synergic principle in psychoanalysis (psychosynergy). II. Three dreams of the disguised heart-image. III. The disguised image of the heart in a case of severe sexual impotence and talent inhibition; the case of the clock chimer (paroxysmal auricular tachycardia in father and son).
Tachycardia, Ventricular
Non-invasive prediction of ST elevation myocardial infarction complications by left ventricular Tei index.
RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.
Tauopathies
Disruption of normal circadian clock function in a mouse model of tauopathy.
Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy.
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
Telangiectasis
Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction.
Chromatin acetylation, ?-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair.
Clinical features and prognostic factors in 71 eyes over 20 years from patients with Coats' disease in Korea.
Factors Predictive of Subretinal Fluid Resolution in Coats Disease: Analysis of 177 Eyes in 177 Patients at a Single Center.
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Predictors of enucleation in Coats disease: analysis of 259 eyes of 259 patients at a single center.
Teratoma
Role of circadian gene Clock during differentiation of mouse pluripotent stem cells.
Testicular Neoplasms
Clock genes and cancer development in particular in endocrine tissues.
Tetanus
Blocking synaptic transmission with tetanus toxin light chain reveals modes of neurotransmission in the PDF-positive circadian clock neurons of Drosophila melanogaster.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
[Histone acetylation and expression of acetylation-related enzymes in children with tetralogy of Fallot].
Thiamine Deficiency
Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency.
Thrombosis
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.
Circadian rhythms and the molecular clock in cardiovascular biology and disease.
Downregulation of Clock in circulatory system leads to an enhancement of fibrinolysis in mice.
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Thyroid Cancer, Papillary
Circadian clock characteristics are altered in human thyroid malignant nodules.
CITED1 contributes to the progression of papillary thyroid carcinoma via the Wnt/?-catenin signaling pathway.
Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis.
Thyroid Diseases
Analysis of expression of different histone deacetylases in autoimmune thyroid disease.
Thyroid Hormone Resistance Syndrome
Thyroid function in Rubinstein-Taybi syndrome.
Thyroid Neoplasms
Bexarotene via CBP/p300 induces suppression of NF-?B-dependent cell growth and invasion in thyroid cancer.
Circadian clock characteristics are altered in human thyroid malignant nodules.
Effect of the Interaction Between Cadmium Exposure and CLOCK Gene Polymorphisms on Thyroid Cancer: a Case-Control Study in China.
Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.
Identification of Novel Oncogenic Mutations in Thyroid Cancer.
Interconnection between circadian clocks and thyroid function.
PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer.
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.
Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-?B signal pathways in thyroid carcinoma cells.
The search for preoperative biomarkers for thyroid carcinoma: application of the thyroid circadian clock properties.
Thyroid Cancer and Circadian Clock Disruption.
Thyroid Nodule
Circadian clock characteristics are altered in human thyroid malignant nodules.
Thyroid Cancer and Circadian Clock Disruption.
Thyroiditis
Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves' disease but not to Hashimoto's thyroiditis.
Tinnitus
Clocking tinnitus: An audiology symptom of migraine.
Identification of a Circadian Clock in the Inferior Colliculus and Its Dysregulation by Noise Exposure.
Tongue Neoplasms
Alterations of 63 hub genes during lingual carcinogenesis in C57BL/6J mice.
Identification of genes associated with tongue cancer in patients with a history of tobacco and/or alcohol use.
PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs.
Tooth Loss
Periodontitis, tooth loss and cognitive functions among older adults.
Tremor
Abnormal sense of intention preceding voluntary movement in patients with psychogenic tremor.
Symptomatic palatal myoclonus with ear click after tick-borne meningoencephalitis.
The timing of tremor: a biological clock in essential tremor?
Triple Negative Breast Neoplasms
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.
Digging Deeper into Breast Cancer Epigenetics: Insights from Chemical Inhibition of Histone Acetyltransferase TIP60 In Vitro.
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer.
HMGA1 Modulates Gene Transcription Sustaining a Tumor Signalling Pathway Acting on the Epigenetic Status of Triple-Negative Breast Cancer Cells.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer.
Time will tell: Circadian clock dysregulation in triple negative breast cancer.
Trypanosomiasis
Dysregulation of photic induction of Fos-related protein in the biological clock during experimental trypanosomiasis.
Sleep and timekeeping changes, and dysregulation of the biological clock in experimental trypanosomiasis.
Trypanosomiasis, African
Altered neuronal activity rhythm and glutamate receptor expression in the suprachiasmatic nuclei of Trypanosoma brucei-infected rats.
Tuberculoma
N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.
Tuberculosis
A replication clock for Mycobacterium tuberculosis.
A Semi-Mechanistic Model of the Bactericidal Activity of High-Dose Isoniazid Against Multi-Drug-Resistant Tuberculosis: Results from a Randomized Clinical Trial.
Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence.
cAMP-regulated protein lysine acetylases in mycobacteria.
Correlation of N-acetyltransferase 2 genotype with isoniazid acetylation in Polish tuberculosis patients.
Crystal structure of l-glutamate N-acetyltransferase ArgA from Mycobacterium tuberculosis.
Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe.
Development of a limited sampling strategy for the estimation of isoniazid exposure considering N-acetyltransferase 2 genotypes in Korean patients with tuberculosis.
Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.
Epigenetic reader BRD4 supports mycobacterial pathogenesis by co-modulating host lipophagy and angiogenesis.
Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia.
Hypothetical protein Rv3423.1 of Mycobacterium tuberculosis is a histone acetyltransferase.
Inferring patient to patient transmission of Mycobacterium tuberculosis from whole genome sequencing data.
Isoniazid pharmacokinetics in children treated for respiratory tuberculosis.
Mutational and expression analysis of tbnat and its response to isoniazid.
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
N-acetyltransferase and cytochrome P450 2E1 gene polymorphisms and susceptibility to antituberculosis drug hepatotoxicity in an Indian population.
N-acetyltransferase gene polymorphisms & plasma isoniazid concentrations in patients with tuberculosis.
N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis.
NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis.
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis.
Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.
Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis.
Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations.
The molecular clock of Mycobacterium tuberculosis.
Turkish and Japanese Mycobacterium tuberculosis sublineages share a remote common ancestor.
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
World Tuberculosis Day 2021 Theme - 'The Clock is Ticking' - and the world is running out of time to deliver the United Nations General Assembly commitments to End TB due to the COVID-19 pandemic.
[The associations of polymorphism of N-acetyltransferase 2 gene is associated with antituberculosis drug-induced hepatotoxicity in tuberculosis patients.]
Tuberculosis, Meningeal
N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.
Tuberculosis, Multidrug-Resistant
Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia.
Tuberculosis, Pulmonary
N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis.
NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis.
NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy.
The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population.
Tuberous Sclerosis
The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex.
Uremia
A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder.
Ureteral Obstruction
Circadian CLOCK Mediates Activation of Transforming Growth Factor-? Signaling and Renal Fibrosis through Cyclooxygenase 2.
Urinary Bladder Neck Obstruction
New modification of transurethral incision of the prostate in surgical treatment of bladder outlet obstruction: prospective study.
Urinary Bladder Neoplasms
Aromatic amines and cancer.
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.
Arylarnine N-acetyltransferase as a potential biornarker in bladder cancer: fluorescent in situ hybridization and irnmunohistochernistry studies.
Association between N-Acetyltransferase 2 Polymorphism and Bladder Cancer Risk: a Meta-Analysis in a Single Ethnic Group.
Association Between N-acetyltransferase 2 Polymorphism and Bladder Cancer Risk: Results From Studies of the Past Decade and a Meta-Analysis.
Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.
Association of N-acetyltransferase 1 polymorphism and bladder cancer risk: an updated meta-analysis and trial sequential analysis.
Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.
Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction.
Bladder cancer risk from the perspective of genetic polymorphisms in the carcinogen metabolizing enzymes.
Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction.
Circadian clock protein CRY1 prevents paclitaxel?induced senescence of bladder cancer cells by promoting p53 degradation.
Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males.
CYP1A2 activity as a risk factor for bladder cancer.
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.
Distribution and Role of N-acetyltransferase 2 Genetic Polymorphisms in Bladder Cancer Risk in a Lebanese Population
Double primary cancers of the prostate and bladder: a literature review.
Effect of NAT2 gene polymorphism on bladder cancer risk in Slovak population.
Ellagic [correction of ellagica] acid inhibits arylamine N-acetyltransferase activity and DNA adduct formation in human bladder tumor cell lines (T24 and TSGH 8301).
Ellagica acid inhibits arylamine N-acetyltransferase activity and DNA adduct formation in human bladder tumor cell lines (T24 and TSGH 8301).
Environmental factors promoting bladder cancer.
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients.
Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer.
Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.
Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer.
Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.
Genotyping of the polymorphic N-acetyltransferase (NAT2) and loss of heterozygosity in bladder cancer patients.
HBO1 promotes cell proliferation in bladder cancer via activation of Wnt/?-catenin signaling.
Highlight report: N-acetyltransferase 2 and urinary bladder cancer risk.
Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.
Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo.
Impact of misclassification in genotype-exposure interaction studies: example of N-acetyltransferase 2 (NAT2), smoking, and bladder cancer.
Influence Networks Compared with Reaction Networks: Semantics, Expressivity and Attractors.
Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinking.
Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene accompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line.
Modifying Effect of Smoking on GSTM1 and NAT2 in Relation to the Risk of Bladder Cancer in Mongolian Population: A Case-Control Study.
N-Acetyltransferase 1 (NAT1) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population.
N-acetyltransferase 1 polymorphism and bladder cancer susceptibility: a meta-analysis of epidemiological studies.
N-acetyltransferase 1*10 genotype in bladder cancer patients.
N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.
N-acetyltransferase 2 gene polymorphism as a biomarker for susceptibility to bladder cancer in Bangladeshi population.
N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.
N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure.
N-acetyltransferase 2 phenotype in painters with bladder cancer and controls.
N-acetyltransferase 2 polymorphism is associated with bladder cancer risk: An updated meta-analysis based on 54 case-control studies.
N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium.
N-acetyltransferase activity in the urine in Japanese subjects: comparison in healthy persons and bladder cancer patients.
N-acetyltransferase activity is involved in paclitaxel-induced N-acetylation of 2-aminofluorene in human bladder cancer cells (T24).
N-acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark.
N-acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark. Environmental Health Perspectives;1979:71-79.
N-Acetyltransferase phenotype of patients with bladder cancer.
N-acetyltransferase phenotypes in bladder tumour patients with and without carcinoma in situ in selected site biopsies.
N-acetyltransferase phenotypes of bladder cancer patients in a low-risk population.
NAT1 genotypic and phenotypic contribution to urinary bladder cancer risk: a systematic review and meta-analysis.
NAT2 acetylator phenotype, occupation and bladder cancer risk: Results from the EPIC cohort.
Occupational bladder cancer: Polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis.
p21 and CK2 interaction-mediated HDAC2 phosphorylation modulates KLF4 acetylation to regulate bladder cancer cell proliferation.
p300 mediates cellular resistance to doxorubicin in bladder cancer.
p53 mutations in bladder cancer: evidence for exogenous versus endogenous risk factors.
Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry.
Polymorphism in the N-acetyltransferase 1 alleles NAT1*10 and NAT1*14A and cytological gradings of exfoliated urothelial cells in benzidine-exposed Chinese workers: discussion of ethnic differences.
Polymorphism of N-acetyltransferase 2 (NAT2) gene polymorphism in shanghai population: occupational and non-occupational bladder cancer patient groups.
Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary.
Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias.
Prognostic Significance of CREB-Binding Protein and CD81 Expression in Primary High Grade Non-Muscle Invasive Bladder Cancer: Identification of Novel Biomarkers for Bladder Cancer Using Antibody Microarray.
Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk.
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer.
Risks on N-acetyltransferase 2 and bladder cancer: a meta-analysis.
Role of N-acetyltransferase phenotype in human susceptibility to bladder carcinogenic arylamines.
Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.
rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.
RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking.
Scientific and ethical aspects of genetic screening of workers for cancer risk: the case of the N-acetyltransferase phenotype.
Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer.
The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer.
The inhibition of N-acetyltransferase activity and gene expression in human bladder cancer cells (T24) by shikonin.
The role of genetic factors in bladder cancer.
The role of genetically-based metabolic polymorphisms in human cancer: an ecological study of bladder cancer and N-acetyltransferase in 23 populations.
Tobacco use and occupational exposure to carcinogens, but not N-acetyltransferase 2 genotypes are major risk factors for bladder cancer in the Japanese.
Ultra-slow N-Acetyltransferase 2 Is Associated with Recurrence-free Time in Bladder Cancer Patients.
Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany.
[Determination of the N-acetyltransferase phenotype in urothelial cancer patients and healthy controls]
[Significance of N-acetyltransferase phenotype in development of bladder neoplasms]
Urinary Incontinence
Caring for stroke survivors: baseline and 1-year determinants of caregiver burden.
Urinary incontinence: The bladder sets its own clock.
Urinary Tract Infections
Antibiotic Treatment for Febrile Urinary Tract Infection: The Clock Is Ticking.
Urologic Diseases
Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry.
Uterine Cervical Neoplasms
Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells.
E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60.
Identification of lysine acetylome in cervical cancer by label-free quantitative proteomics.
Knockdown of MIR9?3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR?498 via EP300.
Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma.
N-acetyltransferase 2 gene polymorphism in patients with cervical cancer.
N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski).
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Swelling-activated taurine and K+ transport in human cervical cancer cells: association with cell cycle progression.
Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells.
Varicose Veins
Upregulation of the gene expression of CLOCK is correlated with hypoxia-inducible factor 1? in advanced varicose lesions.
Vascular Calcification
Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications.
Vascular Diseases
Circadian clock and vascular disease.
CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species.
Pressed for time: the circadian clock and hypertension.
The executive clock drawing task (CLOX) is a poor screening test for executive dysfunction in Chinese elderly patients with subcortical ischemic vascular disease.
Time microscopy of circadian expression of cardiac clock gene mRNA transcription: chronodiagnostic and chrono-therapeutic implications.
Vascular disease in mice with a dysfunctional circadian clock.
Vascular Headaches
Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function.
Vascular System Injuries
Vascular disease in mice with a dysfunctional circadian clock.
Venous Thromboembolism
Circadian variation within hemostasis: an underrecognized link between biology and disease?
Vesicular Stomatitis
Punctuated equilibrium and positive Darwinian evolution in vesicular stomatitis virus.
Virus Diseases
A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients.
C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock.
Circadian Clock-Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases.
Circadian Molecular Clock in Lung Pathophysiology.
Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.
Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection.
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.
Inducer-specific enhanceosome formation controls tumor necrosis factor alpha gene expression in T lymphocytes.
Interplay between circadian clock and viral infection.
N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study.
Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.
Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus.
The Circadian Clock and Viral Infections.
The circadian clock gene Bmal1: Role in COVID-19 and periodontitis.
The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction.
The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells.
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
Vision Disorders
Combination of capsular tension ring and capsular tension segment for the management of lens coloboma >4 clock hours.
The assessment of cognition in visually impaired older adults.
Vision, Low
Usability of assistive listening devices by older adults with low vision.
Vitamin A Deficiency
Circadian expression of clock genes is maintained in the liver of Vitamin A-deficient mice.
Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A-deficient rats.
Retinoic acid receptors move in time with the clock in the hippocampus. Effect of a vitamin-A-deficient diet.
Temporal patterns of lipoperoxidation and antioxidant enzymes are modified in the hippocampus of vitamin A-deficient rats.
Vitreoretinopathy, Proliferative
Pneumatic retinopexy in 50 patients.
Pneumatic retinopexy. A multicenter randomized controlled clinical trial comparing pneumatic retinopexy with scleral buckling. The Retinal Detachment Study Group.
Pneumatic retinopexy. A two-step outpatient operation without conjunctival incision.
Pneumatic retinopexy: a survey of current practice patterns among the vitreous society members.
Surgical outcome and risk stratification for primary retinal detachment repair: results from the Scottish Retinal Detachment study.
The treatment of bullous rhegmatogenous retinal detachment.
TRAUMATIC RETINAL DETACHMENT CAUSED BY NERF GUN SHOT IN A PEDIATRIC PATIENT.
Vitreous Detachment
[Giant retinal tears treated with lens sparing, bimanual 23 g vitrectomy without scleral buckle].
Vitreous Hemorrhage
Effects of Early Treatment of Retinopathy of Prematurity at a Tertiary Care Hospital in Saudi Arabia: A Retrospective Study.
Pneumatic retinopexy: a survey of current practice patterns among the vitreous society members.
Whooping Cough
Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters.
Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines.
The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal 'clock' gene expression in striatal neurons in vitro.
Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.
Wilms Tumor
Reversible histone acetylation involved in transcriptional regulation of WT1 gene.
Xeroderma Pigmentosum
From xeroderma pigmentosum to the biological clock contributions of Dirk Bootsma to human genetics.
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis.
Yellow Fever
Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera:Culicidae).
CREB-binding protein regulates metamorphosis and compound eye development in the yellow fever mosquito, Aedes aegypti.