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Synonyms
serine acetyltransferase, sat-1, satase, hisat, serat, serine transacetylase, serine o-acetyltransferase, ehsat1, atsat1, l-serine o-acetyltransferase,
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acetyltransferase, serine
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cytosolic serine acetyltransferase
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L-serine acetyltransferase
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L-serine O-acetyltransferase
L-serineO-acetyltransferase
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plastidic serine acetyltransferase
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serine acetlytransferase
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serine acetyltransferase 1
serine acetyltransferase 2,1
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serine O-acetyltransferase
serine O-acetyltransferase 1
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serine transacetylase
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CysE
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DcsE
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EhSAT1
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L-serine O-acetyltransferase
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L-serine O-acetyltransferase
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L-serine O-acetyltransferase
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SAT
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SAT1
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SAT3
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SATase
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SERAT
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Serat1,1
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Serat2,1
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Serat2,2
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Serat3,1
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Serat3,2
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
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serine acetyltransferase
A0A3L6DLJ7
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serine acetyltransferase 1
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serine acetyltransferase 1
A0A3L6DLJ7
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serine O-acetyltransferase
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serine O-acetyltransferase
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serine O-acetyltransferase
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serine O-acetyltransferase
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Spn cysE
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SP_0589
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additional information
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serine acetyltransferase and O-acetylserine (thiol) lyase form the cysteine synthase complex, consisting of 2 of each enzymes as a tetramer
additional information
serine acetyltransferase and O-acetylserine (thiol) lyase form the cysteine synthase complex
additional information
serine acetyltransferase and O-acetylserine (thiol) lyase form the cysteine synthase complex
additional information
serine acetyltransferase and O-acetylserine (thiol) lyase form the cysteine synthase complex
additional information
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serine acetyltransferase and O-acetylserine (thiol) lyase form the cysteine synthase complex
additional information
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physical association of serine acetyltransferase with about 5% of the total cellular O-acetylserine sulfhydrylase to form a multienzyme complex given the trivial name cysteine synthethase
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
ping pong bi bi mechanism
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
steady-state random-order mechanism
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
a C-terminal hexapeptide-repeat domain is common for Arabidopsis thaliana isoforms and several other enzyme DNA sequences, it has a catalytic bifunctionality as serine acetyltransferase and in interaction with O-acetylserine (thiol) lyase and is involved in cysteine biosynthesis regulation, computational modeling
acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
binding motif for O-acetylserine (thiol) lyase is located within 10 amino acid residues at the C-terminal end
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
ordered kinetic mechanism with acetyl CoA bound prior to L-serine and O-acetyl-L-serine released prior to CoA. The rate-limiting step along the reaction pathway is the nucleophilic attack of the serine hydroxyl on the thioester of acetyl CoA. Product release contributes to rate-limitation at saturating concentrations of reactants. The reaction is catalyzed by an active site general base with a pK of 7, which accepts a proton from the serine hydroxyl as a tetrahedral intermediate is formed between the reactants, and donates it to the thiol of CoA as the intermediate collapses to give products
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
there is no conformational difference in the enzyme between the apo and the substrate-bound states, indicating lock and key binding and the absence of an induced fit mechanism
acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
there is no conformational difference in the enzyme between the apo and the substrate-bound states, indicating lock and key binding and the absence of an induced fit mechanism
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
ping pong bi bi mechanism
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acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
L-serine + acetyl-CoA
O-acetyl serine + CoA
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subsequently, cysteine synthase forms L-cysteine from O-acetyl serine
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
L-serine + acetyl-CoA
O-acetylserine + CoA
no major contribution to total cysteine biosynthesis
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propionyl-CoA + L-serine
CoA + O-propionyl-L-serine
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additional information
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
key enzyme in L-cysteine biosynthesis
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
rate-limiting step of cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
regulatory role in cysteine biosynthesis
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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the complex array of compartment-specific SATase isoforms with distinct enzymatic properties and expression patterns ensures the provision of Cys in response to revelopmental and environmental changes
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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cysteine biosynthesis in plants is partly regulated by the physical association of O-acetylserine sulfhydrylase and serine acetyltransferase. Thermodynamics of the interaction is analyzed
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
each serine acetyltransferase isoform seems to have its specific role for cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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simultaneous expression of serine acetyltransferase and cysteine synthase results in enhanced sulfate uptake and increased biomass in Ipomaea aquatica
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
O13389
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme is involved in cysteine biosynthesis. Increase in cysteine production confers enhanced resistance against osmotic stress in the osmosensitive yeast strain. Cysteine biosynthesis is a limiting factor in osmotic stress tolerance in yeast
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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dependent on L-serine and acetyl-CoA
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme activity is sensitive to feedback inhibition by L-cysteine. Enzyme synthesis is repressed by L-methionine. Corynebacterium glutamicum synthesizes L-cysteine from L-serine via O-acetyl-L-serine through the pathway involving L-serineO-acetyltransferase and O-acetyl-L-serine sulfhydrylase. The enzyme is regulated at both the transcriptional and posttranslational level
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
first step of L-cysteine synthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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L-serine acetylation is an equilibrium ordered mechanism
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme catalyzes the committed step in the de novo synthesis of L-cysteine. Serine acetyltransferase is regulated by feedback inhibition by the end product L-cysteine, which acts by binding to the serine site in the active site and inducing a conformational change that prevents reactant binding
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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serine acetyltransferase is a key enzyme in the sulfur assimilation pathway and forms a bienzyme complex with O-acetylserine sulfhydrylase, the last enzyme in the cysteine biosynthetic pathway. Serine acetyltransferase can inhibit O-acetylserine sulfhydrylase catalytic activity with a double mechanism, the competition with O-acetylserine for binding to the enzyme active site and the stabilization of a closed conformation that is less accessible to the natural substrate
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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specific for L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme in metabolic pathway of sulfur from sulfide to methionine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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specific for L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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r
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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r
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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equilibrium constant in direction of L-serine acetylation
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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r
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
equilibrium constant in direction of L-serine acetylation
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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-
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
A0A3L6DLJ7
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acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
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2.3.1.30 serine O-acetyltransferase
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