Information on EC 2.3.1.281 - 5-hydroxydodecatetraenal polyketide synthase

for references in articles please use BRENDA:EC2.3.1.281
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IUBMB Comments
This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyses the first reaction in the biosynthesis of coelimycin P1. The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains. An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyses the reductive release of the product.
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The expected taxonomic range for this enzyme is: Streptomyces coelicolor
Synonyms
cpkAB, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6 malonyl-CoA + 5 NADPH + NADH + 6 H+ = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O
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PATHWAY SOURCE
PATHWAYS
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