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Information on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

for references in articles please use BRENDA:EC2.3.1.244

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IUBMB Comments

This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by α-methylation, β-ketoreduction, dehydration, and α,β-enoyl reduction.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
2
+
[2-methylbutanoate polyketide synthase]
+
2
+
3
+
=
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
+
2
+
2
+
2
+
+

Synonyms
lovastatin diketide synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 3 H+ + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + 2 CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
lovastatin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links