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EC Tree
IUBMB Comments This bacterial enzyme catalyses the second step in the formation of ornithine lipids.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a lyso-ornithine lipid
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olsA
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a lyso-ornithine lipid + an acyl-[acyl-carrier protein] = an ornithine lipid + a holo-[acyl-carrier protein]
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Nalpha-[(3R)-hydroxy-acyl]-L-ornithine O-acyltransferase
This bacterial enzyme catalyses the second step in the formation of ornithine lipids.
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a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
lyso-ornithine lipid + palmitoyl-[acyl-carrier protein]
?
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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-
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
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-
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?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
-
-
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-
?
a lyso-ornithine lipid + an acyl-[acyl-carrier protein]
an ornithine lipid + a holo-[acyl-carrier protein]
-
-
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?
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no activity in Vibrio cholerae
Vibrio cholerae lacks the operon containing olsBA genes
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UniProt
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physiological function
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the enzyme mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility
metabolism
the O-acyltransferase is involved in ornithine lipid biosynthesis
metabolism
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the ornitihine lipid synthesis-specific enzyme also acts as an alternative lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) acyltransferase that is specific for ornithine lipid synthesis
metabolism
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the ornitihine lipid synthesis-specific enzyme also acts as an alternative lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) acyltransferase that is specific for ornithine lipid synthesis
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OLSA_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
258
1
28305
Swiss-Prot
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OLSA_RHIME
Rhizobium meliloti (strain 1021)
292
1
32337
Swiss-Prot
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OLSA_RHOCB
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
276
2
30719
Swiss-Prot
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OLSA_BRUA2
Brucella abortus (strain 2308)
267
1
29662
Swiss-Prot
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Q9KIH9_RHIML
292
0
32337
TrEMBL
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expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli strain SM2-1
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enzyme expression is induced under phosphatelimiting conditions
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Gao, J.L.; Weissenmayer, B.; Taylor, A.M.; Thomas-Oates, J.; Lopez-Lara, I.M.; Geiger, O.
Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids
Mol. Microbiol.
53
1757-1770
2004
Sinorhizobium meliloti
brenda
Lewenza, S.; Falsafi, R.; Bains, M.; Rohs, P.; Stupak, J.; Sprott, G.; Hancock, R.
The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility
FEMS Microbiol. Lett.
320
95-102
2011
Pseudomonas aeruginosa
brenda
Aygun-Sunar, S.; Bilaloglu, R.; Goldfine, H.; Daldal, F.
Rhodobacter capsulatus OlsA is a bifunctional enyzme active in both ornithine lipid and phosphatidic acid biosynthesis
J. Bacteriol.
189
8564-8574
2007
Rhodobacter capsulatus, Rhodobacter capsulatus MT1131
brenda
Weissenmayer, B.; Gao, J.; Lopez-Lara, I.; Geiger, O.
Identification of a gene required for the biosynthesis of ornithine-derived lipids
Mol. Microbiol.
45
721-733
2002
Sinorhizobium meliloti (Q9KIH9)
brenda
Barbosa, L.; Goulart, C.; Avellar, M.; Bisch, P.; von Kruger, W.
Accumulation of ornithine lipids in Vibrio cholerae under phosphate deprivation is dependent on VC0489 (OlsF) and PhoBR system
Microbiology
164
395-399
2018
no activity in Vibrio cholerae
brenda
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History
Enzyme Nomenclature
2.3.1.270 lyso-ornithine lipid O-acyltransferase
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