Reference on EC 2.3.1.294 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sridharan, S.; Wang, L.; Brown, A.K.; Dover, L.G.; Kremer, L.; Besra, G.S.; Sacchettini, J.C.
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)
J. Mol. Biol.
366
469-480
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Borgaro, J.; Chang, A.; MacHutta, C.; Zhang, X.; Tonge, P.
Substrate recognition by beta-ketoacyl-ACP synthases
Biochemistry
50
10678-10686
2011
Escherichia coli
Kremer, L.; Douglas, J.D.; Baulard, A.R.; Morehouse, C.; Guy, M.R.; Alland, D.; Dover, L.G.; Lakey, J.H.; Jacobs, W.R.; Brennan, P.J.; Minnikin, D.E.; Besra, G.S.
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
J. Biol. Chem.
275
16857-16864
2000
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Schaeffer, M.L.; Agnihotri, G.; Volker, C.; Kallender, H.; Brennan, P.J.; Lonsdale, J.T.
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB
J. Biol. Chem.
276
47029-47037
2001
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Molle, V.; Brown, A.; Besra, G.; Cozzone, A.; Kremer, L.
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation
J. Biol. Chem.
281
30094-30103
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Machutta, C.A.; Bommineni, G.R.; Luckner, S.R.; Kapilashrami, K.; Ruzsicska, B.; Simmerling, C.; Kisker, C.; Tonge, P.J.
Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin
J. Biol. Chem.
285
6161-6169
2010
Mycobacterium tuberculosis
Sridharan, S.; Wang, L.; Brown, A.; Dover, L.; Kremer, L.; Besra, G.; Sacchettini, J.
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)
J. Mol. Biol.
366
469-480
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Gao, L.Y.; Laval, F.; Lawson, E.H.; Groger, R.K.; Woodruff, A.; Morisaki, J.H.; Cox, J.S.; Daffe, M.; Brown, E.J.
Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival implications for therapy
Mol. Microbiol.
49
1547-1563
2003
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bhatt, A.; Molle, V.; Besra, G.; Jacobs Jr., W.; Kremer, L.
The Mycobacterium tuberculosis FAS-II condensing enzymes Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development
Mol. Microbiol.
64
1442-1454
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Vilcheze, C.; Molle, V.; Carrere-Kremer, S.; Leiba, J.; Mourey, L.; Shenai, S.; Baronian, G.; Tufariello, J.; Hartman, T.; Veyron-Churlet, R.; Trivelli, X.; Tiwari, S.; Weinrick, B.; Alland, D.; Guerardel, Y.; Jacobs Jr., W.; Kremer, L.
Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis
PLoS Pathog.
10
e1004115
2014
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bhatt, A.; Fujiwara, N.; Bhatt, K.; Gurcha, S.S.; Kremer, L.; Chen, B.; Chan, J.; Porcelli, S.A.; Kobayashi, K.; Besra, G.S.; Jacobs, W.R.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice
Proc. Natl. Acad. Sci. USA
104
5157-5162
2007
Mycobacterium tuberculosis
Slayden, R.; Barry III, C.
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
Tuberculosis
82
149-160
2002
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Schaeffer, M.L.; Carson, J.D.; Kallender, H.; Lonsdale, J.T.
Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis
Tuberculosis
84
353-360
2004
Mycobacterium tuberculosis
Yamada, H.; Bhatt, A.; Danev, R.; Fujiwara, N.; Maeda, S.; Mitarai, S.; Chikamatsu, K.; Aono, A.; Nitta, K.; Jacobs Jr., W.; Nagayama, K.
Non-acid-fastness in Mycobacterium tuberculosis DELTAkasB mutant correlates with the cell envelope electron density
Tuberculosis
92
351-357
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC1551
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