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Information on EC 2.3.1.25 - plasmalogen synthase
for references in articles please use BRENDA:EC2.3.1.25
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EC Tree 2 Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.25 plasmalogen synthase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.3.1.25
- transglutaminase
- tgase-2
- cystamine
-
tg2-mediated
-
syndecan-4
Reaction Schemes
showSynonyms
1-alkenyl-gpc acyltransferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase
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-
-
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1-alkenyl-GPC acyltransferase
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-
-
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EC 2.3.1.104
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formerly
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lyso-PmeC ATase
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-
-
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lysophosphatidylcholine acyltransferase
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-
-
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lysoplasmenylcholine acyltransferase
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-
-
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MeHAD
MELS_0169
O-1-alkenylglycero-3-phosphorylcholine acyltransferase
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-
-
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synthase, plasmalogen
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
37257-10-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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Substrates: -
Products: -
Products: -
r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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Substrates: heart enzyme is highly specific for linoleoyl-CoA
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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Substrates: -
Products: -
Products: -
r
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
-
Substrates: -
Products: -
Products: -
r
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
20
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
Show AA Sequence and Transmembrane Helices (332 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli BL21 (DE3) pLysS. Escherichia coli expressing SrPlsAR from Selenomonas ruminantium produces plasmalogen, comprising almost 60% of the total phospholipid content under anaerobic conditions. Both plasmenylethanolamine and plasmenylglycerol are detected, and the major acyl aldehyde derived from sn-1 vinyl ether is C16:1
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heterologous expression of the MeHAD gene into a nonplasmalogen-producing Escherichia coli strain. The single gene encoded plasmalogen synthase in Megasphaera elsdenii and establishes a recombinant Escherichia coli strain with plasmalogen production potential
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Choy, P.C.; Skrzypczak, M.; Lee, D.; Jay, F.T.
Acyl-GPC and alkenyl/alkyl-GPC:acyl-CoA acyltransferases
Biochim. Biophys. Acta
1348
124-133
1997
Cavia porcellus
brenda
Waku, K.; Lands, W.E.M.
Acyl coenzyme A:1-alkenyl-glycero-3-phosphorylcholine acyltransferase action in plasmalogen biosynthesis
J. Biol. Chem.
243
2654-2659
1968
Homo sapiens, Oryctolagus cuniculus
brenda
Kameyama, Y.; Shinkai, A.
Characterization of 1-alkenyl-sn-glycero-3-phosphorylcholine acyltransferase activity in the microsomes from rat parotid gland
Shika Kiso Igakkai Zasshi
42
319-325
2000
Rattus norvegicus
-
brenda
Okada, A.
Composition of ether-linked glycerophospholipids and properties of microsomal lysoplasmenylcholine acyltransferase in rat submandibular and sublingual glands
Shika Kiso Igakkai Zasshi
33
428-445
1991
Rattus norvegicus
-
brenda
Zhang, F.; Yang, Z.; Zhou, Y.; Wang, B.; Xie, Z.; Yu, N.; Zhao, J.; Goldfine, H.; Dai, S.; Zhang, G.; Tian, B.
Characterization and heterologous expression of plasmalogen synthase MeHAD from Megasphaera elsdenii
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1868
159358
2023
Megasphaera elsdenii (G0VRE7), Megasphaera elsdenii ATCC 17752 (G0VRE7)
brenda
Yoshii, N.; Higuchi, K.; Onodera, T.; Abe, N.; Kaneko, J.
Anaerobic plasmalogen production in recombinant Escherichia coli carrying plasmalogen synthase gene from Selenomonas ruminantium
Biosci. Biotechnol. Biochem.
89
594-598
2024
Selenomonas ruminantium
brenda
EXTERNAL LINKS (specific for EC-Number 2.3.1.25)
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Release 2026.1 (March 2026)
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