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Information on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase and Organism(s) Homo sapiens and UniProt Accession Q9NTG7
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EC Tree
2.3.1.286 protein acetyllysine N-acetyltransferaseIUBMB Comments
The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
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Word Map
- 2.3.1.286
-
deacetylation
- resveratrol
-
nad+-dependent
- nicotinamide
- deacetylases
- endothelial
-
longevity
- peroxisome
- cardiac
- tnf
- obesity
-
proliferator-activated
- cardiovascular
- dismutase
- neurodegenerative
- chromatin
-
neuroprotective
-
lifespan
- sirna
- myocardial
-
amp-activated
- fibrosis
- adipose
-
polyphenolic
-
high-fat
- cardiomyocytes
-
forkhead
-
calorie
- alzheimer
- hdacs
-
obese
- adipocytes
- sod2
- steatosis
- caspase-3
- nafld
-
cardioprotective
-
foxo3a
-
senescence-associated
-
aging-related
-
mir-34a
-
hyperacetylation
-
anti-aging
- nampt
- tfam
- mnsod
-
p-ampk
-
monophosphate-activated
- coactivator-1
-
non-histone
- medicine
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
sirt1, sirt3, sirtuin, sirt2, sirtuin 1, sirtuin 3, sir2p, silent information regulator 2, sir2alpha, nad-dependent histone deacetylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SIRT3
-
NAD+-dependent protein deacetylase
-
-
-
-
protein lysine deacetylase
-
-
-
-
Sir2
SIRT1
SIRT2
Sir2
-
-
-
-
SIRT1
Q96EB6
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
broad specificity with respect to chain length of the acyl chain
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SYSTEMATIC NAME
IUBMB Comments
[protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NAD+ + N2-benzyloxycarbonyl-N6-succinyl-L-lysine-7-amido-4-methylcoumarin
nicotinamide + N2-benzyloxycarbonyl-L-lysine-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP ribose
i.e. 3-[(5-[[(benzyloxy)carbonyl]amino]-5-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]pentyl)carbamoyl]-propanoic acid
-
-
?
NAD+ + QTAR(N6-acetyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
acetylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-palmitoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose
myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-succinyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
-
-
?
NAD+ + TRSG(N6-acetyl)KVMR
nicotinamide + TRSGKVMR + 2'-O-acetyl-ADP-ribose
peptide based on an acetyl-CoA synthetase 2 acetylation site
-
-
?
NAD+ + TRSG(N6-acetyl)KVMRRLLR
nicotinamide + TRSGKVMRRLLR + 2'-O-acetyl-ADP-ribose
Q96EB6, Q9NTG7
acetylated substrate peptide based on the sequence of acetyl-coenzyme A synthetase 2
-
-
?
NAD+ + [chicken erythrocyte histone]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP ribose
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine
nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
KSTGGK(Ac)APRKQ + beta-2'-deoxy-2'-fluororibo-NAD+ + H2O
?
-
the rates with beta-2'-deoxy-2'-fluororibo-NAD+ are about 1200fold slower than the exchange rates determined with NAD+ under similar conditions
-
-
?
KSTGGK(Ac)APRKQ + NAD+ + H2O
KSTGGKAPRKQ + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
an 11-mer histone H3 peptide
-
-
?
NAD+ + N2-benzyloxycarbonyl-N6-succinyl-L-lysine-7-amido-4-methylcoumarin
nicotinamide + N2-benzyloxycarbonyl-L-lysine-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP-ribose
i.e. 3-[(5-[[(benzyloxy)carbonyl]amino]-5-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]pentyl)carbamoyl]-propanoic acid
-
-
?
NAD+ + QTAR(N6-acetyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
acetylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-myristoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + TRSG(N6-acetyl)KVMRRLLR
nicotinamide + TRSGKVMRRLLR + 2'-O-acetyl-ADP-ribose
Q96EB6, Q9NTG7
acetylated substrate peptide based on the sequence of acetyl-coenzyme A synthetase 2
-
-
?
NAD+ + [alpha-tubulin peptide]-N6-acetyl-L-lysine
nicotinamide + [alpha-tubulin peptide]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acetyl-L-lysine40
nicotinamide + [alpha-tubulin]-L-lysine40 + 2'-O-acetyl-ADP ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [BHJH-TM1 protein]-N6-myristoyl-L-lysine
nicotinamide + [BHJH-TM1 protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine
nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
Fluor de Lys is a fluorogenic, acetylated peptide substrate for human sirtuin 1, based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases
-
-
?
NAD+ + [histone H2B]-N6-acetyl-L-lysine12
nicotinamide + [histone H2B]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H2B]-N6-myristoyl-L-lysine12
nicotinamide + [histone H2B]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
NAD+ + [histone H3]-N6-myristoyl-L-lysine9
nicotinamide + [histone H3]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
NAD+ + [histone H4]-N6-acetyl-L-lysine8
nicotinamide + [histone H4]-L-lysine8 + 2'-O-acetyl-ADP-ribose
deacetylated at high concentrations of enzyme
-
-
?
NAD+ + [histone H4]-N6-myristoyl-L-lysine16
nicotinamide + [histone H4]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [nuclear receptor LXRalpha]-N6-acetyl-L-lysine432
nicotinamide + [nuclear receptor LXRalpha]-L-lysine432 + 2'-O-acetyl-ADP ribose
Q96EB6
-
-
-
?
NAD+ + [nuclear receptor LXRbeta]-N6-acetyl-L-lysine433
nicotinamide + [nuclear receptor LXRbeta]-L-lysine433 + 2'-O-acetyl-ADP ribose
Q96EB6
-
-
-
?
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine
nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose
Q96EB6
SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [protein]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
NAD+ + [protein]-N6-myristoyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
demyristoylase activity of SIRT2 is 5fold more efficient than its deacetylase activity
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
[alpha-tubulin]-N6-acetyl-L-lysine40 + NAD+ + H2O
[alpha-tubulin]-L-lysine40 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-crotonyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-crotonyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
deacetylated at high concentrations of enzyme
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
strong preference for histone H4K16Ac in their deacetylation activity in vitro and in vivo
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
Q96EB6
-
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
Q96EB6
Sir2 is involved in the regulation of p53 function via deacetylation
-
-
?
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
deacetylation and stimulation of the thymine DNA glycosylase activity by SIRT1 enhances DNA demethylation
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
overall reaction
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
overall reaction
-
-
?
additional information
?
-
no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG
-
-
?
additional information
?
-
Q96EB6
no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG
-
-
?
additional information
?
-
no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG
-
-
?
additional information
?
-
Sirt3 has almost no activity against acetylated cytochrome c
-
-
?
additional information
?
-
-
Sirt3 has almost no activity against acetylated cytochrome c
-
-
?
additional information
?
-
no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG
-
-
?
additional information
?
-
Q96EB6
no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG
-
-
?
additional information
?
-
no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NAD+ + [chicken erythrocyte histone]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP ribose
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase
-
-
?
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine
nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin
-
-
?
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine
nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose
Q96EB6
SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
Q96EB6
Sir2 is involved in the regulation of p53 function via deacetylation
-
-
?
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
-
?
NAD+ + [protein]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
NAD+ + [protein]-N6-myristoyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
demyristoylase activity of SIRT2 is 5fold more efficient than its deacetylase activity
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
deacetylation and stimulation of the thymine DNA glycosylase activity by SIRT1 enhances DNA demethylation
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
overall reaction
-
-
?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
overall reaction
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Zn2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(5E)-5-(1H-indol-3-ylmethylidene)-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
17% inhibition at 0.05 mM
(5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
13% inhibition at 0.05 mM
(5E)-5-[4-(benzyloxy)benzylidene]-1-ethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
25% inhibition at 0.05 mM
(5E)-5-[4-(benzyloxy)benzylidene]-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
22% inhibition at 0.05 mM
(5E)-5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
41% inhibition at 0.05 mM
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
i.e. Ro 31-8220
5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
14% inhibition at 0.05 mM
5-(biphenyl-4-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[(1-benzyl-1H-indol-3-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[(6-methoxynaphthalen-1-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-(benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-(propan-2-yl)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
13% inhibition at 0.05 mM
5-[4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-[(4-bromobenzyl)oxy]benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
30% inhibition at 0.05 mM
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
i.e. EX-527
(4R)-1-(tert-butoxycarbonyl)-4-hydroxyprolyl-N-benzyl-N6-ethanethioyl-L-lysinamide
Q96EB6
0.05 mM, 83.4% inhibition
(4R)-1-(tert-butoxycarbonyl)-N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-4-hydroxyprolinamide
Q96EB6
0.05 mM, 97.1% inhibition
(4R)-4-hydroxyprolyl-N-benzyl-N6-ethanethioyl-L-lysinamide
Q96EB6
0.05 mM, 89.3% inhibition
(4R)-N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-4-hydroxyprolinamide
Q96EB6
0.05 mM, 96.8% inhibition
(5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
(5E)-5-[4-(benzyloxy)benzylidene]-1-ethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
(5E)-5-[4-(benzyloxy)benzylidene]-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
(5E)-5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
1-(tert-butoxycarbonyl)prolyl-N-benzyl-N6-ethanethioyl-L-lysinamide
Q96EB6
0.05 mM, 93.7% inhibition
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)isonicotinamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)isonicotinamide
selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
i.e. Ro 31-8220
3-((2-methoxynaphthalen-1-yl)methyl)-7-((2-methylbenzyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
i.e. ICL-SIRT078, a substrate-competitive SIRT2 inhibitor with more than 50fold selectivity against SIRT1, 3 and 5. Treatment of MCF-7 breast cancer cells with ICL-SIRT078 results in hyperacetylation of alpha-tubulin, an established SIRT2 biomarker, at doses comparable with the biochemical IC50 data, while suppressing MCF-7 proliferation at higher concentrations
3-((2-methoxynaphthalen-1-yl)methyl)-7-((thiophen-2-ylmethyl)-amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
3-((2-methoxynaphthalen-1-yl)methyl)-7-(neopentylamino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-chlorophenyl)benzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1, low inhibition of and SIRT3
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(5-chloropyridin-2-yl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3
3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-(4-chloro-2-fluorophenyl)-N-methylbenzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfinyl)phenyl)benzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1, low inhibition of and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfonyl)phenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-cyanopyridin-2-yl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-fluoropyridin-2-yl)benzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-chloropyridazin-3-yl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1
3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
4-bromo-N-(3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)phenyl)benzamide
selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-(biphenyl-4-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[(6-methoxynaphthalen-1-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-(benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-(propan-2-yl)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[4-[(4-bromobenzyl)oxy]benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
7-((3-fluorobenzyl)amino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
7-((3-methoxybenzyl)amino)-3-((2-methoxynaphthalen-1-yl)-methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
7-(benzylamino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
-
macrocyclic peptide inhibitor S2iL5
the inhibitor binds to the active site of SIRT2 through extensive interactions. The inhibitor induces an open-to-closed domain movement and a helix-to-coil transition in a SIRT2-specific region
-
meta-azi-propofol
only binds specifically and competitively to the enzyme when co-equilibrated with other substrates
methyl N2-(tert-butoxycarbonyl)-N6-ethanethioyl-L-lysyl-D-alaninate
Q96EB6
0.05 mM, 81.3% inhibition
N-(3-(N-(4-chlorophenyl)-N-methylsulfamoyl)phenyl)-4-cyanobenzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3
N-(4-acetylphenyl)-3-(N-(4-acetylphenyl)-N-methylsulfamoyl)benzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3
N-(4-bromo-2-fluorophenyl)-3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-methylbenzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3
N-(4-chlorophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
highly selective inhibitor for SIRT2, no inhibition of SIRT1 and SIRT3
N-(4-cyanophenyl)-3-(N-(4-(1-hydroxyethyl)phenyl)-N-methylsulfamoyl)benzamide
-
N-(4-cyanophenyl)-3-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
N-(4-cyanophenyl)-3-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1 and SIRT3
N-(4-cyanophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
highly selective inhibitor for SIRT2, low inhibition of SIRT1, no inhibition of and SIRT3
N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-5-oxoprolinamide
Q96EB6
0.05 mM, 98.2% inhibition
N-[(2S)-6-(ethanethioylamino)-1-[[2-(morpholin-4-yl)ethyl]amino]-1-oxohexan-2-yl]-6-oxoheptanamide
Q96EB6
0.05 mM, 61.1% inhibition
N2-(tert-butoxycarbonyl)-N6-ethanethioyl-N-[2-(4-methoxyphenyl)-2-oxoethyl]-L-lysinamide
Q96EB6
0.05 mM, 95.6% inhibition
N2-(tert-butoxycarbonyl)-N6-ethanethioyl-N-[2-(morpholin-4-yl)ethyl]-L-lysinamide
Q96EB6
0.05 mM, 37.5% inhibition
N2-[(benzyloxy)carbonyl]-N6-ethanethioyl-N-[2-(morpholin-4-yl)ethyl]-L-lysinamide
Q96EB6
0.05 mM, 54.9% inhibition
N6-ethanethioyl-N2-(6-oxoheptanoyl)-N-(2-oxo-2-phenylethyl)-L-lysinamide
Q96EB6
0.05 mM, 97.7% inhibition
propofol
only binds specifically and competitively to the enzyme when co-equilibrated with other substrates
nicotinamide
Q96EB6, Q9NTG7
mixed noncompetitive inhibitor. Inhibition of SIRT3 involves apparent competition between the inhibitor and the enzyme cofactor NAD+
(5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
(5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
10% inhibition at 0.05 mM
(5E)-5-(1H-indol-3-ylmethylidene)-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
(5E)-5-(1H-indol-3-ylmethylidene)-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
20% inhibition at 0.05 mM
5-[(1-benzyl-1H-indol-3-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
5-[(1-benzyl-1H-indol-3-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
20% inhibition at 0.05 mM
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
i.e. EX-527
additional information
no inhibition at 0.05 mM: (5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
additional information
Q96EB6
no inhibition at 0.05 mM: (5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
additional information
no inhibition at 0.05 mM: (5E)-1-ethyl-5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
additional information
no inhibition at 0.05 mM: (5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
additional information
Q96EB6
no inhibition at 0.05 mM: (5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
additional information
no inhibition at 0.05 mM: (5E)-5-[4-(benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Acquired Immunodeficiency Syndrome
New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.
Acquired Immunodeficiency Syndrome
p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc.
Acute Coronary Syndrome
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Acute Kidney Injury
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury.
Acute Kidney Injury
Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury.
Acute Kidney Injury
Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury).
Acute Kidney Injury
Acute kidney injury: Sirtuin 3-a master regulator of mitochondrial integrity in AKI.
Acute Kidney Injury
Calcitonin Gene-Related Peptide Attenuates LPS-Induced Acute Kidney Injury by Regulating Sirt1.
Acute Kidney Injury
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Acute Kidney Injury
Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation.
Acute Kidney Injury
Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-?B signaling pathway.
Acute Kidney Injury
Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats.
Acute Kidney Injury
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
Acute Kidney Injury
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.
Acute Kidney Injury
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Acute Kidney Injury
Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1.
Acute Kidney Injury
Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice.
Acute Kidney Injury
Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1.
Acute Kidney Injury
Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury.
Acute Kidney Injury
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Acute Kidney Injury
Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1.
Acute Kidney Injury
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Acute Kidney Injury
S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury.
Acute Kidney Injury
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.
Acute Kidney Injury
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
Acute Kidney Injury
SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury.
Acute Kidney Injury
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury.
Acute Kidney Injury
SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.
Acute Kidney Injury
SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53.
Acute Kidney Injury
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Acute Kidney Injury
SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.
Acute Kidney Injury
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
Acute Kidney Injury
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.
Acute Kidney Injury
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Acute Kidney Injury
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
Acute Kidney Injury
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.
Acute Kidney Injury
The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.
Acute Lung Injury
Acute down-regulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1.
Acute Lung Injury
Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-?B via activation of SIRT1 in mice.
Acute Lung Injury
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.
Acute Lung Injury
Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway.
Acute Lung Injury
Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1.
Acute Lung Injury
Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-?B pathway.
Acute Lung Injury
Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1.
Acute Lung Injury
GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1.
Acute Lung Injury
Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1.
Acute Lung Injury
Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression.
Acute Lung Injury
Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression.
Acute Lung Injury
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
Acute Lung Injury
MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury.
Acute Lung Injury
Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation.
Acute Lung Injury
Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis.
Acute Lung Injury
Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation.
Acute Lung Injury
Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction.
Acute Lung Injury
Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1.
Acute Lung Injury
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1.
Acute Lung Injury
Silencing angiopoietin-like protein 4 (ANGPTL4) protects against lipopolysaccharide-induced acute lung injury via regulating SIRT1 /NF-kB pathway.
Acute Lung Injury
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Acute Lung Injury
Suppression of NLRP3 and NF-?B signaling pathways by ?-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
Acute Lung Injury
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Adenocarcinoma
Cellular molecular and proteomic profiling deciphers the SIRT1 controlled cell death pathways in esophageal adenocarcinoma cells.
Adenocarcinoma
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Adenocarcinoma
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Adenocarcinoma
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
Adenocarcinoma
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Adenocarcinoma
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Adenocarcinoma
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Adenocarcinoma
Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer.
Adenocarcinoma
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta).
Adenocarcinoma
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Adenocarcinoma
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
Adenocarcinoma
MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3.
Adenocarcinoma
RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
Adenocarcinoma
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
Adenocarcinoma
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
Adenocarcinoma
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
Adenocarcinoma
[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].
Adenocarcinoma of Lung
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Adenocarcinoma of Lung
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Adenocarcinoma of Lung
Expression and role of lncRNAs in the regeneration of skeletal muscle following contusion injury.
Adenocarcinoma of Lung
Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.
Adenocarcinoma of Lung
Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo.
Adenocarcinoma of Lung
Prognostic and Predictive Role of Sirtuin1 Expression in Lung Adenocarcinoma.
Adenocarcinoma of Lung
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma.
Adenocarcinoma of Lung
Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma.
Adenoma
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas.
Adenoma
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
Adenoma
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
Adenoviridae Infections
SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
Adenoviridae Infections
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Adrenoleukodystrophy
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.
Adrenoleukodystrophy
Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration.
Albuminuria
Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.
Albuminuria
Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension.
Albuminuria
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Albuminuria
Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.
Albuminuria
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Albuminuria
SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
Albuminuria
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Alzheimer Disease
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
Alzheimer Disease
A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1.
Alzheimer Disease
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Alzheimer Disease
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Alzheimer Disease
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Alzheimer Disease
Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.
Alzheimer Disease
Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples.
Alzheimer Disease
Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer's disease.
Alzheimer Disease
Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up-regulating SIRT1.
Alzheimer Disease
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease.
Alzheimer Disease
Correlation Between SIRT2 3'UTR Gene Polymorphism and the Susceptibility to Alzheimer's Disease.
Alzheimer Disease
Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease.
Alzheimer Disease
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer's Disease.
Alzheimer Disease
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
Alzheimer Disease
Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells.
Alzheimer Disease
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Alzheimer Disease
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Alzheimer Disease
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Alzheimer Disease
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.
Alzheimer Disease
Honokiol Alleviates Cognitive Deficits of Alzheimer's Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3.
Alzheimer Disease
Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting A? cascade pathogenesis.
Alzheimer Disease
Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease.
Alzheimer Disease
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Alzheimer Disease
Intracerebroventricular injection of resveratrol ameliorated A?-induced learning and cognitive decline in mice.
Alzheimer Disease
miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease.
Alzheimer Disease
Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Alzheimer Disease
Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway.
Alzheimer Disease
Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer's Disease.
Alzheimer Disease
Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1.
Alzheimer Disease
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
Alzheimer Disease
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
Alzheimer Disease
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.
Alzheimer Disease
Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients.
Alzheimer Disease
Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer's disease.
Alzheimer Disease
Potential of chromatin modifying compounds for the treatment of Alzheimer's disease.
Alzheimer Disease
Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease.
Alzheimer Disease
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling.
Alzheimer Disease
Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease.
Alzheimer Disease
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.
Alzheimer Disease
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Alzheimer Disease
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Alzheimer Disease
RTN4B-mediated suppression of Sirtuin 2 activity ameliorates ?-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model.
Alzheimer Disease
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
Alzheimer Disease
SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview.
Alzheimer Disease
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Alzheimer Disease
SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion.
Alzheimer Disease
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice.
Alzheimer Disease
SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes.
Alzheimer Disease
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.
Alzheimer Disease
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.
Alzheimer Disease
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Alzheimer Disease
SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.
Alzheimer Disease
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.
Alzheimer Disease
SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
Alzheimer Disease
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Alzheimer Disease
Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-? Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.
Alzheimer Disease
Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer's Disease Patients: A Bioinformatic and Data Mining Approach.
Alzheimer Disease
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Alzheimer Disease
Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease.
Alzheimer Disease
Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease.
Alzheimer Disease
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Alzheimer Disease
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Alzheimer Disease
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
Alzheimer Disease
SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease.
Alzheimer Disease
The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of ?7 nicotinic acetylcholine receptors.
Alzheimer Disease
The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease.
Alzheimer Disease
The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer's Disease.
Alzheimer Disease
The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy.
Alzheimer Disease
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
Alzheimer Disease
The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.
Alzheimer Disease
The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.
Alzheimer Disease
The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer's Disease: A Meta-analysis.
Alzheimer Disease
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations.
Alzheimer Disease
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
Alzheimer Disease
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Alzheimer Disease
[Neuroprotective role of silent information regulator 1 in Alzheimer's disease].
Alzheimer Disease
[Sirt3 gene knockout protects mice from Alzheimer's disease through activating autophagy].
Amyotrophic Lateral Sclerosis
Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?.
Amyotrophic Lateral Sclerosis
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Amyotrophic Lateral Sclerosis
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Amyotrophic Lateral Sclerosis
Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis.
Amyotrophic Lateral Sclerosis
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Reduced sirtuin 1/adenosine monophosphate-activated protein kinase in amyotrophic lateral sclerosis patient-derived mesenchymal stem cells can be restored by resveratrol.
Amyotrophic Lateral Sclerosis
Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Amyotrophic Lateral Sclerosis
Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.
Amyotrophic Lateral Sclerosis
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.
Amyotrophic Lateral Sclerosis
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Amyotrophic Lateral Sclerosis
The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk.
Amyotrophic Lateral Sclerosis
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Anaphylaxis
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Aneurysm
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
Aneurysm, Dissecting
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
Aneurysm, Dissecting
SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation.
Aneurysm, Dissecting
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
Aneurysm, Dissecting
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Angiomyolipoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Anhedonia
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex.
Anhedonia
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Anosmia
Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions.
Aortic Aneurysm, Abdominal
Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms.
Aortic Aneurysm, Abdominal
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.
Aortic Aneurysm, Abdominal
Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation.
Aortic Valve Stenosis
Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis.
Apnea
[The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance].
Arteritis
An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation.
Arthritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Arthritis
Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis.
Arthritis
Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis.
Arthritis
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Arthritis
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Arthritis
TNF?-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes.
Arthritis
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Experimental
Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation.
Arthritis, Experimental
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Arthritis, Experimental
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
Arthritis, Experimental
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Arthritis, Experimental
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Rheumatoid
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.
Arthritis, Rheumatoid
A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis.
Arthritis, Rheumatoid
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Arthritis, Rheumatoid
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.
Arthritis, Rheumatoid
Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Arthritis, Rheumatoid
Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis.
Arthritis, Rheumatoid
MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3.
Arthritis, Rheumatoid
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Arthritis, Rheumatoid
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.
Arthritis, Rheumatoid
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Arthritis, Rheumatoid
Retraction: Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis.
Arthritis, Rheumatoid
Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis.
Arthritis, Rheumatoid
SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-?B pathway.
Arthritis, Rheumatoid
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
Arthritis, Rheumatoid
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
Arthritis, Rheumatoid
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
Arthritis, Rheumatoid
[Effect of Warm Needle Moxibustion Intervention on Knee-joint Swelling and Expression of Synovial SIRT 1 and NF-?B in Rats with Rheumatoid Arthritis].
Asthma
Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN.
Asthma
Bergenin-activated SIRT1 inhibits TNF-?-induced proinflammatory response by blocking the NF-?B signaling pathway.
Asthma
Effects of SIRT1/Akt pathway on chronic inflammatory response and lung function in patients with asthma.
Asthma
Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma?
Asthma
miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1.
Asthma
Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.
Asthma
SIRT7 regulates the TGF-?1-induced proliferation and migration of mouse airway smooth muscle cells by modulating the expression of TGF-? receptor I.
Asthma
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Asthma
Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?
Asthma
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.
Asthma
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
Astrocytoma
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND.
Ataxia
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Ataxia
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Ataxia
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Ataxia Telangiectasia
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
Ataxia Telangiectasia
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Ataxia Telangiectasia
SIRT2 directs the replication stress response through CDK9 deacetylation.
Ataxia Telangiectasia
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Ataxia Telangiectasia
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Atherosclerosis
A Paradigm Shift in the Management of Atherosclerosis: Protective Role of Sirtuins in Atherosclerosis.
Atherosclerosis
A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population.
Atherosclerosis
Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals.
Atherosclerosis
Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis.
Atherosclerosis
ApoE-/- PGC-1?-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis.
Atherosclerosis
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Atherosclerosis
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages.
Atherosclerosis
Ca2+/calmodulin-dependent protein kinase kinase ? phosphorylation of Sirtuin 1 in endothelium is atheroprotective.
Atherosclerosis
Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation.
Atherosclerosis
Correlation between endothelial cell apoptosis and SIRT3 gene expression in atherosclerosis rats.
Atherosclerosis
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Atherosclerosis
Does Metformin Protect Diabetic Patients from Oxidative Stress and Leukocyte-Endothelium Interactions?
Atherosclerosis
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Atherosclerosis
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial.
Atherosclerosis
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Atherosclerosis
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy.
Atherosclerosis
Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1.
Atherosclerosis
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis.
Atherosclerosis
Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling.
Atherosclerosis
Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells.
Atherosclerosis
Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis.
Atherosclerosis
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Atherosclerosis
Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5.
Atherosclerosis
Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction.
Atherosclerosis
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.
Atherosclerosis
MicroRNA?217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1.
Atherosclerosis
MiR-132 relieves vascular endothelial inflammation and improve endothelial function in atherosclerosis rats by regulating SIRT1.
Atherosclerosis
miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide-induced vascular smooth muscle cells.
Atherosclerosis
Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis.
Atherosclerosis
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.
Atherosclerosis
mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.
Atherosclerosis
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
Atherosclerosis
Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications.
Atherosclerosis
Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins.
Atherosclerosis
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Atherosclerosis
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats.
Atherosclerosis
Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men.
Atherosclerosis
Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis.
Atherosclerosis
Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis.
Atherosclerosis
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
Atherosclerosis
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Atherosclerosis
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
Atherosclerosis
SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy.
Atherosclerosis
SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes.
Atherosclerosis
SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells.
Atherosclerosis
SIRT1 prevents atherosclerosis via liver?X?receptor and NF??B signaling in a U937 cell model.
Atherosclerosis
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.
Atherosclerosis
SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells.
Atherosclerosis
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
Atherosclerosis
SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells.
Atherosclerosis
SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis.
Atherosclerosis
SIRT4 suppresses the PI3K/Akt/NF??B signaling pathway and attenuates HUVEC injury induced by oxLDL.
Atherosclerosis
Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide.
Atherosclerosis
Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease.
Atherosclerosis
The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1.
Atherosclerosis
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.
Atherosclerosis
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.
Atherosclerosis
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE?/? mice through inhibiting vascular inflammatory response.
Atherosclerosis
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Atherosclerosis
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
Atherosclerosis
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Atherosclerosis
Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.
Atherosclerosis
Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis.
Atherosclerosis
[Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response].
Atrial Fibrillation
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Atrial Fibrillation
Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery.
Atrial Fibrillation
Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3.
Atrial Fibrillation
[Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation].
Autoimmune Diseases
Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease.
Autoimmune Diseases
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Autoimmune Diseases
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Autoimmune Diseases
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
Autoimmune Diseases
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
Autoimmune Diseases
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.
Autoimmune Diseases
Three novel acetylation sites in the foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
Azoospermia
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Bacteremia
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Bacterial Infections
A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.
Bacterial Infections
Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins.
Bacterial Infections
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Bacterial Infections
Effects of Resveratrol on the Treatment of Inflammatory Response Induced by Severe Burn.
Bacterial Infections
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Barrett Esophagus
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
Bicuspid Aortic Valve Disease
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.
Blast Crisis
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib.
Bone Diseases
Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration.
Bone Diseases
Overexpression of SIRT1 prevents hypoxia?induced apoptosis in osteoblast cells.
Bone Diseases, Metabolic
SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.
Bone Diseases, Metabolic
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Bone Marrow Failure Disorders
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
Bone Neoplasms
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission.
Bone Resorption
Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.
Bone Resorption
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Bone Resorption
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
Bone Resorption
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency.
Bone Resorption
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Bone Resorption
Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.
Bone Resorption
SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells.
Bone Resorption
SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency.
Bone Resorption
Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.
Bowen's Disease
Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report.
Bowen's Disease
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Brain Diseases
Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders.
Brain Diseases
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Brain Edema
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1? expression and protects mouse brain against focal ischemia.
Brain Edema
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
Brain Edema
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
Brain Edema
PDGFR-? modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-?B pathway in subarachnoid hemorrhage rats.
Brain Edema
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
Brain Edema
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Brain Edema
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
Brain Edema
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Brain Edema
The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.
Brain Edema
Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats.
Brain Infarction
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission.
Brain Injuries
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
Brain Injuries
c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression.
Brain Injuries
Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.
Brain Injuries
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Brain Injuries
Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway.
Brain Injuries
Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway.
Brain Injuries
Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3.
Brain Injuries
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
Brain Injuries
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo.
Brain Injuries
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Brain Injuries
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Brain Injuries
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Brain Injuries
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Brain Injuries
NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases.
Brain Injuries
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.
Brain Injuries
Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria.
Brain Injuries
Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.
Brain Injuries
Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1.
Brain Injuries
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
Brain Injuries
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
Brain Injuries
SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.
Brain Injuries
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
Brain Injuries
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Brain Injuries
Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons.
Brain Injuries
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Brain Injuries
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
Brain Injuries
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Brain Injuries
SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
Brain Injuries
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Brain Injuries
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Brain Injuries
The molecular mechanism of Sirt1 signaling pathway in brain injury of newborn rats exposed to hyperoxia.
Brain Injuries
The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation.
Brain Injuries
Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?
Brain Injuries, Traumatic
Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury.
Brain Injuries, Traumatic
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.
Brain Injuries, Traumatic
Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.
Brain Injuries, Traumatic
Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1.
Brain Injuries, Traumatic
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
Brain Injuries, Traumatic
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.
Brain Injuries, Traumatic
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
Brain Injuries, Traumatic
SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury.
Brain Injuries, Traumatic
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury.
Brain Injuries, Traumatic
Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.
Brain Injuries, Traumatic
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
Brain Ischemia
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Brain Ischemia
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Brain Ischemia
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Brain Ischemia
Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats.
Brain Ischemia
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Brain Ischemia
Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway.
Brain Ischemia
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Brain Ischemia
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Brain Ischemia
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Brain Ischemia
Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Brain Ischemia
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation.
Brain Ischemia
Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation.
Brain Ischemia
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
Brain Ischemia
Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1.
Brain Ischemia
Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage.
Brain Ischemia
Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3? pathway.
Brain Ischemia
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
Brain Ischemia
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Brain Ischemia
SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
Brain Ischemia
Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.
Brain Ischemia
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway.
Brain Ischemia
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Brain Ischemia
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Brain Ischemia
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.
Brain Ischemia
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Brain Ischemia
The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation.
Brain Ischemia
[Acute cerebral ischemia-induced down-regulation of Sirt3 protein expression contributes to neuronal injury via damaging mitochondrial function].
Brain Neoplasms
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
Brain Neoplasms
FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
Brain Neoplasms
Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours.
Brain Neoplasms
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Brain Neoplasms
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
Breast Neoplasms
4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization.
Breast Neoplasms
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation.
Breast Neoplasms
A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Breast Neoplasms
A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer.
Breast Neoplasms
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Breast Neoplasms
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
Breast Neoplasms
Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer.
Breast Neoplasms
Altered sirtuin expression is associated with node-positive breast cancer.
Breast Neoplasms
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Breast Neoplasms
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1.
Breast Neoplasms
Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.
Breast Neoplasms
Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1.
Breast Neoplasms
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function.
Breast Neoplasms
BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.
Breast Neoplasms
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Breast Neoplasms
CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.
Breast Neoplasms
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Breast Neoplasms
Checkpoint suppressor 1 suppresses transcriptional activity of ER? and breast cancer cell proliferation via deacetylase SIRT1.
Breast Neoplasms
CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
Breast Neoplasms
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Breast Neoplasms
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Breast Neoplasms
Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.
Breast Neoplasms
Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.
Breast Neoplasms
Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.
Breast Neoplasms
DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.
Breast Neoplasms
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Breast Neoplasms
Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.
Breast Neoplasms
Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer.
Breast Neoplasms
Defining the Role of Histone Deacetylases in the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction (DER): Effects of Suberoylanilide Hydroxamic Acid (SAHA) and DER in a Rat Model.
Breast Neoplasms
Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
Breast Neoplasms
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Breast Neoplasms
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Breast Neoplasms
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Breast Neoplasms
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.
Breast Neoplasms
Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.
Breast Neoplasms
Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
Breast Neoplasms
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Breast Neoplasms
Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer.
Breast Neoplasms
Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
Breast Neoplasms
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
Breast Neoplasms
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Breast Neoplasms
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Breast Neoplasms
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Breast Neoplasms
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Breast Neoplasms
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Breast Neoplasms
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Breast Neoplasms
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells.
Breast Neoplasms
Frizzled 7 expression is positively regulated by SIRT1 and ?-catenin in breast cancer cells.
Breast Neoplasms
HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer.
Breast Neoplasms
High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through Activating of Akt.
Breast Neoplasms
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.
Breast Neoplasms
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.
Breast Neoplasms
I157172, a novel inhibitor of cystathionine ?-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.
Breast Neoplasms
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Breast Neoplasms
Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.
Breast Neoplasms
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
Breast Neoplasms
Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells.
Breast Neoplasms
Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.
Breast Neoplasms
Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles.
Breast Neoplasms
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Breast Neoplasms
Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.
Breast Neoplasms
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of ?-tubulin acetylation and inhibition of breast cancer cell migration.
Breast Neoplasms
Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment.
Breast Neoplasms
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1.
Breast Neoplasms
MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53.
Breast Neoplasms
MicroRNA?3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.
Breast Neoplasms
miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway.
Breast Neoplasms
miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells.
Breast Neoplasms
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
Breast Neoplasms
miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression.
Breast Neoplasms
MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1.
Breast Neoplasms
MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype.
Breast Neoplasms
Molecular characterization, alternative splicing and expression analysis of bovine DBC1.
Breast Neoplasms
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma.
Breast Neoplasms
New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.
Breast Neoplasms
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Breast Neoplasms
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly.
Breast Neoplasms
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
Breast Neoplasms
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Breast Neoplasms
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Breast Neoplasms
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.
Breast Neoplasms
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization.
Breast Neoplasms
PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
Breast Neoplasms
pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel.
Breast Neoplasms
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Breast Neoplasms
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Breast Neoplasms
Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima.
Breast Neoplasms
Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/?-catenin signaling pathway in breast cancer.
Breast Neoplasms
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Breast Neoplasms
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Breast Neoplasms
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Breast Neoplasms
SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.
Breast Neoplasms
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
Breast Neoplasms
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
Breast Neoplasms
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Breast Neoplasms
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Breast Neoplasms
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
Breast Neoplasms
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
Breast Neoplasms
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
Breast Neoplasms
SIRT1 promotes formation of breast cancer through modulating Akt activity.
Breast Neoplasms
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
Breast Neoplasms
SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
Breast Neoplasms
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
Breast Neoplasms
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
Breast Neoplasms
SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer.
Breast Neoplasms
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
Breast Neoplasms
Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells.
Breast Neoplasms
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization.
Breast Neoplasms
SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production.
Breast Neoplasms
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Breast Neoplasms
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
Breast Neoplasms
Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.
Breast Neoplasms
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Breast Neoplasms
Sirtuin 3 interacts with Lon protease and regulates its acetylation status.
Breast Neoplasms
SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1.
Breast Neoplasms
SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells.
Breast Neoplasms
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Breast Neoplasms
Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.
Breast Neoplasms
Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion.
Breast Neoplasms
The beneficial role of SIRT1 activator on chemo- and radiosensitization of breast cancer cells in response to IL-6.
Breast Neoplasms
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
Breast Neoplasms
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
Breast Neoplasms
The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level.
Breast Neoplasms
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
Breast Neoplasms
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
Breast Neoplasms
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
Breast Neoplasms
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Breast Neoplasms
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Breast Neoplasms
The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients.
Breast Neoplasms
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
Breast Neoplasms
The study of sirtuins in breast cancer patients before and after radiotherapy
Breast Neoplasms
Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
Breast Neoplasms
[Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells]
Bronchopulmonary Dysplasia
Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Bronchopulmonary Dysplasia
Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants.
Bronchopulmonary Dysplasia
[Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure].
Bulbo-Spinal Atrophy, X-Linked
Sirtuin deacetylases in neurodegenerative diseases of aging.
Burkitt Lymphoma
Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3? by increased SIRT3 expression.
Candidiasis
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Candidiasis
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Carcinogenesis
3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line.
Carcinogenesis
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
Carcinogenesis
A New Regulatory Mechanism Between P53 And YAP Crosstalk By SIRT1 Mediated Deacetylation To Regulate Cell Cycle And Apoptosis In A549 Cell Lines.
Carcinogenesis
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
Carcinogenesis
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Carcinogenesis
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Carcinogenesis
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Carcinogenesis
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Carcinogenesis
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
Carcinogenesis
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
Carcinogenesis
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Carcinogenesis
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Carcinogenesis
Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.
Carcinogenesis
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.
Carcinogenesis
Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells.
Carcinogenesis
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Carcinogenesis
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
Carcinogenesis
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Carcinogenesis
Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.
Carcinogenesis
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Carcinogenesis
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Carcinogenesis
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Carcinogenesis
Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.
Carcinogenesis
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Carcinogenesis
Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells.
Carcinogenesis
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Carcinogenesis
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
Carcinogenesis
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Carcinogenesis
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Carcinogenesis
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Carcinogenesis
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer.
Carcinogenesis
Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells.
Carcinogenesis
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Carcinogenesis
ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
Carcinogenesis
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Carcinogenesis
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Carcinogenesis
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Carcinogenesis
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Carcinogenesis
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1.
Carcinogenesis
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Carcinogenesis
Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
Carcinogenesis
Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
Carcinogenesis
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
Carcinogenesis
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Carcinogenesis
Hepatotoxic Effects of Hexafluoropropylene Oxide Trimer Acid (HFPO-TA), A Novel Perfluorooctanoic Acid (PFOA) Alternative, on Mice.
Carcinogenesis
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
Carcinogenesis
hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.
Carcinogenesis
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
Carcinogenesis
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Carcinogenesis
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Carcinogenesis
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Carcinogenesis
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
Carcinogenesis
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Carcinogenesis
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
Carcinogenesis
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Carcinogenesis
Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
Carcinogenesis
Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis.
Carcinogenesis
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
Carcinogenesis
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Carcinogenesis
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
Carcinogenesis
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Carcinogenesis
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Carcinogenesis
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
Carcinogenesis
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
Carcinogenesis
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
Carcinogenesis
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
Carcinogenesis
miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
Carcinogenesis
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
Carcinogenesis
Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study.
Carcinogenesis
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
Carcinogenesis
Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.
Carcinogenesis
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Carcinogenesis
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.
Carcinogenesis
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Carcinogenesis
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
Carcinogenesis
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
Carcinogenesis
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Carcinogenesis
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Carcinogenesis
Publisher Correction: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Carcinogenesis
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Carcinogenesis
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Carcinogenesis
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Carcinogenesis
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Carcinogenesis
Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis.
Carcinogenesis
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.
Carcinogenesis
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Carcinogenesis
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.
Carcinogenesis
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
Carcinogenesis
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Carcinogenesis
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
Carcinogenesis
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Carcinogenesis
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
Carcinogenesis
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Carcinogenesis
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
Carcinogenesis
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Carcinogenesis
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
Carcinogenesis
SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.
Carcinogenesis
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
Carcinogenesis
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
Carcinogenesis
SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
Carcinogenesis
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
Carcinogenesis
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
Carcinogenesis
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.
Carcinogenesis
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
Carcinogenesis
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
Carcinogenesis
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
Carcinogenesis
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
Carcinogenesis
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
Carcinogenesis
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
Carcinogenesis
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
Carcinogenesis
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
Carcinogenesis
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Carcinogenesis
SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
Carcinogenesis
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
Carcinogenesis
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
Carcinogenesis
SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells.
Carcinogenesis
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
Carcinogenesis
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
Carcinogenesis
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
Carcinogenesis
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Carcinogenesis
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Carcinogenesis
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
Carcinogenesis
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
Carcinogenesis
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
Carcinogenesis
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
Carcinogenesis
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Carcinogenesis
SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production.
Carcinogenesis
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
Carcinogenesis
SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer.
Carcinogenesis
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-?B Signaling Pathway.
Carcinogenesis
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Carcinogenesis
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Carcinogenesis
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Carcinogenesis
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Carcinogenesis
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Carcinogenesis
Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
Carcinogenesis
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
Carcinogenesis
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Carcinogenesis
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Carcinogenesis
Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer.
Carcinogenesis
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Carcinogenesis
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer.
Carcinogenesis
Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Carcinogenesis
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Carcinogenesis
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Carcinogenesis
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription.
Carcinogenesis
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Carcinogenesis
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
Carcinogenesis
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Carcinogenesis
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
Carcinogenesis
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
Carcinogenesis
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
Carcinogenesis
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
Carcinogenesis
The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy.
Carcinogenesis
The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.
Carcinogenesis
The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.
Carcinogenesis
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Carcinogenesis
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Carcinogenesis
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Carcinogenesis
Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.
Carcinogenesis
USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
Carcinogenesis
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
Carcinogenesis
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Carcinoma
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Carcinoma
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Carcinoma
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
Carcinoma
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
Carcinoma
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Carcinoma
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Carcinoma
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Carcinoma
Autophagy inhibition enhanced 5?FU?induced cell death in human gastric carcinoma BGC?823 cells.
Carcinoma
Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Carcinoma
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Carcinoma
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Carcinoma
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Carcinoma
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Carcinoma
Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.
Carcinoma
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Carcinoma
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Carcinoma
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Carcinoma
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Carcinoma
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Carcinoma
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas.
Carcinoma
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Carcinoma
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Carcinoma
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Carcinoma
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Carcinoma
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Carcinoma
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Carcinoma
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Carcinoma
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Carcinoma
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Carcinoma
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Carcinoma
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Carcinoma
Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma.
Carcinoma
MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma.
Carcinoma
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
Carcinoma
MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling.
Carcinoma
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Carcinoma
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Carcinoma
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Carcinoma
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Carcinoma
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Carcinoma
Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway.
Carcinoma
Overexpression of SIRT1 in urothelial carcinoma of the urinary bladder is associated with local recurrence and poor survival.
Carcinoma
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Carcinoma
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Carcinoma
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Carcinoma
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Carcinoma
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Carcinoma
Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
Carcinoma
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Carcinoma
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Carcinoma
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Carcinoma
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
Carcinoma
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
Carcinoma
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
Carcinoma
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
Carcinoma
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
Carcinoma
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
Carcinoma
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
Carcinoma
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
Carcinoma
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Carcinoma
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Carcinoma
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Carcinoma
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Carcinoma
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Carcinoma
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Carcinoma
Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27.
Carcinoma
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
Carcinoma
The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.
Carcinoma
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Carcinoma, Basal Cell
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Carcinoma, Basal Cell
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Carcinoma, Ductal
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Carcinoma, Ductal
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Carcinoma, Ductal
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
Carcinoma, Hepatocellular
3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line.
Carcinoma, Hepatocellular
?-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner.
Carcinoma, Hepatocellular
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Carcinoma, Hepatocellular
An insulin-inducible transcription factor, SHARP-1, represses transcription of the SIRT1 longevity gene.
Carcinoma, Hepatocellular
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Carcinoma, Hepatocellular
Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo.
Carcinoma, Hepatocellular
Bioinformatics Prediction and Experimental Validation of MicroRNAs Involved in Cross-Kingdom Interaction.
Carcinoma, Hepatocellular
Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth.
Carcinoma, Hepatocellular
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
Carcinoma, Hepatocellular
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Carcinoma, Hepatocellular
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.
Carcinoma, Hepatocellular
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Carcinoma, Hepatocellular
Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism.
Carcinoma, Hepatocellular
Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells.
Carcinoma, Hepatocellular
Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes.
Carcinoma, Hepatocellular
Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Erratum: microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
Carcinoma, Hepatocellular
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Carcinoma, Hepatocellular
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Carcinoma, Hepatocellular
Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
Carcinoma, Hepatocellular
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Increased SIRT3 Expression and Antioxidant Defense under Hyperglycemic Conditions in HepG2 Cells.
Carcinoma, Hepatocellular
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions.
Carcinoma, Hepatocellular
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
Carcinoma, Hepatocellular
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Carcinoma, Hepatocellular
Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.
Carcinoma, Hepatocellular
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
Carcinoma, Hepatocellular
MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1.
Carcinoma, Hepatocellular
MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1.
Carcinoma, Hepatocellular
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
Carcinoma, Hepatocellular
microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression.
Carcinoma, Hepatocellular
MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-?/SMAD signaling pathway.
Carcinoma, Hepatocellular
Modulation of antioxidant enzymes, SIRT1 and NF-?B by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
Carcinoma, Hepatocellular
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts.
Carcinoma, Hepatocellular
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
Carcinoma, Hepatocellular
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Carcinoma, Hepatocellular
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Carcinoma, Hepatocellular
Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Carcinoma, Hepatocellular
SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.
Carcinoma, Hepatocellular
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Carcinoma, Hepatocellular
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
Carcinoma, Hepatocellular
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice.
Carcinoma, Hepatocellular
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
Carcinoma, Hepatocellular
SIRT1 in the Development and Treatment of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.
Carcinoma, Hepatocellular
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
Carcinoma, Hepatocellular
SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation.
Carcinoma, Hepatocellular
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
Carcinoma, Hepatocellular
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Carcinoma, Hepatocellular
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions.
Carcinoma, Hepatocellular
SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
Carcinoma, Hepatocellular
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
Carcinoma, Hepatocellular
SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells.
Carcinoma, Hepatocellular
SIRT3 functions as a tumor suppressor in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
Carcinoma, Hepatocellular
Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
Carcinoma, Hepatocellular
SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPK?/mTOR Axis.
Carcinoma, Hepatocellular
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Carcinoma, Hepatocellular
Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Carcinoma, Hepatocellular
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Carcinoma, Hepatocellular
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Carcinoma, Hepatocellular
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway.
Carcinoma, Hepatocellular
Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.
Carcinoma, Hepatocellular
Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model.
Carcinoma, Hepatocellular
Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1.
Carcinoma, Hepatocellular
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
Carcinoma, Hepatocellular
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Carcinoma, Hepatocellular
The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC).
Carcinoma, Hepatocellular
The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects.
Carcinoma, Hepatocellular
The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Carcinoma, Hepatocellular
The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and Sirt1 expression].
Carcinoma, Hepatocellular
[Role of SIRT3 in regulating proliferation of hepatocellular carcinoma cells in vitro].
Carcinoma, Hepatocellular
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Carcinoma, Non-Small-Cell Lung
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884].
Carcinoma, Non-Small-Cell Lung
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Carcinoma, Non-Small-Cell Lung
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Carcinoma, Non-Small-Cell Lung
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
Carcinoma, Non-Small-Cell Lung
RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression.
Carcinoma, Non-Small-Cell Lung
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
Carcinoma, Non-Small-Cell Lung
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
Carcinoma, Non-Small-Cell Lung
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
Carcinoma, Non-Small-Cell Lung
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
Carcinoma, Non-Small-Cell Lung
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
Carcinoma, Non-Small-Cell Lung
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
Carcinoma, Non-Small-Cell Lung
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
Carcinoma, Non-Small-Cell Lung
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
Carcinoma, Non-Small-Cell Lung
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells.
Carcinoma, Non-Small-Cell Lung
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
Carcinoma, Non-Small-Cell Lung
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
Carcinoma, Non-Small-Cell Lung
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Carcinoma, Non-Small-Cell Lung
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Carcinoma, Ovarian Epithelial
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Carcinoma, Ovarian Epithelial
microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Carcinoma, Papillary
Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Carcinoma, Renal Cell
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
Carcinoma, Renal Cell
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Carcinoma, Renal Cell
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Carcinoma, Renal Cell
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
Carcinoma, Renal Cell
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Carcinoma, Renal Cell
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Carcinoma, Renal Cell
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Carcinoma, Renal Cell
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Carcinoma, Renal Cell
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Carcinoma, Renal Cell
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
Carcinoma, Renal Cell
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Carcinoma, Squamous Cell
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Carcinoma, Squamous Cell
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Carcinoma, Squamous Cell
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Carcinoma, Squamous Cell
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Carcinoma, Squamous Cell
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Carcinoma, Squamous Cell
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Carcinoma, Squamous Cell
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Carcinoma, Squamous Cell
MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling.
Carcinoma, Squamous Cell
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
Carcinoma, Squamous Cell
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
Carcinoma, Squamous Cell
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
Carcinoma, Squamous Cell
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Carcinoma, Squamous Cell
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Carcinoma, Squamous Cell
Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27.
Carcinoma, Squamous Cell
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
Cardio-Renal Syndrome
SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome.
Cardiomegaly
1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level.
Cardiomegaly
A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling.
Cardiomegaly
Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling.
Cardiomegaly
Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the {alpha}-myosin heavy chain expression.
Cardiomegaly
Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.
Cardiomegaly
ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.
Cardiomegaly
CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
Cardiomegaly
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Cardiomegaly
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Cardiomegaly
Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure.
Cardiomegaly
Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.
Cardiomegaly
Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
Cardiomegaly
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Cardiomegaly
Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1.
Cardiomegaly
High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.
Cardiomegaly
Hispidulin Attenuates Cardiac Hypertrophy by Improving Mitochondrial Dysfunction.
Cardiomegaly
Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.
Cardiomegaly
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Cardiomegaly
LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway.
Cardiomegaly
Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox.
Cardiomegaly
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Cardiomegaly
miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation.
Cardiomegaly
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Cardiomegaly
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
Cardiomegaly
PPAR?-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.
Cardiomegaly
Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
Cardiomegaly
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Cardiomegaly
Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.
Cardiomegaly
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Cardiomegaly
Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
Cardiomegaly
SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy.
Cardiomegaly
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
Cardiomegaly
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
Cardiomegaly
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Cardiomegaly
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Cardiomegaly
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Cardiomegaly
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
Cardiomegaly
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
Cardiomegaly
Sirtuin 1 represses PKC-? activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.
Cardiomegaly
Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-?BTGF-?1/Smad Signaling Pathway.
Cardiomegaly
Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.
Cardiomegaly
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
Cardiomegaly
The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension.
Cardiomegaly
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
Cardiomegaly
The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.
Cardiomegaly
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
Cardiomegaly
The protective effects of 17-? estradiol and SIRT1 against cardiac hypertrophy: a review.
Cardiomegaly
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging.
Cardiomegaly
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Cardiomyopathies
?-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice.
Cardiomyopathies
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Cardiomyopathies
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Cardiomyopathies
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Cardiomyopathies
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Cardiomyopathies
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
Cardiomyopathies
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Cardiomyopathies
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Cardiomyopathies
Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.
Cardiomyopathies
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1.
Cardiomyopathies
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Cardiomyopathies
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Cardiomyopathies
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1? in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Cardiomyopathies
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Cardiomyopathies
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Cardiomyopathies
Role of Deranged Energy Deprivation Signaling in the Pathogenesis of Cardiac and Renal Disease in States of Perceived Nutrient Overabundance.
Cardiomyopathies
SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.
Cardiomyopathies
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Cardiomyopathies
SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.
Cardiomyopathies
SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.
Cardiomyopathies
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Cardiomyopathies
Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.
Cardiomyopathies
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Cardiomyopathies
The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.
Cardiomyopathy, Dilated
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Cardiomyopathy, Dilated
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Cardiomyopathy, Dilated
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Cardiomyopathy, Dilated
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
Cardiomyopathy, Dilated
TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity.
Cardiotoxicity
Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress.
Cardiotoxicity
Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts.
Cardiotoxicity
Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.
Cardiotoxicity
Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway.
Cardiotoxicity
Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.
Cardiotoxicity
Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress.
Cardiotoxicity
Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.
Cardiotoxicity
Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p.
Cardiotoxicity
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Cardiotoxicity
Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
Cardiotoxicity
MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2.
Cardiotoxicity
MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1.
Cardiotoxicity
Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin.
Cardiotoxicity
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways.
Cardiotoxicity
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.
Cardiotoxicity
PGC1? activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades.
Cardiotoxicity
Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway.
Cardiotoxicity
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
Cardiotoxicity
Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes.
Cardiotoxicity
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway.
Cardiotoxicity
Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway.
Cardiotoxicity
Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
Cardiotoxicity
Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1.
Cardiotoxicity
Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of Sirt1 and Mn-SOD pathway.
Cardiotoxicity
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites ?- and ?-zearalenol through an autophagy-dependent pathway.
Cardiotoxicity
SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways.
Cardiotoxicity
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Cardiotoxicity
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro.
Cardiotoxicity
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Cardiotoxicity
Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.
Cardiovascular Diseases
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
Cardiovascular Diseases
Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1.
Cardiovascular Diseases
Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling.
Cardiovascular Diseases
ACTIVATION OF SIRT1 BY RESVERATROL INDUCES KLF2 EXPRESSION CONFERRING AN ENDOTHELIAL VASOPROTECTIVE PHENOTYPE.
Cardiovascular Diseases
Adverse childhood events and cardiovascular diseases: the potential role of Sirt1.
Cardiovascular Diseases
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice.
Cardiovascular Diseases
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Cardiovascular Diseases
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Cardiovascular Diseases
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Cardiovascular Diseases
Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.
Cardiovascular Diseases
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Cardiovascular Diseases
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis.
Cardiovascular Diseases
CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Cardiovascular Diseases
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Cardiovascular Diseases
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Cardiovascular Diseases
Distribution of the longevity gene product, SIRT1, in developing mouse organs.
Cardiovascular Diseases
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.
Cardiovascular Diseases
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea.
Cardiovascular Diseases
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
Cardiovascular Diseases
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Cardiovascular Diseases
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Cardiovascular Diseases
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells.
Cardiovascular Diseases
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.
Cardiovascular Diseases
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Cardiovascular Diseases
Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway.
Cardiovascular Diseases
Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1.
Cardiovascular Diseases
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Cardiovascular Diseases
Omarigliptin Prevents TNF-?-Induced Cellular Senescence in Rat Aorta Vascular Smooth Muscle Cells.
Cardiovascular Diseases
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Cardiovascular Diseases
Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases.
Cardiovascular Diseases
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
Cardiovascular Diseases
Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS.
Cardiovascular Diseases
Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1.
Cardiovascular Diseases
Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature.
Cardiovascular Diseases
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Cardiovascular Diseases
Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression.
Cardiovascular Diseases
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
Cardiovascular Diseases
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Cardiovascular Diseases
SIRT1 and Gender Differences in Atherosclerotic Cardiovascular Disease.
Cardiovascular Diseases
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
Cardiovascular Diseases
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Cardiovascular Diseases
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
Cardiovascular Diseases
Sirt1 during childhood is associated with microvascular function later in life.
Cardiovascular Diseases
SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.
Cardiovascular Diseases
Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress.
Cardiovascular Diseases
SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway.
Cardiovascular Diseases
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Cardiovascular Diseases
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Cardiovascular Diseases
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.
Cardiovascular Diseases
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
Cardiovascular Diseases
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Cardiovascular Diseases
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Cardiovascular Diseases
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
Cardiovascular Diseases
Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems.
Cardiovascular Diseases
Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension.
Cardiovascular Diseases
The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease.
Cardiovascular Diseases
The relationship of SIRT3 with cellular metabolism and cardiovascular diseases.
Cardiovascular Diseases
The role of SIRT2 in vascular-related and heart-related diseases: A review.
Cardiovascular Diseases
The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm.
Cardiovascular Diseases
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and ?Klotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
Cardiovascular Diseases
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Cardiovascular Diseases
Tumor Necrosis Factor-alpha (TNF-?) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1).
Carotid Artery Diseases
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.
Carotid Artery Thrombosis
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Carotid Stenosis
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
Carotid Stenosis
SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.
Cartilage Diseases
Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1.
Cataract
Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract.
Cataract
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Cataract
Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans.
Cataract
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.
Cataract
Expression of SIRT1 and P53 in Rat Lens Epithelial cells in Experimentally Induced DM.
Cataract
MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator.
Cataract
miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts.
Cataract
miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells.
Cataract
Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells.
Cataract
Relationship between SIRT1 gene expression level and disease in age-related cataract cases
Cataract
Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM.
Cataract
SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis.
Central Nervous System Diseases
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
Central Nervous System Diseases
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
Cerebellar Ataxia
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.
Cerebral Hemorrhage
Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis.
Cerebral Hemorrhage
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Cerebral Hemorrhage
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Cerebral Infarction
Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through Sirt1/Mapt Pathway.
Cerebral Infarction
XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition.
Cerebrovascular Disorders
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Cerebrovascular Disorders
The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets.
Cervical Intraepithelial Neoplasia
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Chagas Disease
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.
Chagas Disease
Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway.
Chagas Disease
Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages.
Chagas Disease
Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models.
Chemical and Drug Induced Liver Injury
The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury.
Cholangiocarcinoma
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Cholangiocarcinoma
Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma.
Cholangiocarcinoma
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
Cholangitis
Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
Cholestasis
18?-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Cholestasis
Baicalin Protects Against 17?-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1?/Farnesoid X Receptor Pathway.
Cholestasis
Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.
Cholestasis
Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.
Cholestasis
MITOCHONDRIAL BIOGENESIS FAILS IN SECONDARY BILIARY CIRRHOSIS IN RATS LEADING TO MITOCHONDRIAL DNA DEPLETION AND DELETIONS.
Cholestasis
Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target.
Cholestasis
Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.
Cholestasis
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Cholestasis
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis.
Cholestasis
[Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway].
Cholestasis, Extrahepatic
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Cholestasis, Intrahepatic
Advances in the role of silence information regulator family in pathological pregnancy.
Chondrosarcoma
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.
Chondrosarcoma
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
Choroidal Neovascularization
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?.
Choroidal Neovascularization
Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization.
Choroidal Neovascularization
SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.
Cockayne Syndrome
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Colitis
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Colitis
Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet.
Colitis
Bergenin, Acting as an Agonist of PPAR?, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-?B-Mediated Macrophage Activation.
Colitis
Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway.
Colitis
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
Colitis
Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice.
Colitis
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Colitis
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
Colitis
Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR?/NF-?B signaling pathways.
Colitis
Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.
Colitis
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis.
Colitis
Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling.
Colitis
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
Colitis
Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1.
Colitis
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells.
Colitis, Ulcerative
Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.
Colitis, Ulcerative
Effect of Selenium Supplementation on Expression of SIRT1 and PGC-1? Genes in Ulcerative Colitis Patients: a Double Blind Randomized Clinical Trial.
Colitis, Ulcerative
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Colitis, Ulcerative
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
Colonic Neoplasms
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Colonic Neoplasms
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Colonic Neoplasms
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Colonic Neoplasms
Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells.
Colonic Neoplasms
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Colonic Neoplasms
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Colonic Neoplasms
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Colonic Neoplasms
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
Colonic Neoplasms
Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells.
Colonic Neoplasms
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Colonic Neoplasms
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
Colonic Neoplasms
Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D.
Colonic Neoplasms
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Colonic Neoplasms
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
Colonic Neoplasms
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Colonic Neoplasms
IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1.
Colonic Neoplasms
Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate.
Colonic Neoplasms
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation.
Colonic Neoplasms
Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p.
Colonic Neoplasms
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Colonic Neoplasms
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Colonic Neoplasms
RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
Colonic Neoplasms
Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy.
Colonic Neoplasms
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Colonic Neoplasms
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
Colonic Neoplasms
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
Colonic Neoplasms
Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.
Colonic Neoplasms
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Colonic Neoplasms
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells.
Colonic Neoplasms
Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer.
Colonic Neoplasms
Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
Colonic Neoplasms
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
Colonic Neoplasms
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Colonic Neoplasms
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
Colonic Neoplasms
The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
Colorectal Neoplasms
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Colorectal Neoplasms
Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer.
Colorectal Neoplasms
Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer.
Colorectal Neoplasms
Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells.
Colorectal Neoplasms
Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation.
Colorectal Neoplasms
BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil.
Colorectal Neoplasms
BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells.
Colorectal Neoplasms
Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
Colorectal Neoplasms
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Colorectal Neoplasms
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Colorectal Neoplasms
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Colorectal Neoplasms
Colorectal Cancer Apoptosis Induced by Dietary ?-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3.
Colorectal Neoplasms
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Colorectal Neoplasms
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Colorectal Neoplasms
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.
Colorectal Neoplasms
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
Colorectal Neoplasms
ETHE1 overexpression promotes SIRT1 and PGC1? mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer.
Colorectal Neoplasms
Frameshift mutation of SIRT1 gene in gastric and colorectal carcinomas with microsatellite instability.
Colorectal Neoplasms
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
Colorectal Neoplasms
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Colorectal Neoplasms
Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers.
Colorectal Neoplasms
Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
Colorectal Neoplasms
Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells.
Colorectal Neoplasms
Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/?-catenin signaling pathway.
Colorectal Neoplasms
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.
Colorectal Neoplasms
MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1.
Colorectal Neoplasms
Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells
Colorectal Neoplasms
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Colorectal Neoplasms
Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells.
Colorectal Neoplasms
Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.
Colorectal Neoplasms
Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer.
Colorectal Neoplasms
Regulation of SIRT2 by Wnt/?-catenin signaling pathway in colorectal cancer cells.
Colorectal Neoplasms
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Colorectal Neoplasms
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer.
Colorectal Neoplasms
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Colorectal Neoplasms
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
Colorectal Neoplasms
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
Colorectal Neoplasms
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
Colorectal Neoplasms
SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness.
Colorectal Neoplasms
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Colorectal Neoplasms
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
Colorectal Neoplasms
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Colorectal Neoplasms
Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway.
Colorectal Neoplasms
SIRT3-Mediated SOD2 and PGC-1? Contribute to Chemoresistance in Colorectal Cancer Cells.
Colorectal Neoplasms
SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3?/CyclinD1 pathway.
Colorectal Neoplasms
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Colorectal Neoplasms
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Colorectal Neoplasms
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
Colorectal Neoplasms
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
Colorectal Neoplasms
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
Colorectal Neoplasms
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Colorectal Neoplasms
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
Colorectal Neoplasms
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
Colorectal Neoplasms
The pluripotency network in colorectal cancer pathogenesis and prognosis: an update.
Colorectal Neoplasms
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Colorectal Neoplasms
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Colorectal Neoplasms
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Colorectal Neoplasms
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Corneal Injuries
Sirt3 regulates mitophagy level to promote diabetic corneal epithelial wound healing.
Coronary Artery Disease
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Coronary Artery Disease
Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1? and serum antioxidant enzymes in patients with coronary artery disease.
Coronary Artery Disease
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Coronary Artery Disease
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.
Coronary Artery Disease
Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes".
Coronary Artery Disease
Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease.
Coronary Artery Disease
Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-?B, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial.
Coronary Artery Disease
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
Coronary Artery Disease
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Coronary Artery Disease
Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort.
Coronary Artery Disease
MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up.
Coronary Artery Disease
MicroRNA-34a regulates the longevity-associated protein, SIRT1, in coronary artery disease: Effect of statins on SIRT1 and microRNA-34a expression.
Coronary Artery Disease
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
Coronary Artery Disease
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
Coronary Artery Disease
Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease.
Coronary Artery Disease
SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease.
Coronary Artery Disease
SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease.
Coronary Artery Disease
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Coronary Artery Disease
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
Coronary Artery Disease
The relationship between coronary artery disease and SIRT1 protein.
Coronary Artery Disease
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Coronary Disease
MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2.
Coronary Disease
Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease.
Coronary Thrombosis
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Coronavirus Infections
A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.
COVID-19
COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.
COVID-19
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients.
Cysts
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Cysts
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Cysts
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Cytomegalovirus Infections
The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection.
Deafness
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Dementia
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Dementia
Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.
Dementia
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
Dementia
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke.
Dementia
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Dementia
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia.
Dementia, Vascular
[Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-?B signaling pathway].
Demyelinating Diseases
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Demyelinating Diseases
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Demyelinating Diseases
SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease.
Demyelinating Diseases
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Dengue
Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway.
Depression, Postpartum
Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor.
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Dermatitis
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Dermatitis, Atopic
A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model.
Dermatitis, Atopic
Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality.
Dermatitis, Atopic
The Expression of Epidermal Stem Cell Marker and SIRT1 in Atopic Dermatitis: A Discussion of Regenerative Potential.
Dermatitis, Phototoxic
The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study.
Desmoplastic Small Round Cell Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Diabetes Complications
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
Diabetes Complications
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
Diabetes Complications
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Diabetes Complications
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Diabetes Complications
Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus.
Diabetes Complications
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
Diabetes Complications
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
Diabetes Complications
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetes Mellitus
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Diabetes Mellitus
Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
Diabetes Mellitus
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Diabetes Mellitus
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Diabetes Mellitus
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Diabetes Mellitus
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Diabetes Mellitus
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Diabetes Mellitus
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Diabetes Mellitus
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
Diabetes Mellitus
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Diabetes Mellitus
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Diabetes Mellitus
Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.
Diabetes Mellitus
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
Diabetes Mellitus
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Diabetes Mellitus
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Diabetes Mellitus
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Diabetes Mellitus
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Diabetes Mellitus
Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway.
Diabetes Mellitus
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Diabetes Mellitus
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Diabetes Mellitus
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Diabetes Mellitus
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Diabetes Mellitus
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Diabetes Mellitus
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
Diabetes Mellitus
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Diabetes Mellitus
Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis.
Diabetes Mellitus
Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM.
Diabetes Mellitus
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Diabetes Mellitus
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Diabetes Mellitus
Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM.
Diabetes Mellitus
Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus.
Diabetes Mellitus
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
Diabetes Mellitus
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Diabetes Mellitus
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Diabetes Mellitus
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
Diabetes Mellitus
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
Diabetes Mellitus
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Diabetes Mellitus
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
Diabetes Mellitus
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Diabetes Mellitus
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
Diabetes Mellitus
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Diabetes Mellitus
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Diabetes Mellitus
Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Diabetes Mellitus
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
Diabetes Mellitus
The effect of hesperidin and quercetin on oxidative stress, NF-?B and SIRT1 levels in a STZ-induced experimental diabetes model.
Diabetes Mellitus
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
Diabetes Mellitus
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Diabetes Mellitus
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Diabetes Mellitus
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Diabetes Mellitus
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
Diabetes Mellitus
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Diabetes Mellitus
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Diabetes Mellitus, Experimental
Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction.
Diabetes Mellitus, Type 1
Can Functionally Mature Islet ?-Cells Be Derived from Pluripotent Stem Cells? - A Step Towards Ready-To-Use ?-Cells in Type 1 Diabetes.
Diabetes Mellitus, Type 1
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Diabetes Mellitus, Type 1
Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients.
Diabetes Mellitus, Type 1
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
Diabetes Mellitus, Type 1
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.
Diabetes Mellitus, Type 1
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Diabetes Mellitus, Type 1
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
Diabetes Mellitus, Type 1
SIRT1 activation attenuates ? cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice.
Diabetes Mellitus, Type 1
Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway.
Diabetes Mellitus, Type 1
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Diabetes Mellitus, Type 1
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
Diabetes Mellitus, Type 2
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
Diabetes Mellitus, Type 2
A Phase II, Randomized, Placebo-Controlled, Double-Blind, Multi-Dose Study of SRT2104, a SIRT1 Activator, in Subjects With Type 2 Diabetes.
Diabetes Mellitus, Type 2
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
Diabetes Mellitus, Type 2
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Diabetes Mellitus, Type 2
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Diabetes Mellitus, Type 2
Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes.
Diabetes Mellitus, Type 2
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Diabetes Mellitus, Type 2
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus, Type 2
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Diabetes Mellitus, Type 2
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Diabetes Mellitus, Type 2
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Diabetes Mellitus, Type 2
Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review.
Diabetes Mellitus, Type 2
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Diabetes Mellitus, Type 2
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Diabetes Mellitus, Type 2
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Diabetes Mellitus, Type 2
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Diabetes Mellitus, Type 2
Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans.
Diabetes Mellitus, Type 2
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
Diabetes Mellitus, Type 2
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Diabetes Mellitus, Type 2
Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.
Diabetes Mellitus, Type 2
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial.
Diabetes Mellitus, Type 2
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Diabetes Mellitus, Type 2
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT.
Diabetes Mellitus, Type 2
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Diabetes Mellitus, Type 2
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Diabetes Mellitus, Type 2
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Diabetes Mellitus, Type 2
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Diabetes Mellitus, Type 2
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Diabetes Mellitus, Type 2
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Diabetes Mellitus, Type 2
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Diabetes Mellitus, Type 2
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Diabetes Mellitus, Type 2
Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility.
Diabetes Mellitus, Type 2
Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells.
Diabetes Mellitus, Type 2
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Diabetes Mellitus, Type 2
In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database.
Diabetes Mellitus, Type 2
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
Diabetes Mellitus, Type 2
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Diabetes Mellitus, Type 2
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Diabetes Mellitus, Type 2
Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial.
Diabetes Mellitus, Type 2
Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.
Diabetes Mellitus, Type 2
Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Diabetes Mellitus, Type 2
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
Diabetes Mellitus, Type 2
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
Diabetes Mellitus, Type 2
Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.
Diabetes Mellitus, Type 2
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Diabetes Mellitus, Type 2
Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis.
Diabetes Mellitus, Type 2
Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes.
Diabetes Mellitus, Type 2
PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial.
Diabetes Mellitus, Type 2
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Diabetes Mellitus, Type 2
Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial.
Diabetes Mellitus, Type 2
Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation.
Diabetes Mellitus, Type 2
Pro-inflammatory Cytokine Interleukin 1? Disrupts ? cell Circadian Clock Function and Regulation of Insulin Secretion.
Diabetes Mellitus, Type 2
Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis.
Diabetes Mellitus, Type 2
Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes.
Diabetes Mellitus, Type 2
Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM.
Diabetes Mellitus, Type 2
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.
Diabetes Mellitus, Type 2
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Diabetes Mellitus, Type 2
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Diabetes Mellitus, Type 2
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Diabetes Mellitus, Type 2
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Diabetes Mellitus, Type 2
Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs.
Diabetes Mellitus, Type 2
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Diabetes Mellitus, Type 2
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Diabetes Mellitus, Type 2
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Diabetes Mellitus, Type 2
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
Diabetes Mellitus, Type 2
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Diabetes Mellitus, Type 2
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study.
Diabetes Mellitus, Type 2
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
Diabetes Mellitus, Type 2
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
Diabetes Mellitus, Type 2
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
Diabetes Mellitus, Type 2
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
Diabetes Mellitus, Type 2
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
Diabetes Mellitus, Type 2
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Diabetes Mellitus, Type 2
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.
Diabetes Mellitus, Type 2
Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity.
Diabetes Mellitus, Type 2
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Diabetes Mellitus, Type 2
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
Diabetes Mellitus, Type 2
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.
Diabetes Mellitus, Type 2
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Diabetes Mellitus, Type 2
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
Diabetes Mellitus, Type 2
Sirtuins in Vascular Diseases: Emerging Roles and Therapeutic Potential.
Diabetes Mellitus, Type 2
Sirtuins--novel therapeutic targets to treat age-associated diseases.
Diabetes Mellitus, Type 2
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
Diabetes Mellitus, Type 2
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Diabetes Mellitus, Type 2
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetes Mellitus, Type 2
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
Diabetes Mellitus, Type 2
The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.
Diabetes Mellitus, Type 2
The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes.
Diabetes Mellitus, Type 2
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Diabetes Mellitus, Type 2
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
Diabetes Mellitus, Type 2
The Sirtuin family: therapeutic targets to treat diseases of aging.
Diabetes Mellitus, Type 2
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.
Diabetes Mellitus, Type 2
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.
Diabetes Mellitus, Type 2
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Diabetes Mellitus, Type 2
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
Diabetes Mellitus, Type 2
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Diabetes Mellitus, Type 2
Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats.
Diabetes Mellitus, Type 2
Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-?1 gene expression.
Diabetes Mellitus, Type 2
Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.
Diabetes Mellitus, Type 2
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
Diabetes Mellitus, Type 2
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
Diabetes Mellitus, Type 2
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Diabetes, Gestational
Advances in the role of silence information regulator family in pathological pregnancy.
Diabetes, Gestational
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Diabetes, Gestational
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Diabetic Angiopathies
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway.
Diabetic Angiopathies
SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication.
Diabetic Angiopathies
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Diabetic Cardiomyopathies
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions.
Diabetic Cardiomyopathies
Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway.
Diabetic Cardiomyopathies
An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Diabetic Cardiomyopathies
Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway.
Diabetic Cardiomyopathies
Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2.
Diabetic Cardiomyopathies
LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.
Diabetic Cardiomyopathies
Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation.
Diabetic Cardiomyopathies
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3.
Diabetic Cardiomyopathies
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Diabetic Cardiomyopathies
SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice.
Diabetic Cardiomyopathies
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
Diabetic Cardiomyopathies
SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes.
Diabetic Cardiomyopathies
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
Diabetic Cardiomyopathies
Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Diabetic Cardiomyopathies
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
Diabetic Cardiomyopathies
Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like receptor protein 3 pathway.
Diabetic Cardiomyopathies
Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway.
Diabetic Cardiomyopathies
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Diabetic Cardiomyopathies
The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy.
Diabetic Cardiomyopathies
The role of SIRT2 in vascular-related and heart-related diseases: A review.
Diabetic Foot
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Diabetic Foot
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetic Nephropathies
3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats.
Diabetic Nephropathies
AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells.
Diabetic Nephropathies
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Diabetic Nephropathies
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Diabetic Nephropathies
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.
Diabetic Nephropathies
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Diabetic Nephropathies
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis.
Diabetic Nephropathies
Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.
Diabetic Nephropathies
Correlations between SIRT1 gene polymorphisms and diabetic kidney disease.
Diabetic Nephropathies
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Diabetic Nephropathies
Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-?B p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt.
Diabetic Nephropathies
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Diabetic Nephropathies
Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy.
Diabetic Nephropathies
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
Diabetic Nephropathies
Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice.
Diabetic Nephropathies
Inhibition of miRNA?135a?5p ameliorates TGF??1?induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy.
Diabetic Nephropathies
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.
Diabetic Nephropathies
Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.
Diabetic Nephropathies
miR-133b and miR-199b knockdown attenuate TGF-?1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy.
Diabetic Nephropathies
Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017.
Diabetic Nephropathies
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-?1 in rat glomerular messangial cells.
Diabetic Nephropathies
Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-?B and STAT3.
Diabetic Nephropathies
Role of ketogenic starvation sensors in mediating the renal protective effects of SGLT2 inhibitors in type 2 diabetes.
Diabetic Nephropathies
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Diabetic Nephropathies
Salidroside stimulates the Sirt1/PGC-1? axis and ameliorates diabetic nephropathy in mice.
Diabetic Nephropathies
Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy.
Diabetic Nephropathies
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
Diabetic Nephropathies
Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy.
Diabetic Nephropathies
SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.
Diabetic Nephropathies
Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat.
Diabetic Nephropathies
SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy.
Diabetic Nephropathies
SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy.
Diabetic Nephropathies
Sirt3 overexpression alleviates hyperglycemia-induced vascular inflammation through regulating redox balance, cell survival, and AMPK-mediated mitochondrial homeostasis.
Diabetic Nephropathies
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Diabetic Nephropathies
Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway.
Diabetic Nephropathies
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells.
Diabetic Nephropathies
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats.
Diabetic Nephropathies
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
Diabetic Nephropathies
[The renal protective effect and mechanism of liraglutide in diabetic mice induced by high-fat diet].
Diabetic Neuropathies
Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF.
Diabetic Neuropathies
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
Diabetic Neuropathies
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Diabetic Neuropathies
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Diabetic Neuropathies
SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy.
Diabetic Retinopathy
Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1.
Diabetic Retinopathy
Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1.
Diabetic Retinopathy
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Diabetic Retinopathy
Deacetylation of MnSOD by PARP-regulated SIRT3 protects retinal capillary endothelial cells from hyperglycemia-induced damage.
Diabetic Retinopathy
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Diabetic Retinopathy
Effects of microRNA?217 on high glucose?induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE?19) and its underlying mechanism.
Diabetic Retinopathy
Feno?brate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway.
Diabetic Retinopathy
LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1.
Diabetic Retinopathy
Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway.
Diabetic Retinopathy
MicroRNA-29b-3p Promotes Human Retinal Microvascular Endothelial Cell Apoptosis via Blocking SIRT1 in Diabetic Retinopathy.
Diabetic Retinopathy
MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy.
Diabetic Retinopathy
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
Diabetic Retinopathy
MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions.
Diabetic Retinopathy
Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy.
Diabetic Retinopathy
Overexpression of histone deacetylase SIRT1 exerts an anti-angiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1?/VEGFA depletion.
Diabetic Retinopathy
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Diabetic Retinopathy
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Diabetic Retinopathy
Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1.
Diabetic Retinopathy
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.
Diabetic Retinopathy
The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.
Diabetic Retinopathy
The role of sirt1 in the retinal ganglion cells cultured by high glucose.
DNA Repair-Deficiency Disorders
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Dry Eye Syndromes
PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland.
Dyslipidemias
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
Dyslipidemias
Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-? coactivator-1?.
Dyslipidemias
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver.
Dyslipidemias
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Dyslipidemias
Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1? pathway.
Dyslipidemias
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Dyslipidemias
[Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat].
Encephalitis
Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia.
Encephalitis
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Encephalomyelitis
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Encephalomyelitis
Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity.
Encephalomyelitis
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Encephalomyelitis
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Encephalomyelitis
Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Encephalomyelitis
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
Encephalomyelitis
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
Encephalomyelitis
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Encephalomyelitis, Autoimmune, Experimental
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Encephalomyelitis, Autoimmune, Experimental
Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity.
Encephalomyelitis, Autoimmune, Experimental
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Encephalomyelitis, Autoimmune, Experimental
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Encephalomyelitis, Autoimmune, Experimental
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
Encephalomyelitis, Autoimmune, Experimental
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
Encephalomyelitis, Autoimmune, Experimental
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Encephalomyelitis, Autoimmune, Experimental
Sirtuin-1 in immunotherapy: A Janus-headed target.
End Stage Liver Disease
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats.
Endocrine System Diseases
Resveratrol reduces the progression of titanium particle-induced osteolysis via the Wnt/?-catenin signaling pathway in vivo and in vitro.
Endodermal Sinus Tumor
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Endometrial Neoplasms
Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.
Endometrial Neoplasms
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
Endometrial Neoplasms
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
Endometrial Neoplasms
Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
Endometrial Neoplasms
Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.
Endometrial Neoplasms
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
Endometrial Neoplasms
Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer.
Endometriosis
A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.
Endometriosis
Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
Endometriosis
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women.
Endometriosis
Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis.
Endometriosis
Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?
Endometriosis
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.
Endometriosis
miR-9-5p promotes the invasion and migration of endometrial stromal cells in endometriosis patients through the SIRT1/NF-?B pathway.
Endometriosis
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Endometriosis
Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway.
Endometriosis
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Endotoxemia
Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats.
Endotoxemia
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Endotoxemia
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.
Endotoxemia
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Endotoxemia
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Endotoxemia
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Endotoxemia
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
Endotoxemia
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Enterocolitis
Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1).
Enterocolitis, Necrotizing
Melatonin-induced lncRNA LINC01512 prevents Treg/Th17 imbalance by promoting SIRT1 expression in necrotizing enterocolitis.
Enterocolitis, Necrotizing
miR?34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression.
Enterocolitis, Necrotizing
SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a.
Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Epilepsy
Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.
Epilepsy
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Epilepsy
miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy.
Epilepsy
miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade.
Epilepsy
Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression.
Epilepsy
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
Epiretinal Membrane
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Epiretinal Membrane
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Erectile Dysfunction
MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition.
Erectile Dysfunction
[Aging-related change of erectile function and the expression of SIRT1].
Esophageal Neoplasms
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Esophageal Neoplasms
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Esophageal Neoplasms
Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer.
Esophageal Neoplasms
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
Esophageal Neoplasms
Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer.
Esophageal Squamous Cell Carcinoma
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
Esophageal Squamous Cell Carcinoma
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Esophageal Squamous Cell Carcinoma
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Esophageal Squamous Cell Carcinoma
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Esophageal Squamous Cell Carcinoma
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Essential Hypertension
Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Essential Hypertension
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Essential Hypertension
Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Essential Hypertension
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Eye Diseases
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Eye Diseases
Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment.
Eye Diseases
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Fanconi Anemia
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.
Fasciitis
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Fatty Liver
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Fatty Liver
Activation of the aryl hydrocarbon receptor sensitizes mice to non-alcoholic steatohepatitis by deactivating the mitochondrial sirtuin deacetylase Sirt3.
Fatty Liver
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Fatty Liver
Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1month using the rat intragastric tube feeding model.
Fatty Liver
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa.
Fatty Liver
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Fatty Liver
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Fatty Liver
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Fatty Liver
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Fatty Liver
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
Fatty Liver
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Fatty Liver
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Fatty Liver
Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin.
Fatty Liver
Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway.
Fatty Liver
Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice.
Fatty Liver
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
Fatty Liver
Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet.
Fatty Liver
Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Fatty Liver
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
Fatty Liver
Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation.
Fatty Liver
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Fatty Liver
Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling.
Fatty Liver
Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/- Mice: A Role of Lipid Mobilization and Inflammation.
Fatty Liver
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
Fatty Liver
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Fatty Liver
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Fatty Liver
Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way.
Fatty Liver
Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose.
Fatty Liver
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
Fatty Liver
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
Fatty Liver
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Fatty Liver
Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
Fatty Liver
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Fatty Liver
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Fatty Liver
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Fatty Liver
PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.
Fatty Liver
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Fatty Liver
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Fatty Liver
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
Fatty Liver
Renalase Attenuates Mouse Fatty Liver Ischemia/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1.
Fatty Liver
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Fatty Liver
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
Fatty Liver
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Fatty Liver
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Fatty Liver
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Fatty Liver
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
Fatty Liver
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Fatty Liver
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
Fatty Liver
Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins.
Fatty Liver
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Fatty Liver
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Fatty Liver
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Fatty Liver
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Fatty Liver
Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice.
Fatty Liver
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
Fatty Liver
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
Fatty Liver
Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice.
Fatty Liver
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Fatty Liver, Alcoholic
2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy.
Fatty Liver, Alcoholic
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Fatty Liver, Alcoholic
Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease.
Fatty Liver, Alcoholic
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Fatty Liver, Alcoholic
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Fatty Liver, Alcoholic
Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
Fatty Liver, Alcoholic
MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.
Fatty Liver, Alcoholic
The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Fetal Diseases
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Fetal Growth Retardation
Advances in the role of silence information regulator family in pathological pregnancy.
Fetal Growth Retardation
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
Fibromatosis, Aggressive
The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor.
Fibrosarcoma
Activation of SIRT1 protects pancreatic ?-cells against palmitate-induced dysfunction.
Fibrosarcoma
miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-?B factor in human fibrosarcoma cells.
Fibrosarcoma
Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells.
Fragile X Syndrome
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Friedreich Ataxia
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Friedreich Ataxia
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Frontotemporal Dementia
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Gallbladder Neoplasms
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
Gallstones
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
Ganglion Cysts
Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats.
Gastritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Gastrointestinal Diseases
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Gastrointestinal Neoplasms
Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Genetic Diseases, Inborn
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Giant Cell Arteritis
An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation.
Glaucoma
Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma.
Glaucoma
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Glaucoma, Open-Angle
The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma.
Glioblastoma
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
Glioblastoma
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Glioblastoma
Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells.
Glioblastoma
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Glioblastoma
Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells.
Glioblastoma
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Glioblastoma
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
Glioblastoma
miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1.
Glioblastoma
Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
Glioblastoma
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
Glioblastoma
[Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway].
Glioblastoma
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Glioma
Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA.
Glioma
Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100? secretion by regulating sirtuin 1 in C6 rat glioma cells.
Glioma
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
Glioma
Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1.
Glioma
CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression.
Glioma
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
Glioma
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Glioma
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
Glioma
Exendin-4 inhibits glioma cell migration, invasion and epithelial-to-mesenchymal transition through GLP-1R/sirt3 pathway.
Glioma
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
Glioma
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Glioma
Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1.
Glioma
Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a.
Glioma
Long noncoding RNA-GAS5 attenuates progression of glioma by eliminating microRNA-10b and Sirtuin 1 in U251 and A172 cells.
Glioma
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
Glioma
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Glioma
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes.
Glioma
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
Glioma
MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1.
Glioma
miR?34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage.
Glioma
Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI.
Glioma
Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study.
Glioma
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
Glioma
Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation.
Glioma
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.
Glioma
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
Glioma
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
Glioma
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Glioma
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Glioma
Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway.
Glioma
Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.
Glioma
Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas.
Glomerulonephritis
Resveratrol possesses protective effects in a pristane-induced lupus mouse model.
Glomerulonephritis
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Glomerulonephritis, IGA
IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-?B/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1.
Glomus Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Glucose Intolerance
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.
Glucose Intolerance
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Glucose Intolerance
Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice.
Glucose Intolerance
Intra-arterial Targeted Islet-specific Expression of Sirt1 Protects ? Cells From Streptozotocin-induced Apoptosis in Mice.
Glucose Intolerance
Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity.
Glucose Intolerance
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Glucose Intolerance
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Glucose Intolerance
Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding.
Glucose Intolerance
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Glucose Intolerance
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
Glucose Intolerance
SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
Glucose Intolerance
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Glucose Intolerance
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
Glucose Intolerance
Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.
Glucose Metabolism Disorders
Inhibition of silent information regulator 1 induces glucose metabolism disorders of hepatocytes and enhances hepatitis C virus replication.
Glucose Metabolism Disorders
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Glycogen Storage Disease
Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
Glycogen Storage Disease
Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia.
Glycosuria
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Gout
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Gout
Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway.
Graft vs Host Disease
[SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].
Graves Disease
Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease.
Hashimoto Disease
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Head and Neck Neoplasms
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
Head and Neck Neoplasms
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Head and Neck Neoplasms
SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
Hearing Loss
Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging.
Hearing Loss
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
Hearing Loss
Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis.
Hearing Loss
Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss.
Hearing Loss
Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
Hearing Loss
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
Hearing Loss
SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss.
Hearing Loss
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy.
Hearing Loss
SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
Hearing Loss
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Hearing Loss
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Hearing Loss
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Hearing Loss
Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating Sirt1 activity and Bak1 expression.
Hearing Loss
Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice.
Hearing Loss, Noise-Induced
Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss.
Hearing Loss, Noise-Induced
The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss.
Hearing Loss, Sensorineural
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Heart Arrest
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Heart Diseases
1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes.
Heart Diseases
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.
Heart Diseases
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Heart Diseases
Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway.
Heart Diseases
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Heart Diseases
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways.
Heart Diseases
Protection of the heart against ischemia/reperfusion by silent information regulator 1.
Heart Diseases
Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.
Heart Diseases
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Heart Diseases
Sirtuin 1 Activation Reduces Transforming Growth Factor-?1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Heart Diseases
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.
Heart Diseases
The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule.
Heart Failure
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Heart Failure
Application of a real-ambient fine particulate matter exposure system on different animal models.
Heart Failure
Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation.
Heart Failure
Cardiac Rehabilitation Increases SIRT1 Activity and ?-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction.
Heart Failure
Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.
Heart Failure
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Heart Failure
Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Heart Failure
Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction.
Heart Failure
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Heart Failure
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Heart Failure
Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure.
Heart Failure
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Heart Failure
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
Heart Failure
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.
Heart Failure
Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1.
Heart Failure
Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway.
Heart Failure
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
Heart Failure
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Heart Failure
MicroRNA?138?5p drives the progression of heart failure via inhibiting sirtuin 1 signaling.
Heart Failure
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Heart Failure
Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential.
Heart Failure
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure.
Heart Failure
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Heart Failure
Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3.
Heart Failure
Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure.
Heart Failure
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy.
Heart Failure
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Heart Failure
Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Heart Failure
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
Heart Failure
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Heart Failure
Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes.
Heart Failure
Sirt1 improves heart failure through modulating the NF-?B p65/microRNA-155/BNDF signaling cascade.
Heart Failure
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Heart Failure
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
Heart Failure
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Heart Failure
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
Heart Failure
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Heart Failure
Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.
Heart Neoplasms
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Heart Septal Defects, Ventricular
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Heart Valve Diseases
[Association between single nucleotide polymorphism in promoter region of SIRT1 gene and senile degenerative heart valvular disease].
Hematologic Neoplasms
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Hematologic Neoplasms
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Hematologic Neoplasms
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Hematologic Neoplasms
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Hematologic Neoplasms
Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.
Hepatic Encephalopathy
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats.
Hepatic Encephalopathy
Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity.
Hepatitis
Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions.
Hepatitis
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Hepatitis
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.
Hepatitis
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
Hepatitis
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Hepatitis A
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Hepatitis B
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
Hepatitis B
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Hepatitis B
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Hepatitis B
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
Hepatitis B
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Hepatitis B
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
Hepatitis B
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
Hepatitis B
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Hepatitis B
Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.
Hepatitis B
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Hepatitis B
The metabolic sensors FXR?, PGC-1?, and SIRT1 cooperatively regulate hepatitis B virus transcription.
Hepatitis B
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Hepatitis B
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Hepatitis, Alcoholic
The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3.
Hepatoblastoma
Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3.
Herpes Zoster
A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes.
Herpes Zoster
Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes.
Herpes Zoster
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Herpes Zoster
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
HIV Infections
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.
HIV Infections
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
HIV-Associated Lipodystrophy Syndrome
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Hodgkin Disease
Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting.
Hodgkin Disease
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.
Huntington Disease
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase.
Huntington Disease
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Huntington Disease
Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1? deacetylation.
Huntington Disease
An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Huntington Disease
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Huntington Disease
Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington's Disease.
Huntington Disease
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.
Huntington Disease
Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
Huntington Disease
Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.
Huntington Disease
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Huntington Disease
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Huntington Disease
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1.
Huntington Disease
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Huntington Disease
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Huntington Disease
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Huntington Disease
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Huntington Disease
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Huntington Disease
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Huntington Disease
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Huntington Disease
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease.
Huntington Disease
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
Huntington Disease
SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
Huntington Disease
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
Huntington Disease
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
Huntington Disease
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.
Huntington Disease
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Huntington Disease
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
Huntington Disease
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
Huntington Disease
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
Huntington Disease
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Huntington Disease
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Huntington Disease
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Huntington Disease
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Huntington Disease
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Hyperalgesia
Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.
Hyperalgesia
Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve.
Hyperalgesia
Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1.
Hyperalgesia
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
Hyperalgesia
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Hyperalgesia
Reduction of Silent Information Regulator 1 Activates Interleukin-33/ST2 Signaling and Contributes to Neuropathic Pain Induced by Spared Nerve Injury in Rats.
Hyperalgesia
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib.
Hyperalgesia
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Hyperalgesia
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
Hyperalgesia
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Hyperandrogenism
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Hypercholesterolemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hyperglycemia
Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production.
Hyperglycemia
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Hyperglycemia
Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.
Hyperglycemia
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Hyperglycemia
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Hyperglycemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hyperglycemia
Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF.
Hyperglycemia
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Hyperglycemia
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Hyperglycemia
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Hyperglycemia
High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.
Hyperglycemia
High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway.
Hyperglycemia
Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.
Hyperglycemia
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Hyperglycemia
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Hyperglycemia
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Hyperglycemia
Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway.
Hyperglycemia
Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes.
Hyperglycemia
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Hyperglycemia
SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells.
Hyperglycemia
SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.
Hyperglycemia
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
Hyperglycemia
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
Hyperglycemia
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Hyperglycemia
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Hyperglycemia
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
Hyperglycemia
Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis.
Hyperglycemia
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
Hyperglycemia
The Relationship between Diabetes Mellitus Type II and Intervertebral Disc Degeneration in Diabetic Rodent Models: A Systematic and Comprehensive Review.
Hyperglycemia
Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression.
Hyperhomocysteinemia
Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis.
Hyperinsulinism
Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice.
Hyperinsulinism
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Hyperinsulinism
Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia.
Hyperinsulinism
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Hyperlipidemias
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Hyperlipidemias
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Hyperlipidemias
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Hyperlipidemias
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Hyperlipidemias
Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort.
Hyperlipidemias
Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.
Hyperlipidemias
Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster.
Hyperlipidemias
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
Hyperlipidemias
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Hyperlipidemias
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
Hyperphosphatemia
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence].
Hypersensitivity
Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome.
Hypersensitivity
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
Hypersensitivity
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Hypersensitivity
SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.
Hypersensitivity
Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-? activity in dendritic cells.
Hypertension
15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia.
Hypertension
?-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux.
Hypertension
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Hypertension
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
Hypertension
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Hypertension
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells.
Hypertension
Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Hypertension
Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.
Hypertension
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Hypertension
Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension.
Hypertension
Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.
Hypertension
Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
Hypertension
Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3.
Hypertension
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Hypertension
Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.
Hypertension
Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
Hypertension
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Hypertension
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
Hypertension
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.
Hypertension
Hypertension and Mitochondrial Oxidative Stress Revisited: Sirtuin 3, the Improved "Antioxidant".
Hypertension
Inhibition of Mitochondrial Oxidative Damage Improves Reendothelialization Capacity of Endothelial Progenitor Cells via SIRT3 (Sirtuin 3)-Enhanced SOD2 (Superoxide Dismutase 2) Deacetylation in Hypertension.
Hypertension
Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Hypertension
Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring.
Hypertension
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
Hypertension
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.
Hypertension
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Hypertension
Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.
Hypertension
NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway.
Hypertension
Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice.
Hypertension
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Hypertension
Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Hypertension
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension.
Hypertension
Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring.
Hypertension
SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for hypertension.
Hypertension
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Hypertension
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro.
Hypertension
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension.
Hypertension
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Hypertension
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Hypertension
Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy.
Hypertension
The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension.
Hypertension
The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population.
Hypertension
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
Hypertension
The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1? (Gly482Ser), UCP2 -866 G/A and SIRT1 -1400 T/C polymorphisms with T2D in the population of Punjab.
Hypertension
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Hypertension
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Hypertension, Portal
Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
Hypertension, Portal
MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1.
Hypertension, Pulmonary
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
Hyperthyroidism
Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.
Hypertrophy, Left Ventricular
Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients.
Hypertrophy, Left Ventricular
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Hypertrophy, Left Ventricular
Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
Hypoglycemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hypothyroidism
Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk.
Hypothyroidism
The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level.
Idiopathic Pulmonary Fibrosis
Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition.
Idiopathic Pulmonary Fibrosis
SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment.
Idiopathic Pulmonary Fibrosis
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts.
Idiopathic Pulmonary Fibrosis
Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat.
Infarction, Middle Cerebral Artery
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Infarction, Middle Cerebral Artery
Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner.
Infarction, Middle Cerebral Artery
N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway.
Infarction, Middle Cerebral Artery
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Infarction, Middle Cerebral Artery
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Infarction, Middle Cerebral Artery
Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia.
Infarction, Middle Cerebral Artery
Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells.
Infarction, Middle Cerebral Artery
QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPAR?-PGC-1? axis.
Infarction, Middle Cerebral Artery
Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice.
Infarction, Middle Cerebral Artery
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Infarction, Middle Cerebral Artery
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
Infarction, Middle Cerebral Artery
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Infarction, Middle Cerebral Artery
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Infections
2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization.
Infections
A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.
Infections
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Infections
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
Infections
Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.
Infections
Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1.
Infections
Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk.
Infections
Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis.
Infections
Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i.
Infections
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Infections
EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation.
Infections
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Infections
Helicobacter pylori inhibits autophagic flux and promotes its intracellular survival and colonization by down-regulating SIRT1.
Infections
Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells.
Infections
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Infections
Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking.
Infections
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Infections
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Infections
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis.
Infections
Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein.
Infections
Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes.
Infections
Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis.
Infections
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
Infections
MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A.
Infections
microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway.
Infections
microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection.
Infections
MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS.
Infections
Modulation of the AMPK/Sirt1 axis during neuronal infection by herpes simplex virus type 1.
Infections
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Infections
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
Infections
Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection.
Infections
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Infections
Plant defence suppression is mediated by a fungal sirtuin during rice infection by Magnaporthe oryzae.
Infections
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Infections
Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation.
Infections
Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy.
Infections
Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1.
Infections
Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-?B binding site.
Infections
Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis.
Infections
Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.
Infections
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
Infections
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
Infections
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
Infections
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
Infections
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Infections
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
Infections
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Infections
Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.
Infections
Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.
Infections
Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells.
Infections
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain.
Infections
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Infections
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Infections
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Infections
Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death.
Infections
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
Infections
Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?.
Infections
Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.
Infections
Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans.
Infections
Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species.
Infections
The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection.
Infections
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
Infections
The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 protein.
Infections
The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.
Infections
The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections.
Infections
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Infections
Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence.
Infections
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3).
Infertility
3 SIRT1-A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES?
Infertility
Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF-1.
Infertility
Melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3 in testicular Leydig cells.
Infertility
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Infertility, Male
MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death.
Infertility, Male
Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele.
Infertility, Male
The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling.
Inflammatory Bowel Diseases
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Inflammatory Bowel Diseases
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
Inflammatory Bowel Diseases
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells.
Inflammatory Bowel Diseases
The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice.
Influenza, Human
Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.
Insulin Resistance
A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome.
Insulin Resistance
A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA
Insulin Resistance
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Insulin Resistance
AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance.
Insulin Resistance
Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes).
Insulin Resistance
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Insulin Resistance
Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans.
Insulin Resistance
Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect.
Insulin Resistance
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.
Insulin Resistance
Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.
Insulin Resistance
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine.
Insulin Resistance
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Insulin Resistance
Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced "Stemness" through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration.
Insulin Resistance
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
Insulin Resistance
Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity.
Insulin Resistance
Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.
Insulin Resistance
Alzheimer's Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies.
Insulin Resistance
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
Insulin Resistance
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
Insulin Resistance
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Insulin Resistance
Application of resveratrol in diabetes: rationale, strategies and challenges.
Insulin Resistance
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Insulin Resistance
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.
Insulin Resistance
Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance.
Insulin Resistance
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
Insulin Resistance
CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice.
Insulin Resistance
CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1.
Insulin Resistance
Connecting the dots: molecular and epigenetic mechanisms in type 2 diabetes.
Insulin Resistance
Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation.
Insulin Resistance
Correction to: Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes.
Insulin Resistance
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Insulin Resistance
DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression.
Insulin Resistance
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Insulin Resistance
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells.
Insulin Resistance
Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.
Insulin Resistance
Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.
Insulin Resistance
Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism.
Insulin Resistance
Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.
Insulin Resistance
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity.
Insulin Resistance
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Insulin Resistance
Effects of metformin and Exenatide on insulin resistance and AMPK?-SIRT1 molecular pathway in PCOS rats.
Insulin Resistance
Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
Insulin Resistance
Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice.
Insulin Resistance
ELECTROACUPUNCTURE IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS FEMORIS.
Insulin Resistance
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Insulin Resistance
Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle.
Insulin Resistance
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Insulin Resistance
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Insulin Resistance
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1? Pathway in Zucker Diabetic Fatty Rats.
Insulin Resistance
GLP?1 improves palmitate?induced insulin resistance in human skeletal muscle via SIRT1 activity.
Insulin Resistance
Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility.
Insulin Resistance
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.
Insulin Resistance
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Insulin Resistance
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
Insulin Resistance
High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression.
Insulin Resistance
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Insulin Resistance
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction.
Insulin Resistance
Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice.
Insulin Resistance
Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide.
Insulin Resistance
Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid.
Insulin Resistance
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.
Insulin Resistance
Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake.
Insulin Resistance
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
Insulin Resistance
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
Insulin Resistance
Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice.
Insulin Resistance
Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
Insulin Resistance
Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia.
Insulin Resistance
Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1.
Insulin Resistance
Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Insulin Resistance
Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3.
Insulin Resistance
Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial.
Insulin Resistance
Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway.
Insulin Resistance
Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK.
Insulin Resistance
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
Insulin Resistance
miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1).
Insulin Resistance
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
Insulin Resistance
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Insulin Resistance
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.
Insulin Resistance
Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance.
Insulin Resistance
Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPAR? Receptor Activators.
Insulin Resistance
Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
Insulin Resistance
Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet.
Insulin Resistance
Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.
Insulin Resistance
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
Insulin Resistance
N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation.
Insulin Resistance
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues.
Insulin Resistance
New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis.
Insulin Resistance
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Insulin Resistance
Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster.
Insulin Resistance
Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.
Insulin Resistance
Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role.
Insulin Resistance
Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1.
Insulin Resistance
Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.
Insulin Resistance
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.
Insulin Resistance
Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.
Insulin Resistance
Peripheral and central regulation of insulin by the intestine and microbiome.
Insulin Resistance
Peroxisome Proliferator-Activated Receptor -?/?, -? Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism.
Insulin Resistance
PGRN exerts inflammatory effects via SIRT1-NF-?B in adipose insulin resistance.
Insulin Resistance
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Insulin Resistance
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.
Insulin Resistance
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Insulin Resistance
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.
Insulin Resistance
Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial.
Insulin Resistance
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Insulin Resistance
Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine 1-Phosphate.
Insulin Resistance
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Insulin Resistance
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
Insulin Resistance
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats.
Insulin Resistance
Relationship between insulin sensitivity and gene expression in human skeletal muscle.
Insulin Resistance
Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance.
Insulin Resistance
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.
Insulin Resistance
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Insulin Resistance
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio.
Insulin Resistance
Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway.
Insulin Resistance
Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet.
Insulin Resistance
Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion.
Insulin Resistance
Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities.
Insulin Resistance
Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK.
Insulin Resistance
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.
Insulin Resistance
Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.
Insulin Resistance
Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis.
Insulin Resistance
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Insulin Resistance
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Insulin Resistance
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.
Insulin Resistance
Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice.
Insulin Resistance
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway.
Insulin Resistance
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Insulin Resistance
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Insulin Resistance
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Insulin Resistance
Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function.
Insulin Resistance
SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells.
Insulin Resistance
SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150.
Insulin Resistance
SIRT1 deacetylates mitochondrial trifunctional enzyme ? subunit to inhibit ubiquitylation and decrease insulin resistance.
Insulin Resistance
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.
Insulin Resistance
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
Insulin Resistance
SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting.
Insulin Resistance
SirT1 gain of function increases energy efficiency and prevents diabetes in mice.
Insulin Resistance
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study.
Insulin Resistance
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
Insulin Resistance
SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
Insulin Resistance
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Insulin Resistance
SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats.
Insulin Resistance
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Insulin Resistance
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Insulin Resistance
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Insulin Resistance
SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria.
Insulin Resistance
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
Insulin Resistance
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
Insulin Resistance
SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol.
Insulin Resistance
SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes.
Insulin Resistance
SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.
Insulin Resistance
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
Insulin Resistance
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Insulin Resistance
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
Insulin Resistance
SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.
Insulin Resistance
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Insulin Resistance
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Insulin Resistance
Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1.
Insulin Resistance
Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice.
Insulin Resistance
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Insulin Resistance
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
Insulin Resistance
Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans.
Insulin Resistance
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.
Insulin Resistance
Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice.
Insulin Resistance
Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?
Insulin Resistance
Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis.
Insulin Resistance
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
Insulin Resistance
The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats.
Insulin Resistance
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
Insulin Resistance
The effects of Sea buckthorn seed protein on glucose metabolism in streptozotocin-induced diabetic ICR mice.
Insulin Resistance
The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial.
Insulin Resistance
The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1.
Insulin Resistance
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
Insulin Resistance
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing.
Insulin Resistance
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Insulin Resistance
The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease.
Insulin Resistance
Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway.
Insulin Resistance
TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1.
Insulin Resistance
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Insulin Resistance
Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats.
Insulin Resistance
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
Insulin Resistance
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
Insulin Resistance
Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling.
Insulin Resistance
Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome.
Insulin Resistance
[Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet].
Insulin Resistance
[Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus].
Insulin Resistance
[Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat].
Insulin Resistance
[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.]
Insulin Resistance
[The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle].
Insulinoma
High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin.
Intellectual Disability
Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1.
Intellectual Disability
Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.
Intellectual Disability
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Intervertebral Disc Degeneration
Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration.
Intervertebral Disc Degeneration
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Intervertebral Disc Degeneration
MiR-138-5p promotes TNF-?-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling.
Intervertebral Disc Degeneration
Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro.
Intervertebral Disc Degeneration
Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration.
Intervertebral Disc Degeneration
SIRT1 Inhibits the Catabolic Effect of IL-1? Through TLR2/SIRT1/NF-?B Pathway in Human Degenerative Nucleus Pulposus Cells.
Intervertebral Disc Degeneration
SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model.
Intervertebral Disc Degeneration
Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun.
Intervertebral Disc Degeneration
SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress-induced senescence of nucleus pulposus cells.
Intervertebral Disc Degeneration
SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3/FOXO3/SOD2 signaling pathway.
Intervertebral Disc Degeneration
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Intervertebral Disc Degeneration
Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration.
Intervertebral Disc Degeneration
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.
Intervertebral Disc Displacement
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Iron Deficiencies
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Iron Overload
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Iron Overload
PPAR? agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and ?-catenin signaling.
Ischemic Stroke
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.
Ischemic Stroke
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Ischemic Stroke
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Ischemic Stroke
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Ischemic Stroke
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Ischemic Stroke
Long non?coding RNA H19 inhibition ameliorates oxygen?glucose deprivation?induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA?29b/SIRT1/PGC?1? axis.
Ischemic Stroke
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Ischemic Stroke
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Ischemic Stroke
Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature.
Ischemic Stroke
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Ischemic Stroke
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Ischemic Stroke
Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
Ischemic Stroke
PPAR-? promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3.
Ischemic Stroke
Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes.
Ischemic Stroke
Silent information regulator 1 protects the brain against cerebral ischemic damage.
Ischemic Stroke
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke.
Ischemic Stroke
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Ischemic Stroke
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Ischemic Stroke
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Ischemic Stroke
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Ischemic Stroke
The Anti-apoptosis Effect of Single Electroacupuncture Treatment via Suppressing Neuronal Autophagy in the Acute Stage of Ischemic Stroke Without Infarct Alleviation.
Ischemic Stroke
The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies.
Keratosis, Actinic
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Ketosis
Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1.
Ketosis
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Ketosis
Sirtuin 3 inhibits nuclear factor-?B signaling activated by a fatty acid challenge in bovine mammary epithelial cells.
Kidney Calculi
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Kidney Calculi
Re: SIRT3 Inhibited the Formation of Calcium Oxalate-Induced Kidney Stones through Regulating NRF2/HO-1 Signaling Pathway.
Kidney Calculi
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury.
Kidney Calculi
SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway.
Kidney Calculi
Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy.
Kidney Calculi
Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages.
Kidney Diseases
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Kidney Diseases
Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin.
Kidney Diseases
Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.
Kidney Diseases
Genistein Ameliorates Ischemia/Reperfusion-Induced Renal Injury in a SIRT1-Dependent Manner.
Kidney Diseases
Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system.
Kidney Diseases
Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline.
Kidney Diseases
Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis.
Kidney Diseases
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.
Kidney Diseases
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.
Kidney Diseases
Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway.
Kidney Diseases
The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress.
Kidney Diseases
Up-Regulation of SIRT1 Reduces Endoplasmic Reticulum Stress and Renal Fibrosis.
Kidney Failure, Chronic
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy.
Kidney Neoplasms
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Legionnaires' Disease
Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes.
Leiomyoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Leiomyosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Leishmaniasis
Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis.
Leishmaniasis
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Leishmaniasis
Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis.
Leishmaniasis
Sir2-Related Protein 1 from Leishmania amazonensis is a glycosylated NAD+-dependent deacetylase.
Lentivirus Infections
Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1.
Lentivirus Infections
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Lentivirus Infections
SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14.
Lentivirus Infections
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.
Leukemia
A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.
Leukemia
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib.
Leukemia
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Leukemia
Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression.
Leukemia
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Leukemia
CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1.
Leukemia
Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling.
Leukemia
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia.
Leukemia
Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Leukemia
Deregulation of mitochondrial sirtuins and OGG1-2a acts as a prognostic and diagnostic biomarker in leukemia.
Leukemia
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Leukemia
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Leukemia
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Leukemia
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).
Leukemia
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
Leukemia
High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Leukemia
Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.
Leukemia
Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Leukemia
Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation.
Leukemia
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Leukemia
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
Leukemia
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
Leukemia
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
Leukemia
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Leukemia
Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells.
Leukemia
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Leukemia
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Leukemia
[Construction of SIRT1 Promoter Expression Vector and Its Activity Analysis as well as Influence of AML1-ETO on Transcriptional Regulation of SIRT1 Gene].
Leukemia
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Leukemia
[New strategy of adult T-cell leukemia treatment targeted for anti-tumor immunity and a longevity gene-encoded protein].
Leukemia, Erythroblastic, Acute
Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1.
Leukemia, Lymphocytic, Chronic, B-Cell
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
Leukemia, Lymphocytic, Chronic, B-Cell
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).
Leukemia, Lymphocytic, Chronic, B-Cell
HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance.
Leukemia, Lymphocytic, Chronic, B-Cell
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Leukemia, Lymphocytic, Chronic, B-Cell
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Role of SIRT1 in hematologic malignancies.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor ? B-reactive oxygen species signaling axis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sirtuins in hematological aging and malignancy.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Leukemia, Myeloid
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
Leukemia, Myeloid
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Leukemia, Myeloid, Acute
A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.
Leukemia, Myeloid, Acute
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Leukemia, Myeloid, Acute
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
Leukemia, Myeloid, Acute
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
Leukemia, Myeloid, Acute
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
Leukemia, Myeloid, Acute
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.
Leukemia, Myeloid, Acute
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
SIRT2 mediates multidrug resistance in acute myelogenous leukemia cells via ERK1/2 signaling pathway.
Leukemia, Myeloid, Acute
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Leukemia, Myeloid, Acute
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Leukemia, Myeloid, Acute
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Leukemia, Promyelocytic, Acute
Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Leukemia-Lymphoma, Adult T-Cell
Deciphering microRNA-mRNA regulatory network in adult T-cell leukemia/lymphoma; the battle between oncogenes and anti-oncogenes.
Leukemia-Lymphoma, Adult T-Cell
High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Leukemia-Lymphoma, Adult T-Cell
KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells.
Leukemia-Lymphoma, Adult T-Cell
SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair.
Lipid Metabolism Disorders
Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.
Lipid Metabolism Disorders
Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats.
Lipid Metabolism Disorders
Silent information regulator 1 inhibition induces lipid metabolism disorders of hepatocytes and enhances hepatitis C virus replication.
Lipodystrophy
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Lipoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Liposarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Listeriosis
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Liver Cirrhosis
?-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.
Liver Cirrhosis
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Liver Cirrhosis
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.
Liver Cirrhosis
Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-?1/Smad3 and autophagy pathway.
Liver Cirrhosis
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Liver Cirrhosis
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Liver Cirrhosis
Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis.
Liver Cirrhosis
Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1.
Liver Cirrhosis
Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis.
Liver Cirrhosis
Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis.
Liver Cirrhosis
GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway.
Liver Cirrhosis
Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.
Liver Cirrhosis
MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1.
Liver Cirrhosis
Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway.
Liver Cirrhosis
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
Liver Cirrhosis
PKC? Mediates NF-?B Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis.
Liver Cirrhosis
Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis.
Liver Cirrhosis
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Liver Cirrhosis
SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.
Liver Cirrhosis
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Liver Cirrhosis
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Liver Cirrhosis
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy.
Liver Cirrhosis
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Liver Cirrhosis
Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis.
Liver Cirrhosis
TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence.
Liver Cirrhosis
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Liver Cirrhosis, Biliary
Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
Liver Diseases
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Liver Diseases
A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress.
Liver Diseases
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Liver Diseases
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization.
Liver Diseases
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Liver Diseases
Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1.
Liver Diseases
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Liver Diseases
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Liver Diseases
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Liver Diseases
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
Liver Diseases
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Liver Diseases
Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease.
Liver Diseases
Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling.
Liver Diseases
Cysteine cathepsins control hepatic NF-?B-dependent inflammation via sirtuin-1 regulation.
Liver Diseases
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
Liver Diseases
DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model.
Liver Diseases
Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling.
Liver Diseases
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Liver Diseases
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Liver Diseases
Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.
Liver Diseases
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK.
Liver Diseases
Hepatoprotection of Berberine Against Hydrogen Peroxide-induced Apoptosis by Upregulation of Sirtuin 1.
Liver Diseases
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Liver Diseases
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
Liver Diseases
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
Liver Diseases
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Liver Diseases
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Liver Diseases
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
Liver Diseases
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
Liver Diseases
MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1.
Liver Diseases
MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.
Liver Diseases
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Liver Diseases
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7).
Liver Diseases
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Liver Diseases
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Liver Diseases
Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model.
Liver Diseases
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Liver Diseases
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Liver Diseases
Relevance of SIRT1-NF-?B Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease.
Liver Diseases
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Liver Diseases
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.
Liver Diseases
Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease.
Liver Diseases
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
Liver Diseases
Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol.
Liver Diseases
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Liver Diseases
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Liver Diseases
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
Liver Diseases
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
Liver Diseases
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity.
Liver Diseases
SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells.
Liver Diseases
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Liver Diseases
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Liver Diseases
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
Liver Diseases
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.
Liver Diseases
The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation.
Liver Diseases
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Liver Diseases
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
Liver Diseases
[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats]
Liver Diseases, Alcoholic
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.
Liver Diseases, Alcoholic
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Liver Diseases, Alcoholic
Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice.
Liver Diseases, Alcoholic
Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice.
Liver Diseases, Alcoholic
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
Liver Diseases, Alcoholic
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Liver Failure, Acute
Protective role of AGK2 on thioacetamide-induced acute liver failure in mice.
Liver Neoplasms
Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis.
Liver Neoplasms
AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells.
Liver Neoplasms
Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.
Liver Neoplasms
Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells.
Liver Neoplasms
Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
Liver Neoplasms
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Liver Neoplasms
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
Liver Neoplasms
MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization.
Liver Neoplasms
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
Liver Neoplasms
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
Liver Neoplasms
MicroRNA-29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression.
Liver Neoplasms
MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer.
Liver Neoplasms
miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
Liver Neoplasms
miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer.
Liver Neoplasms
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
Liver Neoplasms
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Liver Neoplasms
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Liver Neoplasms
Sirt1 suppresses Wnt/?Catenin signaling in liver cancer cells by targeting ?Catenin in a PKA?-dependent manner.
Liver Neoplasms
Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
Liver Neoplasms
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Liver Neoplasms
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
Liver Neoplasms
The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro.
Liver Neoplasms
Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer.
Lung Diseases
Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
Lung Diseases
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Lung Injury
Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability.
Lung Injury
Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression.
Lung Injury
Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
Lung Injury
Identification of Multiple Anti-inflammatory Pathways Triggered by Resveratrol Leading to Amelioration of Staphylococcal Enterotoxin B-Induced Lung Inflammation.
Lung Injury
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Lung Injury
Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.
Lung Injury
Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway.
Lung Injury
MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1.
Lung Injury
Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.
Lung Injury
p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.
Lung Injury
Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.
Lung Injury
Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis.
Lung Injury
Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury.
Lung Injury
Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs.
Lung Injury
Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways.
Lung Injury
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Lung Injury
Silent information regulator type-1 mediates amelioration of inflammatory response and oxidative stress in lipopolysaccharide-induced acute respiratory distress syndrome.
Lung Injury
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro.
Lung Injury
SIRT1 mediates a primed response to immune challenge after traumatic lung injury.
Lung Injury
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Lung Injury
Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema.
Lung Injury
Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1.
Lung Injury
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-?B acetylation.
Lung Injury
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Lung Injury
[Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs].
Lung Neoplasms
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
Lung Neoplasms
A new series of benzoxazole-based SIRT1 modulators for targeted therapy of non-small-cell lung cancer.
Lung Neoplasms
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
Lung Neoplasms
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
Lung Neoplasms
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer.
Lung Neoplasms
An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer.
Lung Neoplasms
Celecoxib and sulindac inhibit TGF-?1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1.
Lung Neoplasms
Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884].
Lung Neoplasms
Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells.
Lung Neoplasms
Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells.
Lung Neoplasms
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Lung Neoplasms
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Lung Neoplasms
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
Lung Neoplasms
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Lung Neoplasms
Effect of SIRT1 activators and inhibitors on CD44+/CD133+?enriched non?small cell lung cancer cells.
Lung Neoplasms
Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents.
Lung Neoplasms
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Lung Neoplasms
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Lung Neoplasms
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Lung Neoplasms
Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-?B.
Lung Neoplasms
Future treatments for chronic obstructive pulmonary disease and its comorbidities.
Lung Neoplasms
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
Lung Neoplasms
Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.
Lung Neoplasms
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Lung Neoplasms
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Lung Neoplasms
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
Lung Neoplasms
Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
Lung Neoplasms
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
Lung Neoplasms
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Lung Neoplasms
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
Lung Neoplasms
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
Lung Neoplasms
miR-448 promotes progression of non-small-cell lung cancer via targeting SIRT1.
Lung Neoplasms
miR?150 promotes the proliferation and migration of non?small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway.
Lung Neoplasms
miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5.
Lung Neoplasms
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Lung Neoplasms
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Lung Neoplasms
RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression.
Lung Neoplasms
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Lung Neoplasms
Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK.
Lung Neoplasms
Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
Lung Neoplasms
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
Lung Neoplasms
SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.
Lung Neoplasms
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
Lung Neoplasms
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
Lung Neoplasms
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Lung Neoplasms
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
Lung Neoplasms
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
Lung Neoplasms
SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.
Lung Neoplasms
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
Lung Neoplasms
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
Lung Neoplasms
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
Lung Neoplasms
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Lung Neoplasms
SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.
Lung Neoplasms
Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells.
Lung Neoplasms
SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis.
Lung Neoplasms
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
Lung Neoplasms
Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer.
Lung Neoplasms
Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling.
Lung Neoplasms
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Lung Neoplasms
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
Lung Neoplasms
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis.
Lung Neoplasms
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis.
Lung Neoplasms
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Lung Neoplasms
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
Lung Neoplasms
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
Lung Neoplasms
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Lung Neoplasms
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Lupus Erythematosus, Systemic
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Lupus Nephritis
Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-?B/NLRP3 inflammasome and sirtuin 1/autophagy axis.
Lupus Nephritis
The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRL/lpr Mice.
Lupus Nephritis
Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis.
Lymphatic Metastasis
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Lymphatic Metastasis
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Lymphatic Metastasis
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Lymphatic Metastasis
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Lymphatic Metastasis
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Lymphatic Metastasis
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Lymphatic Metastasis
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Lymphatic Metastasis
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Lymphatic Metastasis
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Lymphatic Metastasis
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Lymphatic Metastasis
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
Lymphatic Metastasis
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Lymphatic Metastasis
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Lymphatic Metastasis
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Lymphatic Metastasis
SIRT1 promotes formation of breast cancer through modulating Akt activity.
Lymphatic Metastasis
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
Lymphatic Metastasis
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
Lymphatic Metastasis
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Lymphatic Metastasis
Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
Lymphatic Metastasis
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
Lymphatic Metastasis
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
Lymphatic Metastasis
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Lymphatic Metastasis
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
Lymphatic Metastasis
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Lymphoma
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Lymphoma
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
Lymphoma
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Lymphoma
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
Lymphoma
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
Lymphoma
SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells.
Lymphoma
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
Lymphoma
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
Lymphoma
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
Lymphoma
SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway.
Lymphoma
Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma.
Lymphoma
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Lymphoma, B-Cell
Aging-Related Functional and Structural Changes in Renal Tissues: Lesson from a Camel Model.
Lymphoma, B-Cell
Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway.
Lymphoma, B-Cell
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Lymphoma, B-Cell
Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM-9 through regulating the SIRT1-NF-?B pathway.
Lymphoma, B-Cell
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Lymphoma, B-Cell
Effect of charcoal:dextran stripped fetal bovine serum on in vitro development of bovine embryos.
Lymphoma, B-Cell
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Lymphoma, B-Cell
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Lymphoma, B-Cell
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Lymphoma, B-Cell
Fibronectin protected bovine preantral follicles from the deleterious effects of kisspeptin.
Lymphoma, B-Cell
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Lymphoma, B-Cell
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
Lymphoma, B-Cell
MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions.
Lymphoma, B-Cell
Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats.
Lymphoma, B-Cell
Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.
Lymphoma, B-Cell
Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway.
Lymphoma, B-Cell
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
Lymphoma, B-Cell
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway.
Lymphoma, B-Cell
SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
Lymphoma, B-Cell
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
Lymphoma, B-Cell
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation.
Lymphoma, B-Cell
Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis.
Lymphoma, Large B-Cell, Diffuse
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway.
Lymphoma, Large B-Cell, Diffuse
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
Lymphoma, Large B-Cell, Diffuse
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Lymphoma, Primary Effusion
SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells.
Lymphoma, T-Cell
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.
Lymphoma, T-Cell
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
Lymphoma, T-Cell
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
Lymphoma, T-Cell, Cutaneous
SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis.
Lymphoma, T-Cell, Peripheral
Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-?B pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options.
Machado-Joseph Disease
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Machado-Joseph Disease
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo.
Macular Degeneration
Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium.
Macular Degeneration
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?.
Macular Degeneration
Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case-Control Pilot Study.
Macular Degeneration
SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.
Macular Degeneration
SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration.
Malaria
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Malaria
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Malaria
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Malaria, Cerebral
Biochemical characterization of Plasmodium falciparum Sir2, a NAD(+)-dependent deacetylase.
Malnutrition
Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy Aging.
Malnutrition
Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy-sensing of AMPK/SIRT1 in malnutrition.
Malnutrition
SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.
Malnutrition
Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.
Marfan Syndrome
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Massive Hepatic Necrosis
Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-?B.
Massive Hepatic Necrosis
The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
Medulloblastoma
Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.
Medulloblastoma
Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
Melanoma
4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
Melanoma
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Melanoma
AC-93253 triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation.
Melanoma
Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis.
Melanoma
Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells.
Melanoma
Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.
Melanoma
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Melanoma
Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
Melanoma
MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels.
Melanoma
MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1.
Melanoma
Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach.
Melanoma
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Melanoma
RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis.
Melanoma
Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
Melanoma
SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation.
Melanoma
SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells.
Melanoma
SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.
Melanoma
SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib.
Melanoma
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
Melanoma
Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism.
Memory Disorders
Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression.
Memory Disorders
Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations.
Memory Disorders
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction.
Memory Disorders
Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1.
Memory Disorders
Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3.
Memory Disorders
Obesity caused by a high-fat diet regulates the Sirt1/PGC-1?/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice.
Memory Disorders
Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1.
Memory Disorders
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?.
Memory Disorders
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Memory Disorders
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Memory Disorders
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Memory Disorders
Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice.
Mesothelioma
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.
Mesothelioma
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Mesothelioma
SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells.
Mesothelioma
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
Mesothelioma, Malignant
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Mesothelioma, Malignant
SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells.
Metabolic Diseases
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.
Metabolic Diseases
A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases.
Metabolic Diseases
Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases.
Metabolic Diseases
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Metabolic Diseases
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases.
Metabolic Diseases
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Metabolic Diseases
Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3.
Metabolic Diseases
Controlling SIRT1 expression by microRNAs in health and metabolic disease.
Metabolic Diseases
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Metabolic Diseases
Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans.
Metabolic Diseases
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Metabolic Diseases
Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide.
Metabolic Diseases
E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans.
Metabolic Diseases
Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes.
Metabolic Diseases
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Metabolic Diseases
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Metabolic Diseases
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.
Metabolic Diseases
Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1.
Metabolic Diseases
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
Metabolic Diseases
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Metabolic Diseases
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.
Metabolic Diseases
Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation.
Metabolic Diseases
Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.
Metabolic Diseases
Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes.
Metabolic Diseases
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Metabolic Diseases
Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis.
Metabolic Diseases
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Metabolic Diseases
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation.
Metabolic Diseases
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Metabolic Diseases
Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells.
Metabolic Diseases
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.
Metabolic Diseases
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Metabolic Diseases
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Metabolic Diseases
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Metabolic Diseases
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
Metabolic Diseases
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Metabolic Diseases
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents.
Metabolic Diseases
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
Metabolic Diseases
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
Metabolic Diseases
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
Metabolic Diseases
SIRT4 overexpression protects against diabetic nephropathy by inhibiting podocyte apoptosis.
Metabolic Diseases
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
Metabolic Diseases
Sirtuin 3: A major control point for obesity-related metabolic diseases?
Metabolic Diseases
Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
Metabolic Diseases
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Metabolic Diseases
Sirtuins as endogenous regulators of lung fibrosis: A current perspective.
Metabolic Diseases
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise.
Metabolic Diseases
Suppression of native defense mechanisms, SIRT1 and PPAR?, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases.
Metabolic Diseases
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
Metabolic Diseases
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Metabolic Syndrome
A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress.
Metabolic Syndrome
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Metabolic Syndrome
Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy.
Metabolic Syndrome
At the Crossroads of Longevity and Metabolism: The Metabolic Syndrome and Life-Span Determinant Pathways.
Metabolic Syndrome
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation.
Metabolic Syndrome
Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice.
Metabolic Syndrome
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Metabolic Syndrome
Development of a dietary-induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1.
Metabolic Syndrome
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Metabolic Syndrome
Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome.
Metabolic Syndrome
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
Metabolic Syndrome
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Metabolic Syndrome
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Metabolic Syndrome
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Metabolic Syndrome
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Metabolic Syndrome
Metabolomic connections between schizophrenia, antipsychotic drugs and metabolic syndrome: A variety of players.
Metabolic Syndrome
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Metabolic Syndrome
Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.
Metabolic Syndrome
Molecular Mechanisms of Latent Inflammation in Metabolic Syndrome. Possible Role of Sirtuins and Peroxisome Proliferator-Activated Receptor Type ?.
Metabolic Syndrome
Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet.
Metabolic Syndrome
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
Metabolic Syndrome
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome.
Metabolic Syndrome
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.
Metabolic Syndrome
Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role.
Metabolic Syndrome
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Metabolic Syndrome
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Metabolic Syndrome
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Metabolic Syndrome
Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome.
Metabolic Syndrome
Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism.
Metabolic Syndrome
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Metabolic Syndrome
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Metabolic Syndrome
SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism.
Metabolic Syndrome
SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome.
Metabolic Syndrome
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.
Metabolic Syndrome
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.
Metabolic Syndrome
Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome.
Metabolic Syndrome
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Metabolic Syndrome
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Metabolic Syndrome
Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders and induces a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp/NDmcr rats.
Metabolic Syndrome
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.
Metabolic Syndrome
The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome.
Metabolic Syndrome
Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness.
Metabolic Syndrome
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Metabolism, Inborn Errors
Sirtuin activation as a therapeutic approach against inborn errors of metabolism.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.
Migraine Disorders
miR-34a-5p up-regulates the IL-1?/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.
Migraine Disorders
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Migraine Disorders
[Effects of electroacupuncture on miR-34a-5p/SIRT1 signaling in the trigeminal ganglion of rats with migraine].
Mitochondrial Diseases
Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells.
Mitochondrial Diseases
Extranuclear localization of SIRT1 and PGC-1?: an insight into possible roles in diseases associated with mitochondrial dysfunction.
Mitochondrial Diseases
Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway.
Mitochondrial Diseases
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Mitochondrial Diseases
Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.
Mitochondrial Diseases
Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress.
Mitral Valve Insufficiency
Regulation of left atrial fibrosis induced by mitral regurgitation by SIRT1.
Mouth Neoplasms
Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling.
Mouth Neoplasms
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Mouth Neoplasms
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Mouth Neoplasms
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Movement Disorders
Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders.
MPTP Poisoning
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism.
mrna m6a methyltransferase deficiency
METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing.
Mucositis
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice.
Multiple Myeloma
Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.
Multiple Myeloma
Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
Multiple Myeloma
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
Multiple Myeloma
Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma.
Multiple Myeloma
SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma.
Multiple Myeloma
Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma.
Multiple Myeloma
The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.
Multiple Sclerosis
Association of miRNA and mRNA Levels of the Clinical Onset of Multiple Sclerosis Patients.
Multiple Sclerosis
Dysregulation of SIRT-1 Signaling in Multiple Sclerosis and Neuroimmune Disorders: A Systematic Review on SIRTUIN Activators as Potential Immunomodulators and Influences on other Dysfunctions.
Multiple Sclerosis
Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.
Multiple Sclerosis
Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes.
Multiple Sclerosis
Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes.
Multiple Sclerosis
Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis.
Multiple Sclerosis
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Multiple Sclerosis
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
Multiple Sclerosis
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
Multiple Sclerosis
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Multiple Sclerosis
SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
SIRT1 is decreased during relapses in patients with multiple sclerosis.
Multiple System Atrophy
Role of TPPP/p25 on ?-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Muscular Atrophy
Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-?B and activating SIRT1.
Muscular Atrophy
Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Muscular Atrophy
HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation.
Muscular Atrophy
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Muscular Atrophy
Isoflavones Derived from Soy Beans Prevent MuRF1-Mediated Muscle Atrophy in C2C12 Myotubes through SIRT1 Activation.
Muscular Atrophy
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Muscular Atrophy
Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism.
Muscular Atrophy
Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation.
Muscular Atrophy
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.
Muscular Atrophy
SIRT1 by blocking the activities of FoxO1 and 3 inhibits muscle atrophy and promotes muscle growth.
Muscular Atrophy
Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy.
Muscular Atrophy
Tart Cherry (Fruit of Prunus cerasus) Concentrated Powder (TCcp) Ameliorates Glucocorticoid-Induced Muscular Atrophy in Mice.
Muscular Atrophy
The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms.
Muscular Diseases
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.
Muscular Diseases
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
Muscular Disorders, Atrophic
PGC-1?-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging.
Muscular Dystrophies
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Muscular Dystrophies
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.
Muscular Dystrophies
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy.
Muscular Dystrophies
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
Muscular Dystrophy, Duchenne
A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy.
Muscular Dystrophy, Duchenne
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.
Muscular Dystrophy, Oculopharyngeal
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Mycobacterium Infections, Nontuberculous
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
Mycoses
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Myelodysplastic Syndromes
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Myelodysplastic Syndromes
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Myocardial Infarction
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Myocardial Infarction
A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population.
Myocardial Infarction
Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3.
Myocardial Infarction
Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway.
Myocardial Infarction
Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction.
Myocardial Infarction
Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats.
Myocardial Infarction
Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway.
Myocardial Infarction
Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1.
Myocardial Infarction
Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction.
Myocardial Infarction
Genetic analysis of the SIRT1 gene promoter in myocardial infarction.
Myocardial Infarction
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.
Myocardial Infarction
Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling-modulated mitochondrial dysfunction and oxidative stress.
Myocardial Infarction
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress.
Myocardial Infarction
Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1.
Myocardial Infarction
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Myocardial Infarction
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
Myocardial Infarction
miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1? pathway.
Myocardial Infarction
MiR-34a promotes myocardial infarction in rats by inhibiting the activity of SIRT1.
Myocardial Infarction
Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction.
Myocardial Infarction
PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction.
Myocardial Infarction
Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3.
Myocardial Infarction
Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility.
Myocardial Infarction
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.
Myocardial Infarction
Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway.
Myocardial Infarction
Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation.
Myocardial Infarction
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Myocardial Infarction
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
Myocardial Infarction
Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1.
Myocardial Infarction
SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression.
Myocardial Infarction
SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury.
Myocardial Infarction
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Myocardial Infarction
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Myocardial Infarction
SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.
Myocardial Infarction
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Myocardial Infarction
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
Myocardial Infarction
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.
Myocardial Infarction
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
Myocardial Infarction
The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.
Myocardial Infarction
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
Myocardial Infarction
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
Myocardial Infarction
Theacrine attenuates myocardial fibrosis after myocardial infarction via the SIRT3/?-catenin/PPAR? pathway in estrogen-deficient mice.
Myocardial Infarction
Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction.
Myocardial Infarction
[Cardioprotective Effect and Its Mechanism of Total Saponins of Panacis Majoris Rhizoma in Myocardial Infarction Rats].
Myocardial Infarction
[Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism].
Myocardial Ischemia
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
Myocardial Ischemia
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
Myocardial Ischemia
Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes.
Myocardial Ischemia
Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement.
Myocardial Ischemia
Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1.
Myocardial Ischemia
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
Myocardial Ischemia
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
Myocardial Ischemia
Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.
Myocardial Ischemia
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury.
Myocardial Ischemia
Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury.
Myocardial Reperfusion Injury
Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.
Myocardial Reperfusion Injury
Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury.
Myocarditis
miR?217 and miR?543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF??B signaling pathway.
Myositis
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.
nadh:ubiquinone reductase (h+-translocating) deficiency
Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.
nadh:ubiquinone reductase (h+-translocating) deficiency
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.
nadh:ubiquinone reductase (h+-translocating) deficiency
Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K.
nadh:ubiquinone reductase (h+-translocating) deficiency
Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3.
Nasal Polyps
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Nasal Polyps
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Nasopharyngeal Carcinoma
[Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma].
Neoplasm Metastasis
A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer.
Neoplasm Metastasis
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Neoplasm Metastasis
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
Neoplasm Metastasis
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer.
Neoplasm Metastasis
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Neoplasm Metastasis
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Neoplasm Metastasis
Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1.
Neoplasm Metastasis
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Neoplasm Metastasis
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Neoplasm Metastasis
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Neoplasm Metastasis
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Neoplasm Metastasis
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Neoplasm Metastasis
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Neoplasm Metastasis
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Neoplasm Metastasis
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Neoplasm Metastasis
Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes.
Neoplasm Metastasis
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Neoplasm Metastasis
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
Neoplasm Metastasis
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
Neoplasm Metastasis
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Neoplasm Metastasis
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Neoplasm Metastasis
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Neoplasm Metastasis
Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
Neoplasm Metastasis
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Neoplasm Metastasis
Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma.
Neoplasm Metastasis
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Neoplasm Metastasis
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Neoplasm Metastasis
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Neoplasm Metastasis
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Neoplasm Metastasis
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Neoplasm Metastasis
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
Neoplasm Metastasis
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Neoplasm Metastasis
Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
Neoplasm Metastasis
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Neoplasm Metastasis
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Neoplasm Metastasis
Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.
Neoplasm Metastasis
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
Neoplasm Metastasis
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Neoplasm Metastasis
Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
Neoplasm Metastasis
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
Neoplasm Metastasis
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
Neoplasm Metastasis
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1.
Neoplasm Metastasis
miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1.
Neoplasm Metastasis
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
Neoplasm Metastasis
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
Neoplasm Metastasis
MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
Neoplasm Metastasis
MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway.
Neoplasm Metastasis
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Neoplasm Metastasis
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Neoplasm Metastasis
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Neoplasm Metastasis
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Neoplasm Metastasis
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Neoplasm Metastasis
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Neoplasm Metastasis
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
Neoplasm Metastasis
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Neoplasm Metastasis
Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima.
Neoplasm Metastasis
Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
Neoplasm Metastasis
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Neoplasm Metastasis
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Neoplasm Metastasis
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis.
Neoplasm Metastasis
Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
Neoplasm Metastasis
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
Neoplasm Metastasis
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
Neoplasm Metastasis
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
Neoplasm Metastasis
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
Neoplasm Metastasis
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
Neoplasm Metastasis
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
Neoplasm Metastasis
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Neoplasm Metastasis
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
Neoplasm Metastasis
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
Neoplasm Metastasis
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
Neoplasm Metastasis
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
Neoplasm Metastasis
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
Neoplasm Metastasis
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
Neoplasm Metastasis
SIRT1 promotes formation of breast cancer through modulating Akt activity.
Neoplasm Metastasis
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
Neoplasm Metastasis
SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells.
Neoplasm Metastasis
SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
Neoplasm Metastasis
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
Neoplasm Metastasis
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
Neoplasm Metastasis
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
Neoplasm Metastasis
SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.
Neoplasm Metastasis
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
Neoplasm Metastasis
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Neoplasm Metastasis
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
Neoplasm Metastasis
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
Neoplasm Metastasis
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
Neoplasm Metastasis
SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway.
Neoplasm Metastasis
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Neoplasm Metastasis
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Neoplasm Metastasis
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Neoplasm Metastasis
Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
Neoplasm Metastasis
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
Neoplasm Metastasis
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Neoplasm Metastasis
Sulforaphane-cisplatin combination inhibits the stemness and metastatic potential of TNBCs via down regulation of sirtuins-mediated EMT signaling axis.
Neoplasm Metastasis
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
Neoplasm Metastasis
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
Neoplasm Metastasis
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
Neoplasm Metastasis
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
Neoplasm Metastasis
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
Neoplasm Metastasis
The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy.
Neoplasm Metastasis
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Neoplasm Metastasis
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Neoplasm Metastasis
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
Neoplasm Metastasis
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
Neoplasm Metastasis
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Neoplasm Metastasis
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Neoplasm Metastasis
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Neoplasm Metastasis
Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway.
Neoplasm Metastasis
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Neoplasm Metastasis
[SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells in vitro by regulating Snail expression].
Neoplasms
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.
Neoplasms
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
Neoplasms
75-kd sirtuin 1 blocks tumor necrosis factor ?-mediated apoptosis in human osteoarthritic chondrocytes.
Neoplasms
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
Neoplasms
?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells.
Neoplasms
A biotin switch-based proteomics approach identifies 14-3-3? as a target of Sirt1 in the metabolic regulation of caspase-2.
Neoplasms
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.
Neoplasms
A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes.
Neoplasms
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
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A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
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A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and Sirtuin gene (SIRT1) down-regulation.
Neoplasms
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose exposed HepG2 cells.
Neoplasms
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Neoplasms
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
Neoplasms
A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography.
Neoplasms
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.
Neoplasms
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Neoplasms
A Provocative Molecular Link between Mammographic Density and BRCA1-loss associated TNBC.
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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.
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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.
Neoplasms
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Neoplasms
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells.
Neoplasms
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Neoplasms
ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation.
Neoplasms
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity.
Neoplasms
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
Neoplasms
Advances in characterization of SIRT3 deacetylation targets in mitochondrial function.
Neoplasms
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Neoplasms
Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.
Neoplasms
Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment.
Neoplasms
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
Neoplasms
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Neoplasms
Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells.
Neoplasms
Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis.
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Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
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Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling.
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Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
Neoplasms
Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer.
Neoplasms
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Neoplasms
Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo.
Neoplasms
Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.
Neoplasms
Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway.
Neoplasms
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma.
Neoplasms
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Neoplasms
Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy.
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Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Neoplasms
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
Neoplasms
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Neoplasms
Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration.
Neoplasms
Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
Neoplasms
Benzodeazaoxaflavins as Sirtuin Inhibitors with Antiproliferative Properties in Cancer Stem Cells.
Neoplasms
BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes.
Neoplasms
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis.
Neoplasms
BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.
Neoplasms
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Neoplasms
Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation.
Neoplasms
Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells.
Neoplasms
Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Neoplasms
Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells.
Neoplasms
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1.
Neoplasms
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.
Neoplasms
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Neoplasms
Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
Neoplasms
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Neoplasms
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis.
Neoplasms
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Neoplasms
Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.
Neoplasms
Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
Neoplasms
Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model.
Neoplasms
Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.
Neoplasms
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
Neoplasms
CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Neoplasms
Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma.
Neoplasms
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.
Neoplasms
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Neoplasms
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Neoplasms
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Neoplasms
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Neoplasms
Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells.
Neoplasms
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Neoplasms
Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer.
Neoplasms
Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.
Neoplasms
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Neoplasms
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Neoplasms
Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3.
Neoplasms
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.
Neoplasms
Correction for Shah et al., "A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes".
Neoplasms
Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth.
Neoplasms
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
Neoplasms
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
Neoplasms
Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins.
Neoplasms
Cyanidin 3-O-?-Glucoside Ameliorates Ethanol-Induced Acute Liver Injury by Attenuating Oxidative Stress and Apoptosis: The Role of SIRT1/FOXO1 Signaling.
Neoplasms
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Neoplasms
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
Neoplasms
d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.
Neoplasms
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Neoplasms
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
Neoplasms
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.
Neoplasms
Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.
Neoplasms
Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay.
Neoplasms
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Neoplasms
Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation.
Neoplasms
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Neoplasms
Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.
Neoplasms
Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1.
Neoplasms
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
Neoplasms
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Neoplasms
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5.
Neoplasms
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
Neoplasms
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Neoplasms
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
Neoplasms
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Neoplasms
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Neoplasms
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Neoplasms
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Neoplasms
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Neoplasms
Differential expression of selected histone modifier genes in human solid cancers.
Neoplasms
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Neoplasms
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas.
Neoplasms
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Neoplasms
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Neoplasms
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Neoplasms
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1.
Neoplasms
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Neoplasms
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
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Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses.
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Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
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Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
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Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Neoplasms
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
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Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
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Docosahexaenoic acid-enriched phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 pathways.
Neoplasms
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
Neoplasms
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study.
Neoplasms
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.
Neoplasms
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
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Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
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Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism.
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Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
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Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Neoplasms
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
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Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients.
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Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
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E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
Neoplasms
E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans.
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E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
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Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1.
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Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.
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Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
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Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
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Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea.
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Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
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Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
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Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
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Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer.
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Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.
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Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
Neoplasms
Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1).
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Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
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Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
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Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
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Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.
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Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina.
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Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention.
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Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
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ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
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Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1.
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Evaluation of The Relationship among The Levels of SIRT1 and SIRT3 with Oxidative Stress and DNA Fragmentation in Asthenoteratozoospermic Men.
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EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.
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Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B.
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Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology.
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Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
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Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
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Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
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Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
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Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer.
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Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
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Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
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Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
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Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting.
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Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
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Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
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Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
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Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
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Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
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Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
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Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
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Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
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Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice.
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Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
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Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
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Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway.
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FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
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Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1.
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FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
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From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas?
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Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
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Functional benefit and molecular mechanism of vitamin C against perfluorooctanesulfonate-associated leukemia.
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Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome.
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Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
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Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
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Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
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Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse.
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Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
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Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
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Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence.
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Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
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Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
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Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
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Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development.
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HDAC4 mediates IFN-? induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
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HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS.
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Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
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Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
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HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).
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High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
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High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
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High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
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High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.
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High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
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High-Intensity Training and Saffron: Effects on Breast Cancer-related Gene Expression.
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Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
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Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
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Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis.
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Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking.
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HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
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Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription.
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Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
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Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression.
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Identification of a novel polyprenylated acylphloroglucinol?derived SIRT1 inhibitor with cancer?specific anti-proliferative and invasion-suppressing activities.
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Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
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Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
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Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity.
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Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.
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Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways.
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Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.
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IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1.
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Impact of Sirtuin Enzymes on the Altered Metabolic Phenotype of Malignantly Transformed Cells.
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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
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Improved Expression of Sirt1 on Thymic Epithelial Cells of SAMP10 after Intra Bone Marrow-Bone Marrow Transplantation.
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Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats.
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In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
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Increase of Hspa1a and Hspa1b genes in the resting B cells of Sirt1 knockout mice.
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Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.
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Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
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Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
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Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs.
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Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions.
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Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
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Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation.
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Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.
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Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
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Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
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Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
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Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).
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Inhibitory effect of baicalin on collagen-induced arthritis in rats through the nuclear factor-?B pathway.
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Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).
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Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
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Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
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Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.
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Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
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Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
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Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.
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Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.
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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
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Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer.
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Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.
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Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells.
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Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
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JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway.
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Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy.
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JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
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K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
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Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1.
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KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma.
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Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells.
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Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
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Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
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Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling.
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Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.
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Lipopolysaccharide-induced depression is associated with estrogen receptor-?/SIRT1/NF-?B signaling pathway in old female mice.
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Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.
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Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy.
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Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
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Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
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Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
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Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
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Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
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Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma.
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Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
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Lysine Acetylome Study of Human Hepatocellular Carcinoma Tissues for Biomarkers and Therapeutic Targets Discovery.
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Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.
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Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
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MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells.
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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators.
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Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction.
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Mechanistic understanding of ?-cryptoxanthin and lycopene in cancer prevention in animal models.
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Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
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Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
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Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway.
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Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects.
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Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model.
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Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages.
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Metformin activates AMPK/SIRT1/NF-?B pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis.
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Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
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Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1?/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.
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Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer.
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MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma.
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MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
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MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
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MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
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MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
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MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background.
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MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1.
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microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.
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MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer.
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microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
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miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
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miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
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miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
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Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
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miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells.
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MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma.
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MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
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miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-?B/B7-H3/TNF-? axis.
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MiR-34a reverses radiation resistance on ECA-109 cells by inhibiting PI3K/AKT/mTOR signal pathway through downregulating the expression of SIRT1.
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miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade.
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Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells
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Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
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Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
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Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
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MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype.
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Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats.
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Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
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Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.
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Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
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Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA.
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Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review.
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Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding.
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Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
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Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
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Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
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mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.
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Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma.
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Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells.
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Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
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Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.
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n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
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NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells.
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Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
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Natural products with anti-aging potential: Affected targets and molecular mechanisms.
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Neuroprotective properties of resveratrol in different neurodegenerative disorders.
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New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.
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New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng.
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Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
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Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
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Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation.
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Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis.
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Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI.
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Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
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Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
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O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
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Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway.
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Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.
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Oncogene Ras/Phosphatidylinositol 3-kinase (PI3K) signaling targets histone H3 acetylation at lysine K56.
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Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation.
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Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
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Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
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Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
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Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization.
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Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.
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Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
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Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
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Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
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Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
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Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
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Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report.
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Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
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Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
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Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
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PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
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Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
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Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
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Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.
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Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.
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Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease.
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PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
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PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.
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PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland.
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Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.
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Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
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Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
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Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection.
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Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.
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Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.
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Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation.
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Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.
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Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
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Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
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QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives.
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Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.
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Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer.
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RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes.
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Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy.
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Rebamipide reduces amyloid-? 1-42 (A?42) production and ameliorates A?43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
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Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers.
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Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
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Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1.
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Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
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Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
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Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice.
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Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
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Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
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Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
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RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.
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Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
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Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells.
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Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
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Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-?B.
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Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs.
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Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
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Resveratrol inhibits high-glucose-induced inflammatory "metabolic memory" in human retinal vascular endothelial cells through SIRT1-dependent signaling.
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Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
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Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
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Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
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Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.
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Rhein lysinate decreases the generation of ?-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress.
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Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells.
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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure.
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Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
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Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells.
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Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
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Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
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Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
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ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
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Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1.
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Salermide upregulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells.
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Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
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Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
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Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
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Selenium?enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SirT1 pathway.
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Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles.
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Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
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Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study.
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Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
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Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
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Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy.
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SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells.
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SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.
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SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
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SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
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SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
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SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
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SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells.
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SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
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SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
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SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.
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SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.
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SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms.
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SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
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SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation.
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SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.
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SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.
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SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
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SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.
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SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.
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SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
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SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
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SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22.
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SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.
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SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
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SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
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SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
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SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
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SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
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Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
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SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw.
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SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
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SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
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SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells.
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SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
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SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-?B signaling with anti-inflammatory functions.
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SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
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SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
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SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
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SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
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SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis.
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SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
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SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
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SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
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SIRT1 inhibits TNF-?-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1.
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SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.
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SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling.
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SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
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SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.
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Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
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SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis.
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SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation.
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SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
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SIRT1 overexpression decreases cisplatin-induced acetylation of NF-?B p65 subunit and cytotoxicity in renal proximal tubule cells.
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SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
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SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
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SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
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SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.
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SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
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SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
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SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
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SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
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SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.
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SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
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SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
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SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
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SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells.
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Sirt1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis.
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SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
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SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
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SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
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SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma.
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SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
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SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
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SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
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SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
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SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
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Sirt1's systemic protective roles and its promise as a target in antiaging medicine.
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SIRT1-dependent regulation of chromatin and transcription: Linking NAD(+) metabolism and signaling to the control of cellular functions.
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SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with A?: An Early but Transient Response Rescued by Melatonin.
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SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness.
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SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells.
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SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
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SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma.
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SIRT1/PGC1?-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer.
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SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor.
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Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin.
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SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
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SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
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SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.
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SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
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SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
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SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
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SIRT2 Interacts with ?-Catenin to Inhibit Wnt Signaling Output in Response to Radiation-Induced Stress.
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SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
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SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia.
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SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.
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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
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SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
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SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
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SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
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SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
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SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90.
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SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
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SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
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SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.
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SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
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SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
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SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
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Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
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SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
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SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
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SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
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SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells.
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Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells.
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SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1.
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SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
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Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
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SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
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SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
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SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization.
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SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
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Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
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SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
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SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis.
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SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
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SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
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SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
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Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
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SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production.
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SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.
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SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
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SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.
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SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
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SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway.
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Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation.
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SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
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SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.
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Sirtuin 1 (SIRT1) Deacetylase Activity and NAD?/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
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Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production.
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Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
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Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
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Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
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Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
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Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.
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Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
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Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.
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Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
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Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
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Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
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Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.
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Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-?B and expression of the long-noncoding RNA HAS2-AS1.
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Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.
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Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
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Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer.
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Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.
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Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
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Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
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Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway.
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Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells.
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Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
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Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.
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Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling.
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Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
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Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
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Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation.
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Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer.
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Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.
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Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.
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Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
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Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway.
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Sirtuin1 and Chronic Myeloid Leukemia: a Comprehensive Glance at Drug Resistance.
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Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
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Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
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Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
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Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
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Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
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Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
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SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
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SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis.
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SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells.
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SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
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Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116?cells with SIRT2 suppression.
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Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR).
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Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
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Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.
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Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
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Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders.
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Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
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Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
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Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer.
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Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
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Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1.
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Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
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Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
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Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
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Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma.
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Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
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Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes.
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Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner.
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Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.
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The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
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The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis.
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The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
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The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin.
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The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
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The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
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The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.
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The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
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The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
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The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
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The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects.
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The Function of PPAR?/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.
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The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition.
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The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma.
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The HMGB1-RAGE/TLR-TNF-? signaling pathway may contribute to kidney injury induced by hypoxia.
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The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
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The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
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The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia.
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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
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The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
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The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
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The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
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The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
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The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
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The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
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The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
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The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
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The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.
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Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.
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Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
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TNF-? and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells.
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TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
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Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
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Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
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Translating cell survival and cell longevity into treatment strategies with SIRT1.
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TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage.
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Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
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Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage.
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Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.
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TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence.
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Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
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Ubiquitin-Specific Protease 22/Silent Information Regulator 1 Axis Plays a Pivotal Role in the Prognosis and 5-Fluorouracil Resistance in Hepatocellular Carcinoma.
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Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
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UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
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Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer.
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Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.
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Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
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Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells.
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Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
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Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway.
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Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells.
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Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors.
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VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1?/HO-1 pathway.
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Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.
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Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation.
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X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.
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ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.
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Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
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[Dexmedetomidine alleviates postoperative cognitive dysfunction in aged rats probably via silent information regulator 1 pathway].
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[Effect of electroacupuncture on SIRT1/NF-?B signaling pathway in adipose tissue of obese rats].
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[Effects of activating silent information regulator 1 on early kidney damage in rats with severe burn].
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[Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism].
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[Feasibility of integrating tumor therapy with therapeutic effect evaluation using siRNA-loaded microbubbles].
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[Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing ? amyloid protein level].
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[Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma].
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[Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
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[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Nephritis
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
Nephrocalcinosis
Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1.
Nephrolithiasis
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Nephrolithiasis
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury.
Nephrolithiasis
Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy.
Nephrosclerosis
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Nervous System Diseases
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
Nervous System Diseases
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Nervous System Diseases
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Nervous System Diseases
Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.
Nervous System Diseases
Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.
Nervous System Diseases
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease.
Nervous System Diseases
Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity.
Nervous System Diseases
SIRT1 activation by minocycline on regulation of microglial polarization homeostasis.
Nervous System Diseases
SIRT1/PGC-1? signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells.
Nervous System Diseases
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Nervous System Diseases
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
Nervous System Diseases
SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.
Nervous System Diseases
Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders.
Nervous System Diseases
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Nervous System Diseases
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Neural Tube Defects
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Neural Tube Defects
Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos.
Neuralgia
Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats.
Neuralgia
Combination of Botulinum Toxin and minocycline Ameliorates Neuropathic Pain Through Antioxidant Stress and Anti-Inflammation via Promoting SIRT1 Pathway.
Neuralgia
Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve.
Neuralgia
Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity.
Neuralgia
Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner.
Neuralgia
Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat.
Neuralgia
Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats.
Neuralgia
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
Neuralgia
MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1.
Neuralgia
miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain.
Neuralgia
Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway.
Neuralgia
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Neuralgia
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib.
Neuralgia
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal sirt1.
Neuralgia
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
Neuralgia
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Neuralgia
SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKII? Deacetylation in Central Amygdala.
Neuralgia
SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway.
Neuralgia
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
Neuralgia
SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.
Neuralgia
Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.
Neuralgia
Synergistic interaction between total glucosides and total flavonoids on chronic constriction injury induced neuropathic pain in rats.
Neurilemmoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Neuroblastoma
A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1.
Neuroblastoma
Effect of atorvastatin on A?1-42 -induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures.
Neuroblastoma
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Neuroblastoma
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Leptin attenuates BACE1 expression and amyloid-? genesis via the activation of SIRT1 signaling pathway.
Neuroblastoma
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3.
Neuroblastoma
Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.
Neuroblastoma
Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1.
Neuroblastoma
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Neuroblastoma Cells: Role of Sirtuin 1.
Neuroblastoma
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
Neuroblastoma
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
Neuroblastoma
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
Neuroblastoma
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
Neuroblastoma
SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma.
Neuroblastoma
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.
Neuroblastoma
Treatment with the neurotoxic A? (25-35) peptide modulates the expression of neuroprotective factors Pin1, Sirtuin 1, and brain-derived neurotrophic factor in SH-SY5Y human neuroblastoma cells.
Neurodegenerative Diseases
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
Neurodegenerative Diseases
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Neurodegenerative Diseases
After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders.
Neurodegenerative Diseases
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice.
Neurodegenerative Diseases
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Neurodegenerative Diseases
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.
Neurodegenerative Diseases
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Neurodegenerative Diseases
Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases.
Neurodegenerative Diseases
Attenuation of Pb-induced A? generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol.
Neurodegenerative Diseases
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity.
Neurodegenerative Diseases
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
Neurodegenerative Diseases
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.
Neurodegenerative Diseases
CELLULAR STRESS RESPONSES, THE HORMESIS PARADIGM AND VITAGENES: NOVEL TARGETS FOR THERAPEUTIC INTERVENTION IN NEURODEGENERATIVE DISORDERS.
Neurodegenerative Diseases
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.
Neurodegenerative Diseases
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.
Neurodegenerative Diseases
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Neurodegenerative Diseases
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Neurodegenerative Diseases
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5.
Neurodegenerative Diseases
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Neurodegenerative Diseases
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Neurodegenerative Diseases
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
Neurodegenerative Diseases
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Neurodegenerative Diseases
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Neurodegenerative Diseases
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Neurodegenerative Diseases
Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse.
Neurodegenerative Diseases
Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells.
Neurodegenerative Diseases
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
Neurodegenerative Diseases
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Neurodegenerative Diseases
Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain.
Neurodegenerative Diseases
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Neurodegenerative Diseases
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Neurodegenerative Diseases
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Neurodegenerative Diseases
Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway.
Neurodegenerative Diseases
Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.
Neurodegenerative Diseases
Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage.
Neurodegenerative Diseases
Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.
Neurodegenerative Diseases
Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?
Neurodegenerative Diseases
JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression.
Neurodegenerative Diseases
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
Neurodegenerative Diseases
Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure.
Neurodegenerative Diseases
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Neurodegenerative Diseases
Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations.
Neurodegenerative Diseases
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Neurodegenerative Diseases
Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020).
Neurodegenerative Diseases
Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.
Neurodegenerative Diseases
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.
Neurodegenerative Diseases
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Neurodegenerative Diseases
Potential role of sirtuin as a therapeutic target for neurodegenerative diseases.
Neurodegenerative Diseases
Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine.
Neurodegenerative Diseases
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Neurodegenerative Diseases
Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-?B pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis.
Neurodegenerative Diseases
Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection.
Neurodegenerative Diseases
Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases.
Neurodegenerative Diseases
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Neurodegenerative Diseases
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.
Neurodegenerative Diseases
Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease.
Neurodegenerative Diseases
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.
Neurodegenerative Diseases
Resveratrol:New Avenues For A Natural Compound In Neuroprotection.
Neurodegenerative Diseases
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Neurodegenerative Diseases
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain.
Neurodegenerative Diseases
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
Neurodegenerative Diseases
Silent information regulator, Sirtuin 1, and age-related diseases.
Neurodegenerative Diseases
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
Neurodegenerative Diseases
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
Neurodegenerative Diseases
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Neurodegenerative Diseases
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Neurodegenerative Diseases
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Neurodegenerative Diseases
SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis.
Neurodegenerative Diseases
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
Neurodegenerative Diseases
SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.
Neurodegenerative Diseases
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.
Neurodegenerative Diseases
SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan.
Neurodegenerative Diseases
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
Neurodegenerative Diseases
SIRT1: new avenues of discovery for disorders of oxidative stress.
Neurodegenerative Diseases
Sirt1s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?
Neurodegenerative Diseases
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
Neurodegenerative Diseases
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
Neurodegenerative Diseases
SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
Neurodegenerative Diseases
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.
Neurodegenerative Diseases
SIRT2: Controversy and multiple roles in disease and physiology.
Neurodegenerative Diseases
SIRT3 activator Honokiol attenuates ?-Amyloid by modulating amyloidogenic pathway.
Neurodegenerative Diseases
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Neurodegenerative Diseases
SIRT3 regulates progression and development of diseases of aging.
Neurodegenerative Diseases
SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases.
Neurodegenerative Diseases
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Neurodegenerative Diseases
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Neurodegenerative Diseases
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.
Neurodegenerative Diseases
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Neurodegenerative Diseases
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.
Neurodegenerative Diseases
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Neurodegenerative Diseases
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Neurodegenerative Diseases
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Neurodegenerative Diseases
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
Neurodegenerative Diseases
Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.
Neurodegenerative Diseases
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
Neurodegenerative Diseases
Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors.
Neurodegenerative Diseases
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Neurodegenerative Diseases
The neurobiology of sirtuins and their role in neurodegeneration.
Neurodegenerative Diseases
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Neurodegenerative Diseases
The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders.
Neurodegenerative Diseases
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Neurodegenerative Diseases
The Sirtuin family: therapeutic targets to treat diseases of aging.
Neurodegenerative Diseases
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Neurodegenerative Diseases
The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
Neurodegenerative Diseases
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
Neurodegenerative Diseases
Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.
Neurodegenerative Diseases
Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
Neurodegenerative Diseases
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Neurodegenerative Diseases
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Neurodegenerative Diseases
Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.
Neurofibrosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Neuroinflammatory Diseases
17?-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication.
Neuroinflammatory Diseases
5-Heptadecylresorcinol, a Biomarker for Whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP/PS1 Transgenic Mice.
Neuroinflammatory Diseases
Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
Neuroinflammatory Diseases
Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-?B/p65.
Neuroinflammatory Diseases
AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1.
Neuroinflammatory Diseases
All Trans Retinoic Acid Attenuates Markers of Neuroinflammation in Rat Brain by Modulation of SIRT1 and NF?B.
Neuroinflammatory Diseases
AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.
Neuroinflammatory Diseases
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Neuroinflammatory Diseases
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Neuroinflammatory Diseases
Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms.
Neuroinflammatory Diseases
Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats.
Neuroinflammatory Diseases
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Neuroinflammatory Diseases
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.
Neuroinflammatory Diseases
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Neuroinflammatory Diseases
Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats.
Neuroinflammatory Diseases
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Neuroinflammatory Diseases
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
Neuroinflammatory Diseases
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
Neuroinflammatory Diseases
Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain.
Neuroinflammatory Diseases
Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells.
Neuroinflammatory Diseases
Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.
Neuroinflammatory Diseases
Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry.
Neuroinflammatory Diseases
Laquinimod inhibits MMP+?induced NLRP3 inflammasome activation in human neuronal cells.
Neuroinflammatory Diseases
Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.
Neuroinflammatory Diseases
Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.
Neuroinflammatory Diseases
Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices.
Neuroinflammatory Diseases
MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1.
Neuroinflammatory Diseases
Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.
Neuroinflammatory Diseases
NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1? pathway.
Neuroinflammatory Diseases
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Neuroinflammatory Diseases
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Neuroinflammatory Diseases
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Neuroinflammatory Diseases
Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease.
Neuroinflammatory Diseases
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Neuroinflammatory Diseases
Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration.
Neuroinflammatory Diseases
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Neuroinflammatory Diseases
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Neuroinflammatory Diseases
Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery.
Neuroinflammatory Diseases
Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent.
Neuroinflammatory Diseases
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Neuroinflammatory Diseases
Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Neuroinflammatory Diseases
Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1.
Neuroinflammatory Diseases
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
Neuroinflammatory Diseases
SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro.
Neuroinflammatory Diseases
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
Neuroinflammatory Diseases
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
Neuroinflammatory Diseases
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Neuroinflammatory Diseases
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Neuroinflammatory Diseases
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Neuroinflammatory Diseases
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury.
Neuroinflammatory Diseases
Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia.
Neuroinflammatory Diseases
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.
Neuroinflammatory Diseases
Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.
Neuroinflammatory Diseases
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
Neuroinflammatory Diseases
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
Neuroinflammatory Diseases
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Neuroinflammatory Diseases
The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery.
Neuroinflammatory Diseases
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Neuroinflammatory Diseases
Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM.
Neuroinflammatory Diseases
Yes-associated protein reduces neuroinflammation through upregulation of Sirt3 and inhibition of JNK signaling pathway.
Nevus
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Nevus, Pigmented
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
nicotinamide phosphoribosyltransferase deficiency
Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.
Nijmegen Breakage Syndrome
Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis.
Nijmegen Breakage Syndrome
SIRT1 regulates the function of the Nijmegen breakage syndrome protein.
Non-alcoholic Fatty Liver Disease
A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice.
Non-alcoholic Fatty Liver Disease
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Non-alcoholic Fatty Liver Disease
A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats.
Non-alcoholic Fatty Liver Disease
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Non-alcoholic Fatty Liver Disease
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization.
Non-alcoholic Fatty Liver Disease
Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats.
Non-alcoholic Fatty Liver Disease
Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.
Non-alcoholic Fatty Liver Disease
Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1.
Non-alcoholic Fatty Liver Disease
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Non-alcoholic Fatty Liver Disease
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Non-alcoholic Fatty Liver Disease
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.
Non-alcoholic Fatty Liver Disease
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Non-alcoholic Fatty Liver Disease
Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis.
Non-alcoholic Fatty Liver Disease
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
Non-alcoholic Fatty Liver Disease
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Non-alcoholic Fatty Liver Disease
Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1? in a rat model.
Non-alcoholic Fatty Liver Disease
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Non-alcoholic Fatty Liver Disease
Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes".
Non-alcoholic Fatty Liver Disease
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
Non-alcoholic Fatty Liver Disease
DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model.
Non-alcoholic Fatty Liver Disease
Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway.
Non-alcoholic Fatty Liver Disease
Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.
Non-alcoholic Fatty Liver Disease
Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling.
Non-alcoholic Fatty Liver Disease
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Non-alcoholic Fatty Liver Disease
Effect of miR-34a in regulating steatosis by targeting PPAR? expression in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver.
Non-alcoholic Fatty Liver Disease
Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats.
Non-alcoholic Fatty Liver Disease
Eliciting the mitochondrial unfolded protein response via NAD(+) repletion reverses fatty liver disease.
Non-alcoholic Fatty Liver Disease
Elucidation of SIRT-1/PGC-1?-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Non-alcoholic Fatty Liver Disease
Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study.
Non-alcoholic Fatty Liver Disease
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK.
Non-alcoholic Fatty Liver Disease
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
Non-alcoholic Fatty Liver Disease
GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway.
Non-alcoholic Fatty Liver Disease
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Non-alcoholic Fatty Liver Disease
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Non-alcoholic Fatty Liver Disease
Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Hugan Qingzhi Exerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention.
Non-alcoholic Fatty Liver Disease
Lipidomic Analysis of the Protective Effects of Shenling Baizhu San on Non-Alcoholic Fatty Liver Disease in Rats.
Non-alcoholic Fatty Liver Disease
Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway.
Non-alcoholic Fatty Liver Disease
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Non-alcoholic Fatty Liver Disease
Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro.
Non-alcoholic Fatty Liver Disease
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy.
Non-alcoholic Fatty Liver Disease
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Non-alcoholic Fatty Liver Disease
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
Non-alcoholic Fatty Liver Disease
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1.
Non-alcoholic Fatty Liver Disease
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Non-alcoholic Fatty Liver Disease
miR-34a/SIRT1/p53 is Suppressed by Ursodeoxycholic Acid in Rat Liver and Activated by Disease Severity in Human Non-alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Non-alcoholic Fatty Liver Disease
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin.
Non-alcoholic Fatty Liver Disease
Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1.
Non-alcoholic Fatty Liver Disease
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Non-alcoholic Fatty Liver Disease
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Non-alcoholic Fatty Liver Disease
Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Regulation of Mitochondrial Trifunctional Protein Modulates Nonalcoholic Fatty Liver Disease in Mice.
Non-alcoholic Fatty Liver Disease
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Non-alcoholic Fatty Liver Disease
Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis.
Non-alcoholic Fatty Liver Disease
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Non-alcoholic Fatty Liver Disease
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Non-alcoholic Fatty Liver Disease
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
Non-alcoholic Fatty Liver Disease
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
Non-alcoholic Fatty Liver Disease
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity.
Non-alcoholic Fatty Liver Disease
SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells.
Non-alcoholic Fatty Liver Disease
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Non-alcoholic Fatty Liver Disease
Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity.
Non-alcoholic Fatty Liver Disease
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Non-alcoholic Fatty Liver Disease
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
Non-alcoholic Fatty Liver Disease
The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats.
Non-alcoholic Fatty Liver Disease
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
Non-alcoholic Fatty Liver Disease
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Non-alcoholic Fatty Liver Disease
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism.
Non-alcoholic Fatty Liver Disease
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Non-alcoholic Fatty Liver Disease
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Non-alcoholic Fatty Liver Disease
Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol.
Non-alcoholic Fatty Liver Disease
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Non-alcoholic Fatty Liver Disease
[Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease].
Non-alcoholic Fatty Liver Disease
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
Non-alcoholic Fatty Liver Disease
[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats]
Non-alcoholic Fatty Liver Disease
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Obesity
?-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPAR? Pathways in High-Fat Diet-Induced Obese Mice.
Obesity
Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect.
Obesity
Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.
Obesity
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Obesity
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
Obesity
Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.
Obesity
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Obesity
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Obesity
Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet.
Obesity
Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1.
Obesity
Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes.
Obesity
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity.
Obesity
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Obesity
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa.
Obesity
Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice.
Obesity
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.
Obesity
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Obesity
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline.
Obesity
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Obesity
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.
Obesity
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study.
Obesity
Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.
Obesity
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Obesity
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Obesity
Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats.
Obesity
Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT.
Obesity
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Obesity
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.
Obesity
Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.
Obesity
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Obesity
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
Obesity
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study.
Obesity
Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment.
Obesity
Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
Obesity
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
Obesity
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Obesity
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Obesity
High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction.
Obesity
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Obesity
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Obesity
Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators.
Obesity
In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
Obesity
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.
Obesity
Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index.
Obesity
Lactobacillus sakei Alleviates High-Fat-Diet-Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota-Mediated NF-?B Activation.
Obesity
Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice.
Obesity
LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice.
Obesity
Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Obesity
Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways.
Obesity
Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice.
Obesity
Metabolic programming of sirtuin 1 (SIRT1) expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life.
Obesity
Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression.
Obesity
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function.
Obesity
Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways.
Obesity
MiR-22 modulates the expression of lipogenesis-related genes and promotes hepatic steatosis in vitro.
Obesity
miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1).
Obesity
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
Obesity
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Obesity
Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats.
Obesity
Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity.
Obesity
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
Obesity
Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice.
Obesity
Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.
Obesity
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity
Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1.
Obesity
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Obesity
Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function.
Obesity
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Obesity
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.
Obesity
Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo.
Obesity
Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1.
Obesity
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Obesity
PPAR? and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.
Obesity
Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
Obesity
Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.
Obesity
Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.
Obesity
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Obesity
Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis.
Obesity
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Obesity
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Obesity
Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life.
Obesity
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway.
Obesity
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Obesity
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Obesity
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
Obesity
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.
Obesity
SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.
Obesity
SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status.
Obesity
SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY.
Obesity
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
Obesity
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Obesity
Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice.
Obesity
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Obesity
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
Obesity
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents.
Obesity
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways.
Obesity
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
Obesity
Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice.
Obesity
SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK.
Obesity
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Obesity
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
Obesity
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
Obesity
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Obesity
Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice.
Obesity
Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes.
Obesity
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
Obesity
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Obesity
Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction.
Obesity
Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.
Obesity
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Obesity
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Obesity
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise.
Obesity
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
Obesity
Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant alphaMUPA mice.
Obesity
Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders.
Obesity
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
Obesity
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.
Obesity
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Obesity
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Obesity
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
Obesity
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Obesity
Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review.
Obesity
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
Obesity
Visfatin/Nampt and SIRT1: Roles in Postterm Delivery in Pregnancies Associated With Obesity.
Obesity
[Effect of electroacupuncture on silent information regulator 1, fork head transcription factor O1 and proopiomelanocortin in the hypothalamus of rats with obesity induced by high-fat diet].
Obesity
[Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats].
Obesity
[Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet].
Obesity
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Obesity
[Mechanism of electroacupuncture for regulation of lipid production and improvement in obesity by mediating Wnt/ ?-catenin pathway through activating SIRT1].
Obesity, Abdominal
SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.
Obesity, Abdominal
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
Obesity, Abdominal
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Obesity, Maternal
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Obesity, Maternal
Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers.
Obesity, Maternal
Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning.
Obesity, Maternal
Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding.
Obesity, Maternal
SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
Obesity, Maternal
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Obesity, Morbid
Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity.
Obesity, Morbid
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity.
Obesity, Morbid
The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy.
Ophthalmoplegia, Chronic Progressive External
Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases.
Ophthalmoplegia, Chronic Progressive External
Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.
Optic Atrophy, Autosomal Dominant
Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.
Optic Atrophy, Autosomal Dominant
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Optic Atrophy, Autosomal Dominant
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
Optic Atrophy, Autosomal Dominant
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
Optic Atrophy, Autosomal Dominant
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Optic Nerve Diseases
Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1.
Optic Nerve Diseases
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
Optic Nerve Diseases
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Optic Nerve Diseases
SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.
Optic Nerve Injuries
Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1.
Optic Nerve Injuries
Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration.
Optic Neuritis
Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development?
Optic Neuritis
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
Optic Neuritis
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Optic Neuritis
SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.
Oral Ulcer
The Anti-Inflammatory Effect of Zhibaidihuang Decoction on Recurrent Oral Ulcer with Sirt1 as the Key Regulatory Target.
Osteoarthritis
Curcumin Inhibits the PERK-eIF2?-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.
Osteoarthritis
Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway.
Osteoarthritis
Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice.
Osteoarthritis
Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice.
Osteoarthritis
Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis.
Osteoarthritis
Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway.
Osteoarthritis
Fisetin inhibits IL-1?-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.
Osteoarthritis
Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway.
Osteoarthritis
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis.
Osteoarthritis
Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1.
Osteoarthritis
Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2?
Osteoarthritis
Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice.
Osteoarthritis
LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Osteoarthritis
Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/?-catenin activity.
Osteoarthritis
miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis.
Osteoarthritis
Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions.
Osteoarthritis
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.
Osteoarthritis
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Osteoarthritis
Resveratrol inhibits interleukin 1?-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-?B activity.
Osteoarthritis
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis.
Osteoarthritis
Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.
Osteoarthritis
Sirt1 and osteoarthritis. Comments on the paper by Gabay et al.: "Sirt1-deficient mice exhibit an altered cartilage phenotype", Joint Bone Spine 2013.
Osteoarthritis
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
Osteoarthritis
Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men.
Osteoarthritis
Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways.
Osteoarthritis
SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis.
Osteoarthritis
SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway.
Osteoarthritis
Sulforaphane protects against oxidative stress?induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Osteoarthritis
Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes.
Osteoarthritis
[Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis].
Osteoarthritis, Knee
Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1.
Osteoarthritis, Knee
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis.
Osteoarthritis, Knee
The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity.
Osteolysis
Hydrogen sulfide protects against particle-induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening.
Osteolysis
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
Osteolysis
miR-9-5p promotes wear-particle-induced osteoclastogenesis through activation of the SIRT1/NF-?B pathway.
Osteolysis
Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.
Osteolysis
Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3?/?-catenin signalling pathway.
Osteolysis
SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening.
Osteolysis
The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-?B deacetylation in aseptic loosening.
Osteonecrosis
miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis.
Osteonecrosis
SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw.
Osteonecrosis
Therapeutic effect of SIRT3 on glucocorticoid-induced osteonecrosis of femoral head via intracellular oxidative suppression.
Osteophyte
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis.
Osteoporosis
Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells.
Osteoporosis
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Osteoporosis
Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice.
Osteoporosis
Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt/?-catenin pathways.
Osteoporosis
Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-?B in neonatal rats with glucocorticoid-induced osteoporosis.
Osteoporosis
MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating Sirt1.
Osteoporosis
MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor ?/?-dependent manner.
Osteoporosis
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency.
Osteoporosis
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Osteoporosis
Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-?B signaling pathway in rats.
Osteoporosis
Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-?B signaling pathway.
Osteoporosis
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.
Osteoporosis
Resveratrol promotes osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis.
Osteoporosis
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis.
Osteoporosis
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.
Osteoporosis
SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.
Osteoporosis
Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.
Osteoporosis
SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis.
Osteoporosis
Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis.
Osteoporosis
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency.
Osteoporosis
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
Osteoporosis
Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing ?-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors.
Osteoporosis
The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats.
Osteoporosis
The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells.
Osteoporosis
The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.
Osteoporosis, Postmenopausal
17?-Estradiol improves osteoblastic cell function through the Sirt1/NF-?B/MMP-8 pathway.
Osteoporosis, Postmenopausal
Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice.
Osteoporosis, Postmenopausal
Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis.
Osteosarcoma
Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.
Osteosarcoma
Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma.
Osteosarcoma
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
Osteosarcoma
LncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting MiR-34a-5p in Osteosarcoma Cells.
Osteosarcoma
MicroRNA-133b Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting Sirt1.
Osteosarcoma
MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1.
Osteosarcoma
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Osteosarcoma
MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma.
Osteosarcoma
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.
Osteosarcoma
SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
Osteosarcoma
Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy.
Osteosarcoma
SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma.
Osteosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Osteosarcoma
Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.
Osteosarcoma
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
Osteosarcoma
Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1.
Osteosarcoma
[Retracted] MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1.
Ototoxicity
Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.
Ototoxicity
Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism.
Ototoxicity
Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity.
Ototoxicity
Sirt3 confers protection against acrolein-induced oxidative stress in cochlear nucleus neurons.
Ototoxicity
Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line.
Ovarian Neoplasms
A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells.
Ovarian Neoplasms
ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation.
Ovarian Neoplasms
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
Ovarian Neoplasms
Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142.
Ovarian Neoplasms
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Ovarian Neoplasms
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Ovarian Neoplasms
Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.
Ovarian Neoplasms
Differential Effects of Estradiol and Bisphenol A on SET8 and SIRT1 Expression in Ovarian Cancer Cells.
Ovarian Neoplasms
Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
Ovarian Neoplasms
Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion.
Ovarian Neoplasms
Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.
Ovarian Neoplasms
Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B.
Ovarian Neoplasms
Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer.
Ovarian Neoplasms
Gene expression and prognosis of sirtuin family members in ovarian cancer.
Ovarian Neoplasms
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
Ovarian Neoplasms
Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression.
Ovarian Neoplasms
Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1.
Ovarian Neoplasms
Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1.
Ovarian Neoplasms
MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1.
Ovarian Neoplasms
Mir-29b Regulates Oxidative Stress by Targeting SIRT1 in Ovarian Cancer Cells.
Ovarian Neoplasms
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
Ovarian Neoplasms
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Ovarian Neoplasms
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Ovarian Neoplasms
ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
Ovarian Neoplasms
Selecting key genes associated with ovarian cancer based on differential expression network.
Ovarian Neoplasms
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
Ovarian Neoplasms
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
Ovarian Neoplasms
SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells.
Ovarian Neoplasms
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer.
Ovarian Neoplasms
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Ovarian Neoplasms
Targeting estrogen receptor beta (ER?) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ER? expression and functionality.
Ovarian Neoplasms
Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer.
Overnutrition
Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases.
Overnutrition
Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice.
Overnutrition
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or ? Cell Metabolism in the Absence of Overnutrition.
Overweight
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Overweight
Aerobic Training Increases Expression Levels of SIRT3 and PGC-1? in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake.
Overweight
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Overweight
Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation.
Overweight
Combined high-intensity interval training and green tea supplementation enhance metabolic and antioxidant status in response to acute exercise in overweight women.
Overweight
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study.
Overweight
Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects.
Overweight
Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration.
Overweight
Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients.
Overweight
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
Overweight
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Overweight
Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.
Overweight
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
Overweight
SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY.
Overweight
Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study.
Overweight
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
Overweight
[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.]
Pancreatic Neoplasms
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.
Pancreatic Neoplasms
Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc.
Pancreatic Neoplasms
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.
Pancreatic Neoplasms
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome.
Pancreatic Neoplasms
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Pancreatic Neoplasms
miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.
Pancreatic Neoplasms
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
Pancreatic Neoplasms
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
Pancreatic Neoplasms
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
Pancreatic Neoplasms
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
Pancreatic Neoplasms
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
Pancreatic Neoplasms
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
Pancreatic Neoplasms
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
Pancreatic Neoplasms
SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.
Pancreatic Neoplasms
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
Pancreatic Neoplasms
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Pancreatic Neoplasms
Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress.
Pancreatic Neoplasms
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
Pancreatic Neoplasms
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Pancreatitis
A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis.
Pancreatitis
Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis.
Pancreatitis
Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis.
Pancreatitis
Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
Pancreatitis
Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.
Pancreatitis
Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.
Pancreatitis
Resveratrol Suppresses Severe Acute Pancreatitis-Induced Microcirculation Disturbance through Targeting SIRT1-FOXO1 Axis.
Pancytopenia
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
Papilloma
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
Papillomavirus Infections
Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors.
Papillomavirus Infections
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Paralysis
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.
Paralysis
Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism.
Parasitemia
Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages.
Parasitic Diseases
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
Parasitic Diseases
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Parkinson Disease
After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders.
Parkinson Disease
Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson's disease models.
Parkinson Disease
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Parkinson Disease
Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.
Parkinson Disease
Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease.
Parkinson Disease
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Parkinson Disease
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Parkinson Disease
Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes.
Parkinson Disease
Elucidating the Neuroprotective Role of Formulated Camel ?-Lactalbumin-Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson's Disease Model.
Parkinson Disease
Erratum to: Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.
Parkinson Disease
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Parkinson Disease
Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.
Parkinson Disease
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Parkinson Disease
Inhibition of SIRT2 by Targeting GSK3?-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells.
Parkinson Disease
Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake.
Parkinson Disease
MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson's Disease.
Parkinson Disease
MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2.
Parkinson Disease
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.
Parkinson Disease
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3.
Parkinson Disease
miR-9-5p modulates the progression of Parkinson's disease by targeting SIRT1.
Parkinson Disease
Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations.
Parkinson Disease
Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.
Parkinson Disease
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Parkinson Disease
Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China.
Parkinson Disease
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease.
Parkinson Disease
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Parkinson Disease
Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
Parkinson Disease
Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population.
Parkinson Disease
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.
Parkinson Disease
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
Parkinson Disease
SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.
Parkinson Disease
SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1?-Mediated Mitochondrial Biogenesis.
Parkinson Disease
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Parkinson Disease
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
Parkinson Disease
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
Parkinson Disease
Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3?/?-catenin pathway.
Parkinson Disease
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Parkinson Disease
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Parkinson Disease
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.
Parkinson Disease
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
Parkinson Disease
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
Parkinson Disease
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Parkinson Disease
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Parkinson Disease
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Parkinson Disease
Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation.
Parkinson Disease
Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.
Parkinsonian Disorders
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.
Parkinsonian Disorders
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant ?-synuclein rat model of parkinsonism.
Parkinsonian Disorders
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Pediatric Obesity
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
Periapical Granuloma
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis.
Periapical Granuloma
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas.
Periapical Periodontitis
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis.
Periapical Periodontitis
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas.
Periodontal Diseases
Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose-binding lectin.
Periodontitis
Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
Periodontitis
Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation.
Periodontitis
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model.
Periodontitis
Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4.
Peripheral Nerve Injuries
MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration.
Peripheral Nerve Injuries
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
Peripheral Nerve Injuries
SIRT2 Inhibition Improves Functional Motor Recovery After Peripheral Nerve Injury.
Peripheral Nervous System Diseases
Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1?-TFAM pathway.
Peripheral Nervous System Diseases
SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
Peripheral Nervous System Diseases
Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury.
Peritoneal Fibrosis
Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study.
Peritonitis
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Peritonitis
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Peroxisomal Disorders
SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.
Persistent Infection
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
Pheochromocytoma
LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells.
Pheochromocytoma
MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction.
Pheochromocytoma
SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis.
Pheochromocytoma
SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury.
Pituitary Neoplasms
Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma.
Pleural Effusion
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Pneumonia
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Pneumonia
Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-? Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.
Pneumonia
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Pneumonia
Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
Pneumonia
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.
Pneumonia
MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1.
Pneumonia
Niacin Pretreatment Attenuates Lung Ischemia and Reperfusion-Induced Pulmonary Barrier Function Impairment by Reducing Oxidative Stress and Activating SIRT1 in an Isolated-Perfused Rat Lung Model.
Pneumonia
Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury.
Pneumonia
Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study.
Pneumonia
SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism.
Pneumonia
Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure.
Pneumonia
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Pneumonia
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Pneumonia, Staphylococcal
MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1.
Polycystic Kidney Diseases
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Polycystic Kidney Diseases
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Polycystic Ovary Syndrome
Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1).
Polycystic Ovary Syndrome
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.
Polycystic Ovary Syndrome
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women.
Polycystic Ovary Syndrome
Role of some MiRNA Affecting Polycystic Ovarian Syndrome and SIRT1 levels.
Polycystic Ovary Syndrome
Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Polycystic Ovary Syndrome
Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome.
Polycythemia
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Pre-Eclampsia
Advances in the role of silence information regulator family in pathological pregnancy.
Pre-Eclampsia
Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia.
Pre-Eclampsia
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
Pre-Eclampsia
SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Morphoproteomics Identifies SIRT1 and EZH2 Pathways as Commonalities in B-cell Acute Lymphoblastic Leukemia: Pathogenetic Implications and Opportunities for Therapeutic Intervention.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Prediabetic State
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Pregnancy Complications
Advances in the role of silence information regulator family in pathological pregnancy.
Premature Birth
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Premature Birth
Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study.
Presbycusis
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model.
Primary Ovarian Insufficiency
Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1).
Primary Ovarian Insufficiency
Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression.
Primary Ovarian Insufficiency
[Effect of SIRT1 on delay of D-gal-induced premature ovarian failure in mice with ginsenoside Rg_1].
Prion Diseases
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Prion Diseases
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity.
Prion Diseases
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Progeria
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
Progeria
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice.
Prostatic Hyperplasia
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1? axis in the development of benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
Prostatic Intraepithelial Neoplasia
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Prostatic Intraepithelial Neoplasia
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
Prostatic Intraepithelial Neoplasia
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Prostatic Neoplasms
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells.
Prostatic Neoplasms
Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling.
Prostatic Neoplasms
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
Prostatic Neoplasms
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Prostatic Neoplasms
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Prostatic Neoplasms
Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1.
Prostatic Neoplasms
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
Prostatic Neoplasms
Editorial comment to inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.
Prostatic Neoplasms
Effect of SIRT1 Gene on Epithelial-Mesenchymal Transition of Human Prostate Cancer PC-3 Cells.
Prostatic Neoplasms
Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1).
Prostatic Neoplasms
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Prostatic Neoplasms
Expression Patterns of ER?, ER?, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue.
Prostatic Neoplasms
Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence.
Prostatic Neoplasms
Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.
Prostatic Neoplasms
Knockdown of TNF receptor-associated factor 2 (TRAF2) modulates in vitro growth of TRAIL-treated prostate cancer cells.
Prostatic Neoplasms
Leptin contributes to long-term stabilization of HIF-1? in cancer cells subjected to oxygen limiting conditions.
Prostatic Neoplasms
Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.
Prostatic Neoplasms
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
Prostatic Neoplasms
Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model.
Prostatic Neoplasms
Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages.
Prostatic Neoplasms
MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.
Prostatic Neoplasms
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Prostatic Neoplasms
MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway.
Prostatic Neoplasms
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms.
Prostatic Neoplasms
miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression.
Prostatic Neoplasms
MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.
Prostatic Neoplasms
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.
Prostatic Neoplasms
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1.
Prostatic Neoplasms
Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.
Prostatic Neoplasms
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP.
Prostatic Neoplasms
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Prostatic Neoplasms
RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.
Prostatic Neoplasms
Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells.
Prostatic Neoplasms
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Prostatic Neoplasms
Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines.
Prostatic Neoplasms
SIRT1 contributes to neuroendocrine differentiation of prostate cancer.
Prostatic Neoplasms
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
Prostatic Neoplasms
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
Prostatic Neoplasms
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
Prostatic Neoplasms
SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
Prostatic Neoplasms
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
Prostatic Neoplasms
SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway.
Prostatic Neoplasms
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.
Prostatic Neoplasms
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
Prostatic Neoplasms
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Prostatic Neoplasms
The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells.
Prostatic Neoplasms
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Prostatic Neoplasms
[Effect of long-chain non-coding RNA-AC024560.2 on proliferation and invasion of prostate cancer cells by targeted regulation of miR-30a-5p].
Prostatic Neoplasms
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Prostatitis
Resveratrol Improved the Progression of Chronic Prostatitis via the Downregulation of c-kit/SCF by Activating Sirt1.
Prostatitis
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.
protein acetyllysine n-acetyltransferase deficiency
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
protein acetyllysine n-acetyltransferase deficiency
A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells.
protein acetyllysine n-acetyltransferase deficiency
A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.
protein acetyllysine n-acetyltransferase deficiency
A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice.
protein acetyllysine n-acetyltransferase deficiency
Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression.
protein acetyllysine n-acetyltransferase deficiency
Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3.
protein acetyllysine n-acetyltransferase deficiency
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
protein acetyllysine n-acetyltransferase deficiency
Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.
protein acetyllysine n-acetyltransferase deficiency
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
protein acetyllysine n-acetyltransferase deficiency
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
protein acetyllysine n-acetyltransferase deficiency
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
protein acetyllysine n-acetyltransferase deficiency
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.
protein acetyllysine n-acetyltransferase deficiency
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
protein acetyllysine n-acetyltransferase deficiency
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.
protein acetyllysine n-acetyltransferase deficiency
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
protein acetyllysine n-acetyltransferase deficiency
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells.
protein acetyllysine n-acetyltransferase deficiency
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
protein acetyllysine n-acetyltransferase deficiency
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
protein acetyllysine n-acetyltransferase deficiency
Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
protein acetyllysine n-acetyltransferase deficiency
Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys.
protein acetyllysine n-acetyltransferase deficiency
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
protein acetyllysine n-acetyltransferase deficiency
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
protein acetyllysine n-acetyltransferase deficiency
Epidermal SIRT1 regulates inflammation, cell migration, and wound healing.
protein acetyllysine n-acetyltransferase deficiency
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
protein acetyllysine n-acetyltransferase deficiency
Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat.
protein acetyllysine n-acetyltransferase deficiency
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
protein acetyllysine n-acetyltransferase deficiency
Geniposide Protects against Obesity-Related Cardiac Injury through AMPK?- and Sirt1-Dependent Mechanisms.
protein acetyllysine n-acetyltransferase deficiency
Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1.
protein acetyllysine n-acetyltransferase deficiency
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
protein acetyllysine n-acetyltransferase deficiency
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
protein acetyllysine n-acetyltransferase deficiency
High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin.
protein acetyllysine n-acetyltransferase deficiency
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
protein acetyllysine n-acetyltransferase deficiency
High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities.
protein acetyllysine n-acetyltransferase deficiency
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
protein acetyllysine n-acetyltransferase deficiency
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
protein acetyllysine n-acetyltransferase deficiency
Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload.
protein acetyllysine n-acetyltransferase deficiency
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
protein acetyllysine n-acetyltransferase deficiency
Inhibition of SIRT2 suppresses hepatic fibrosis.
protein acetyllysine n-acetyltransferase deficiency
Inhibition of transcriptional activity of c-JUN by SIRT1.
protein acetyllysine n-acetyltransferase deficiency
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
protein acetyllysine n-acetyltransferase deficiency
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
protein acetyllysine n-acetyltransferase deficiency
LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway.
protein acetyllysine n-acetyltransferase deficiency
Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1).
protein acetyllysine n-acetyltransferase deficiency
LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy.
protein acetyllysine n-acetyltransferase deficiency
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.
protein acetyllysine n-acetyltransferase deficiency
Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner.
protein acetyllysine n-acetyltransferase deficiency
Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway.
protein acetyllysine n-acetyltransferase deficiency
Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.
protein acetyllysine n-acetyltransferase deficiency
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway.
protein acetyllysine n-acetyltransferase deficiency
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
protein acetyllysine n-acetyltransferase deficiency
Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-?-dependent feedback regulation of SOD2.
protein acetyllysine n-acetyltransferase deficiency
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
protein acetyllysine n-acetyltransferase deficiency
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
protein acetyllysine n-acetyltransferase deficiency
Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.
protein acetyllysine n-acetyltransferase deficiency
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges.
protein acetyllysine n-acetyltransferase deficiency
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.
protein acetyllysine n-acetyltransferase deficiency
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues.
protein acetyllysine n-acetyltransferase deficiency
Neuroprotective role of retinal SIRT3 against acute photo-stress.
protein acetyllysine n-acetyltransferase deficiency
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.
protein acetyllysine n-acetyltransferase deficiency
Oxymatrine attenuates oxidized low?density lipoprotein?induced HUVEC injury by inhibiting NLRP3 inflammasome?mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway.
protein acetyllysine n-acetyltransferase deficiency
Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner.
protein acetyllysine n-acetyltransferase deficiency
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.
protein acetyllysine n-acetyltransferase deficiency
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
protein acetyllysine n-acetyltransferase deficiency
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.
protein acetyllysine n-acetyltransferase deficiency
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
protein acetyllysine n-acetyltransferase deficiency
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
protein acetyllysine n-acetyltransferase deficiency
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
protein acetyllysine n-acetyltransferase deficiency
Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery.
protein acetyllysine n-acetyltransferase deficiency
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.
protein acetyllysine n-acetyltransferase deficiency
Resveratrol possesses protective effects in a pristane-induced lupus mouse model.
protein acetyllysine n-acetyltransferase deficiency
Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-?/Smad3 pathway.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 activation protects the mouse renal medulla from oxidative injury.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 deficiency attenuates spermatogenesis and germ cell function.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block ROS-Induced Apoptosis in Mouse Embryonic Stem Cells.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 deficiency interferes with membrane resealing after cell membrane injury.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F?actin homeostasis-mediated cellular migration.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 is essential for normal cognitive function and synaptic plasticity.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis.
protein acetyllysine n-acetyltransferase deficiency
SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 negatively regulates the mammalian target of rapamycin.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD.
protein acetyllysine n-acetyltransferase deficiency
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
protein acetyllysine n-acetyltransferase deficiency
Sirt1 restrains lung inflammasome activation in a murine model of sepsis.
protein acetyllysine n-acetyltransferase deficiency
SIRT1, is it a tumor promoter or tumor suppressor?
protein acetyllysine n-acetyltransferase deficiency
SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.
protein acetyllysine n-acetyltransferase deficiency
SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 directs the replication stress response through CDK9 deacetylation.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
protein acetyllysine n-acetyltransferase deficiency
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3?.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 consolidates heterochromatin and counteracts senescence.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency exacerbates p53/Parkin?mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency impairs mitochondrial and contractile function in the heart.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency increases mitochondrial oxidative stress and promotes migration of retinal pigment epithelial cells.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
protein acetyllysine n-acetyltransferase deficiency
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
protein acetyllysine n-acetyltransferase deficiency
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency does not impede digit regeneration in mice.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
protein acetyllysine n-acetyltransferase deficiency
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin3 deficiency exacerbates carbon tetrachloride-induced hepatic injury in mice.
protein acetyllysine n-acetyltransferase deficiency
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
protein acetyllysine n-acetyltransferase deficiency
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
protein acetyllysine n-acetyltransferase deficiency
The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes.
protein acetyllysine n-acetyltransferase deficiency
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.
protein acetyllysine n-acetyltransferase deficiency
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
protein acetyllysine n-acetyltransferase deficiency
The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells.
protein acetyllysine n-acetyltransferase deficiency
[Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice].
protein acetyllysine n-acetyltransferase deficiency
[SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].
Protein Deficiency
Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory.
Proteinuria
Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline.
Proteinuria
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Proteinuria
Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1? mediated attenuation of mitochondrial oxidative stress.
Proteinuria
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Proteinuria
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
Proteinuria
[Alpha-mangostin attenuates focal segmental glomerulosclerosis of mice induced by adriamycin].
Psoriasis
A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis.
Psoriasis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Psoriasis
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-?B and MAPKs signaling pathways.
Psoriasis
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Psoriasis
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
Psoriasis
Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis.
Psoriasis
Induction of differentiation in psoriatic keratinocytes by propylthiouracil and fructose.
Psoriasis
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Psoriasis
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1.
Psoriasis
Salidroside inhibits MAPK, NF-?B, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
Psoriasis
Sirt1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A New Insight into the Pathogenetic Mechanisms of Psoriasis.
Psoriasis
SIRT1, a Class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol.
Psoriasis
STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation.
Psoriasis
The Role of Forkhead Box Class O3A and SIRT1 Gene Variants in Early-Onset Psoriasis.
Pulmonary Arterial Hypertension
Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Pulmonary Arterial Hypertension
Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy.
Pulmonary Disease, Chronic Obstructive
3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD.
Pulmonary Disease, Chronic Obstructive
A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population.
Pulmonary Disease, Chronic Obstructive
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.
Pulmonary Disease, Chronic Obstructive
Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.
Pulmonary Disease, Chronic Obstructive
Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD).
Pulmonary Disease, Chronic Obstructive
Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model.
Pulmonary Disease, Chronic Obstructive
Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence.
Pulmonary Disease, Chronic Obstructive
Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients.
Pulmonary Disease, Chronic Obstructive
Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor ?B Axis in Macrophages and Mice Lungs.
Pulmonary Disease, Chronic Obstructive
Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract-induced heme oxygenase-1 by cleaving sirtuin 1.
Pulmonary Disease, Chronic Obstructive
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Pulmonary Disease, Chronic Obstructive
Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1?/NF-?B signaling axis.
Pulmonary Disease, Chronic Obstructive
Future treatments for chronic obstructive pulmonary disease and its comorbidities.
Pulmonary Disease, Chronic Obstructive
Inhibition of miR-494-3p alleviates oxidative stress-induced cell senescence and inflammation in the primary epithelial cells of COPD patients.
Pulmonary Disease, Chronic Obstructive
LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis.
Pulmonary Disease, Chronic Obstructive
LncRNA?mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
Pulmonary Disease, Chronic Obstructive
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1? in rats with COPD.
Pulmonary Disease, Chronic Obstructive
Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.
Pulmonary Disease, Chronic Obstructive
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Pulmonary Disease, Chronic Obstructive
Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins.
Pulmonary Disease, Chronic Obstructive
Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation.
Pulmonary Disease, Chronic Obstructive
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke.
Pulmonary Disease, Chronic Obstructive
Role of sirtuins in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Silent information regulator, Sirtuin 1, and age-related diseases.
Pulmonary Disease, Chronic Obstructive
SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients.
Pulmonary Disease, Chronic Obstructive
SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD.
Pulmonary Disease, Chronic Obstructive
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism.
Pulmonary Disease, Chronic Obstructive
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Pulmonary Disease, Chronic Obstructive
SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD.
Pulmonary Disease, Chronic Obstructive
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Sirtuin 1 and aging theory for chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD.
Pulmonary Disease, Chronic Obstructive
Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Mu?la province.
Pulmonary Disease, Chronic Obstructive
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis.
Pulmonary Edema
Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs.
Pulmonary Fibrosis
Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease.
Pulmonary Fibrosis
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Pulmonary Fibrosis
CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis.
Pulmonary Fibrosis
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Pulmonary Fibrosis
p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.
Pulmonary Fibrosis
Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition.
Pulmonary Fibrosis
SIRT1 Protects Against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Pro-inflammatory and Pro-fibrotic Processes.
Pulmonary Fibrosis
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Pulmonary Fibrosis
SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment.
Pulmonary Fibrosis
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.
Pulmonary Fibrosis
Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis.
Pulpitis
MicroRNA-506 Is Involved in Regulation of the Occurrence of Lipopolysaccharides (LPS)-Induced Pulpitis by Sirtuin 1 (SIRT1).
Purpura, Thrombocytopenic, Idiopathic
SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients.
Radiation Fibrosis Syndrome
Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity.
Radiculopathy
SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.
Rectal Neoplasms
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis.
Relative Energy Deficiency in Sport
Beneficial Effects of Concentrated Growth Factors and Resveratrol on Human Osteoblasts In Vitro Treated with Bisphosphonates.
Renal Insufficiency
Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model.
Renal Insufficiency, Chronic
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis.
Renal Insufficiency, Chronic
Glucagon?like peptide?1 protects mouse podocytes against high glucose?induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro.
Renal Insufficiency, Chronic
Resveratrol-poor Red Wines Modulate SIRT1 in Human Renal Cells.
Renal Insufficiency, Chronic
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
Renal Insufficiency, Chronic
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Renal Insufficiency, Chronic
The decreased SIRT1 level may account for the lipid profile in chronic kidney disease.
Reperfusion Injury
Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
Reperfusion Injury
Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain.
Reperfusion Injury
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
Reperfusion Injury
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Reperfusion Injury
Cross-Talk Between Sirtuin 1 and High-Mobility Box 1 in Steatotic Liver Graft Preservation.
Reperfusion Injury
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.
Reperfusion Injury
Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases.
Reperfusion Injury
Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation.
Reperfusion Injury
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.
Reperfusion Injury
Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK.
Reperfusion Injury
Exploring the role of orexin B-sirtuin 1-HIF-1? in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats.
Reperfusion Injury
Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats.
Reperfusion Injury
Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and regulating NLRP3 and apoptosis pathway.
Reperfusion Injury
Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.
Reperfusion Injury
MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1.
Reperfusion Injury
MiR-7-5p Enhances Cerebral Ischemia-Reperfusion Injury by Degrading sirt1 mRNA.
Reperfusion Injury
MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury.
Reperfusion Injury
Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
Reperfusion Injury
Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3.
Reperfusion Injury
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity.
Reperfusion Injury
PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.
Reperfusion Injury
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Reperfusion Injury
Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI).
Reperfusion Injury
Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1.
Reperfusion Injury
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
Reperfusion Injury
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
Reperfusion Injury
Sirt1 Activation by Post-ischemic Treatment With Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury.
Reperfusion Injury
SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury.
Reperfusion Injury
SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1/NLRP3 pathway.
Reperfusion Injury
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
Reperfusion Injury
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Reperfusion Injury
SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats.
Reperfusion Injury
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Reperfusion Injury
SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1?.
Reperfusion Injury
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.
Reperfusion Injury
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Reperfusion Injury
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission.
Reperfusion Injury
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
Reperfusion Injury
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Reperfusion Injury
Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.
Reperfusion Injury
Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.
Reperfusion Injury
Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy.
Reperfusion Injury
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury.
Reperfusion Injury
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Reperfusion Injury
Suppression of miR-34a Expression in the Myocardium Protects Against Ischemia-Reperfusion Injury Through SIRT1 Protective Pathway.
Reperfusion Injury
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury.
Reperfusion Injury
The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1.
Reperfusion Injury
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
Reperfusion Injury
[Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway].
Reperfusion Injury
[Effect of Shexiang Tongxin dripping pills on coronary microcirculation disorder and cardiac dysfunction in a porcine model of myocardial ischemia-reperfusion injury].
Reperfusion Injury
[Role of short-term starvation in alleviating hepatic ischemia-reperfusion injury in mice and possible mechanism of action].
Respiratory Distress Syndrome
Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation.
Respiratory Distress Syndrome
The Role of SIRT1 in Autophagy in Lipopolysaccharide-Induced Mouse Type II Alveolar Epithelial Cells.
Respiratory Distress Syndrome, Newborn
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Retinal Degeneration
PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress.
Retinal Degeneration
SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-?B pathway.
Retinal Degeneration
Sirtuin 1 participates in the process of age-related retinal degeneration.
Retinal Degeneration
The Resveratrol Prodrug JC19 Delays Retinal Degeneration in rd10 Mice.
Retinal Diseases
SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling.
Retinal Neovascularization
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Retinitis Pigmentosa
The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline.
Retinoblastoma
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells.
Retinoblastoma
MicroRNA?506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1.
Retinoblastoma
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Retinoblastoma
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
Retinoblastoma
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle.
Retinoblastoma
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Retinoblastoma
Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma.
Rhabdomyosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Rheumatic Diseases
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Rhinitis, Allergic
HIF1? Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner.
Rhinitis, Allergic
Resveratrol-mediated SIRT1 activation attenuates ovalbumin-induced allergic rhinitis in mice.
Rhinitis, Allergic
SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway.
Rhinitis, Allergic
TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression.
Sarcoma
Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3.
Sarcoma
ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
Sarcoma
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Sarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
Sarcoma, Alveolar Soft Part
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma, Clear Cell
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma, Ewing
Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity.
Sarcoma, Ewing
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma, Ewing
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
Sarcoma, Ewing
The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
Sarcoma, Synovial
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Schistosomiasis
Computer-Aided Drug Design for the Identification of Novel Antischistosomal Compounds.
Scleroderma, Systemic
Histone deacetylase SIRT1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting TGF-ß signaling.
Scleroderma, Systemic
Sirt1 regulates canonical TGF-? signalling to control fibroblast activation and tissue fibrosis.
Scleroderma, Systemic
SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.
Scrapie
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Scrapie
Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1.
Seizures
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Seizures
Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus.
Seizures
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
Seminoma
Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
Sepsis
Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development.
Sepsis
Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K/Nrf2/HO-1 Signaling Axis.
Sepsis
Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential.
Sepsis
BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-?B Signaling Pathway.
Sepsis
Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens.
Sepsis
Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk.
Sepsis
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality.
Sepsis
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Sepsis
Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.
Sepsis
Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.
Sepsis
Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
Sepsis
Ghrelin Alleviates Intestinal Dysfunction in Sepsis Through the KLF4/MMP2 Regulatory Axis by Activating SIRT1.
Sepsis
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis.
Sepsis
Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses.
Sepsis
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Sepsis
Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.
Sepsis
Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.
Sepsis
Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-?B pathways via targeting SIRT1.
Sepsis
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Sepsis
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2?/Notch3 pathways.
Sepsis
MCPIP1 alleviated lipopolysaccharide-induced liver injury by regulating SIRT1 via modulation of microRNA-9.
Sepsis
Melatonin Alleviates Cardiac Dysfunction Via Increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis.
Sepsis
Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway.
Sepsis
Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction.
Sepsis
Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice.
Sepsis
NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.
Sepsis
NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance.
Sepsis
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Sepsis
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy.
Sepsis
Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation.
Sepsis
Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-?B and NLRP3 Signaling Pathways.
Sepsis
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Sepsis
Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.
Sepsis
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
Sepsis
Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1.
Sepsis
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1.
Sepsis
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Sepsis
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.
Sepsis
Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis.
Sepsis
SirT1 activator represses the transcription of TNF?? in THP?1 cells of a sepsis model via deacetylation of H4K16.
Sepsis
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.
Sepsis
SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells.
Sepsis
SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA.
Sepsis
Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264.7 cells and endotoxemic mice.
Sepsis
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury.
Sepsis
Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle.
Sepsis
Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness.
Sepsis
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
Sepsis
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Sepsis
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.
Sepsis
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
Sepsis
[Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model].
Sepsis
[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].
Sepsis-Associated Encephalopathy
Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice.
Sertoli Cell-Only Syndrome
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Shock, Septic
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Shock, Septic
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Shock, Septic
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
Shock, Septic
The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.
Skin Diseases
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1.
Skin Diseases
Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1.
Skin Neoplasms
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
Skin Neoplasms
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Skin Neoplasms
SIRT1 Inhibition Restores Apoptotic Sensitivity in p53-Mutated Human Keratinocytes.
Skin Neoplasms
SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor.
Skin Neoplasms
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Skin Neoplasms
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Sleep Apnea, Obstructive
Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.
Sleep Apnea, Obstructive
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.
Sleep Apnea, Obstructive
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea.
Sleep Apnea, Obstructive
Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea.
Sleep Deprivation
Melatonin modifies SOX2+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation.
Sleep Deprivation
Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats.
Sleep Deprivation
Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases.
Small Cell Lung Carcinoma
Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer.
Soft Tissue Neoplasms
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Solitary Fibrous Tumors
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Spasm
SIRT1-mediated deacetylation of NF-?B inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm.
Spinal Cord Injuries
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Spinal Cord Injuries
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
Spinal Cord Injuries
MicroRNA?138?5p regulates the development of spinal cord injury by targeting SIRT1.
Spinal Cord Injuries
Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1.
Spinal Cord Injuries
SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494.
Spinal Cord Injuries
The Serum SIRT1 Protein is Associated with the Severity of Injury and Neurological Recovery in Mice with Traumatic Spinal Cord Injury.
Spinal Cord Ischemia
MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1.
Spinal Stenosis
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Spinocerebellar Ataxias
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.
Squamous Cell Carcinoma of Head and Neck
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
Squamous Cell Carcinoma of Head and Neck
Altered expression of SIRT gene family in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Squamous Cell Carcinoma of Head and Neck
Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Squamous Cell Carcinoma of Head and Neck
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Squamous Cell Carcinoma of Head and Neck
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Squamous Cell Carcinoma of Head and Neck
Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
Squamous Cell Carcinoma of Head and Neck
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Squamous Cell Carcinoma of Head and Neck
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Squamous Cell Carcinoma of Head and Neck
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Squamous Cell Carcinoma of Head and Neck
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
Squamous Cell Carcinoma of Head and Neck
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
ST Elevation Myocardial Infarction
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
ST Elevation Myocardial Infarction
MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients.
Staphylococcal Infections
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Starvation
AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.
Starvation
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Starvation
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.
Starvation
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Starvation
Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses.
Starvation
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Starvation
Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Starvation
Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.
Starvation
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
Starvation
Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients.
Starvation
MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.
Starvation
Muscle Wasting in Fasting Requires Activation of NF-?B and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.
Starvation
Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.
Starvation
Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner.
Starvation
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
Starvation
Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium development upon starvation.
Starvation
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
Starvation
SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
Starvation
SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells.
Starvation
SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.
Starvation
SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis.
Starvation
Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.
Status Epilepticus
Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus.
Status Epilepticus
Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus.
Status Epilepticus
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.
Stomach Neoplasms
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Stomach Neoplasms
Activating Transcription Factor 4 Confers a Multidrug Resistance Phenotype to Gastric Cancer Cells through Transactivation of SIRT1 Expression.
Stomach Neoplasms
Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment.
Stomach Neoplasms
Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.
Stomach Neoplasms
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer.
Stomach Neoplasms
Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.
Stomach Neoplasms
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.
Stomach Neoplasms
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Stomach Neoplasms
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Stomach Neoplasms
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1.
Stomach Neoplasms
High glucose promotes gastric cancer chemoresistance in vivo and in vitro.
Stomach Neoplasms
Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression.
Stomach Neoplasms
Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy.
Stomach Neoplasms
Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo.
Stomach Neoplasms
MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1.
Stomach Neoplasms
miR-1301-3p Promotes Cell Proliferation and Facilitates Cell Cycle Progression via Targeting SIRT1 in Gastric Cancer.
Stomach Neoplasms
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
Stomach Neoplasms
MiRNA-12129 Suppresses Cell Proliferation and Block Cell Cycle Progression by Targeting SIRT1 in GASTRIC Cancer.
Stomach Neoplasms
Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.
Stomach Neoplasms
Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer by
Stomach Neoplasms
Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.
Stomach Neoplasms
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
Stomach Neoplasms
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.
Stomach Neoplasms
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
Stomach Neoplasms
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
Stomach Neoplasms
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
Stomach Neoplasms
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment.
Stomach Neoplasms
SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling.
Stomach Neoplasms
SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.
Stomach Neoplasms
SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer.
Stomach Neoplasms
SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism.
Stomach Neoplasms
SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells.
Stomach Neoplasms
SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1.
Stomach Neoplasms
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Stomatitis
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice.
Stroke
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.
Stroke
Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.
Stroke
c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression.
Stroke
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.
Stroke
Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.
Stroke
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Stroke
Effects of rosuvastatin on neuronal apoptosis in cerebral ischemic stroke rats via Sirt1/NF-kappa B signaling pathway.
Stroke
Icariin Inhibits Hydrogen Peroxide-Mediated Cytotoxicity by Up-regulating Sirtuin Type 1-Dependent Catalase and Peroxiredoxin.
Stroke
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Stroke
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Stroke
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Stroke
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Stroke
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Stroke
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Stroke
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Stroke
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
Stroke
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Stroke
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Stroke
Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
Stroke
Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes.
Stroke
Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats.
Stroke
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
Stroke
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Stroke
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Stroke
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Stroke
The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders.
Stroke
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism.
Stroke
Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction.
Subarachnoid Hemorrhage
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
Subarachnoid Hemorrhage
Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-?B Pathway.
Subarachnoid Hemorrhage
Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Subarachnoid Hemorrhage
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.
Subarachnoid Hemorrhage
Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Subarachnoid Hemorrhage
SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
Subarachnoid Hemorrhage
SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage.
Subarachnoid Hemorrhage
SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
Subarachnoid Hemorrhage
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Subarachnoid Hemorrhage
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Subarachnoid Hemorrhage
Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats.
Sudden Unexpected Death in Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Synovitis
Oleanolic Acid Decreases IL-1?-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-?B Axis in Osteoarthritis.
Synucleinopathies
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Tauopathies
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Tauopathies
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Tauopathies
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
Teratoma
SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells.
Teratozoospermia
SirT1 is required in the male germ cell for differentiation and fecundity in mice.
Thrombocytopenia
Antioxidant and anti-inflammatory properties of alpha lipoic acid protect against valproic acid induced liver injury.
Thrombocytopenia
Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.
Thrombosis
A Novel Antithrombotic Mechanism Mediated by the Receptors of the Kallikrein/Kinin and Renin-Angiotensin Systems.
Thrombosis
Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway.
Thrombosis
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis.
Thrombosis
Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator.
Thrombosis
Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway.
Thrombosis
Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model.
Thrombosis
Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3.
Thrombosis
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Thrombosis
MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients.
Thrombosis
Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems.
Thrombosis
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Thrombosis
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Thrombosis
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.
Thrombosis
SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets.
Thrombosis
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Thrombosis
Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.
Thrombosis
Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2.
Thyroid Cancer, Papillary
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Thyroid Cancer, Papillary
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
Thyroid Cancer, Papillary
Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer.
Thyroid Diseases
Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.
Thyroid Diseases
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Thyroid Neoplasms
Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
Thyroid Neoplasms
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
Thyroid Neoplasms
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Thyroid Neoplasms
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
Thyroid Neoplasms
[Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
Tics
Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells.
Tongue Neoplasms
Retraction Note: Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Tongue Neoplasms
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Trichothiodystrophy Syndromes
Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
Trigeminal Neuralgia
Puerarin Attenuates Complete Freund's Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-?1/Smad3 Inhibition.
Triple Negative Breast Neoplasms
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Triple Negative Breast Neoplasms
Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells.
Triple Negative Breast Neoplasms
Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.
Triple Negative Breast Neoplasms
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Triple Negative Breast Neoplasms
Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Triple Negative Breast Neoplasms
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Triple Negative Breast Neoplasms
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Triple Negative Breast Neoplasms
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Triple Negative Breast Neoplasms
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Triple Negative Breast Neoplasms
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Triple Negative Breast Neoplasms
Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.
Triple Negative Breast Neoplasms
Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
Trypanosomiasis
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Tuberculosis
A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis.
Tuberculosis
Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
Tuberculosis
Cloning and characterization of NAD-dependent protein deacetylase (Rv1151c) from Mycobacterium tuberculosis.
Tuberculosis
Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis.
Tuberculosis
Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism.
Tuberculosis
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Tuberculosis
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Tuberculosis
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
Tuberculosis
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
Tuberculosis
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP.
Tuberculosis
Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation.
Tuberculosis
Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.
Tuberculosis
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
Tuberculosis
Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death.
Tuberculosis
Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?.
Tuberculosis
The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.
Tuberous Sclerosis
Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.
Tuberous Sclerosis
Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling.
Tuberous Sclerosis
Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.
Tuberous Sclerosis
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
Tuberous Sclerosis
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
udp-3-o-acyl-n-acetylglucosamine deacetylase deficiency
Stoichiometry of site-specific lysine acetylation in an entire proteome.
ulp1 peptidase deficiency
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Ureteral Obstruction
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis.
Ureteral Obstruction
CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner.
Ureteral Obstruction
Downregulation of angiotensin type 1 receptor and nuclear factor-?B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction.
Ureteral Obstruction
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway.
Ureteral Obstruction
Sirt1 activation protects the mouse renal medulla from oxidative injury.
Urethral Obstruction
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Urinary Bladder Neoplasms
Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and ?-catenin acetylation in bladder cancer cells.
Urinary Bladder Neoplasms
Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).
Urinary Bladder Neoplasms
HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin.
Urinary Bladder Neoplasms
LncRNA MST1P2/miR-133b axis affects the chemoresistance of bladder cancer to cisplatin-based therapy via Sirt1/p53 signaling.
Urinary Bladder Neoplasms
Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines.
Urinary Bladder Neoplasms
SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population.
Urinary Bladder Neoplasms
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
Urinary Bladder Neoplasms
SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis.
Uterine Cervical Neoplasms
?2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells.
Uterine Cervical Neoplasms
Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense.
Uterine Cervical Neoplasms
Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation.
Uterine Cervical Neoplasms
Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity.
Uterine Cervical Neoplasms
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Uterine Cervical Neoplasms
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Uterine Cervical Neoplasms
Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells.
Uterine Cervical Neoplasms
Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice.
Uterine Cervical Neoplasms
MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
Uterine Cervical Neoplasms
Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells.
Uterine Cervical Neoplasms
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
Uterine Cervical Neoplasms
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Uterine Cervical Neoplasms
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Uterine Cervical Neoplasms
Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Uterine Cervical Neoplasms
The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2.
Uterine Cervical Neoplasms
The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the ?-catenin/SIRT3 signaling pathway in cervical cancer.
Uterine Cervical Neoplasms
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Uterine Neoplasms
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Uveitis
SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling.
Varicocele
Seminal SIRT1-oxidative stress relationship in infertile oligoasthenoteratozoospermic men with varicocele after its surgical repair.
Vascular Calcification
Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1.
Vascular Calcification
Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification.
Vascular Calcification
Peroxisome Proliferator-Activated Receptor-? Coactivator-1? Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Vascular Calcification
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
Vascular Calcification
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Vascular Calcification
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.
Vascular Calcification
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence].
Vascular Calcification
[Molecular mechanism of vascular calcification: essential role of mammalian sirtuin SIRT1 in cellular senescence].
Vascular Calcification
[Regulatory Mechanisms and Practical Management in Vascular Calcification. Molecular Mechanism of Vascular Aging : Impact of Vascular Smooth Muscle Cell Calcification via Cellular Senescence.]
Vascular Diseases
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
Vascular Diseases
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.
Vascular Diseases
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.
Vascular Diseases
Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs.
Vascular Diseases
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
Vascular Diseases
Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Vascular Diseases
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
Vascular Diseases
SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice.
Vascular Diseases
SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases.
Vascular Diseases
SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells.
Vascular Diseases
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Vascular Diseases
Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome.
Vascular Diseases
The role of SIRT2 in vascular-related and heart-related diseases: A review.
Vascular Diseases
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
Vascular System Injuries
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation.
Vascular System Injuries
SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice.
Vascular System Injuries
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Vasospasm, Intracranial
SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage.
Venous Thrombosis
Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway.
Venous Thrombosis
Data for DHK effect on thrombus weight, blood coagulation, blood cell counts and whole blood viscosity in deep vein thrombosis rats.
Venous Thrombosis
Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model.
Venous Thrombosis
LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis.
Venous Thrombosis
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Ventricular Dysfunction
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Ventricular Dysfunction, Left
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress.
Vesicular Stomatitis
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
Virus Diseases
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
Virus Diseases
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Virus Diseases
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis.
Virus Diseases
Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway.
Virus Diseases
Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.
Virus Diseases
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.
Virus Diseases
Transcriptome Profiling Reveals a Novel Mechanism of Antiviral Immunity Upon Sacbrood Virus Infection in Honey Bee Larvae (Apis cerana).
Virus Diseases
Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors.
Vitamin D Deficiency
Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind randomized clinical trial.
Vitiligo
Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo.
Vitiligo
SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival.
Vitiligo
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Vitiligo
The long noncoding RNA MALAT1 suppresses miR-211 to confer protection from ultraviolet-mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1.
Werner Syndrome
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Werner Syndrome
Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.
Werner Syndrome
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Wilms Tumor
Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice.
Wilms Tumor
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Wilms Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Xeroderma Pigmentosum
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
Xeroderma Pigmentosum
Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.
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IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00062
3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
pH 7.5, temperature not specified in the publication
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0037
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
Homo sapiens
pH 8.0, 37°C
0.0403
5-(biphenyl-4-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.116
5-[(1-benzyl-1H-indol-3-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0433
5-[(6-methoxynaphthalen-1-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0293
5-[4-(benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0464
5-[4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0303
5-[4-[(4-bromobenzyl)oxy]benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.049
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Homo sapiens
pH 8.0, 37°C
13800
Isonicotinamide
Homo sapiens
Q96EB6, Q9NTG7
pH 8, 37°C, weak competitive inhibitor of hSIRT3 with respect to NAD+ in vitro
0.0144
(5E)-5-[4-(benzyloxy)benzylidene]-1-ethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.01
(5E)-5-[4-(benzyloxy)benzylidene]-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0097
(5E)-5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0102
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)isonicotinamide
Homo sapiens
pH and temperature not specified in the publication
0.0049
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)isonicotinamide
Homo sapiens
pH and temperature not specified in the publication
0.0008 - 0.0035
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
0.0172
3-((2-methoxynaphthalen-1-yl)methyl)-7-((2-methylbenzyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.00145
3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.006
3-((2-methoxynaphthalen-1-yl)methyl)-7-((thiophen-2-ylmethyl)-amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.00652
3-((2-methoxynaphthalen-1-yl)methyl)-7-(neopentylamino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0108
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0068
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-chlorophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0073
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0132
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(5-chloropyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0075
3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-(4-chloro-2-fluorophenyl)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0095
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfinyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0098
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfonyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0066
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0061
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0199
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-cyanopyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0091
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-fluoropyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0156
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-chloropyridazin-3-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0061
3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0063
4-bromo-N-(3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0203
5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0087
5-(biphenyl-4-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0117
5-[(6-methoxynaphthalen-1-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0098
5-[4-(benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0147
5-[4-(propan-2-yl)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0075
5-[4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0034
5-[4-[(4-bromobenzyl)oxy]benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.0104
5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
pH 8.0, 37°C
0.004
7-((3-fluorobenzyl)amino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0019
7-((3-methoxybenzyl)amino)-3-((2-methoxynaphthalen-1-yl)-methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0211
7-(benzylamino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0038
N-(3-(N-(4-chlorophenyl)-N-methylsulfamoyl)phenyl)-4-cyanobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0189
N-(4-acetylphenyl)-3-(N-(4-acetylphenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0069
N-(4-bromo-2-fluorophenyl)-3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0159
N-(4-chlorophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0115
N-(4-cyanophenyl)-3-(N-(4-(1-hydroxyethyl)phenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0094
N-(4-cyanophenyl)-3-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0096
N-(4-cyanophenyl)-3-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0095
N-(4-cyanophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0008
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
Homo sapiens
pH 8.0, 37°C
0.0035
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
Homo sapiens
pH 8.0, 37°C
0.0001 - 0.001
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Homo sapiens
pH 8.0, 37°C
0.02 - 0.033
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Homo sapiens
pH 8.0, 37°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Q96EB6
SIRT1 and p53 colocalize in nuclear bodies (punctate structures found in the nuclei of certain cells) upon upregulation of the promyelocytic leukemia protein
brenda
SIRT3 is localized to the inner membrane of the mitochondria
brenda
Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix
brenda
the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis
brenda
in the G2/M transition and in mitosis the enzyme is localized in association with chromatin
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
the enzyme can regulate flux and anapleurosis of this central metabolic cycle
malfunction
Q96EB6
SIRT1 depletion by RNA interference attenuates capsaicin-induced apoptosis in A-549 cancer cells and autophagy in MRC-5 cells
metabolism
physiological function
metabolism
Q96EB6
caloric restriction can extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells
metabolism
Q96EB6
Sir2 is involved in the regulation of p53 function via deacetylation
metabolism
Q96EB6
SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage
metabolism
the deacetylation of [histone H4]-N6-acetyl-L-lysine16 by Sirt2 may be pivotal to the formation of condensed chromatin
physiological function
-
enzyme expression is crucial for the survival of the cell
physiological function
Sirt2 may act as a tumor suppressor and may function to control the cell cycle by acetylation of alpha-tubulin
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). SIR3_HUMAN
399
0
43573
Swiss-Prot
Mitochondrion (Reliability: 4)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of Sirt3 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt3 in complex with fluor-de-Lys peptide and piceatannol
in complex with ADP ribose, microseed matrix seeding, using 25% (w/v) PEG 3350, 0.2 M MgCl2 in 0.1 M bis-Tris buffer pH 5.5
crystallization at 4°C by the sitting-drop vapor diffusion method. Crystal structure of human SIRT2 in complex with a macrocyclic peptide inhibitor S2iL5, at 2.5 A resolution
hanging drop vapor diffusion using a 1:1 drop ratio. The 2.5 A crystal structure of the SIRT1 catalytic domain bound to NAD+ and 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EX527)
Q96EB6
in complex with ADP ribose, microseed matrix seeding, using 17.5% (w/v) PEG 10000, 0.1 M ammonium acetate in 0.1 M bis-Tris buffer pH 6.8 at 20°C
in complex with BHJH-TM1 protein, hanging drop vapor diffusion method, using 25% (w/v) PEG 3350, 0.1 M HEPES buffer, pH 7.5
recombinant sirtuin 1 comprising residues 140747 is crystallized using the hanging-drop vapour diffusion method. The crystal diffracted to 3.4 A resolution and belong to space group P622, with unit-cell parameters a = b = 203.1, c = 625.3 A , and is estimated to contain between six and 12 molecules per asymmetric unit
Q96EB6
Sirt2 is crystallized in complex with the product analog, ADP-ribose, and this crystal structure is solved at 2.3 A resolution
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
a gene encoding the C-terminally His-tagged SIRT1 catalytic domain is expressed in SF9 cells
Q96EB6
recombinant human SIRT2 (43-356) is expressed as a His-Sumo fusion protein in Escherichia coli
SIRT1-FL (full-length human SIRT1) is cloned in the pECE vector (clone 1791) and N-terminally truncated SIRT1 (SIRT1-NT with residues 783 deleted) cloned in the pCDNA3.1 vector. To express the FLAGtagged hSIRT1 (human SIRT1) proteins, the hSIRT1 constructs are transfected into HEK (human embryonic kidney)-293T cells
Q96EB6
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
down-regulation of intratumoral and peritumoral Sirt3 are both associated with poor outcome in hepatocellular carcinoma
expression of SIRT3 shows a strong negative correlation with the progression of Alzheimers disease
expression of SIRT1 is induced in human cells that are treated with human serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response
Q96EB6
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
down-regulation of intratumoral and peritumoral Sirt3 are both associated with poor outcome in hepatocellular carcinoma. Intratumoral Sirt3 is a favorable prognostic predictor in early stage patients
medicine
medicine
3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (ICL-SIRT078) has a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line and an optimised derivative thereof, is a candidate neuroprotective agent in in vivo models of Parkinson's disease
medicine
inhibitors of sirtuin-2 deacetylase are protective in various models of Huntingtons disease by decreasing polyglutamine aggregation, a hallmark of pathology of Huntingtons disease
medicine
Q96EB6
the enzyme is a promising drug target in the treatment of age-related diseases, such as neurodegenerative diseases and cancer
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holbourn, K.P.; Lloyd, M.D.; Thompson, A.S.; Threadgill, M.D.; Acharya, K.R.
Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1
Acta Crystallogr. Sect. F
67
461-463
2011
Homo sapiens (Q96EB6), Homo sapiens
brenda
Maurer, B.; Rumpf, T.; Scharfe, M.; Stolfa, D.A.; Schmitt, M.L.; He, W.; Verdin, E.; Sippl, W.; Jung, M.
Inhibitors of the NAD(+)-dependent protein desuccinylase and demalonylase Sirt5
ACS Med. Chem. Lett.
3
1050-1053
2012
Homo sapiens (Q8IXJ6), Homo sapiens (Q96EB6), Homo sapiens (Q9NTG7)
brenda
Madabushi, A.; Hwang, B.J.; Jin, J.; Lu, A.L.
Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase
Biochem. J.
456
89-98
2013
Homo sapiens (Q96EB6), Homo sapiens
brenda
Wang, J.X.; Yi, Y.; Li, Y.W.; Cai, X.Y.; He, H.W.; Ni, X.C.; Zhou, J.; Cheng, Y.F.; Jin, J.J.; Fan, J.; Qiu, S.J.
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection
BMC Cancer
14
297
2014
Homo sapiens (Q9NTG7)
brenda
Vaziri, H.; Dessain, S.K.; Ng Eaton, E.; Imai, S.I.; Frye, R.A.; Pandita, T.K.; Guarente, L.; Weinberg, R.A.
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
Cell
107
149-159
2001
Homo sapiens (Q96EB6)
brenda
Asher, G.; Gatfield, D.; Stratmann, M.; Reinke, H.; Dibner, C.; Kreppel, F.; Mostoslavsky, R.; Alt, F.W.; Schibler, U.
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Cell
134
317-328
2008
Homo sapiens (Q96EB6)
brenda
Di Fruscia, P.; Zacharioudakis, E.; Liu, C.; Moniot, S.; Laohasinnarong, S.; Khongkow, M.; Harrison, I.F.; Koltsida, K.; Reynolds, C.R.; Schmidtkunz, K.; Jung, M.; Chapman, K.L.; Steegborn, C.; Dexter, D.T.; Sternberg, M.J.; Lam, E.W.; Fuchter, M.J.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model
ChemMedChem
10
69-82
2015
Homo sapiens (Q8IXJ6)
brenda
Langley, E.; Pearson, M.; Faretta, M.; Bauer, U.M.; Frye, R.A.; Minucci, S.; Pelicci, P.G.; Kouzarides, T.
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
EMBO J.
21
2383-2396
2002
Homo sapiens (Q96EB6), Homo sapiens
brenda
Khanfar, M.A.; Quinti, L.; Wang, H.; Choi, S.H.; Kazantsev, A.G.; Silverman, R.B.
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors
Eur. J. Med. Chem.
76
414-426
2014
Homo sapiens (Q8IXJ6), Homo sapiens
brenda
Kokkonen, P.; Mellini, P.; Nyrhil, O.; Rahnasto-Rilla, M.; Suuronen, T.; Kiviranta P.; Huhtiniemi, T.; Poso, A.; Jarho, E.; Lahtela-Kakkonen, M.
Quantitative insights for the design of substrate-based SIRT1 inhibitors
Eur. J. Pharm. Sci.
59
12-19
2014
Homo sapiens (Q96EB6), Homo sapiens
brenda
Jeong, J.; Juhn, K.; Lee, H.; Kim, S.H.; Min, B.H.; Lee, K.M.; Cho, M.H.; Park, G.H.; Lee, K.H.
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Exp. Mol. Med.
39
8-13
2007
Homo sapiens (Q96EB6), Homo sapiens
brenda
Vaquero, A.; Scher, M.B.; Lee, D.H.; Sutton, A.; Cheng, H.L.; Alt, F.W.; Serrano, L.; Sternglanz, R.; Reinberg, D.
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
Genes Dev.
20
1256-1261
2006
Homo sapiens (Q8IXJ6)
brenda
Feldman, J.L.; Baeza, J.; Denu, J.M.
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
J. Biol. Chem.
288
31350-31356
2013
Homo sapiens (Q8IXJ6), Homo sapiens (Q96EB6), Homo sapiens (Q9NTG7)
brenda
Zhao, X.; Allison, D.; Condon, B.; Zhang, F.; Gheyi, T.; Zhang, A.; Ashok, S.; Russell, M.; MacEwan, I.; Qian, Y.; Jamison, J.A.; Luz, J.G.
The 2.5 A crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition
J. Med. Chem.
56
963-969
2013
Homo sapiens (Q96EB6), Homo sapiens
brenda
Schlicker, C.; Gertz, M.; Papatheodorou, P.; Kachholz, B.; Becker, C.F.; Steegborn, C.
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
J. Mol. Biol.
382
790-801
2008
Homo sapiens (Q9NTG7), Homo sapiens
brenda
Moniot, S.; Schutkowski, M.; Steegborn, C.
Crystal structure analysis of human Sirt2 and its ADP-ribose complex
J. Struct. Biol.
182
136-143
2013
Homo sapiens (Q8IXJ6), Homo sapiens
brenda
Li, X.; Zhang, S.; Blander, G.; Tse, J.G.; Krieger, M.; Guarente, L.
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
Mol. Cell.
28
91-106
2007
Homo sapiens (Q96EB6)
brenda
Lutz, M.I.; Milenkovic, I.; Regelsberger, G.; Kovacs, G.G.
Distinct patterns of sirtuin expression during progression of Alzheimer's disease
Neuromolecular Med.
16
405-414
2014
Homo sapiens (Q9NTG7)
brenda
Guan, X.; Lin, P.; Knoll, E.; Chakrabarti, R.
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies
PLoS One
15
e107729
2014
Homo sapiens (Q96EB6), Homo sapiens (Q9NTG7), Homo sapiens
brenda
Fischer, F.; Gertz, M.; Suenkel, B.; Lakshminarasimhan, M.; Schutkowski, M.; Steegborn, C.
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
PLoS One
7
e45098
2012
Homo sapiens (Q9NTG7), Homo sapiens
brenda
Gertz, M.; Nguyen, G.T.; Fischer, F.; Suenkel, B.; Schlicker, C.; Frnzel, B.; Tomaschewski, J.; Aladini, F.; Becker, C.; Wolters, D.; Steegborn, C.
A molecular mechanism for direct sirtuin activation by resveratrol
PLoS One
7
e49761
2012
Homo sapiens (Q9NTG7), Homo sapiens
brenda
Onyango, P.; Celic, I.; McCaffery, J.M.; Boeke, J.D.; Feinberg, A.P.
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
Proc. Natl. Acad. Sci. USA
99
13653-13658
2002
Homo sapiens (Q9NTG7), Homo sapiens
brenda
Cohen, H.Y.; Miller, C.; Bitterman, K.J.; Wall, N.R.; Hekking, B.; Kessler, B.; Howitz, K.T.; Gorospe, M.; de Cabo, R.; Sinclair, D.A.
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Science
305
390-392
2004
Homo sapiens (Q96EB6), Homo sapiens, Rattus norvegicus (Q96EB6)
brenda
Yamagata, K.; Goto, Y.; Nishimasu, H.; Morimoto, J.; Ishitani, R.; Dohmae, N.; Takeda, N.; Nagai, R.; Komuro, I.; Suga, H.; Nureki, O.
Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change
Structure
22
345-352
2014
Homo sapiens (Q8IXJ6), Homo sapiens
brenda
Rumpf, T.; Gerhardt, S.; Einsle, O.; Jung, M.
Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking
Acta Crystallogr. Sect. F
71
1498-1510
2015
Homo sapiens (Q8IXJ6), Homo sapiens (Q9NTG7), Homo sapiens
brenda
Bhalla, S.; Gordon, L.I.
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL)
Cancer Biol. Ther.
17
300-309
2016
Homo sapiens
brenda
Yang, H.; Zhou, L.; Shi, Q.; Zhao, Y.; Lin, H.; Zhang, M.; Zhao, S.; Yang, Y.; Ling, Z.Q.; Guan, K.L.; Xiong, Y.; Ye, D.
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth
EMBO J.
34
1110-1125
2015
Homo sapiens (Q9NTG7), Homo sapiens
brenda
Lee, Y.H.; Chen, H.Y.; Su, L.J.; Chueh, P.J.
Sirtuin 1 (SIRT1) deacetylase activity and NAD+/NADH ratio are imperative for capsaicin-mediated programmed cell death
J. Agric. Food Chem.
63
7361-7370
2015
Homo sapiens (Q96EB6), Homo sapiens
brenda
Weiser, B.P.; Eckenhoff, R.G.
Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site
J. Biol. Chem.
290
8559-8568
2015
Rattus norvegicus, Homo sapiens (Q8IXJ6), Homo sapiens
brenda
Song, H.Y.; Park, S.H.; Kang, H.J.; Vassilopoulos, A.
Deacetylation assays to unravel the interplay between sirtuins (SIRT2) and specific protein-substrates
J. Vis. Exp.
108
53563
2016
Homo sapiens (Q8IXJ6)
brenda
Fang, M.; Guo, W.R.; Park, Y.; Kang, H.G.; Zarbl, H.
Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells
Oncotarget
6
42879-42891
2015
Rattus norvegicus, Homo sapiens (Q96EB6), Homo sapiens
brenda
Teng, Y.B.; Jing, H.; Aramsangtienchai, P.; He, B.; Khan, S.; Hu, J.; Lin, H.; Hao, Q.
Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies
Sci. Rep.
5
8529
2015
Homo sapiens (Q8IXJ6)
brenda
Pasha, J.; Kandagatla, B.; Sen, S.; Seerapu, G.; Bujji, S.; Haldar, D.; Nanduri, S.; Oruganti, S.
Amberlyst-15 catalyzed Povarov reaction of N-arylidene-1H-indazol-6-amines and indoles: a greener approach to the synthesis of exo-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines as potential sirtuin inhibitors
Tetrahedron Lett.
56
2289-2292
2015
Homo sapiens (Q8IXJ6)
-
brenda
Smith, B.C.; Denu, J.M.
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide
Biochemistry
46
14478-14486
2007
Saccharomyces cerevisiae, Homo sapiens
brenda
North, B.J.; Verdin, E.
Sirtuins Sir2-related NAD-dependent protein deacetylases
Genome Biol.
5
224
2004
Archaeoglobus fulgidus (O28597), Saccharomyces cerevisiae (P53686), Homo sapiens (Q8IXJ6), Homo sapiens, Archaeoglobus fulgidus ATCC 49558 (O28597)
brenda
Jackson, M.D.; Schmidt, M.T.; Oppenheimer, N.J.; Denu, J.M.
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases
J. Biol. Chem.
278
50985-50998
2003
Saccharomyces cerevisiae, Homo sapiens
brenda
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