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(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-6-(pentanoyloxy)-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl benzoate
-
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl dipentanoate
-
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl 3-methylbutanoate
-
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate
-
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-3-(butanoyloxy)-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl hexanoate
-
(3S,4S,4aR,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-4,12,12b-trihydroxy-6a-methyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl (2E)-pent-2-enoate
-
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(1-methylethyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
-
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(2-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
-
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(4-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
-
(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
inhibition of both isoforms ACAT1 and ACAT2
(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT1
(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT1
(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT1
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
aurasperone A
isolation from the culture broth of Aspergillus species
aurasperone D
isolation from the culture broth of Aspergillus species
averufanin
isolation from the culture broth of Aspergillus species
beauveriolide I
selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay
beauveriolide III
selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay . Beauveriolide III binds to a putative active site responsible for SOAT1 that is located on the cytosolic side of the ER, while Beauveriolide III is not accessible to the corresponding active site for SOAT2 located on the luminal side
celludinone A1
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone A2
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone B
an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform
FD-549
benzophenone inhibitor
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-6-(pentanoyloxy)-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl benzoate
selective for isoform ACAT2
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl dipentanoate
selective for isoform ACAT2
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl 3-methylbutanoate
selective for isoform ACAT2
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate
i.e. pyripyropene A,selective for isoform ACAT2
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-3-(butanoyloxy)-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl hexanoate
selective for isoform ACAT2
(3S,4S,4aR,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-4,12,12b-trihydroxy-6a-methyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl (2E)-pent-2-enoate
selective for isoform ACAT2
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(1-methylethyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
selective for isoform ACAT2
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(2-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
selective for isoform ACAT2
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(4-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
selective for isoform ACAT2
(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
inhibition of both isoforms ACAT1 and ACAT2
(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT2
(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
-
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT2
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
selective inhibition of isoform ACAT2
aurasperone A
isolation from the culture broth of Aspergillus species
aurasperone D
isolation from the culture broth of Aspergillus species
averufanin
isolation from the culture broth of Aspergillus species
celludinone A1
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone A2
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone B
an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform
FD-549
benzophenone inhibitor
flavasperone
isolation from the culture broth of Aspergillus species, selective for isoform ACAT2
sterigmatocystin
isolation from the culture broth of Aspergillus species, selective for isoform ACAT2
beauvericin
-
IC50: 0.00035 mM, ACAT1
beauvericin
-
IC50: 0.00035 mM, ACAT2
beauveriolide I
-
IC50: 0.0019 mM, ACAT2
beauveriolide I
-
IC50: 0.0022 mM, ACAT1
beauveriolide III
-
IC50: 0.003 mM, ACAT1
beauveriolide III
-
IC50: 0.003 mM, ACAT2
CL-283,546
-
IC50: 0.00006 mM, ACAT2
CL-283,546
-
IC50: 0.00012 mM, ACAT1
glisoprenin A
-
IC50: 0.0004 mM, ACAT1
glisoprenin A
-
IC50: 0.0013 mM, ACAT2
K97-0239A
-
IC50: 0.038 mM, ACAT2
K97-0239A
-
IC50: 0.04 mM, ACAT1
K97-0239B
-
IC50: above 0.07 mM, ACAT1
K97-0239B
-
IC50: above 0.7 mM, ACAT2
phenochalasin A
-
IC50: above 0.1 mM, ACAT1
phenochalasin A
-
IC50: above 0.1 mM, ACAT2
purpactin A
-
IC50: 0.0009 mM, ACAT1
purpactin A
-
IC50: 0.0018 mM, ACAT2
purpactin B
-
IC50: 0.012 mM, ACAT2
purpactin B
-
IC50: 0.022 mM, ACAT1
purpactin C
-
IC50: 0.028 mM, ACAT1
purpactin C
-
IC50: 0.03 mM, ACAT2
pyripyropene A
-
-
pyripyropene A
-
IC50: 0.00006 mM, ACAT2
pyripyropene A
-
IC50: above 0.03 mM, ACAT1
pyripyropene B
-
IC50: 0.0008 mM, ACAT2
pyripyropene B
-
IC50: 0.03 mM, ACAT1
pyripyropene C
-
IC50: 0.00035 mM, ACAT2
pyripyropene C
-
IC50: 0.015 mM, ACAT1
pyripyropene D
-
IC50: 0.0012 mM, ACAT2
pyripyropene D
-
IC50: 0.015 mM, ACAT1
sespendole
-
IC50: 0.012 mM, ACAT2
sespendole
-
IC50: 0.02 mM, ACAT1
spylidone
-
IC50: 0.003 mM, ACAT2
spylidone
-
IC50: 0.007 mM, ACAT1
terpendole C
-
IC50: 0.0005 mM, ACAT2
terpendole C
-
IC50: 0.008 mM, ACAT1
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0.00009
(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.001
(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.02
(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.0001
(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.00015
(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.004
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.01
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT1, 37°C
0.00006
(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.04
(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.00025
(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.004
(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.0065
(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.0001
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
0.00027
(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
isoform ACAT2, 37°C
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0.000025
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-6-(pentanoyloxy)-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl benzoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.00001
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl dipentanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0035
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl 3-methylbutanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.08
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0028
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-3-(butanoyloxy)-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl hexanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0042
(3S,4S,4aR,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-4,12,12b-trihydroxy-6a-methyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl (2E)-pent-2-enoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0007
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(1-methylethyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0032
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(2-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.0038
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(4-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT1, cell-based assay
0.006
aurasperone A
Chlorocebus aethiops
isoform ACAT1, 37°C, cell-based assay
0.007
aurasperone D
Chlorocebus aethiops
isoform ACAT1, 37°C, cell-based assay
0.0218
averufanin
Chlorocebus aethiops
isoform ACAT1, 37°C, cell-based assay
0.0009 - 0.003
beauveriolide I
0.0006 - 0.0012
beauveriolide III
0.0088
celludinone A1
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.015
celludinone A2
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.0028
celludinone B
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.0099
FD-549
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.03
sterigmatocystin
Chlorocebus aethiops
isoform ACAT1, 37°C, cell-based assay
0.000062
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-6-(pentanoyloxy)-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl benzoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00007
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl dipentanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.000006
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl 3-methylbutanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00007
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.000012
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-3-(butanoyloxy)-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl hexanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00001
(3S,4S,4aR,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-4,12,12b-trihydroxy-6a-methyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl (2E)-pent-2-enoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00001
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(1-methylethyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00001
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(2-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.00001
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(4-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
Chlorocebus aethiops
isoform ACAT2, cell-based assay
0.0015
aurasperone A
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.0015
aurasperone D
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.012
averufanin
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.0019 - 0.0022
beauveriolide I
0.0048
celludinone A1
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.0061
celludinone A2
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.00015
celludinone B
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.00006 - 0.00012
CL-283,546
0.00091
FD-549
Chlorocebus aethiops
cell-based assay, 37°C, pH not specified in the publication
0.006
flavasperone
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.0004 - 0.0013
glisoprenin A
0.0009 - 0.0018
purpactin A
0.012 - 0.022
purpactin B
0.00006 - 0.03
pyripyropene A
0.0008 - 0.03
pyripyropene B
0.00035 - 0.015
pyripyropene C
0.0012 - 0.015
pyripyropene D
0.0024
sterigmatocystin
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.0005 - 0.008
terpendole C
0.0009
beauveriolide I
Chlorocebus aethiops
cell-based assay, pH 7.2, 37°C
0.003
beauveriolide I
Chlorocebus aethiops
enzyme-based assay, pH 7.2, 37°C
0.0006
beauveriolide III
Chlorocebus aethiops
cell-based assay, pH 7.2, 37°C
0.0012
beauveriolide III
Chlorocebus aethiops
enzyme-based assay, pH 7.2, 37°C
0.00035
beauvericin
Chlorocebus aethiops
-
IC50: 0.00035 mM, ACAT1
0.00035
beauvericin
Chlorocebus aethiops
-
IC50: 0.00035 mM, ACAT2
0.0019
beauveriolide I
Chlorocebus aethiops
-
IC50: 0.0019 mM, ACAT2
0.0022
beauveriolide I
Chlorocebus aethiops
-
IC50: 0.0022 mM, ACAT1
0.003
beauveriolide III
Chlorocebus aethiops
-
IC50: 0.003 mM, ACAT1
0.003
beauveriolide III
Chlorocebus aethiops
-
IC50: 0.003 mM, ACAT2
0.00006
CL-283,546
Chlorocebus aethiops
-
IC50: 0.00006 mM, ACAT2
0.00012
CL-283,546
Chlorocebus aethiops
-
IC50: 0.00012 mM, ACAT1
0.0004
glisoprenin A
Chlorocebus aethiops
-
IC50: 0.0004 mM, ACAT1
0.0013
glisoprenin A
Chlorocebus aethiops
-
IC50: 0.0013 mM, ACAT2
0.038
K97-0239A
Chlorocebus aethiops
-
IC50: 0.038 mM, ACAT2
0.04
K97-0239A
Chlorocebus aethiops
-
IC50: 0.04 mM, ACAT1
0.07
K97-0239B
Chlorocebus aethiops
-
IC50: above 0.07 mM, ACAT1
0.7
K97-0239B
Chlorocebus aethiops
-
IC50: above 0.7 mM, ACAT2
0.1
phenochalasin A
Chlorocebus aethiops
-
IC50: above 0.1 mM, ACAT1
0.1
phenochalasin A
Chlorocebus aethiops
-
IC50: above 0.1 mM, ACAT2
0.0009
purpactin A
Chlorocebus aethiops
-
IC50: 0.0009 mM, ACAT1
0.0018
purpactin A
Chlorocebus aethiops
-
IC50: 0.0018 mM, ACAT2
0.012
purpactin B
Chlorocebus aethiops
-
IC50: 0.012 mM, ACAT2
0.022
purpactin B
Chlorocebus aethiops
-
IC50: 0.022 mM, ACAT1
0.028
purpactin C
Chlorocebus aethiops
-
IC50: 0.028 mM, ACAT1
0.03
purpactin C
Chlorocebus aethiops
-
IC50: 0.03 mM, ACAT2
0.00006
pyripyropene A
Chlorocebus aethiops
-
IC50: 0.00006 mM, ACAT2
0.03
pyripyropene A
Chlorocebus aethiops
-
IC50: above 0.03 mM, ACAT1
0.0008
pyripyropene B
Chlorocebus aethiops
-
IC50: 0.0008 mM, ACAT2
0.03
pyripyropene B
Chlorocebus aethiops
-
IC50: 0.03 mM, ACAT1
0.00035
pyripyropene C
Chlorocebus aethiops
-
IC50: 0.00035 mM, ACAT2
0.015
pyripyropene C
Chlorocebus aethiops
-
IC50: 0.015 mM, ACAT1
0.0012
pyripyropene D
Chlorocebus aethiops
-
IC50: 0.0012 mM, ACAT2
0.015
pyripyropene D
Chlorocebus aethiops
-
IC50: 0.015 mM, ACAT1
0.012
sespendole
Chlorocebus aethiops
-
IC50: 0.012 mM, ACAT2
0.02
sespendole
Chlorocebus aethiops
-
IC50: 0.02 mM, ACAT1
0.003
spylidone
Chlorocebus aethiops
-
IC50: 0.003 mM, ACAT2
0.007
spylidone
Chlorocebus aethiops
-
IC50: 0.007 mM, ACAT1
0.0005
terpendole C
Chlorocebus aethiops
-
IC50: 0.0005 mM, ACAT2
0.008
terpendole C
Chlorocebus aethiops
-
IC50: 0.008 mM, ACAT1
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Temel, R.E.; Gebre, A.K.; Parks, J.S.; Rudel, L.L.
Compared with acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol
J. Biol. Chem.
278
47594-47601
2003
Chlorocebus aethiops
brenda
Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes
J. Antibiot.
60
43-51
2007
Chlorocebus aethiops, Cricetulus griseus, Mus musculus, Rattus norvegicus
brenda
Das, A.; Davis, M.A.; Tomoda, H.; Omura, S.; Rudel, L.L.
Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A
J. Biol. Chem.
283
10453-10460
2008
Chlorocebus aethiops
brenda
Das, A.; Davis, M.A.; Rudel, L.L.
Identification of putative active site residues of ACAT enzymes
J. Lipid Res.
49
1770-1781
2008
Chlorocebus aethiops, Chlorocebus sabaeus
brenda
Ohshiro, T.; Matsuda, D.; Nagai, K.; Doi, T.; Sunazuka, T.; Takahashi, T.; Rudel, L.L.; Omura, S.; Tomoda, H.
The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase
Chem. Pharm. Bull.
57
377-381
2009
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
brenda
Ohshiro, T.; Ohte, S.; Matsuda, D.; Ohtawa, M.; Nagamitsu, T.; Sunazuka, T.; Harigaya, Y.; Rudel, L.L.; Omura, S.; Tomoda, H.
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme
J. Antibiot.
61
503-508
2008
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
brenda
Sakai, K.; Ohte, S.; Ohshiro, T.; Matsuda, D.; Masuma, R.; Rudel, L.L.; Tomoda, H.
Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species
J. Antibiot.
61
568-572
2008
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
brenda
Ohshiro, T.; Seki, R.; Fukuda, T.; Uchida, R.; Tomoda, H.
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
J. Antibiot.
71
1000-1007
2018
Homo sapiens (O75908), Homo sapiens (P35610), Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
brenda
Ohshiro, T.; Kobayashi, K.; Ohba, M.; Matsuda, D.; Rudel, L.L.; Takahashi, T.; Doi, T.; Tomoda, H.
Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells
Sci. Rep.
7
4163
2017
Chlorocebus aethiops (O77760), Homo sapiens (P35610)
brenda