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Information on EC 2.3.1.332 - medium-chain-alcohol O-fatty-acyltransferase

for references in articles please use BRENDA:EC2.3.1.332

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IUBMB Comments

The enzyme transfers an acyl group from an acyl-CoA to a medium-chain fatty alcohol, forming a wax ester. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants.The enzyme from the plant Petunia × hybrida prefers medium chain alcohols and saturated very long-chain acyl-CoAs. The human enzyme AWAT1 prefers decan-1-ol (C10) and has lower activity with C16, C18, and C20 alcohols. cf. EC 2.3.1.75, long-chain-alcohol O-fatty-acyltransferase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
hide
acyl-CoA
+
a medium-chain alcohol
=
CoA
+
a medium-chain alcohol wax ester
+
a medium-chain alcohol
=
+
a medium-chain alcohol wax ester

Synonyms
acyl-CoA wax alcohol acyltransferase, acyl-CoA:fatty acyl alcohol acyltransferase, ATF, AWAT 1, AWAT 2, DAcT, diacylglycerol acetyltransferase, KTR9_3844, Maqu_0168, MFAT, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + a medium-chain alcohol = CoA + a medium-chain alcohol wax ester
show the reaction diagram
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links