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Information on EC 2.3.1.25 - plasmalogen synthase for references in articles please use BRENDA:EC2.3.1.25
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
1-alkenyl-gpc acyltransferase,
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1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase
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1-alkenyl-GPC acyltransferase
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lysophosphatidylcholine acyltransferase
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lysoplasmenylcholine acyltransferase
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O-1-alkenylglycero-3-phosphorylcholine acyltransferase
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synthase, plasmalogen
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acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine
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Acyl group transfer
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acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase
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arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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heart enzyme is highly specific for linoleoyl-CoA
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
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arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
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r
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1-acyl-glycero-3-phosphorylcholine
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non competitive
Ca2+
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mitochondrial enzyme
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Ca2+
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enhances activity of microsomal enzyme
Mg2+
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enhances activity of microsomal enzyme
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Celiac Disease
Cosilencing Intestinal Transglutaminase-2 and Interleukin-15 Using Gelatin-Based Nanoparticles in an in Vitro Model of Celiac Disease.
Celiac Disease
Serum auto-antibodies directed against transglutaminase-2 have a low avidity as compared to allo-antibodies against gliadin in celiac disease.
Celiac Disease
Usefulness of Small-bowel Mucosal Transglutaminase-2 Specific Autoantibody Deposits in the Diagnosis and Follow-up of Celiac Disease.
Colorectal Neoplasms
miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer.
Gingival Overgrowth
Gingival Crevicular Fluid and Plasma Levels of Transglutaminase-2 and Oxidative Stress Markers in Cylosporin A-Induced Gingival Overgrowth.
Glomerulonephritis, IGA
Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis.
Melanoma
Involvement of Transglutaminase-2 in ?-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells.
Neoplasm Metastasis
miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer.
Neoplasms
Expression of transglutaminase-2 isoforms in normal human tissues and cancer cell lines: dysregulation of alternative splicing in cancer.
Neoplasms
Novel suppressive effects of cardamonin on the activity and expression of transglutaminase-2 lead to blocking the migration and invasion of cancer cells.
Nephritis
Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis.
Neuroblastoma
Transglutaminase-2 Is Involved in All-Trans Retinoic Acid-Induced Invasion and Matrix Metalloproteinases Expression of SH-SY5Y Neuroblastoma Cells via NF-?B Pathway.
Osteoarthritis
Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis.
Osteophyte
Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis.
Osteosarcoma
Transglutaminase-2 is Involved in Cell Apoptosis of Osteosarcoma Cell Line U2OS Under Hypoxia Condition.
Osteosarcoma
Transglutaminase-2 Is Involved in Expression of Osteoprotegerin in MG-63 Osteosarcoma Cells.
Osteosarcoma
Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma.
Ovarian Neoplasms
Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer.
Purpura
Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis.
Stomach Neoplasms
Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer.
Stomach Neoplasms
Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway.
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0.0265 - 0.0297
1-alkenyl-glycero-3-phosphorylcholine
0.00077 - 0.00091
oleoyl-CoA
0.0265
1-alkenyl-glycero-3-phosphorylcholine
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submandibular gland
0.0267
1-alkenyl-glycero-3-phosphorylcholine
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sublingual gland
0.0297
1-alkenyl-glycero-3-phosphorylcholine
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0.00077
oleoyl-CoA
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submandibular gland
0.0008 - 0.0009
oleoyl-CoA
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0.00086
oleoyl-CoA
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sublingual gland
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additional information
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specific activity for various acyl-CoAs
additional information
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specific activity for various acyl-CoAs
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7.4
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assay at
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20
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assay at
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guinea pig
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brenda
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brenda
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male Wistar
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brenda
Sprague Dawley
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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additional information
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no activity in rabbit brain and heart
brenda
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brenda
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of muscle
brenda
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brenda
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brenda
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LPCT1_ARATH
398
1
44713
Swiss-Prot
LPCT2_ARATH
539
0
61022
Swiss-Prot
A0A2G9H4L8_9LAMI
383
2
43396
TrEMBL
A0A2G9GD04_9LAMI
394
1
44424
TrEMBL
A0A072VER2_MEDTR
383
2
42981
TrEMBL
A0A072TP83_MEDTR
530
2
60576
TrEMBL
A0A2P6PYL4_ROSCH
378
2
42209
TrEMBL
G7L639_MEDTR
382
2
42842
TrEMBL
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55
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90% loss of activity after 1 min
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partial
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Choy, P.C.; Skrzypczak, M.; Lee, D.; Jay, F.T.
Acyl-GPC and alkenyl/alkyl-GPC:acyl-CoA acyltransferases
Biochim. Biophys. Acta
1348
124-133
1997
Cavia porcellus
brenda
Waku, K.; Lands, W.E.M.
Acyl coenzyme A:1-alkenyl-glycero-3-phosphorylcholine acyltransferase action in plasmalogen biosynthesis
J. Biol. Chem.
243
2654-2659
1968
Homo sapiens, Oryctolagus cuniculus
brenda
Kameyama, Y.; Shinkai, A.
Characterization of 1-alkenyl-sn-glycero-3-phosphorylcholine acyltransferase activity in the microsomes from rat parotid gland
Shika Kiso Igakkai Zasshi
42
319-325
2000
Rattus norvegicus
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brenda
Okada, A.
Composition of ether-linked glycerophospholipids and properties of microsomal lysoplasmenylcholine acyltransferase in rat submandibular and sublingual glands
Shika Kiso Igakkai Zasshi
33
428-445
1991
Rattus norvegicus
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brenda
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2.3.1.25 plasmalogen synthase
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