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Information on EC 2.3.1.295 - mycoketide-CoA synthase

for references in articles please use BRENDA:EC2.3.1.295

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IUBMB Comments

The enzyme, found in mycobacteria, is involved in the synthesis of beta-D-mannosyl phosphomycoketides. It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules. It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units. Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths.

The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Reaction Schemes
+
5
+
5
+
22
+
22
=
a mycoketide-CoA
+
10
+
10
+
22
+
11

Synonyms
pks12, polyketide synthase 12, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ = a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
show the reaction diagram
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-
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links