show all | hide all No of entries

Information on EC 2.3.1.254 - N-terminal methionine Nalpha-acetyltransferase NatB

for references in articles please use BRENDA:EC2.3.1.254
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
N-terminal acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(3 overall reactions are displayed. Show all (4)>>)
+
an N-terminal L-methionyl-L-asparaginyl-[protein]
=
an N-terminal Nalpha-acetyl-L-methionyl-L-asparaginyl-[protein]
+
+
an N-terminal L-methionyl-L-glutaminyl-[protein]
=
an N-terminal Nalpha-acetyl-L-methionyl-L-glutaminyl-[protein]
+
+
an N-terminal L-methionyl-L-aspartyl-[protein]
=
an N-terminal Nalpha-acetyl-L-methionyl-L-aspartyl-[protein]
+
Synonyms
CRA-1, N-acetyltransferase 3, NAA20, NAA25, Naa50p, NAT3, NAT5/SAN, NatB N-alpha-terminal acetylation complex, TCU2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal L-methionyl-L-asparaginyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA
show the reaction diagram
(1)
-
-
-
acetyl-CoA + an N-terminal L-methionyl-L-aspartyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-aspartyl-[protein] + CoA
show the reaction diagram
(3)
-
-
-
acetyl-CoA + an N-terminal L-methionyl-L-glutaminyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA
show the reaction diagram
(2)
-
-
-
acetyl-CoA + an N-terminal L-methionyl-L-glutamyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutamyl-[protein] + CoA
show the reaction diagram
(4)
-
-
-
Select items on the left to see more content.