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Information on EC - N-terminal methionine Nalpha-acetyltransferase NatF

for references in articles please use BRENDA:EC2.3.1.259
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EC Tree
IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. NatF is found only in higher eukaryotes, and is absent from yeast. Unlike other Nat systems the enzyme is located in the Golgi apparatus. It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol. NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.
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Word Map
  • ribosome-associated
  • amphipathic
  • organellar
  • co-translational
  • multicellular
  • post-translationally
  • n-termini
  • apparatus
  • golgi-associated
  • analysis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
an N-terminal-L-methionyl-[transmembrane protein]
an N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein]
N-terminal acetyltransferase, Naa60, Naa60p, Nalpha-acetyltransferase 60, NatF, more
acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein] + CoA
show the reaction diagram
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