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Information on EC - phloroglucinol synthase

for references in articles please use BRENDA:EC2.3.1.253
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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
       phloroglucinol synthase
IUBMB Comments
The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming 6-(polyoxoalkyl)-alpha-pyrones by sequential condensation with malonyl-CoA.
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The expected taxonomic range for this enzyme is: Pseudomonas fluorescens group
Reaction Schemes
phloroglucinol synthase, more
3 malonyl-CoA = phloroglucinol + 3 CO2 + 3 CoA
show the reaction diagram
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