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Information on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase and Organism(s) Gallus gallus and UniProt Accession P53760

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EC Tree
IUBMB Comments
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
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This record set is specific for:
Gallus gallus
UNIPROT: P53760
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
lecithin:cholesterol acyltransferase, lecithin-cholesterol acyltransferase, lecithin cholesterol acyltransferase, lecithin cholesterol acyl transferase, lecithin-cholesterol acyl transferase, plasma lecithin-cholesterol acyltransferase, lecithin/cholesterol acyltransferase, lecithin:cholesterol acyl-transferase, tglcat, phospholipid-cholesterol acyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acyltransferase, lecithin-cholesterol
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lecithin-cholesterol acyltransferase
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lecithin:cholesterol acyltransferase
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lysolecithin acyltransferase
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phospholipid-cholesterol acyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine:sterol O-acyltransferase
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-14-5
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
apolipoprotein A-I
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
chicken
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LCAT_CHICK
413
0
47804
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
64000
x * 64000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 64000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial, using phenyl-Sepharose chromatography
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hengstschlaeger-Ottnad, E.; Kuchler, K.; Schneider, W.J.
Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern
J. Biol. Chem.
270
26139-26145
1995
Gallus gallus (P53760), Gallus gallus
Manually annotated by BRENDA team