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Disease on EC 2.3.1.297 - very-long-chain ceramide synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Albuminuria
A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND.
Chronic kidney disease: novel insights from genome-wide association studies.
Alzheimer Disease
Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease.
Asthma
Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells.
Breast Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype.
Alternative splicing of CERS2 promotes cell proliferation and migration in luminal B subtype breast cancer cells.
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.
[Expression of CERS2 in invasive breast cancer tissues and its clinical significance].
Carcinogenesis
Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-?1-Smad4-PAI-1 axis.
Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/?-catenin signaling.
Carcinoma
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
Repression of the miR-93-enhanced sensitivity of bladder carcinoma to chemotherapy involves the regulation of LASS2.
Carcinoma, Hepatocellular
Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.
Co-expression of LASS2 and TGF-?1 predicts poor prognosis in hepatocellular carcinoma.
Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
[LASS2 interacts with V-ATPase and inhibits cell growth of hepatocellular carcinoma]
Carcinoma, Squamous Cell
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Cardiovascular Diseases
A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND.
Chemical and Drug Induced Liver Injury
Protection of a Ceramide Synthase 2 Null Mouse from Drug-Induced Liver Injury: Role of Gap Junction Dysfunction and Connexin 32 Mislocalization.
Colitis
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.
Cystic Fibrosis
Ceramide and sphingosine in pulmonary infections.
Dementia
Astrocytic ceramide as possible indicator of neuroinflammation.
Dermatitis
IFN-? Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model.
Dermatitis, Exfoliative
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.
Diabetic Cardiomyopathies
Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.
Encephalomyelitis
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Endometrial Neoplasms
LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer.
Fatty Liver
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
CerS2 Haploinsufficiency Inhibits ?-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Frontotemporal Lobar Degeneration
Astrocytic ceramide as possible indicator of neuroinflammation.
Glucose Intolerance
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study.
Goiter, Nodular
Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer.
Hyperglycemia
Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration.
Ichthyosiform Erythroderma, Congenital
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Ichthyosis
Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes.
Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations.
Congenital ichthyosis in Prader-Willi syndrome associated with maternal chromosome 15 uniparental disomy: Case report and review of autosomal recessive conditions unmasked by UPD.
Identification of Mutations in SDR9C7 in 6 Families with Autosomal Recessive Congenital Ichthyosis.
Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.
Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.
Infections
Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.
Protection of a Ceramide Synthase 2 Null Mouse from Drug-Induced Liver Injury: Role of Gap Junction Dysfunction and Connexin 32 Mislocalization.
Inflammatory Bowel Diseases
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Insulin Resistance
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
CerS2 Haploinsufficiency Inhibits ?-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.
Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance.
Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.
Kidney Calculi
Genome-wide association studies in nephrology research.
Liver Diseases
Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance.
Liver Failure, Acute
Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization.
Lymphatic Metastasis
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer.
Meningioma
Decreased expression of LASS2 is associated with worse prognosis in meningiomas.
Metabolic Diseases
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study.
Multiple Sclerosis
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Myoclonic Epilepsies, Progressive
Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy.
Neoplasm Metastasis
C24 -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation.
Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers.
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.
miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2.
Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway.
Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer.
Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/?-catenin signaling.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
Neoplasms
A Pilot Study on the Potential of RNA-Associated to Urinary Vesicles as a Suitable Non-Invasive Source for Diagnostic Purposes in Bladder Cancer.
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization.
Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype.
C24 -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation.
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers.
Decreased expression of LASS2 is associated with worse prognosis in meningiomas.
Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy.
Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-?1-Smad4-PAI-1 axis.
Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer.
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.
Hsa-miR-3658 Promotes Cell Proliferation, Migration and Invasion by Effecting LASS2 in Bladder Cancer.
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
LASS2 regulates invasion and chemoresistance via ERK/Drp1 modulated mitochondrial dynamics in bladder cancer cells.
LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.
miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2.
Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway.
Repression of the miR-93-enhanced sensitivity of bladder carcinoma to chemotherapy involves the regulation of LASS2.
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.
Newcastle Disease
Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer.
Non-alcoholic Fatty Liver Disease
Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases.
Ovarian Neoplasms
Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.
High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.
Pheochromocytoma
Development of pheochromocytoma in ceramide synthase 2 null mice.
Pick Disease of the Brain
Astrocytic ceramide as possible indicator of neuroinflammation.
Prostatic Neoplasms
LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.
Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/?-catenin signaling.
Psoriasis
Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes.
Renal Insufficiency, Chronic
Genome-wide association studies in nephrology research.
Shock, Septic
LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNF?-converting enzyme.
sphingoid base n-stearoyltransferase deficiency
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
Thyroid Cancer, Papillary
Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer.
Urinary Bladder Neoplasms
Association of rs8444 polymorphism in the LASS2 3'-UTR and bladder cancer risk in Chinese population.
Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer.
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
Hsa-miR-3658 Promotes Cell Proliferation, Migration and Invasion by Effecting LASS2 in Bladder Cancer.
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
LASS2 regulates invasion and chemoresistance via ERK/Drp1 modulated mitochondrial dynamics in bladder cancer cells.
MicroRNA-20a Targeting LASS2 Promotes the Proliferation, Invasiveness and Migration of Bladder Cancer.
MicroRNA-98 promotes drug resistance and regulates mitochondrial dynamics by targeting LASS2 in bladder cancer cells.
miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2.
miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer.
The role of LASS2 in regulating bladder cancer cell tumorigenicity in a nude mouse model.
very-long-chain ceramide synthase deficiency
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.
Ceramide synthase 2 deletion decreases the infectivity of HIV-1.
Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance.
Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.