Information on EC 2.3.1.25 - plasmalogen synthase

for references in articles please use BRENDA:EC2.3.1.25
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The enzyme appears in viruses and cellular organisms

top print hide
EC NUMBER
COMMENTARY hide
2.3.1.25
-
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RECOMMENDED NAME
GeneOntology No.
plasmalogen synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Ether lipid metabolism
-
-
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase
-
top
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CAS REGISTRY NUMBER
COMMENTARY hide
37257-10-6
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
guinea pig
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
show the reaction diagram
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
show the reaction diagram
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
arachidonoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-arachidonoyl-glycero-3-phosphorylcholine
show the reaction diagram
linoleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-linoleoyl-glycero-3-phosphorylcholine
show the reaction diagram
oleoyl-CoA + 1-alkenyl-glycero-3-phosphorylcholine
CoA + 1-alkenyl-2-oleoyl-glycero-3-phosphorylcholine
show the reaction diagram
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-acyl-glycero-3-phosphorylcholine
-
non competitive
Ca2+
-
mitochondrial enzyme
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
enhances activity of microsomal enzyme
Mg2+
-
enhances activity of microsomal enzyme
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0265 - 0.0297
1-alkenyl-glycero-3-phosphorylcholine
0.00077 - 0.00091
oleoyl-CoA
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
no activity in rabbit brain and heart
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
top print hide
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
60 min stable
55
-
90% loss of activity after 1 min
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.25)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)