Reference on EC 2.3.1.297 - very-long-chain ceramide synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kremser, C.; Klemm, A.L.; van Uelft, M.; Imgrund, S.; Ginkel, C.; Hartmann, D.; Willecke, K.
Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues
Histochem. Cell Biol.
140
533-547
2013
Mus musculus (Q924Z4), Mus musculus, Mus musculus C57BL/6 (Q924Z4)
Erez-Roman, R.; Pienik, R.; Futerman, A.H.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression
Biochem. Biophys. Res. Commun.
391
219-223
2010
Homo sapiens (Q96G23), Homo sapiens
Mizutani, Y.; Kihara, A.; Igarashi, Y.
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
Biochem. J.
390
263-271
2005
Mus musculus (Q924Z4), Mus musculus (Q9D6J1), Mus musculus
Mizutani, Y.; Kihara, A.; Igarashi, Y.
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity
Biochem. J.
398
531-538
2006
Mus musculus (Q1A3B0), Mus musculus
Kageyama-Yahara, N.; Riezman, H.
Transmembrane topology of ceramide synthase in yeast
Biochem. J.
398
585-593
2006
Saccharomyces cerevisiae (P28496 AND P38703 AND Q03579), Saccharomyces cerevisiae RH382 (P28496 AND P38703 AND Q03579)
Luttgeharm, K.D.; Cahoon, E.B.; Markham, J.E.
Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis
Biochem. J.
473
593-603
2016
Arabidopsis thaliana (Q6NQI8), Arabidopsis thaliana (Q9LDF2)
Sribney, M.
Enzymatic synthesis of ceramide
Biochim. Biophys. Acta
125
542-547
1966
Cavia porcellus, Gallus gallus
Narimatsu, S.; Soeda, S.; Tanaka, T.; Kishimoto, Y.
Solubilization and partial characterization of fatty acyl-CoA sphingosine acyltransferase (ceramide synthetase) from rat liver and brain
Biochim. Biophys. Acta
877
334-341
1986
Rattus norvegicus
Mesicek, J.; Lee, H.; Feldman, T.; Jiang, X.; Skobeleva, A.; Berdyshev, E.V.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R.
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
Cell. Signal.
22
1300-1307
2010
Homo sapiens (Q96G23)
Vallee, B.; Riezman, H.
Lip1p a novel subunit of acyl-CoA ceramide synthase
EMBO J.
24
730-741
2005
Saccharomyces cerevisiae (P28496 AND P38703 AND Q03579), Saccharomyces cerevisiae RH4838 (P28496 AND P38703 AND Q03579)
Merrill, A.H.; van Echten, G.; Wang, E.; Sandhoff, K.
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
J. Biol. Chem.
268
27299-27306
1993
Mus musculus, Mus musculus NMRI
Laviad, E.L.; Albee, L.; Pankova-Kholmyansky, I.; Epstein, S.; Park, H.; Merrill, A.H.; Futerman, A.H.
Characterization of ceramide synthase 2 tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
J. Biol. Chem.
283
5677-5684
2008
Mus musculus (Q924Z4), Mus musculus C57BL/6 (Q924Z4)
Lahiri, S.; Park, H.; Laviad, E.L.; Lu, X.; Bittman, R.; Futerman, A.H.
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
J. Biol. Chem.
284
16090-16098
2009
Homo sapiens (Q96G23)
Berdyshev, E.V.; Gorshkova, I.; Skobeleva, A.; Bittman, R.; Lu, X.; Dudek, S.M.; Mirzapoiazova, T.; Garcia, J.G.; Natarajan, V.
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells
J. Biol. Chem.
284
5467-5477
2009
Homo sapiens
Pewzner-Jung, Y.; Brenner, O.; Braun, S.; Laviad, E.L.; Ben-Dor, S.; Feldmesser, E.; Horn-Saban, S.; Amann-Zalcenstein, D.; Raanan, C.; Berkutzki, T.; Erez-Roman, R.; Ben-David, O.; Levy, M.; Holzman, D.; Park, H.; Nyska, A.; Merrill, A.H.; Futerman, A.H.
A critical role for ceramide synthase 2 in liver homeostasis II. insights into molecular changes leading to hepatopathy
J. Biol. Chem.
285
10911-10923
2010
Mus musculus (Q924Z4), Mus musculus
Mullen, T.D.; Jenkins, R.W.; Clarke, C.J.; Bielawski, J.; Hannun, Y.A.; Obeid, L.M.
Ceramide synthase-dependent ceramide generation and programmed cell death involvement of salvage pathway in regulating postmitochondrial events
J. Biol. Chem.
286
15929-15942
2011
Homo sapiens (Q96G23)
Laviad, E.L.; Kelly, S.; Merrill, A.H.; Futerman, A.H.
Modulation of ceramide synthase activity via dimerization
J. Biol. Chem.
287
21025-21033
2012
Homo sapiens (Q96G23)
Ferreira, N.S.; Engelsby, H.; Neess, D.; Kelly, S.L.; Volpert, G.; Merrill, A.H.; Futerman, A.H.; Faergeman, N.J.
Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein
J. Biol. Chem.
292
7588-7597
2017
Mus musculus
Mizutani, Y.; Kihara, A.; Chiba, H.; Tojo, H.; Igarashi, Y.
2-Hydroxy-ceramide synthesis by ceramide synthase family enzymatic basis for the preference of FA chain length
J. Lipid Res.
49
2356-2364
2008
Homo sapiens (Q96G23), Homo sapiens (Q9HA82)
Couttas, T.A.; Lim, X.Y.; Don, A.S.
A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC
Lipids
50
101-109
2015
Homo sapiens (Q96G23)
Lim, X.Y.; Pickford, R.; Don, A.S.
Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry
Methods Mol. Biol.
1376
11-22
2016
Homo sapiens (Q96G23)
Park, W.J.; Brenner, O.; Kogot-Levin, A.; Saada, A.; Merrill, A.H.; Pewzner-Jung, Y.; Futerman, A.H.
Development of pheochromocytoma in ceramide synthase 2 null mice
Endocr. Relat. Cancer
22
623-632
2015
Mus musculus
Saroha, A.; Pewzner-Jung, Y.; Ferreira, N.S.; Sharma, P.; Jouan, Y.; Kelly, S.L.; Feldmesser, E.; Merrill, A.H.; Trottein, F.; Paget, C.; Lang, K.S.; Futerman, A.H.
Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis
Front. Immunol.
8
1386
2017
Mus musculus
Kim, Y.R.; Volpert, G.; Shin, K.O.; Kim, S.Y.; Shin, S.H.; Lee, Y.; Sung, S.H.; Lee, Y.M.; Ahn, J.H.; Pewzner-Jung, Y.; Park, W.J.; Futerman, A.H.; Park, J.W.
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability
J. Cell. Mol. Med.
21
3565-3578
2017
Mus musculus
Mikami, D.; Sakai, S.; Sasaki, S.; Igarashi, Y.
Effects of Asterias amurensis-derived sphingoid bases on the de novo ceramide synthesis in cultured normal human epidermal keratinocytes
J. Oleo Sci.
65
671-680
2016
Homo sapiens
Markham, J.E.; Molino, D.; Gissot, L.; Bellec, Y.; Hematy, K.; Marion, J.; Belcram, K.; Palauqui, J.C.; Satiat-Jeunemaitre, B.; Faure, J.D.
Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis
Plant Cell
23
2362-2378
2011
Arabidopsis thaliana
Xie, L.; Chen, Q.; Chen, M.; Yu, L.; Huang, L.; Chen, L.; Wang, F.; Xia, F.; Zhu, T.; Wu, J.; Yin, J.; Liao, B.; Shi, J.; Zhang, J.; Aharoni, A.; Yao, N.; Shu, W.; Xiao, S.
Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis
PLoS Genet.
11
e1005143
2015
Arabidopsis thaliana
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