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IUBMB CommentsIsolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.
The expected taxonomic range for this enzyme is: Erythroxylum coca
Synonyms
BAHD7, more
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benzoyl-CoA + ecgonine methyl ester = CoA + cocaine
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benzoyl-CoA:ecgonine methyl ester O-benzoyltransferase
Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.
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4-coumaryoyl-CoA + ecgonine methyl ester
CoA + ?
Substrates: 1% activity compared to benzoyl-CoA
Products: -
?
benzoyl-CoA + ecgonine methyl ester
CoA + cocaine
cinnamoyl-CoA + ecgonine methyl ester
CoA + cinnamoylcocaine
Substrates: 27% activity compared to benzoyl-CoA
Products: -
?
hexanoyl-CoA + ecgonine methyl ester
CoA + ?
Substrates: 19% activity compared to benzoyl-CoA
Products: -
?
additional information
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Substrates: no activity with tropine or nortropine
Products: -
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benzoyl-CoA + ecgonine methyl ester
CoA + cocaine
Substrates: -
Products: -
?
benzoyl-CoA + ecgonine methyl ester
CoA + cocaine
Substrates: 100% activity
Products: -
?
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benzoyl-CoA + ecgonine methyl ester
CoA + cocaine
Substrates: -
Products: -
?
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0.093
benzoyl-CoA
at pH 9.4 and 20°C
0.103
cinnamoyl-CoA
at pH 9.4 and 20°C
0.062 - 0.37
ecgonine methyl ester
0.062
ecgonine methyl ester
with cinnamoyl-CoA as sosubstrate, at pH 9.4 and 20°C
0.37
ecgonine methyl ester
with benzoyl-CoA as sosubstrate, at pH 9.4 and 20°C
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7.6
benzoyl-CoA
at pH 9.4 and 20°C
46
cinnamoyl-CoA
at pH 9.4 and 20°C
9.7 - 19
ecgonine methyl ester
9.7
ecgonine methyl ester
with benzoyl-CoA as sosubstrate, at pH 9.4 and 20°C
19
ecgonine methyl ester
with cinnamoyl-CoA as sosubstrate, at pH 9.4 and 20°C
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82
benzoyl-CoA
at pH 9.4 and 20°C
450
cinnamoyl-CoA
at pH 9.4 and 20°C
26 - 306
ecgonine methyl ester
26
ecgonine methyl ester
with benzoyl-CoA as sosubstrate, at pH 9.4 and 20°C
306
ecgonine methyl ester
with cinnamoyl-CoA as sosubstrate, at pH 9.4 and 20°C
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9.1 - 10.4
the enzyme activities are reduced to 39% and 44% of maximum activity at a pH of 9.1 or 10.4
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UniProt
brenda
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the enzyme activity is highest in young developing leaves, especially in the palisade parenchyma and spongy mesophyll
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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A0A059Q4T4_ERYCB
437
0
48753
TrEMBL
Secretory Pathway (Reliability: 1)
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monomer
1 * 43900, enzyme bound to StrepTAGII, SDS-PAGE
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expressed in Saccharomyces cerevisiae
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Schmidt, G.W.; Jirschitzka, J.; Porta, T.; Reichelt, M.; Luck, K.; Torre, J.C.; Dolke, F.; Varesio, E.; Hopfgartner, G.; Gershenzon, J.; D'Auria, J.C.
The last step in cocaine biosynthesis is catalyzed by a BAHD acyltransferase
Plant Physiol.
167
89-101
2015
Erythroxylum coca (A0A059Q4T4)
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brenda
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