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Information on EC 2.3.1.28 - chloramphenicol O-acetyltransferase and Organism(s) Pseudomonas aeruginosa and UniProt Accession P26841

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This record set is specific for:
Pseudomonas aeruginosa
UNIPROT: P26841 not found.
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
chloramphenicol acetyltransferase, cat-86, cat i, cat ii, chloramphenicol transacetylase, cat iii, acetyl-coa:chloramphenicol 3-o-acetyltransferase, chloramphenicol o-acetyltransferase, chloramphenicol acetylase, pacat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetyltransferase, chloramphenicol
-
-
-
-
CAT
-
-
-
-
CAT I
-
-
-
-
CAT III
-
-
-
-
chloramphenicol acetylase
-
-
-
-
chloramphenicol acetyltransferase
chloramphenicol transacetylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:chloramphenicol 3-O-acetyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9040-07-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.094 - 0.821
acetyl-CoA
0.011 - 11
chloramphenicol
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
23351
-
x * 23351, electrospray injection mass spectrometry
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 23351, electrospray injection mass spectrometry
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G61S
-
G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1
G61S/Y105C
-
G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1
Y105C
-
G61S and Y105C contrtibute synergistically to the resistance phenotype of strain PAhcr1
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of enzyme form CATB7
-
overexpression in Escherichia coli harboring the plasmid pYT1
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tian, Y.; Beaman, T.W.; Roderick, S.L.
Purification and crystallization of Pseudomonas aeruginosa chloramphenicol acetyltransferase
Proteins
28
298-300
1997
Pseudomonas aeruginosa
Manually annotated by BRENDA team
White, P.A.; Stokes, H.W.; Bunny, K.L.; Hall, R.M.
Characterization of a chloramphenicol acetyltransferase determinant found in the chromosome of Pseudomonas aeruginosa
FEMS Microbiol. Lett.
175
27-35
1999
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Wang, J.; Liu, J.H.
Mutations in the chloramphenicol acetyltransferase (S61G, Y105C) increase accumulated amounts and resistance in Pseudomonas aeruginosa
FEMS Microbiol. Lett.
236
197-204
2004
Pseudomonas aeruginosa, Pseudomonas aeruginosa Pahcr
Manually annotated by BRENDA team
Beaman, T.W.; Sugantino, M.; Roderick, S.L.
Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa
Biochemistry
37
6689-6696
1998
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA 103
Manually annotated by BRENDA team