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Information on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase and Organism(s) Homo sapiens and UniProt Accession Q8IVS2
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2.3.1.39 [acyl-carrier-protein] S-malonyltransferaseIUBMB Comments
This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis . The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate . This enzyme also forms part of the multienzyme complexes EC 4.1.1.88, biotin-independent malonate decarboxylase and EC 7.2.4.4, biotin-dependent malonate decarboxylase. Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase . In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot whereas the enzyme from Pseudomonas putida can use both as substrates . The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group.
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Word Map
- 2.3.1.39
- fas
- carboxylase
- sterol
- triglyceride
-
lipogenesis
- acetyl-coa
- adipose
-
lipogenic
- peroxisome
- cholesterol
- obesity
-
proliferator-activated
- adipocytes
-
element-binding
- lipoprotein
- carnitine
- lipase
-
high-fat
- steatosis
- hepatocytes
- srebp-1c
- stearoyl-coa
-
obese
-
diet-induced
- protein-1c
- triacylglycerols
- palmitate
-
amp-activated
- leptin
-
anti-obesity
- cerulenin
-
preadipocytes
- nafld
- adiponectin
-
palmitoylation
-
nonalcoholic
-
malic
-
lipolysis
-
hormone-sensitive
-
srebps
-
desaturase-1
-
hfd-induced
- orlistat
-
enoyl
-
atp-citrate
- acyl-acps
- acaca
- medicine
- diagnostics
- drug development
-
palmitoyltransferase-1
- biotechnology
-
chrebp
-
anti-adipogenic
- synthesis
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
fatty acid synthase, malonyl-coa:acp transacylase, malonyl transferase, mtfabd, hpmcat, fabd2, malonyl-coa:acyl carrier protein transacylase, malonyl coa-acyl carrier protein transacylase, malonyl-coa-acyl carrier protein transacylase, mcamt, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
FAS
fatty acid synthase
malonyl coenzyme A-acyl carrier protein transacylase
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malonyl transacylase
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malonyl transferase
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-
-
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malonyl-CoA-acyl carrier protein transacylase
malonyltransferase, [acyl-carrier-protein]
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-
-
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MAT
[acyl carrier protein]malonyltransferase
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malonyl-CoA-acyl carrier protein transacylase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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-
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-
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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis [7]. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate [5]. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88, biotin-independent malonate decarboxylase and EC 7.2.4.4, biotin-dependent malonate decarboxylase. Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase [12]. In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot [10] whereas the enzyme from Pseudomonas putida can use both as substrates [11]. The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group.
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CAS REGISTRY NUMBER
COMMENTARY
37257-17-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
additional information
?
-
-
enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria
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-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
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-
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
absolutely specific for the substrates, type II [acyl-carrier protein]
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
absolutely specific for the substrates, recombinant type II [acyl-carrier protein] lacking the N-terminal 68 amino acid residues from human, or recombinant ACP-A from Bacillus subtilis
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
absolutely specific for the substrates, type II [acyl-carrier protein]
-
-
?
additional information
?
-
-
enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
-
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane.
Aberrant Crypt Foci
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Acidosis
In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells.
Acute Coronary Syndrome
Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome.
Acute Coronary Syndrome
[Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome].
Acute Lung Injury
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
Adenocarcinoma
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Adenocarcinoma
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
Adenocarcinoma
Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.
Adenocarcinoma
Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett's oesophagus and adenocarcinoma.
Adenocarcinoma
Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.
Adenocarcinoma
Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence.
Adenocarcinoma
Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function.
Adenocarcinoma
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Adenocarcinoma
Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma?: A comparison with AMACR.
Adenocarcinoma
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
Adenocarcinoma
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
Adenocarcinoma
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Adenocarcinoma
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Adenocarcinoma of Lung
Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models.
Adenocarcinoma of Lung
Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.
Adenoma
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Adenoma
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Adenoma
Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.
Adenoma
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Adenoma
P53 as a marker of differentiation between hyperplastic and adenomatous parathyroids.
Adenoma, Pleomorphic
Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors.
Adenoma, Pleomorphic
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Alzheimer Disease
CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease.
Ameloblastoma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Arthritis
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Atherosclerosis
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Atherosclerosis
Protective effect of atorvastatin meditated by HMGCR gene on diabetic rats with atherosclerosis: An in vivo and in vitro study.
Azotemia
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Barrett Esophagus
Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis.
Blindness
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
Breast Neoplasms
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
Breast Neoplasms
1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity.
Breast Neoplasms
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
Breast Neoplasms
A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction.
Breast Neoplasms
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
Breast Neoplasms
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Breast Neoplasms
Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells.
Breast Neoplasms
Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.
Breast Neoplasms
Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells.
Breast Neoplasms
Application of chromatography technology in the separation of active alkaloids from Hypecoum leptocarpum and their inhibitory effect on fatty acid synthase.
Breast Neoplasms
Aromatase, CYP1B1 and Fatty Acid Synthase Expression in Breast Tumors of BRCA1 Mutation Carriers.
Breast Neoplasms
Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells.
Breast Neoplasms
Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids.
Breast Neoplasms
Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway.
Breast Neoplasms
Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue.
Breast Neoplasms
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Breast Neoplasms
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.
Breast Neoplasms
Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis.
Breast Neoplasms
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Breast Neoplasms
Dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model.
Breast Neoplasms
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
Breast Neoplasms
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
Breast Neoplasms
Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line.
Breast Neoplasms
Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.
Breast Neoplasms
Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells.
Breast Neoplasms
Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.
Breast Neoplasms
Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China.
Breast Neoplasms
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.
Breast Neoplasms
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
Breast Neoplasms
FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration.
Breast Neoplasms
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Breast Neoplasms
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Breast Neoplasms
Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab'-Immunoliposomes for Gene Silencing in Breast Cancer Cells.
Breast Neoplasms
Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients.
Breast Neoplasms
Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma.
Breast Neoplasms
Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer.
Breast Neoplasms
Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer.
Breast Neoplasms
Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.
Breast Neoplasms
Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells.
Breast Neoplasms
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Breast Neoplasms
Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
Breast Neoplasms
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice.
Breast Neoplasms
Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer.
Breast Neoplasms
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer.
Breast Neoplasms
Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer.
Breast Neoplasms
Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells.
Breast Neoplasms
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.
Breast Neoplasms
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Breast Neoplasms
Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells.
Breast Neoplasms
Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis.
Breast Neoplasms
Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.
Breast Neoplasms
Fatty acid synthesis: a potential selective target for antineoplastic therapy.
Breast Neoplasms
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.
Breast Neoplasms
Hyperglycaemia-induced chemoresistance in breast cancer cells: role of the estrogen receptor.
Breast Neoplasms
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Breast Neoplasms
Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2.
Breast Neoplasms
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Breast Neoplasms
Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue.
Breast Neoplasms
In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy.
Breast Neoplasms
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis.
Breast Neoplasms
Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC.
Breast Neoplasms
Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.
Breast Neoplasms
Inhibition of Fatty Acid synthase and sp1 expression by 3,3'-diindolylmethane in human breast cancer cells.
Breast Neoplasms
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Breast Neoplasms
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Breast Neoplasms
Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
Breast Neoplasms
Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).
Breast Neoplasms
Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.
Breast Neoplasms
Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase.
Breast Neoplasms
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells.
Breast Neoplasms
Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase.
Breast Neoplasms
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Breast Neoplasms
Mechanism of fatty acid synthase in drug tolerance related to epithelial-mesenchymal transition of breast cancer.
Breast Neoplasms
Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols.
Breast Neoplasms
MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study.
Breast Neoplasms
Mitochondrial dysfunction is responsible for fatty acid synthase inhibition-induced apoptosis in breast cancer cells by PdpaMn.
Breast Neoplasms
MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines.
Breast Neoplasms
NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition.
Breast Neoplasms
Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.
Breast Neoplasms
Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
Breast Neoplasms
Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells.
Breast Neoplasms
Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism.
Breast Neoplasms
Patuletin induces apoptosis of human breast cancer SK-BR-3 cell line via inhibiting fatty acid synthase gene expression and activity.
Breast Neoplasms
PdpaMn inhibits fatty acid synthase-mediated glycolysis by down-regulating PI3K/Akt signaling pathway in breast cancer.
Breast Neoplasms
Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells.
Breast Neoplasms
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Breast Neoplasms
Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer.
Breast Neoplasms
Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.
Breast Neoplasms
Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase.
Breast Neoplasms
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids.
Breast Neoplasms
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.
Breast Neoplasms
Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway.
Breast Neoplasms
RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
Breast Neoplasms
Serum fatty acid synthase levels and n-3 fatty acid intake in patients with breast cancer.
Breast Neoplasms
Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.
Breast Neoplasms
Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects.
Breast Neoplasms
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Breast Neoplasms
Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
Breast Neoplasms
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer.
Breast Neoplasms
Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer.
Breast Neoplasms
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
Breast Neoplasms
The anti-cancer effects of (-)-epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells.
Breast Neoplasms
The anti-cancer effects of (-)-Epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells.
Breast Neoplasms
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
Breast Neoplasms
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
Breast Neoplasms
The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells.
Breast Neoplasms
Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
Breast Neoplasms
Thymoquinone Augments Cyclophosphamide-Mediated
Inhibition of Cell Proliferation in Breast Cancer Cells
Breast Neoplasms
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.
Breast Neoplasms
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.
Breast Neoplasms
Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells.
Breast Neoplasms
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.
Breast Neoplasms
Virtual screening-based identification of novel fatty acid synthase inhibitor and evaluation of its antiproliferative activity in breast cancer cells.
Breast Neoplasms
Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis.
Breast Neoplasms
[Expression of epidermal fatty acid-binding protein and fatty acid synthase in infiltrating ductal breast carcinoma.]
Breast Neoplasms
[Expression of fatty acid synthase and adipocyte fatty acid-binding protein and the relationship with the clinicopathological characteristics in human infiltrating ductal breast cancer].
Breast Neoplasms
[Gene expression of H-FABP and FAS and its clinicopathological significance in breast infiltrating ductal carcinoma]
Breast Neoplasms
[Inhibition of triclosan to fatty acid synthase from goose uropygial glands and human breast cancer cells in vitro]
Breast Neoplasms
[Transcriptional activities of human fatty acid synthase promoter in breast cancer cells]
Candidiasis
Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis.
Carcinogenesis
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Carcinogenesis
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Carcinogenesis
Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis.
Carcinogenesis
Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.
Carcinogenesis
Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Carcinogenesis
Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis.
Carcinogenesis
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer.
Carcinogenesis
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Carcinogenesis
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
Carcinogenesis
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.
Carcinogenesis
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Carcinogenesis
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
Carcinogenesis
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis.
Carcinogenesis
Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.
Carcinogenesis
Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma.
Carcinogenesis
LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro.
Carcinogenesis
Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
Carcinogenesis
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Carcinogenesis
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
Carcinogenesis
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
Carcinogenesis
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
Carcinoma
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
Carcinoma
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
Carcinoma
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Carcinoma
Activation of prolyl hydroxylase-2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF-1?/FASN in ER + breast cancer subtype.
Carcinoma
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Carcinoma
Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.
Carcinoma
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Carcinoma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Carcinoma
Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer.
Carcinoma
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
Carcinoma
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Carcinoma
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.
Carcinoma
EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models.
Carcinoma
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
Carcinoma
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Carcinoma
ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes.
Carcinoma
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Carcinoma
Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas.
Carcinoma
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Carcinoma
Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.
Carcinoma
Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma.
Carcinoma
Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
Carcinoma
Expression Staus of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
Carcinoma
FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1.
Carcinoma
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Carcinoma
Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma.
Carcinoma
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Carcinoma
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
Carcinoma
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Carcinoma
Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma.
Carcinoma
Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas.
Carcinoma
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Carcinoma
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Carcinoma
Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.
Carcinoma
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
Carcinoma
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.
Carcinoma
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Carcinoma
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Carcinoma
Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.
Carcinoma
High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma.
Carcinoma
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
Carcinoma
Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma.
Carcinoma
Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas.
Carcinoma
Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.
Carcinoma
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
Carcinoma
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Carcinoma
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
Carcinoma
Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway.
Carcinoma
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Carcinoma
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.
Carcinoma
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
Carcinoma
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer.
Carcinoma
Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
Carcinoma
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
Carcinoma
Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma.
Carcinoma
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Carcinoma
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
Carcinoma
Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.
Carcinoma
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Carcinoma
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Carcinoma
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Carcinoma
Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma.
Carcinoma
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Carcinoma
PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype.
Carcinoma
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Carcinoma
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer.
Carcinoma
Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma.
Carcinoma
Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.
Carcinoma
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids.
Carcinoma
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Carcinoma
Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.
Carcinoma
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Carcinoma
The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma.
Carcinoma
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
Carcinoma
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
Carcinoma
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Carcinoma
[Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR]
Carcinoma
[Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines].
Carcinoma in Situ
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Carcinoma in Situ
Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.
Carcinoma, Adenoid Cystic
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Carcinoma, Adenoid Cystic
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Carcinoma, Ductal
Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma.
Carcinoma, Ductal
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Carcinoma, Ductal
[Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast].
Carcinoma, Hepatocellular
4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis.
Carcinoma, Hepatocellular
?-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.
Carcinoma, Hepatocellular
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Carcinoma, Hepatocellular
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish.
Carcinoma, Hepatocellular
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins.
Carcinoma, Hepatocellular
Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cells.
Carcinoma, Hepatocellular
Expression and roles of fatty acid synthase in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
Carcinoma, Hepatocellular
FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line.
Carcinoma, Hepatocellular
Growth Arrest Induced by C75, A Fatty Acid Synthase Inhibitor, was Partially Modulated by p38 MAPK but Not by p53 In Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP.
Carcinoma, Hepatocellular
Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC.
Carcinoma, Hepatocellular
Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway.
Carcinoma, Hepatocellular
Insulin increases fatty acid synthase gene transcription in human adipocytes.
Carcinoma, Hepatocellular
Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype.
Carcinoma, Hepatocellular
Liver X receptor alpha regulates fatty acid synthase expression in chicken.
Carcinoma, Hepatocellular
LXR? limits TGF?-dependent hepatocellular carcinoma associated fibroblast differentiation.
Carcinoma, Hepatocellular
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
Carcinoma, Hepatocellular
Network analyses identify liver-specific targets for treating liver diseases.
Carcinoma, Hepatocellular
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.
Carcinoma, Hepatocellular
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.
Carcinoma, Hepatocellular
Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Carcinoma, Intraductal, Noninfiltrating
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Carcinoma, Intraductal, Noninfiltrating
[Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast].
Carcinoma, Mucoepidermoid
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Carcinoma, Non-Small-Cell Lung
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
Carcinoma, Non-Small-Cell Lung
Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis.
Carcinoma, Non-Small-Cell Lung
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
Carcinoma, Non-Small-Cell Lung
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Carcinoma, Non-Small-Cell Lung
MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.
Carcinoma, Non-Small-Cell Lung
[Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Significance of fatty acid synthase expression in non-small cell lung cancer]
Carcinoma, Ovarian Epithelial
Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer.
Carcinoma, Ovarian Epithelial
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Carcinoma, Renal Cell
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Carcinoma, Renal Cell
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Carcinoma, Squamous Cell
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
Carcinoma, Squamous Cell
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes.
Carcinoma, Squamous Cell
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Carcinoma, Squamous Cell
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Carcinoma, Squamous Cell
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells.
Carcinoma, Squamous Cell
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
Carcinoma, Squamous Cell
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
Carcinoma, Squamous Cell
[Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR]
Carcinoma, Transitional Cell
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Carcinoma, Transitional Cell
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer.
Cardiovascular Diseases
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Carotid Stenosis
Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated.
Chagas Disease
A fatty acid synthase gene (FASN3) from the integument tissue of Rhodnius prolixus contributes to cuticle water loss regulation.
Cholangiocarcinoma
Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression.
Classical Swine Fever
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.
Colitis, Ulcerative
Alterations in intestinal fatty acid metabolism in inflammatory bowel disease.
Colonic Neoplasms
A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
Colonic Neoplasms
Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study.
Colonic Neoplasms
Cohort study of fatty acid synthase expression and patient survival in colon cancer.
Colonic Neoplasms
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Colonic Neoplasms
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Colonic Neoplasms
Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.
Colonic Neoplasms
Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Colonic Neoplasms
Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells.
Colonic Neoplasms
Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
Colonic Neoplasms
Interaction of molecular markers and physical activity on mortality in patients with colon cancer.
Colonic Neoplasms
[An experimental study on cerulenin induced apoptosis of human colonic cancer cells]
Colorectal Neoplasms
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
Colorectal Neoplasms
Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study.
Colorectal Neoplasms
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Colorectal Neoplasms
Cohort study of fatty acid synthase expression and patient survival in colon cancer.
Colorectal Neoplasms
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Colorectal Neoplasms
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.
Colorectal Neoplasms
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Colorectal Neoplasms
Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes.
Colorectal Neoplasms
Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway.
Colorectal Neoplasms
Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex.
Colorectal Neoplasms
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Colorectal Neoplasms
Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Colorectal Neoplasms
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Colorectal Neoplasms
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
Colorectal Neoplasms
High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.
Colorectal Neoplasms
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
Colorectal Neoplasms
In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation.
Colorectal Neoplasms
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Colorectal Neoplasms
Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration.
Colorectal Neoplasms
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Colorectal Neoplasms
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells.
Colorectal Neoplasms
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
Colorectal Neoplasms
Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.
Colorectal Neoplasms
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.
Colorectal Neoplasms
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Colorectal Neoplasms
Targeting triglyceride metabolism for colorectal cancer prevention and therapy.
Colorectal Neoplasms
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
Colorectal Neoplasms
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
Colorectal Neoplasms
Use of confocal laser endomicroscopy with a fluorescently labeled fatty acid to diagnose colorectal neoplasms.
Coronary Artery Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Coronary Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
COVID-19
Letter to the Editor: Morphoproteomics Confirms the Expression of Fatty Acid Synthase (FAS) in Reactive Alveolar Pneumocytes in a COVID-19 Victim: Biological and Therapeutic Implications.
Cushing Syndrome
Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.
Cystic Fibrosis
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Dehydration
A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.
Dehydration
Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function.
Dehydration
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Dengue
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.
Dengue
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Dengue
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.
Diabetes Mellitus
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Diabetes Mellitus, Type 2
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Diabetes Mellitus, Type 2
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.
Diabetes Mellitus, Type 2
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Diabetic Neuropathies
Electrophysiological changes, plasma vascular endothelial growth factor, fatty acid synthase, and adhesion molecules in diabetic neuropathy.
Diabetic Retinopathy
Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy.
Dyslipidemias
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Dyslipidemias
Green tea leaf powder prevents dyslipidemia in high-fat diet-fed mice by modulating gut microbiota.
Dyslipidemias
The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.
Dyslipidemias
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.
Dyslipidemias
[Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].
Endometrial Hyperplasia
Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy.
Endometrial Neoplasms
Effects of Fatty Acid Synthase Inhibition by Orlistat on Proliferation of Endometrial Cancer Cell Lines.
Endometrial Neoplasms
Fatty acid synthase expression and clinicopathological findings in endometrial cancer.
Endometrial Neoplasms
Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors.
Endometrial Neoplasms
Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma.
Endometrial Neoplasms
Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer.
Endometrial Neoplasms
Relevance of lipogenesis and AMPK/Akt/mTOR signaling pathway in endometrial cancer.
Endometrial Neoplasms
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Epstein-Barr Virus Infections
Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors.
Esophageal Neoplasms
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy.
Fatty Liver
A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis.
Fatty Liver
Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver.
Fatty Liver
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Fatty Liver
Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model.
Fatty Liver
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice.
Fatty Liver
Chronic everolimus treatment of high-fat diet mice leads to a reduction in obesity but impaired glucose tolerance.
Fatty Liver
Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Fatty Liver
Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet.
Fatty Liver
Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Fatty Liver
De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles.
Fatty Liver
Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
Fatty Liver
Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet.
Fatty Liver
Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model.
Fatty Liver
Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease.
Fatty Liver
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Fatty Liver
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPK?/SREBP1 signaling pathway.
Fatty Liver
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.
Fatty Liver
Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism.
Fatty Liver
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Fatty Liver
Molecular Mechanism of Age-Specific Hepatic Lipid Accumulation in PPARalpha (+/-):LDLR (+/-) Mice, an Obese Mouse Model.
Fatty Liver
Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly.
Fatty Liver
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Fatty Liver
Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice.
Fatty Liver
Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis.
Fatty Liver
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Fatty Liver
Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats.
Fatty Liver
Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice.
Fatty Liver
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Fatty Liver
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis.
Fatty Liver
[6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis.
Fetal Growth Retardation
Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.
Fibroma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Fibromatosis, Gingival
Proliferation of fibroblasts cultured from normal gingiva and hereditary gingival fibromatosis is dependent on fatty acid synthase activity.
Fibrosarcoma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumours overexpress fatty acid synthase.
Gastrointestinal Stromal Tumors
Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib.
Glioma
Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma.
Glioma
Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment.
Glioma
Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas.
Glioma
Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells.
Glioma
Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma.
Glioma
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.
Granular Cell Tumor
Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
Hepatitis
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Hepatitis B
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Hepatitis B
Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver.
Hepatitis B
Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha.
Hepatitis C
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.
Hepatitis C
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Hepatitis C
Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase.
Hepatitis C
Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.
Hepatitis C
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core.
Hepatoblastoma
Regulation of fatty acid synthase expression by cholesterol in human cultured cells.
Hepatoblastoma
[Effect of fatty acid synthase gene silencing on lipid metabolism and biological behaviors of human hepatoblastoma HepG2 cells].
Hyperalgesia
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Hyperglycemia
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Hyperglycemia
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Hyperglycemia
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
Hyperglycemia
Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice.
Hyperinsulinism
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
Hyperinsulinism
Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism.
Hyperinsulinism
Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa Zucker Rats.
Hyperinsulinism
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.
Hyperinsulinism
In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues.
Hyperinsulinism
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
Hyperlipidemias
Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition.
Hyperlipidemias
Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes.
Hyperlipidemias
Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease.
Hyperlipidemias
Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia.
Hyperlipidemias
Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.
Hyperlipidemias
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Hyperlipidemias
Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules.
Hyperlipidemias
Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet.
Hyperlipidemias
The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity.
Hyperlipidemias
Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice.
Hyperlipidemias
[Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia].
Hyperparathyroidism, Secondary
Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids.
Hypersensitivity
Copper deficiency induces hepatic fatty acid synthase gene transcription in rats by increasing the nuclear content of mature sterol regulatory element binding protein 1.
Hypersensitivity
DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements.
Hypertension
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Hypertension
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism.
Hypertension, Pulmonary
Inhibition of fatty acid synthase is protective in pulmonary hypertension.
Hypertension, Pulmonary
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Hypertriglyceridemia
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
Hypertriglyceridemia
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
Hypertriglyceridemia
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Hypertriglyceridemia
Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
Hypertriglyceridemia
Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits.
Hypothyroidism
A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations.
Hypothyroidism
A tissue-specific increase in lipogenesis in rat brown adipose tissue in hypothyroidism.
Infections
Adenovirus type 9 enhances differentiation and decreases cytokine release from preadipocytes.
Infections
Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Infections
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Infections
Construction of a cDNA encoding the multifunctional animal fatty acid synthase and expression in Spodoptera frugiperda cells using baculoviral vectors.
Infections
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection.
Infections
Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection.
Infections
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Infections
Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
Infections
Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection.
Infections
Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus.
Infections
Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.
Infections
Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway.
Infections
Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis.
Infections
Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity.
Infections
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Infections
Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods.
Infections
West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids.
Inflammatory Bowel Diseases
Fatty acid synthase inhibitor C75 ameliorates experimental colitis.
Insulin Resistance
A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice.
Insulin Resistance
A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis.
Insulin Resistance
Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice.
Insulin Resistance
Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Insulin Resistance
Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
Insulin Resistance
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet.
Insulin Resistance
Development of insulin sensitivity in white adipose tissue during the suckling-weaning transition in the rat. Involvement of glucose transport and lipogenesis.
Insulin Resistance
Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression.
Insulin Resistance
Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion.
Insulin Resistance
Extracellular Fatty Acid Synthase: a possible surrogate biomarker of insulin resistance.
Insulin Resistance
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Insulin Resistance
Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.
Insulin Resistance
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.
Insulin Resistance
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Insulin Resistance
Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.
Insulin Resistance
MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease.
Insulin Resistance
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.
Insulin Resistance
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
Insulin Resistance
Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes.
Insulin Resistance
Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice.
Insulin Resistance
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
Insulin Resistance
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis.
Insulin Resistance
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Insulin Resistance
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
Insulin Resistance
The 1975 type Japanese diet improves the gut microbial flora and inhibits visceral fat accumulation in mice.
Insulin Resistance
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Insulin Resistance
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
Insulin Resistance
The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue.
Insulin Resistance
[Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia].
Insulin Resistance
[Molecular targets for new drug discovery to treat type 2 diabetes and obesity]
Insulinoma
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
Intellectual Disability
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Ketosis
High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis.
Kidney Failure, Chronic
Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
Kidney Neoplasms
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Kidney Neoplasms
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Leukemia
Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway.
Leukemia
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
Leukemia
[Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor--cerulenin]
Leukemia, T-Cell
Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line.
Lipid Metabolism Disorders
The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet.
Liposarcoma
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.
Liposarcoma
The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells.
Liver Diseases
Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Liver Diseases
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Liver Diseases
Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease.
Liver Diseases
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Liver Diseases
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases
Network analyses identify liver-specific targets for treating liver diseases.
Liver Diseases
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Liver Diseases
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Liver Diseases
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Neoplasms
Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
Liver Neoplasms
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells.
Liver Neoplasms
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Liver Neoplasms
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
Lung Neoplasms
Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer.
Lung Neoplasms
Fast Nanoliter-Scale Cell Assays Using Droplet Microarray-Mass Spectrometry Imaging.
Lung Neoplasms
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.
Lung Neoplasms
FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer.
Lung Neoplasms
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
Lung Neoplasms
Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis.
Lung Neoplasms
Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors.
Lung Neoplasms
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
Lung Neoplasms
MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.
Lung Neoplasms
[Clinical significance and expression of fatty acid synthase mRNA in lung cancer.]
Lung Neoplasms
[Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer]
Lung Neoplasms
[Significance of fatty acid synthase expression in non-small cell lung cancer]
Lymphatic Metastasis
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Lymphatic Metastasis
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Lymphatic Metastasis
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Lymphoma
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Lymphoma
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Lymphoma
Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy.
Lymphoma
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Lymphoma, B-Cell
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
Lymphoma, B-Cell
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Lymphoma, B-Cell
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBP?/SREBP-1 pathway.
Lymphoma, B-Cell
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Lymphoma, Large B-Cell, Diffuse
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Lymphoma, Mantle-Cell
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Lymphoma, T-Cell
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Lymphoma, T-Cell
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Malnutrition
Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism.
Melanoma
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.
Melanoma
Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish.
Melanoma
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Melanoma
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Melanoma
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.
Melanoma
Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis.
Melanoma
Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines.
Melanoma
Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase.
Melanoma
Primary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patients.
Melanoma
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Melanoma
The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma.
Melanoma
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
Melanoma
Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells.
Meningioma
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma.
Meningioma
Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions.
Metabolic Diseases
Cyclopropaneoctanoic Acid 2-Hexyl Upregulates the Expression of Genes Responsible for Lipid Synthesis and Release in Human Hepatic HepG2 Cells.
Metabolic Diseases
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Metabolic Diseases
Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy.
Metabolic Syndrome
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Metabolic Syndrome
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Metabolic Syndrome
Increased activity of the oncogenic fatty acid synthase and the impaired glucose uptake in the metabolic syndrome.
Multiple Myeloma
Increased fatty acid synthase as a potential therapeutic target in multiple myeloma.
Multiple Myeloma
Retraction. Fatty acid synthase is a novel therapeutic target in multiple myeloma.
Multiple Myeloma
[Study on proliferation inhibiting and apoptosis inducing effects of cerulenin on multiple myeloma cells]
Nasopharyngeal Carcinoma
Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.
Nasopharyngeal Carcinoma
Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
Neoplasm Metastasis
8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90? downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells.
Neoplasm Metastasis
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Neoplasm Metastasis
Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells.
Neoplasm Metastasis
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.
Neoplasm Metastasis
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Neoplasm Metastasis
Data supporting the identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Neoplasm Metastasis
Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.
Neoplasm Metastasis
Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway.
Neoplasm Metastasis
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Neoplasm Metastasis
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Neoplasm Metastasis
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Neoplasm Metastasis
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Neoplasm Metastasis
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Neoplasm Metastasis
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Neoplasm Metastasis
Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Neoplasm Metastasis
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Neoplasm Metastasis
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Neoplasm Metastasis
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Neoplasm Metastasis
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Neoplasm Metastasis
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Neoplasm Metastasis
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
Neoplasm Metastasis
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
Neoplasm Metastasis
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
Neoplasm Metastasis
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
Neoplasm Metastasis
The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis.
Neoplasms
(S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation.
Neoplasms
1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity.
Neoplasms
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
Neoplasms
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Neoplasms
A cohort study of p27 localization in colon cancer, body mass index, and patient survival.
Neoplasms
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
Neoplasms
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.
Neoplasms
A human fatty acid synthase inhibitor binds ?-ketoacyl reductase in the keto-substrate site.
Neoplasms
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Neoplasms
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
Neoplasms
A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers.
Neoplasms
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Neoplasms
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.
Neoplasms
Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Neoplasms
Adaptive evolution of the human fatty acid synthase gene: support for the cancer selection and fat utilization hypotheses?
Neoplasms
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance.
Neoplasms
Adipose tissue biomarkers involved in early resolution of type 2 diabetes after bariatric surgery.
Neoplasms
Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis.
Neoplasms
Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease.
Neoplasms
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
Neoplasms
AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.
Neoplasms
An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value.
Neoplasms
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Neoplasms
Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays.
Neoplasms
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
Neoplasms
Anti-Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy.
Neoplasms
Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines.
Neoplasms
Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells.
Neoplasms
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Neoplasms
Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway.
Neoplasms
Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells.
Neoplasms
Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor.
Neoplasms
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
Neoplasms
Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells.
Neoplasms
Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer.
Neoplasms
Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.
Neoplasms
Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model.
Neoplasms
Bioactive ingredients obtained from Cortex Fraxini impair interactions between FAS and GPI.
Neoplasms
Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors.
Neoplasms
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Neoplasms
Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models.
Neoplasms
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.
Neoplasms
Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations.
Neoplasms
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
Neoplasms
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
Neoplasms
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Neoplasms
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Neoplasms
Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?
Neoplasms
Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression.
Neoplasms
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Neoplasms
Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue.
Neoplasms
Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors.
Neoplasms
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells.
Neoplasms
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Neoplasms
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Neoplasms
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Neoplasms
Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.
Neoplasms
Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.
Neoplasms
Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.
Neoplasms
Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.
Neoplasms
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Neoplasms
Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells.
Neoplasms
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Neoplasms
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Neoplasms
Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.
Neoplasms
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Neoplasms
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Neoplasms
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.
Neoplasms
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Neoplasms
Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics.
Neoplasms
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Neoplasms
Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.
Neoplasms
Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.
Neoplasms
Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells.
Neoplasms
Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.
Neoplasms
Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization.
Neoplasms
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75.
Neoplasms
Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet.
Neoplasms
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.
Neoplasms
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death.
Neoplasms
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Neoplasms
Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75.
Neoplasms
Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene.
Neoplasms
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells.
Neoplasms
Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.
Neoplasms
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Neoplasms
Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression.
Neoplasms
Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.
Neoplasms
Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas.
Neoplasms
Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention.
Neoplasms
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Neoplasms
Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma.
Neoplasms
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells.
Neoplasms
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Neoplasms
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
Neoplasms
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Neoplasms
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.
Neoplasms
Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells.
Neoplasms
Ethanolic Fraction of Terminalia tomentosa Attenuates Biochemical and Physiological Derangements in Diet Induced Obese Rat Model by Regulating Key Lipid Metabolizing Enzymes and Adipokines.
Neoplasms
Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase.
Neoplasms
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Neoplasms
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Neoplasms
Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker.
Neoplasms
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
Neoplasms
Expression of fatty acid synthase is regulated by PGC?1? and contributes to increased cell proliferation.
Neoplasms
Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma.
Neoplasms
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
Neoplasms
Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study.
Neoplasms
Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness.
Neoplasms
Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
Neoplasms
Extranodal Nasal NK/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression.
Neoplasms
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.
Neoplasms
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
Neoplasms
FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-?B and SP1.
Neoplasms
Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
Neoplasms
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Neoplasms
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Neoplasms
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
Neoplasms
Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders.
Neoplasms
Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes.
Neoplasms
Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target.
Neoplasms
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Neoplasms
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
Neoplasms
Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer.
Neoplasms
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Neoplasms
Fatty acid synthase expression and clinicopathological findings in endometrial cancer.
Neoplasms
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Neoplasms
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Neoplasms
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Neoplasms
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.
Neoplasms
Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.
Neoplasms
Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex.
Neoplasms
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Neoplasms
Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells.
Neoplasms
Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine.
Neoplasms
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Neoplasms
Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis.
Neoplasms
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Neoplasms
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Neoplasms
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice.
Neoplasms
Fatty Acid synthase inhibitors as possible treatment for cancer: patent highlight.
Neoplasms
Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
Neoplasms
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
Neoplasms
Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Neoplasms
Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.
Neoplasms
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Neoplasms
Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.
Neoplasms
Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine.
Neoplasms
Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane.
Neoplasms
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Neoplasms
Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma.
Neoplasms
Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.
Neoplasms
Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Neoplasms
Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.
Neoplasms
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity.
Neoplasms
Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
Neoplasms
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Neoplasms
Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells.
Neoplasms
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Neoplasms
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
Neoplasms
Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence.
Neoplasms
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Neoplasms
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions.
Neoplasms
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors.
Neoplasms
Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production.
Neoplasms
G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts.
Neoplasms
Gene expression analysis by cDNA microarray in oral cancers from two Western populations.
Neoplasms
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Neoplasms
Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells.
Neoplasms
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.
Neoplasms
Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.
Neoplasms
Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.
Neoplasms
Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation.
Neoplasms
Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations.
Neoplasms
Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation.
Neoplasms
Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.
Neoplasms
Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice.
Neoplasms
Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
Neoplasms
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy.
Neoplasms
High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.
Neoplasms
High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells.
Neoplasms
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy.
Neoplasms
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
Neoplasms
Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer.
Neoplasms
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
Neoplasms
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.
Neoplasms
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Neoplasms
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Neoplasms
Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer.
Neoplasms
Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma.
Neoplasms
Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas.
Neoplasms
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
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Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.
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Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy.
Neoplasms
Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors.
Neoplasms
Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).
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In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines.
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In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells.
Neoplasms
Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer.
Neoplasms
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival.
Neoplasms
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
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Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients.
Neoplasms
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
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Increased fatty acid synthase expression in prostate biopsy cores predicts higher Gleason score in radical prostatectomy specimen.
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Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function.
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Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
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Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors.
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Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
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Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1?/IGFBP1 pathway.
Neoplasms
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.
Neoplasms
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
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Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity.
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Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation.
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Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo.
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Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.
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Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells.
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Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
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Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Neoplasms
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Neoplasms
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells.
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Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.
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Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis.
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Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
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Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.
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Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase.
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Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells.
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Insulin signaling, inflammation, and lipolysis in subcutaneous adipose tissue of transition dairy cows either overfed energy during the prepartum period or fed a controlled-energy diet.
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Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.
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iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells.
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Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.
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Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
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L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-? Signaling Pathway.
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Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression.
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Lambda cyhalothrin toxicity induces alterations in lipogenic genes and inflammatory factors in rat liver.
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Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells.
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Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase.
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Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives.
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Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.
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Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases.
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Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma.
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Long-term effects of maternal magnesium restriction on adiposity and insulin resistance in rat pups.
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Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.
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Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model.
Neoplasms
LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro.
Neoplasms
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
Neoplasms
M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPAR?/? Activation in Tumor Myeloid Cells, Leading to Tumor Progression.
Neoplasms
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.
Neoplasms
Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning.
Neoplasms
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Neoplasms
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.
Neoplasms
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors.
Neoplasms
Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).
Neoplasms
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
Neoplasms
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
Neoplasms
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma.
Neoplasms
Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease.
Neoplasms
Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.
Neoplasms
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Neoplasms
Molecular dynamics simulation of Fe-NO2 At-alpha mangostin as radiopharmaceutical model for detection of fatty acid synthase in cancer.
Neoplasms
Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.
Neoplasms
Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.
Neoplasms
Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention.
Neoplasms
MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines.
Neoplasms
Mulberry Leaf Polyphenol Extract Induced Apoptosis Involving Regulation of Adenosine Monophosphate-Activated Protein Kinase/Fatty Acid Synthase in a p53-Negative Hepatocellular Carcinoma Cell.
Neoplasms
Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation.
Neoplasms
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Neoplasms
N-phenylmaleimides affect adipogenesis and present antitumor activity through reduction of FASN expression.
Neoplasms
NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition.
Neoplasms
Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: A review.
Neoplasms
Nelumbo nucifera Leaves Prevent NMU-Induced Mammary Tumor through Downregulation of Fatty Acid Synthase, Estrogen Receptor-? and Her2 Expression.
Neoplasms
Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis.
Neoplasms
NF-{kappa}B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase.
Neoplasms
Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice.
Neoplasms
Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells.
Neoplasms
Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.
Neoplasms
Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
Neoplasms
Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines.
Neoplasms
Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?
Neoplasms
Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.
Neoplasms
Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade.
Neoplasms
Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.
Neoplasms
Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells.
Neoplasms
Osajin displays potential antiprostate cancer efficacy via impairment of fatty acid synthase and androgen receptor expression.
Neoplasms
Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
Neoplasms
Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells.
Neoplasms
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Neoplasms
Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib.
Neoplasms
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Neoplasms
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.
Neoplasms
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Neoplasms
Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma.
Neoplasms
Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism.
Neoplasms
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.
Neoplasms
Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer.
Neoplasms
Peptides from purified soybean beta-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain.
Neoplasms
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Neoplasms
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Neoplasms
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Neoplasms
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Neoplasms
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Neoplasms
Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
Neoplasms
PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype.
Neoplasms
Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation.
Neoplasms
Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
Neoplasms
Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPAR? in 3T3-L1 Cells.
Neoplasms
Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats.
Neoplasms
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.
Neoplasms
Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.
Neoplasms
Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma.
Neoplasms
Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck.
Neoplasms
Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.
Neoplasms
Prolyl-isomerase Pin1 Impairs Trastuzumab Sensitivity by Up-regulating Fatty Acid Synthase Expression.
Neoplasms
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Neoplasms
Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat.
Neoplasms
Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways.
Neoplasms
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Neoplasms
Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells.
Neoplasms
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy.
Neoplasms
Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors.
Neoplasms
Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase.
Neoplasms
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.
Neoplasms
RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.
Neoplasms
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
Neoplasms
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.
Neoplasms
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.
Neoplasms
Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions.
Neoplasms
S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth.
Neoplasms
Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
Neoplasms
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Neoplasms
Short communication: Effect of heat stress during the dry period on gene expression in mammary tissue and peripheral blood mononuclear cells.
Neoplasms
Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging.
Neoplasms
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Neoplasms
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
Neoplasms
Sodium acetate, propionate, and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes.
Neoplasms
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.
Neoplasms
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Neoplasms
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Neoplasms
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Neoplasms
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia.
Neoplasms
Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway.
Neoplasms
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Neoplasms
Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats.
Neoplasms
Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression.
Neoplasms
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer.
Neoplasms
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
Neoplasms
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells.
Neoplasms
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
Neoplasms
The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma.
Neoplasms
The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model.
Neoplasms
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
Neoplasms
The expression of fatty acid metabolism-associated proteins is correlated with the prognosis of meningiomas.
Neoplasms
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
Neoplasms
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
Neoplasms
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
Neoplasms
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
Neoplasms
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Neoplasms
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Neoplasms
The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells.
Neoplasms
The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells.
Neoplasms
Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors.
Neoplasms
Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice.
Neoplasms
Therapeutic effects of the dipeptidyl peptidase-IV inhibitor, sitagliptin, on non-alcoholic steatohepatitis in FLS-ob/ob male mice.
Neoplasms
Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.
Neoplasms
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.
Neoplasms
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Neoplasms
Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.
Neoplasms
Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase.
Neoplasms
Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats.
Neoplasms
Untargeted mass spectrometry-based metabolomic profiling of pleural effusions: fatty acids as novel cancer biomarkers for malignant pleural effusions.
Neoplasms
Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition.
Neoplasms
Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.
Neoplasms
Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions.
Neoplasms
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Neoplasms
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
Neoplasms
[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
Neoplasms
[An experimental study on cerulenin induced apoptosis of human colonic cancer cells]
Neoplasms
[Clinical significance and expression of fatty acid synthase mRNA in lung cancer.]
Neoplasms, Germ Cell and Embryonal
Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.
Nephrotic Syndrome
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Neuroblastoma
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.
Neuroblastoma
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Neurofibrosarcoma
Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.
Nevus
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Nevus
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Nevus, Epithelioid and Spindle Cell
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Nevus, Pigmented
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Non-alcoholic Fatty Liver Disease
A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.
Non-alcoholic Fatty Liver Disease
A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis.
Non-alcoholic Fatty Liver Disease
Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats.
Non-alcoholic Fatty Liver Disease
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
Non-alcoholic Fatty Liver Disease
Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Non-alcoholic Fatty Liver Disease
Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C.
Non-alcoholic Fatty Liver Disease
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.
Non-alcoholic Fatty Liver Disease
Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Non-alcoholic Fatty Liver Disease
Expression of fatty acid synthase in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
Non-alcoholic Fatty Liver Disease
Fructose consumption as a risk factor for non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Non-alcoholic Fatty Liver Disease
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Non-alcoholic Fatty Liver Disease
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Non-alcoholic Fatty Liver Disease
Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids.
Non-alcoholic Fatty Liver Disease
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Non-alcoholic Fatty Liver Disease
Network analyses identify liver-specific targets for treating liver diseases.
Non-alcoholic Fatty Liver Disease
Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppar?).
Non-alcoholic Fatty Liver Disease
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Non-alcoholic Fatty Liver Disease
Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice.
Non-alcoholic Fatty Liver Disease
Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.
Non-alcoholic Fatty Liver Disease
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Non-alcoholic Fatty Liver Disease
Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats.
Non-alcoholic Fatty Liver Disease
Terminalia paniculata bark extract attenuates nonalcoholic fatty liver via down regulation of fatty acid synthase in high fat diet-fed obese rats.
Non-alcoholic Fatty Liver Disease
Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-? and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet.
Non-alcoholic Fatty Liver Disease
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Obesity
A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse.
Obesity
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.
Obesity
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Obesity
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.
Obesity
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice.
Obesity
Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.
Obesity
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Obesity
Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation.
Obesity
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.
Obesity
Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression.
Obesity
Epigenetic Mediators Between Childhood Socioeconomic Disadvantage and Mid-Life Body Mass Index: The New England Family Study.
Obesity
Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders.
Obesity
Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation.
Obesity
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
Obesity
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.
Obesity
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Obesity
Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
Obesity
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
Obesity
Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Obesity
Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.
Obesity
Hypolipidemic Activity of Peony Seed Oil Rich in ?-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid ?-Oxidation.
Obesity
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.
Obesity
Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro.
Obesity
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.
Obesity
Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Obesity
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Obesity
Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.
Obesity
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Obesity
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.
Obesity
Parasitic loranthus from Loranthaceae rather than Viscaceae potently inhibits fatty acid synthase and reduces body weight in mice.
Obesity
Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats.
Obesity
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Obesity
Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice.
Obesity
Relationship of polymorphisms within metabolic genes and carcass traits in crossbred beef cattle.
Obesity
Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.
Obesity
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Obesity
Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.
Obesity
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
Obesity
The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity.
Obesity
[Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat].
Optic Nerve Diseases
Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.
Osteosarcoma
Acetone immersion enhanced MALDI-MS imaging of small molecule metabolites in biological tissues.
Osteosarcoma
Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models.
Osteosarcoma
Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells.
Osteosarcoma
FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway.
Osteosarcoma
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Osteosarcoma
Gene expression analysis by cDNA microarray in oral cancers from two Western populations.
Osteosarcoma
Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro.
Osteosarcoma
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Osteosarcoma
Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells.
Osteosarcoma
iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells.
Osteosarcoma
microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN.
Osteosarcoma
MicroRNA-320 inhibits osteosarcoma cells proliferation by directly targeting fatty acid synthase.
Osteosarcoma
Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma.
Osteosarcoma
Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase.
Ovarian Neoplasms
Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.
Ovarian Neoplasms
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Ovarian Neoplasms
Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.
Ovarian Neoplasms
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
Ovarian Neoplasms
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Ovarian Neoplasms
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Ovarian Neoplasms
Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.
Ovarian Neoplasms
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival.
Ovarian Neoplasms
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Ovarian Neoplasms
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Ovarian Neoplasms
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells.
Overweight
Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling.
Overweight
Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans.
Overweight
Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats.
Overweight
Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.
Pancreatic Neoplasms
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
Pancreatic Neoplasms
De Novo Lipid Synthesis facilitates Gemcitabine Resistance Through Endoplasmic Reticulum Stress In Pancreatic Cancer.
Pancreatic Neoplasms
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.
Pancreatic Neoplasms
MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway.
Pancreatic Neoplasms
Orlistat Reduces Proliferation and Enhances Apoptosis in Human Pancreatic Cancer Cells (PANC-1).
Pancreatic Neoplasms
Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPK? and miR-33a levels to increase apoptosis in Panc-1 and MiaPaCa-2 cells.
Pancreatic Neoplasms
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers.
Pancreatic Neoplasms
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Pancreatic Neoplasms
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Pancreatic Neoplasms
Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.
Pancreatic Neoplasms
Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Publisher Correction: Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract.
Prostatic Neoplasms
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
Prostatic Neoplasms
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Prostatic Neoplasms
Analysis of androgen-induced increase in lipid accumulation in prostate cancer cells.
Prostatic Neoplasms
Androgens and the control of lipid metabolism in human prostate cancer cells.
Prostatic Neoplasms
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
Prostatic Neoplasms
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
Prostatic Neoplasms
Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis.
Prostatic Neoplasms
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Prostatic Neoplasms
Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression.
Prostatic Neoplasms
Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study.
Prostatic Neoplasms
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Prostatic Neoplasms
Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker.
Prostatic Neoplasms
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.
Prostatic Neoplasms
Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics.
Prostatic Neoplasms
Diet-induced alteration of fatty acid synthase in prostate cancer progression.
Prostatic Neoplasms
Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines.
Prostatic Neoplasms
Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.
Prostatic Neoplasms
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells.
Prostatic Neoplasms
Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [(11) C]acetate PET as a prognostic marker.
Prostatic Neoplasms
Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines.
Prostatic Neoplasms
Exploring a role for fatty acid synthase in prostate cancer cell migration.
Prostatic Neoplasms
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Prostatic Neoplasms
FABP5 coordinates lipid signaling that promotes prostate cancer metastasis.
Prostatic Neoplasms
FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer.
Prostatic Neoplasms
Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-?B Pathway.
Prostatic Neoplasms
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Prostatic Neoplasms
Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.
Prostatic Neoplasms
Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
Prostatic Neoplasms
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.
Prostatic Neoplasms
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Prostatic Neoplasms
Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
Prostatic Neoplasms
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
Prostatic Neoplasms
Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2.
Prostatic Neoplasms
Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer.
Prostatic Neoplasms
Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression.
Prostatic Neoplasms
Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model.
Prostatic Neoplasms
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
Prostatic Neoplasms
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.
Prostatic Neoplasms
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride.
Prostatic Neoplasms
Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells.
Prostatic Neoplasms
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Prostatic Neoplasms
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
Prostatic Neoplasms
KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells.
Prostatic Neoplasms
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases.
Prostatic Neoplasms
Macropinocytosis confers resistance to therapies targeting cancer anabolism.
Prostatic Neoplasms
Metabolic alterations and targeted therapies in prostate cancer.
Prostatic Neoplasms
Metabolic and molecular regulation of dietary polyunsaturated fatty acids on prostate cancer.
Prostatic Neoplasms
MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells.
Prostatic Neoplasms
Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention.
Prostatic Neoplasms
Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.
Prostatic Neoplasms
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.
Prostatic Neoplasms
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.
Prostatic Neoplasms
P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.
Prostatic Neoplasms
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Prostatic Neoplasms
Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues.
Prostatic Neoplasms
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
Prostatic Neoplasms
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.
Prostatic Neoplasms
Selective activation of the fatty acid synthesis pathway in human prostate cancer.
Prostatic Neoplasms
Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase.
Prostatic Neoplasms
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.
Prostatic Neoplasms
Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells.
Prostatic Neoplasms
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells.
Prostatic Neoplasms
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer.
Prostatic Neoplasms
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
Prostatic Neoplasms
Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
Prostatic Neoplasms
Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.
Prostatic Neoplasms
Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.
Prostatic Neoplasms
[Androgens and increased lipogenesis in prostate cancer. Cell biologic and clinical perspectives]
Proteinuria
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Proteinuria
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Proteinuria
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Psoriasis
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Pulmonary Arterial Hypertension
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism.
Pulmonary Disease, Chronic Obstructive
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Reperfusion Injury
Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation.
Retinitis Pigmentosa
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
Retinoblastoma
Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors.
Retinoblastoma
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Retinoblastoma
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells.
Retinoblastoma
Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.
Retinoblastoma
Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness.
Retinoblastoma
Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells.
Retinoblastoma
Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations.
Rhabdoid Tumor
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Sarcoma
Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas.
Sepsis
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.
Sepsis
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
Shock, Septic
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.
Spinal Cord Injuries
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Squamous Cell Carcinoma of Head and Neck
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
Squamous Cell Carcinoma of Head and Neck
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Squamous Cell Carcinoma of Head and Neck
FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1.
Squamous Cell Carcinoma of Head and Neck
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
Starvation
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
Starvation
Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.
Starvation
Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes.
Starvation
High carbohydrate diet and starvation regulate lipogenic mRNA in rats in a tissue-specific manner.
Starvation
Malic enzyme and fatty acid synthase in the uropygial gland and liver of embryonic and neonatal ducklings. Tissue-specific regulation of gene expression.
Starvation
The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats.
Starvation
The fatty acid synthase gene in avian liver. Two mRNAs are expressed and regulated in parallel by feeding, primarily at the level of transcription.
Starvation
Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae.
Starvation
Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect.
Stomach Neoplasms
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Stomach Neoplasms
Elevated levels of serum fatty acid synthase in patients with gastric carcinoma.
Stomach Neoplasms
Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer.
Stomach Neoplasms
Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.
Stomach Neoplasms
FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway.
Stomach Neoplasms
Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine.
Stomach Neoplasms
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Stomach Neoplasms
Identification of diagnostic markers involved in the pathogenesis of gastric cancer through iTRAQ-based quantitative proteomics.
Stomach Neoplasms
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
Stomach Neoplasms
Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer.
Stomach Neoplasms
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Stomach Neoplasms
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
Thymoma
A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation.
Thyroid Cancer, Papillary
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.
Thyroid Neoplasms
Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.
Triple Negative Breast Neoplasms
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
Triple Negative Breast Neoplasms
Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC.
Triple Negative Breast Neoplasms
MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study.
Triple Negative Breast Neoplasms
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b.
Triple Negative Breast Neoplasms
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer.
Trophoblastic Neoplasms
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93.
Tuberculosis
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
Tuberculosis
Characterization and site-directed mutagenesis of the putative novel acyl carrier protein Rv0033 and Rv1344 from Mycobacterium tuberculosis.
Tuberculosis
Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG.
Tuberculosis
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
Tuberculosis
Domain analysis of fatty acid synthase protein (NP_217040) from Mycobacterium tuberculosis H37Rv--a bioinformatics study.
Tuberculosis
Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.
Tuberculosis
Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA.
Tuberculosis
Modeling the Interactions of Herbal Drugs to beta-ketoacyl ACP Synthase of Mycobacterium tuberculosis H37Rv.
Tuberculosis
Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeast mct1Delta Cells.
Tuberculosis
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.
Tuberculosis
Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins.
Tuberculosis
Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG.
Tuberculosis
Purification and characterization of the Mycobacterium tuberculosis FabD2, a novel malonyl-CoA:AcpM transacylase of fatty acid synthase.
Tuberculosis
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
Tuberculosis
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
Tuberculosis
Rv3080c regulates the rate of inhibition of mycobacteria by isoniazid through FabD.
Tuberculosis
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Tuberculosis
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Tuberculosis
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Tuberculosis
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3?Å resolution.
Tuberculosis
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
Tuberculosis
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Urinary Bladder Neoplasms
Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis.
Urinary Bladder Neoplasms
Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer.
Urinary Bladder Neoplasms
Functional genetic variants in apoptosis-associated FAS and FASL genes and risk of bladder cancer in a Turkish population.
Urinary Bladder Neoplasms
Gallic acid inhibits bladder cancer cell proliferation and migration via regulating fatty acid synthase (FAS).
Urinary Bladder Neoplasms
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Urinary Bladder Neoplasms
[Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines].
Usher Syndromes
Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation.
Uterine Cervical Neoplasms
CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression.
Uterine Cervical Neoplasms
Integrated Analysis of a Competing Endogenous RNA Network Revealing a Prognostic Signature for Cervical Cancer.
Uterine Cervical Neoplasms
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Vaccinia
De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection.
Virus Diseases
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.
Virus Diseases
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Virus Diseases
Identification of fatty acid synthase from the Pacific white shrimp, Litopenaeus vannamei and its specific expression profiles during white spot syndrome virus infection.
Virus Diseases
Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
Virus Diseases
Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection.
Virus Diseases
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Virus Diseases
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Vitamin D Deficiency
Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice.
Wilms Tumor
Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor.
Wilms Tumor
Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study.
[acyl-carrier-protein] s-malonyltransferase deficiency
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.14
-
recombinant enzyme with recombinant human mitochondrial [acyl-carrier protein] lacking the first 68 amino acid residues
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria, and contains a mitochondrial targeting sequence
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
the key enzyme of mitochondrial fatty acid synthesis contributes to insulin resistance
malfunction
-
disease variants of the enzyme lead to a structurally unstable protein with significantly reduced intracellular expression
physiological function
-
the enzyme plays an essential role in mitochondrial function and maintenance of retinal ganglion cell axons
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FABD_HUMAN
390
0
42962
Swiss-Prot
Mitochondrion (Reliability: 2)
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
L81R/R212W
-
the mutation is responsible for autosomal recessive optic neuropathy
R606A
R606A
-
the mutation reduces the malonyl transacylase activity and, on the other hand, renders better transferase activity concerning the acetyl moiety
R606A
the mutation severely impairs the malonyl transfer reaction, while leading to a kinetic improvement of the transferase activity for acetyl-CoA
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, phylogenetic tree, expression as GFP-fusion protein containing the mitochondrial targeting sequence in mitochondria of HeLa cells, expression of truncated enzyme forms lacking the first 21 or 59 amino acid residues, respectively, in Escherichia coli strain BL21(DE3) as soluble enzymes, or in Spodoptera frugiperda Sf9 cells via baculovirus infection system
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme protein level is increased about 2.7fold in lymphocytes of umbilical cord blood from gestational diabetes mellitus patients compared with those in healthy pregnant women
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain
J. Biol. Chem.
280
12422-12429
2005
Homo sapiens
brenda
Paiva, P.; Sousa, S.; Ramos, M.; Fernandes, P.
Understanding the catalytic machinery and the reaction pathway of the malonyl-acetyl transferase domain of human fatty acid synthase
ACS Catal.
8
4860-4872
2018
Homo sapiens (P49327)
-
brenda
Paiva, P.; Sousa, S.; Fernandes, P.; Joao Ramos, M.
Human Fatty Acid Synthase A Computational study of the transfer of the acyl moieties from mat to the ACP domain
ChemCatChem
11
3853-3864
2019
Homo sapiens
-
brenda
Li, H.; Yuan, S.; Minegishi, Y.; Suga, A.; Yoshitake, K.; Sheng, X.; Ye, J.; Smith, S.; Bunkoczi, G.; Yamamoto, M.; Iwata, T.
Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy
Hum. Mol. Genet.
29
444-458
2020
Homo sapiens
brenda
Zhang, Y.; Ye, J.; Fan, J.
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia
Oncotarget
8
75254-75263
2017
Homo sapiens (Q8IVS2), Homo sapiens
brenda
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