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mycolipenoyl-CoA:2-(long-chain-fatty acyl)-trehalose 3-mycolipenoyltransferase
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA---trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3.
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a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
Substrates: the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose
a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Substrates: the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
Products: -
?
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malfunction
disruption of the papA3 gene from Mycobacterium tuberculosis results in the loss of polyacyltrehalose from bacterial lipid extracts
malfunction
-
disruption of the papA3 gene from Mycobacterium tuberculosis results in the loss of polyacyltrehalose from bacterial lipid extracts
-
metabolism
the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
metabolism
-
the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
metabolism
the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
metabolism
-
the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Touchette, M.H.; Holsclaw, C.M.; Previti, M.L.; Solomon, V.C.; Leary, J.A.; Bertozzi, C.R.; Seeliger, J.C.
The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis
J. Bacteriol.
197
201-210
2015
Mycobacterium tuberculosis (P9WIK5), Mycobacterium tuberculosis
brenda
Hatzios, S.K.; Schelle, M.W.; Holsclaw, C.M.; Behrens, C.R.; Botyanszki, Z.; Lin, F.L.; Carlson, B.L.; Kumar, P.; Leary, J.A.; Bertozzi, C.R.
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis
J. Biol. Chem.
284
12745-12751
2009
Mycobacterium tuberculosis (P9WIK5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIK5)
brenda
Belardinelli, J.M.; Larrouy-Maumus, G.; Jones, V.; Sorio de Carvalho, L.P.; McNeil, M.R.; Jackson, M.
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis
J. Biol. Chem.
289
27952-27965
2014
Mycobacterium tuberculosis (P9WIK5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIK5)
brenda
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