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Information on EC 2.3.1.277 - 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase and Organism(s) Streptomyces virginiae and UniProt Accession O24738

for references in articles please use BRENDA:EC2.3.1.277
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IUBMB Comments
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
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This record set is specific for:
Streptomyces virginiae
UNIPROT: O24738
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The taxonomic range for the selected organisms is: Streptomyces virginiae
The expected taxonomic range for this enzyme is: Streptomyces
Reaction Schemes
a medium-chain 3-oxoacyl-[acyl-carrier protein]
+
=
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate
+
Synonyms
afsA, barX, scbA, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
afsA
-
-
-
-
barX
-
-
-
-
scbA
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
the enzyme is involved in biosynthesis of the gamma-butyrolactone autoregulator in Streptomyces virginiae
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is involved in biosynthesis of the gamma-butyrolactone autoregulator in Streptomyces virginiae
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BARX_STRVG
294
0
32379
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, Y.; Kitani, S.; Nihira, T.
Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the gamma-butyrolactone autoregulator in Streptomyces virginiae
Microbiology
156
206-210
2010
Streptomyces virginiae (O24738)
Manually annotated by BRENDA team