Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.1.277 - 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase and Organism(s) Streptomyces coelicolor and UniProt Accession Q7AKF0

for references in articles please use BRENDA:EC2.3.1.277
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Streptomyces coelicolor
UNIPROT: Q7AKF0
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The taxonomic range for the selected organisms is: Streptomyces coelicolor
The expected taxonomic range for this enzyme is: Streptomyces
Reaction Schemes
a medium-chain 3-oxoacyl-[acyl-carrier protein]
+
=
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate
+
Synonyms
afsA, barX, scbA, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
afsA
-
-
-
-
barX
-
-
-
-
scbA
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
the enzyme is involved in biosynthesis of gamma-butyrolactone
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
the enzyme is involved in biosynthesis of gamma-butyrolactone
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hsiao, N.; Sding, J.; Linke, D.; Lange, C.; Hertweck, C.; Wohlleben, W.; Takano, E.
ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones
Microbiology
153
1394-1404
2007
Streptomyces coelicolor (Q7AKF0), Streptomyces coelicolor A3(2) (Q7AKF0)
Manually annotated by BRENDA team