Disease on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase

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DISEASE
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Acidosis
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Acute Coronary Syndrome
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Acute Kidney Injury
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury.
Acute kidney injury: Sirtuin 3-a master regulator of mitochondrial integrity in AKI.
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation.
Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-?B signaling pathway.
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.
Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1.
Mitochondrial Sirtuin 3 and Renal Diseases.
Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice.
Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1.
Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury.
Renal protective effect of sirtuin 1.
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury.
SIRT1 and Kidney Function.
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury.
SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53.
SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury.
Sirtuin 3 in acute kidney injury.
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.
Acute Lung Injury
Acute down-regulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1.
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.
Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway.
Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1.
Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1.
Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression.
Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression.
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation.
Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation.
Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1.
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1.
Silencing angiopoietin-like protein 4 (ANGPTL4) protects against lipopolysaccharide-induced acute lung injury via regulating SIRT1 /NF-kB pathway.
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Suppression of NLRP3 and NF-?B signaling pathways by ?-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Adenocarcinoma
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer.
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta).
Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p.
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3.
RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
SIRT1 is significantly elevated in mouse and human prostate cancer.
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
Upregulation of SIRT1 gene in gastric adenocarcinoma.
Adenocarcinoma of Lung
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo.
Prognostic and Predictive Role of Sirtuin1 Expression in Lung Adenocarcinoma.
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma.
Sirt1 is a tumor promoter in lung adenocarcinoma.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
Adenoma
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
Adenoviridae Infections
SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Adrenoleukodystrophy
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.
Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration.
Albuminuria
Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.
Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria.
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy.
Reduction in podocyte SIRT1 accelerates kidney injury in aging mice.
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
SIRT1 and Kidney Function.
SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
Sirtuin and metabolic kidney disease.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Alzheimer Disease
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1.
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Amyloid-? Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease.
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.
Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples.
Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer's disease.
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease.
Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease.
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer's Disease.
Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells.
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.
Honokiol Alleviates Cognitive Deficits of Alzheimer's Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3.
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Intracerebroventricular injection of resveratrol ameliorated A?-induced learning and cognitive decline in mice.
miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease.
Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease.
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway.
Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1.
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients.
Potential of chromatin modifying compounds for the treatment of Alzheimer's disease.
Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease.
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling.
Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease.
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.
Resveratrol--a boon for treating Alzheimer's disease?
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1 and neuronal diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
SIRT1 as a therapeutic target for Alzheimer's disease.
SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion.
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice.
SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes.
Sirt1 in cerebral ischemia.
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.
Sirtuin 1 and Alzheimer's disease: An up-to-date review.
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-? Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease.
Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease.
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Sirtuins in cognitive ageing and Alzheimer's disease.
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
Small-molecule chromatin-modifying agents: therapeutic applications.
SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease.
Synthesis and Assay of SIRT1-Activating Compounds.
The Effects of SIRT1 on Alzheimer's Disease Models.
The emerging role of alternative splicing in senescence and aging.
The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy.
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.
The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.
The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer's Disease: A Meta-analysis.
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations.
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
[Neuroprotective role of silent information regulator 1 in Alzheimer's disease].
[SIRT1/PGC-1: a neuroprotective axis?]
[SIRT1].
Amyotrophic Lateral Sclerosis
Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis.
Reduced sirtuin 1/adenosine monophosphate-activated protein kinase in amyotrophic lateral sclerosis patient-derived mesenchymal stem cells can be restored by resveratrol.
Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Sirtuin deacetylases in neurodegenerative diseases of aging.
The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
[SIRT1].
Anaphylaxis
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Anemia, Aplastic
Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia.
Aneurysm, Dissecting
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Angiomyolipoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Anhedonia
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex.
SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model.
Aortic Aneurysm, Abdominal
Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms.
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.
Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation.
Aortic Valve Stenosis
Sirt1 inhibits resistin expression in aortic stenosis.
Apnea
[The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance].
Arteriosclerosis
[Sir2 gene]
Arthritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.
Seven sirtuins for seven deadly diseases of aging.
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Switching gears to an arthritis gene expression network by SirT1 cleavage.
TNF?-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes.
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Experimental
Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation.
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Gouty
Sirt1 inhibits gouty arthritis via activating PPAR?.
Arthritis, Rheumatoid
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.
A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis.
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.
Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis.
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis.
SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis.
SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-?B pathway.
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.
[Effect of Warm Needle Moxibustion Intervention on Knee-joint Swelling and Expression of Synovial SIRT 1 and NF-?B in Rats with Rheumatoid Arthritis].
Asthma
Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN.
Effects of SIRT1/Akt pathway on chronic inflammatory response and lung function in patients with asthma.
Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma?
Increases in peripheral SIRT1: a new biological characteristic of asthma.
miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1.
SIRT7 regulates the TGF-?1-induced proliferation and migration of mouse airway smooth muscle cells by modulating the expression of TGF-? receptor I.
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Sirtuin 2 enhances allergic asthmatic inflammation.
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
Astrocytoma
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND.
Ataxia
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
AsSIRTing the DNA damage response.
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
SIRT2 directs the replication stress response through CDK9 deacetylation.
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Atherosclerosis
A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population.
ApoE-/- PGC-1?-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis.
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Ca2+/calmodulin-dependent protein kinase kinase ? phosphorylation of Sirtuin 1 in endothelium is atheroprotective.
Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Does Metformin Protect Diabetic Patients from Oxidative Stress and Leukocyte-Endothelium Interactions?
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice.
Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy.
Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1.
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis.
Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling.
Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5.
Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction.
Methods to investigate the role of SIRT1 in endothelial senescence.
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.
MicroRNA?217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1.
miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide-induced vascular smooth muscle cells.
Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis.
mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications.
Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins.
Protective roles of SIRT1 in atherosclerosis.
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats.
Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men.
Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis.
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR.
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.
SIRT1 improves VSMC functions in atherosclerosis.
SIRT1 in cardiovascular aging.
SIRT1 inhibition promotes atherosclerosis through impaired autophagy.
SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy.
SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes.
SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells.
SIRT1 prevents atherosclerosis via liver?X?receptor and NF??B signaling in a U937 cell model.
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.
SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells.
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells.
SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis.
SIRT1: a novel target to prevent atherosclerosis.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT4 suppresses the PI3K/Akt/NF??B signaling pathway and attenuates HUVEC injury induced by oxLDL.
Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide.
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE?/? mice through inhibiting vascular inflammatory response.
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.
Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis.
[Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response].
Atrial Fibrillation
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery.
[Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation].
Autoimmune Diseases
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
sirt1-null mice develop an autoimmune-like condition.
Sirtuin 1 in immune regulation and autoimmunity.
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.
Three novel acetylation sites in the foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
TNF? Regulates SIRT1 Cleavage during Ocular Autoimmune Disease.
Bacteremia
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Bacterial Infections
A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Effects of Resveratrol on the Treatment of Inflammatory Response Induced by Severe Burn.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Barrett Esophagus
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
Blast Crisis
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib.
Bone Diseases
Overexpression of SIRT1 prevents hypoxia?induced apoptosis in osteoblast cells.
Bone Diseases, Metabolic
SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Bone Marrow Failure Disorders
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
Bone Neoplasms
SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission.
Bone Resorption
Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.
SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells.
Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.
Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.
Sirtuins and FoxOs in osteoporosis and osteoarthritis.
The Role of FoxOs in Bone Health and Disease.
Bowen's Disease
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Brain Diseases
Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders.
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Mitochondrial SIRT3 and neurodegenerative brain disorders.
Modulation of sirtuins: new targets for antiageing.
Brain Edema
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1? expression and protects mouse brain against focal ischemia.
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
PDGFR-? modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-?B pathway in subarachnoid hemorrhage rats.
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
Brain Infarction
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission.
Brain Injuries
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases.
Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria.
Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
The molecular mechanism of Sirt1 signaling pathway in brain injury of newborn rats exposed to hyperoxia.
Brain Injuries, Traumatic
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.
Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.
Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1.
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
Brain Ischemia
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
New role of silent information regulator 1 in cerebral ischemia.
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation.
Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation.
Resveratrol and ischemic preconditioning in the brain.
Resveratrol mimics ischemic preconditioning in the brain.
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1.
Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3? pathway.
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.
Sirt1 in cerebral ischemia.
Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.
SIRT1 regulation modulates stroke outcome.
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway.
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Brain Neoplasms
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Breast Neoplasms
4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization.
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation.
A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer.
A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1.
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer.
Altered sirtuin expression is associated with node-positive breast cancer.
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1.
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.
Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1.
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function.
BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Can Sir(2) regulate cancer?
CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Characterization of FOXO Acetylation.
Checkpoint suppressor 1 suppresses transcriptional activity of ER? and breast cancer cell proliferation via deacetylase SIRT1.
CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.
Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.
DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability.
DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Deacetylation of cortactin by SIRT1 promotes cell migration.
Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.
Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer.
Defining the Role of Histone Deacetylases in the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction (DER): Effects of Suberoylanilide Hydroxamic Acid (SAHA) and DER in a Rat Model.
Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness.
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.
Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer.
Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells.
Frizzled 7 expression is positively regulated by SIRT1 and ?-catenin in breast cancer cells.
HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer.
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.
High-throughput screening of Sirtuin family of genes in breast cancer.
Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.
hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.
I157172, a novel inhibitor of cystathionine ?-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells.
Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment.
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1.
MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53.
MicroRNA?3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.
miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway.
miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells.
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1.
MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype.
Molecular characterization, alternative splicing and expression analysis of bovine DBC1.
Negative regulation of the deacetylase SIRT1 by DBC1.
New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly.
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima.
Regulation of SIRT1 activity by genotoxic stress.
Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/?-catenin signaling pathway in breast cancer.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer.
SIRT1 in Secretory Organ Cancer.
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
SIRT1 promotes formation of breast cancer through modulating Akt activity.
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
SIRT1 Regulates Lysosome Function and Exosome Secretion.
SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer.
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
SIRT2: tumour suppressor or tumour promoter in operable breast cancer?
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization.
SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production.
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuin 3 interacts with Lon protease and regulates its acetylation status.
SOD1, an unexpected novel target for cancer therapy.
SRT1720 induces lysosomal-dependent cell death of breast cancer cells.
SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells.
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.
Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion.
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients.
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
[Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells]
Bronchopulmonary Dysplasia
Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia.
Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants.
[Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure].
Bulbo-Spinal Atrophy, X-Linked
Sirtuin deacetylases in neurodegenerative diseases of aging.
Burkitt Lymphoma
Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3? by increased SIRT3 expression.
Candidiasis
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Carcinogenesis
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
A Dual Role for Sirtuin 1 in Tumorigenesis.
A novel role of SIRT1 in gammaherpesvirus latency and replication.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.
Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells.
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
DBC1 is a negative regulator of SIRT1.
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.
Deacetylation of cortactin by SIRT1 promotes cell migration.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.
Diverse roles of SIRT1 in cancer biology and lipid metabolism.
Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer.
Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells.
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1.
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
Hepatotoxic Effects of Hexafluoropropylene Oxide Trimer Acid (HFPO-TA), A Novel Perfluorooctanoic Acid (PFOA) Alternative, on Mice.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Janus-faced role of SIRT1 in tumorigenesis.
Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis.
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Metabolic regulation by SIRT3: implications for tumorigenesis.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
miR-543 promotes gastric cancer cell proliferation by targeting SIRT1.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Multifaceted Modulation of SIRT1 in Cancer and Inflammation.
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Nicotinamide Phosphoribosyltransferase in Malignancy: A Review.
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
p30 DBC is a potential regulator of tumorigenesis.
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Publisher Correction: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
Research progress on SIRT1 and sepsis.
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Role of SIRT1 in homologous recombination.
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Sirt1 and cell migration.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 and p53, effect on cancer, senescence and beyond.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT1 and the clock gene machinery in colorectal cancer.
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
SIRT1 in B[a]P-induced lung tumorigenesis.
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.
Sirt1 is a tumor promoter in lung adenocarcinoma.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 is significantly elevated in mouse and human prostate cancer.
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
SIRT1 promotes metastasis of human osteosarcoma cells.
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SIRT1 regulates UV-induced DNA repair through deacetylating XPA.
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
SIRT1, is it a tumor promoter or tumor suppressor?
SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells.
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT1: Regulator of p53 Deacetylation.
SIRT1: roles in aging and cancer.
SIRT1: tumor promoter or tumor suppressor?
SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
Sirt2 Regulates Radiation-Induced Injury.
Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis.
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production.
Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT7 Is an RNA-Activated Protein Lysine Deacylase.
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-?B Signaling Pathway.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 1 in immune regulation and autoimmunity.
Sirtuin 1 in malignant transformation: Friend or foe?
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Sirtuin 3: A Janus face in cancer (Review).
Sirtuin activators and inhibitors.
Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer.
Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription.
Sorting out functions of sirtuins in cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.
The role of SIRT1 in tumorigenesis.
The Roles of SIRT1 in Cancer.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
[Mechanism of regulating deacetylase SIRT1 expression and activity.].
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Carcinoma
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Autophagy inhibition enhanced 5?FU?induced cell death in human gastric carcinoma BGC?823 cells.
Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas.
Expression and clinical significance of Sirt1 in colorectal cancer.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Function of the SIRT1 protein deacetylase in cancer.
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma.
Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma.
MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway.
Overexpression of SIRT1 in urothelial carcinoma of the urinary bladder is associated with local recurrence and poor survival.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
SIRT1 in Secretory Organ Cancer.
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
SIRT1 prevents hyperuricemia via the PGC-1?/PPAR?-ABCG2 pathway.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT1 regulates endothelial Notch signaling in lung cancer.
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Carcinoma, Basal Cell
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Carcinoma, Ductal
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
Carcinoma, Hepatocellular
?-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner.
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo.
Bioinformatics Prediction and Experimental Validation of MicroRNAs Involved in Cross-Kingdom Interaction.
Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth.
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.
Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism.
Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells.
Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes.
Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells.
Expression and role of SIRT1 in hepatocellular carcinoma.
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Increased SIRT3 Expression and Antioxidant Defense under Hyperglycemic Conditions in HepG2 Cells.
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions.
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1.
MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.
miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression.
MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma.
miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-?/SMAD signaling pathway.
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts.
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Prognostic role of SIRT1 in hepatocellular carcinoma.
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation.
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions.
SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma.
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells.
SIRT3 functions as a tumor suppressor in hepatocellular carcinoma.
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPK?/mTOR Axis.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway.
Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.
Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model.
Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1.
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC).
The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects.
The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
[Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and Sirt1 expression].
[Role of SIRT3 in regulating proliferation of hepatocellular carcinoma cells in vitro].
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Carcinoma, Lewis Lung
SIRT1 regulates endothelial Notch signaling in lung cancer.
Carcinoma, Non-Small-Cell Lung
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884].
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Carcinoma, Ovarian Epithelial
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer.
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Carcinoma, Papillary
Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Carcinoma, Renal Cell
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Carcinoma, Squamous Cell
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
Cardio-Renal Syndrome
SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome.
Cardiomegaly
1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level.
Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the {alpha}-myosin heavy chain expression.
Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.
ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.
Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox.
Mitochondrial SIRT3 and heart disease.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
PPAR?-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.
Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Roles of SIRT3 in heart failure: from bench to bedside.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy.
Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy.
Sirt1 regulates aging and resistance to oxidative stress in the heart.
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
SIRT3 in Cardiac Physiology and Disease.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3: A New Regulator of Cardiovascular Diseases.
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
Sirtuin 1 represses PKC-? activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging.
The role of sirtuins in cardiac disease.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts.
Cardiomyopathies
?-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1.
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.
SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.
Sirt1 regulates aging and resistance to oxidative stress in the heart.
SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.
Cardiomyopathy, Dilated
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
Cardiotoxicity
Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity.
Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts.
Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress.
Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2.
Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin.
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.
Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes.
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway.
Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway.
Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of Sirt1 and Mn-SOD pathway.
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites ?- and ?-zearalenol through an autophagy-dependent pathway.
SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Cardiovascular Diseases
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1.
ACTIVATION OF SIRT1 BY RESVERATROL INDUCES KLF2 EXPRESSION CONFERRING AN ENDOTHELIAL VASOPROTECTIVE PHENOTYPE.
Activators of Sirtuin-1 and their Involvement in Cardioprotection.
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Cardiovascular determinants of life span.
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis.
CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Distribution of the longevity gene product, SIRT1, in developing mouse organs.
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea.
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Emerging roles of SIRT1 in vascular endothelial homeostasis.
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells.
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway.
MicroRNA Regulation of SIRT1.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Renal protective effect of sirtuin 1.
Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1.
Role of sirtuins in kidney disease.
Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression.
Seven sirtuins for seven deadly diseases of aging.
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 and Kidney Function.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 in metabolic syndrome: Where to target matters.
Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT1: recent lessons from mouse models.
SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway.
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3 regulates progression and development of diseases of aging.
SIRT3: A New Regulator of Cardiovascular Diseases.
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuin activators: Designing molecules to extend life span.
Sirtuins and Insulin Resistance.
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems.
Targeting cardiovascular disease with novel SIRT1 pathways.
The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease.
The relationship of SIRT3 with cellular metabolism and cardiovascular diseases.
The role of sirtuins in cardiac disease.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Carotid Artery Diseases
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.
Carotid Artery Thrombosis
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Carotid Stenosis
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.
Cartilage Diseases
Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1.
Cataract
Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract.
Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans.
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.
Expression of SIRT1 and P53 in Rat Lens Epithelial cells in Experimentally Induced DM.
MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator.
miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts.
miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells.
Relationship between SIRT1 gene expression level and disease in age-related cataract cases
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Silent information regulator T1 in aqueous humor of patients with cataract.
SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis.
The role of SIRT1 in ocular aging.
Central Nervous System Diseases
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
Cerebral Hemorrhage
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Cerebral Infarction
[SIRT1].
Cerebrovascular Disorders
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Targeting cardiovascular disease with novel SIRT1 pathways.
Chagas Disease
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.
Chemical and Drug Induced Liver Injury
The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury.
Cholangiocarcinoma
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
Cholestasis
18?-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPAR?.
Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.
MITOCHONDRIAL BIOGENESIS FAILS IN SECONDARY BILIARY CIRRHOSIS IN RATS LEADING TO MITOCHONDRIAL DNA DEPLETION AND DELETIONS.
Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target.
Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis.
SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model.
[Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway].
Cholestasis, Extrahepatic
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Chondrosarcoma
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
Choroidal Neovascularization
Expression of sirt1 in choroidal neovascular membranes.
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?.
Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization.
SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.
Cockayne Syndrome
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Linking DNA damage, NAD(+)/SIRT1, and aging.
Colitis
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Bergenin, Acting as an Agonist of PPAR?, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-?B-Mediated Macrophage Activation.
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice.
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.
Reciprocal Regulation Between Smad7 and Sirt1 in the Gut.
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis.
Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling.
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
Sirtuin-1 in immunotherapy: A Janus-headed target.
Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1.
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells.
Colitis, Ulcerative
Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Colonic Neoplasms
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
HDACs and HDAC inhibitors in colon cancer.
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate.
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation.
MicroRNA Regulation of SIRT1.
miR-34a repression of SIRT1 regulates apoptosis.
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells.
Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer.
Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
Colorectal Neoplasms
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer.
Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells.
Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
ETHE1 overexpression promotes SIRT1 and PGC1? mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer.
Expression and clinical significance of Sirt1 in colorectal cancer.
Frameshift mutation of SIRT1 gene in gastric and colorectal carcinomas with microsatellite instability.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers.
Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells.
Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/?-catenin signaling pathway.
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.
MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1.
Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.
Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer.
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
SIRT1 and the clock gene machinery in colorectal cancer.
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
SIRT1 in Colorectal Cancer: A Friend or Foe?
SIRT1 in Secretory Organ Cancer.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
The pluripotency network in colorectal cancer pathogenesis and prognosis: an update.
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Congenital Abnormalities
Folate and fetal programming: a play in epigenomics?
Corneal Injuries
Sirt3 regulates mitophagy level to promote diabetic corneal epithelial wound healing.
Coronary Artery Disease
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1? and serum antioxidant enzymes in patients with coronary artery disease.
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.
Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes".
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up.
MicroRNA-34a regulates the longevity-associated protein, SIRT1, in coronary artery disease: Effect of statins on SIRT1 and microRNA-34a expression.
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease.
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
Coronary Disease
Targeting cardiovascular disease with novel SIRT1 pathways.
Coronary Thrombosis
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Coronavirus Infections
A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.
Cysts
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
SIRT1 and Kidney Function.
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Deafness
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Dementia
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.
Phytosterols and Dementia.
Seven sirtuins for seven deadly diseases of aging.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia.
[Sir2 gene]
Demyelinating Diseases
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Dermatitis, Phototoxic
The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study.
Desmoplastic Small Round Cell Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Diabetes Complications
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus.
SIRT1 as a therapeutic target in diabetic complications.
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetes Mellitus
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway.
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Phosphorylation regulates SIRT1 function.
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
SIRT1 and insulin resistance.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Sirtuins and Insulin Resistance.
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
The effect of hesperidin and quercetin on oxidative stress, NF-?B and SIRT1 levels in a STZ-induced experimental diabetes model.
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Diabetes Mellitus, Experimental
Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction.
Diabetes Mellitus, Type 1
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients.
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans.
Papers of note in Science Immunology2 (9).
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
SIRT1 activation attenuates ? cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice.
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
Diabetes Mellitus, Type 2
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
A Phase II, Randomized, Placebo-Controlled, Double-Blind, Multi-Dose Study of SRT2104, a SIRT1 Activator, in Subjects With Type 2 Diabetes.
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes.
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review.
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans.
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT.
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database.
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial.
Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.
Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis.
Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes.
PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Phosphorylation regulates SIRT1 function.
Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial.
Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation.
Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes.
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
SIRT1 and insulin resistance.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study.
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.
Sirtuin activators: Designing molecules to extend life span.
Sirtuin biology and relevance to diabetes treatment.
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
Sirtuins and Insulin Resistance.
Sirtuins in Vascular Diseases: Emerging Roles and Therapeutic Potential.
Sirtuins--novel therapeutic targets to treat age-associated diseases.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Targeting sirtuins for the treatment of diabetes.
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.
The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes.
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
The role of sirtuin proteins in obesity.
The Sirtuin family: therapeutic targets to treat diseases of aging.
The sirtuins: Markers of metabolic health.
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Diabetes, Gestational
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Diabetic Angiopathies
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Diabetic Cardiomyopathies
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions.
Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway.
An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy.
Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2.
LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy.
Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.
Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation.
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice.
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy.
Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes.
Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy.
The role of SIRT1 in diabetic cardiomyopathy.
Diabetic Foot
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetic Nephropathies
3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats.
AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.
Correlations between SIRT1 gene polymorphisms and diabetic kidney disease.
Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria.
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-?B p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt.
Epigenetic regulation through SIRT1 in podocytes.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy.
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
miR-133b and miR-199b knockdown attenuate TGF-?1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy.
Nephroprotective action of sirtuin 1 (SIRT1).
Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017.
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-?1 in rat glomerular messangial cells.
Renal protective effect of sirtuin 1.
Renal protective effects of resveratrol.
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Salidroside stimulates the Sirt1/PGC-1? axis and ameliorates diabetic nephropathy in mice.
Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.
Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat.
SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy.
SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy.
Sirtuin and metabolic kidney disease.
Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway.
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells.
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
The Role of SIRT1 in Diabetic Kidney Disease.
[The renal protective effect and mechanism of liraglutide in diabetic mice induced by high-fat diet].
[The role of SIRT1 in the treatment of diabetic nephropathy].
Diabetic Neuropathies
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Diabetic Retinopathy
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Deacetylation of MnSOD by PARP-regulated SIRT3 protects retinal capillary endothelial cells from hyperglycemia-induced damage.
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Feno?brate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway.
miR-195 regulates SIRT1-mediated changes in diabetic retinopathy.
Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy.
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1.
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.
Sirt1: A Guardian of the Development of Diabetic Retinopathy.
The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.
The role of SIRT1 in diabetic retinopathy.
Diphtheria
Intracellular Mono-ADP-Ribosylation in Signaling and Disease.
DNA Repair-Deficiency Disorders
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Dry Eye Syndromes
Expression of SIRT1 and oxidative stress in diabetic dry eye.
Dyslipidemias
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-? coactivator-1?.
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1? pathway.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
[Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat].
Encephalitis
Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia.
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Encephalomyelitis
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Encephalomyelitis, Autoimmune, Experimental
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Sirtuin-1 in immunotherapy: A Janus-headed target.
Endodermal Sinus Tumor
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
Endometrial Neoplasms
Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.
Endometriosis
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway.
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Endotoxemia
Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats.
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.
miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade.
Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression.
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
The Role of Sirt1 in Epileptogenesis.
Epiretinal Membrane
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Erectile Dysfunction
MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition.
SIRT1 as a therapeutic target in diabetic complications.
[Aging-related change of erectile function and the expression of SIRT1].
[Deacetylase SIRT1 and vascular endothelial function].
Esophageal Neoplasms
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer.
Esophageal Squamous Cell Carcinoma
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Essential Hypertension
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Eye Diseases
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Fanconi Anemia
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.
Fasciitis
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Fatty Liver
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Activation of the aryl hydrocarbon receptor sensitizes mice to non-alcoholic steatohepatitis by deactivating the mitochondrial sirtuin deacetylase Sirt3.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1month using the rat intragastric tube feeding model.
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin.
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
Emerging roles of SIRT1 in fatty liver diseases.
Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway.
Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice.
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
Foie gras and liver regeneration: a fat dilemma.
Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet.
Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation.
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/- Mice: A Role of Lipid Mobilization and Inflammation.
Lipids: Celastrol protects against fatty liver through SIRT1.
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose.
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7).
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
SIRT1: recent lessons from mouse models.
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuins and Insulin Resistance.
Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice.
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Fatty Liver, Alcoholic
2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy.
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.
Resveratrol alleviates alcoholic fatty liver in mice.
Sirtuin 1 signaling and alcoholic fatty liver disease.
The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Fetal Growth Retardation
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
Fibrosarcoma
Activation of SIRT1 protects pancreatic ?-cells against palmitate-induced dysfunction.
miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-?B factor in human fibrosarcoma cells.
Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells.
Fragile X Syndrome
Can Sir(2) regulate cancer?
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Sirtuin activators and inhibitors.
Friedreich Ataxia
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Frontotemporal Dementia
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Gallstones
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
Gastritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Gastrointestinal Diseases
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Gastrointestinal Neoplasms
Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Genetic Diseases, Inborn
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Glaucoma
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Sirtuins Expression and Their Role in Retinal Diseases.
The role of SIRT1 in ocular aging.
[SIRT1 promote GTM cell DSBs repair and resist cellular senescence].
Glaucoma, Open-Angle
The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma.
Glioblastoma
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells.
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1.
Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
[Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway].
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
[SIRT2, a multi-talented deacetylase].
Glioma
Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA.
Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100? secretion by regulating sirtuin 1 in C6 rat glioma cells.
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression.
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
Exendin-4 inhibits glioma cell migration, invasion and epithelial-to-mesenchymal transition through GLP-1R/sirt3 pathway.
FoxM1 regulates Sirt1 expression in glioma cells.
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a.
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes.
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1.
MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251.
miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1.
miR?34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage.
miRNA regulation of Sirtuin-1 expression in human astrocytoma.
Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study.
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation.
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
SIRT2 activity is required for the survival of C6 glioma cells.
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis.
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction.
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway.
Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.
Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas.
Glomerulonephritis
Resveratrol possesses protective effects in a pristane-induced lupus mouse model.
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Glomus Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Glucose Intolerance
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Intra-arterial Targeted Islet-specific Expression of Sirt1 Protects ? Cells From Streptozotocin-induced Apoptosis in Mice.
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.
Glucose Metabolism Disorders
Inhibition of silent information regulator 1 induces glucose metabolism disorders of hepatocytes and enhances hepatitis C virus replication.
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Glycogen Storage Disease
Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia.
Glycosuria
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Gout
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway.
Graft vs Host Disease
[SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].
Head and Neck Neoplasms
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
Hearing Loss
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis.
Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss.
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss.
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy.
SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
SIRT3 in calorie restriction: can you hear me now?
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice.
Hearing Loss, Noise-Induced
Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss.
The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss.
Hearing Loss, Sensorineural
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Heart Arrest
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Heart Diseases
1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes.
A sirtuin link between metabolism and heart disease.
Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3.
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway.
Mitochondrial SIRT3 and heart disease.
Protection of the heart against ischemia/reperfusion by silent information regulator 1.
Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT3: A New Regulator of Cardiovascular Diseases.
Sirtuin 1 Activation Reduces Transforming Growth Factor-?1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.
The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule.
The Roles of SIRT1 in Cancer.
Heart Failure
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation.
Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Downregulation of Sirt1 as aging change in advanced heart failure.
Emerging beneficial roles of sirtuins in heart failure.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential.
Non-histone lysine acetylated proteins in heart failure.
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure.
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure.
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy.
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Roles of SIRT3 in heart failure: from bench to bedside.
Silent information regulator, Sirtuin 1, and age-related diseases.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
SIRT3 in Cardiac Physiology and Disease.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.
Heart Neoplasms
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Heart Septal Defects, Ventricular
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Hemangiosarcoma
SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma.
Hematologic Neoplasms
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Role of SIRT1 in hematologic malignancies.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
SIRTUIN 1: regulating the regulator.
Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.
Hepatitis
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Hepatitis A
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Hepatitis B
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
The metabolic sensors FXR?, PGC-1?, and SIRT1 cooperatively regulate hepatitis B virus transcription.
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Hepatitis, Alcoholic
The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3.
Hepatoblastoma
Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3.
Herpes Zoster
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
HIV Infections
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.
Hodgkin Disease
Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting.
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.
Huntington Disease
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1? deacetylation.
An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.
Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Finding a sirtuin truth in Huntington's disease.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Modulation of sirtuins: new targets for antiageing.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Neuronal protection by sirtuins in Alzheimer's disease.
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease.
Resveratrol--a boon for treating Alzheimer's disease?
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
SIRT1 and neuronal diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
Sirt1 in cerebral ischemia.
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
Sirtuin deacetylases in neurodegenerative diseases of aging.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Hyperalgesia
Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1.
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib.
SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Hypercholesterolemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hyperglycemia
Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production.
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.
High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway.
Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Protective Role of SIRT1 in Diabetic Vascular Dysfunction.
Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells.
SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis.
The role of SIRT1 in diabetic cardiomyopathy.
Hyperhomocysteinemia
Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis.
Hyperinsulinism
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Hyperlipidemias
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster.
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
Hyperphosphatemia
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence].
Hypersensitivity
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-? activity in dendritic cells.
Hypertension
15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia.
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.
Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.
Fibroblast growth factor 21 protects the heart from angio