Reference on EC 2.3.1.24 - sphingosine N-acyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimeno, H.; Soeda, S.; Sakamoto, M.; Kouchi, T.; Kowakame, T.; Kihara, T.
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
Lipids
33
601-605
1998
Bos taurus
Xu, Z.; Zhou, J.; McCoy, D.M.; Mallampalli, R.K.
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
J. Lipid Res.
46
1229-1238
2005
Mus musculus (Q9D6K9), Mus musculus
Voss, K.A.; Norred, W.P.; Meredith, F.I.; Riley, R.T.; Stephen Saunders, D.
Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips
J. Toxicol. Environ. Health A
69
1387-1397
2006
Chlorocebus aethiops
Figueiredo, J.M.; Rodrigues, D.C.; Silva, R.C.; Koeller, C.M.; Jiang, J.C.; Jazwinski, S.M.; Previato, J.O.; Mendonca-Previato, L.; Urmenyi, T.P.; Heise, N.
Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi
Mol. Biochem. Parasitol.
182
62-74
2012
Trypanosoma cruzi (G0YYC4), Trypanosoma cruzi
Tirodkar, T.S.; Lu, P.; Bai, A.; Scheffel, M.J.; Gencer, S.; Garrett-Mayer, E.; Bielawska, A.; Ogretmen, B.; Voelkel-Johnson, C.
Expression of ceramide synthase 6 transcriptionally activates acid ceramidase in a c-Jun N-terminal kinase (JNK)-dependent manner
J. Biol. Chem.
290
13157-13167
2015
Mus musculus (Q8C172)
Basnakian, A.G.; Ueda, N.; Hong, X.; Galitovsky, V.E.; Yin, X.; Shah, S.V.
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
Am. J. Physiol.
288
F308-F314
2005
Rattus norvegicus
Erez-Roman, R.; Pienik, R.; Futerman, A.H.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression
Biochem. Biophys. Res. Commun.
391
219-223
2010
Homo sapiens (Q6ZMG9), Homo sapiens (Q9HA82), Homo sapiens
Hirschberg, K.; Rodger, J.; Futerman, A.H.
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
Biochem. J.
290
751-757
1993
Rattus norvegicus, Rattus norvegicus Wistar
Mizutani, Y.; Kihara, A.; Igarashi, Y.
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
Biochem. J.
390
263-271
2005
Mus musculus (Q8C172), Mus musculus (Q9D6K9), Mus musculus
Veret, J.; Coant, N.; Berdyshev, E.V.; Skobeleva, A.; Therville, N.; Bailbe, D.; Gorshkova, I.; Natarajan, V.; Portha, B.; Le Stunff, H.
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 beta-cells
Biochem. J.
438
177-189
2011
Rattus norvegicus (D3ZU86)
Luttgeharm, K.D.; Cahoon, E.B.; Markham, J.E.
Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis
Biochem. J.
473
593-603
2016
Arabidopsis thaliana (Q9LJK3)
Sribney, M.
Enzymatic synthesis of ceramide
Biochim. Biophys. Acta
125
542-547
1966
Cavia porcellus, Gallus gallus
Sridevi, P.; Alexander, H.; Laviad, E.L.; Pewzner-Jung, Y.; Hannink, M.; Futerman, A.H.; Alexander, S.
Ceramide synthase 1 is regulated by proteasomal mediated turnover
Biochim. Biophys. Acta
1793
1218-1227
2009
Mus musculus (Q9D6K9)
Shimeno, H.; Soeda, S.; Yasukouchi, M.; Okamura, N.; Nagamatsu, A.
Fatty acyl-CoA sphingosine acyltransferase in bovine brain mitochondria its solubilization and reconstitution onto the membrane lipid liposomes
Biol. Pharm. Bull.
18
1335-1339
1995
Bos taurus (A0A3Q1MJ30), Bos taurus
Wang, H.; Maurer, B.J.; Reynolds, C.P.; Cabot, M.C.
N-(4-Hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase
Cancer Res.
61
5102-5105
2001
Homo sapiens
Bose, R.; Verheji, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R.
Ceramide synthase mediates daunorubicin-induced apoptosis an alternative mechanism for generating death signals
Cell
82
405-414
1995
Homo sapiens, Mus musculus
Mesicek, J.; Lee, H.; Feldman, T.; Jiang, X.; Skobeleva, A.; Berdyshev, E.V.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R.
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
Cell. Signal.
22
1300-1307
2010
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Bauer, R.; Voelzmann, A.; Breiden, B.; Schepers, U.; Farwanah, H.; Hahn, I.; Eckardt, F.; Sandhoff, K.; Hoch, M.
Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila
EMBO J.
28
3706-3716
2009
Drosophila melanogaster
Choi, S.; Snider, J.M.; Olakkengil, N.; Lambert, J.M.; Anderson, A.K.; Ross-Evans, J.S.; Cowart, L.A.; Snider, A.J.
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells
FASEB J.
32
5724-5736
2018
Mus musculus (Q8C172), Mus musculus (Q9D6K9)
Wang, E.; Norred, W.P.; Bacon, C.W.; Riley, R.T.; Merrill, A.H.
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
J. Biol. Chem.
266
14486-14490
1991
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Mandon, E.C.; Ehses, I.; Rother, J.; van Echten, G.; Sandhoff, K.
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
J. Biol. Chem.
267
11144-11148
1992
Mus musculus
Merrill, A.H.; van Echten, G.; Wang, E.; Sandhoff, K.
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
J. Biol. Chem.
268
27299-27306
1993
Mus musculus, Mus musculus NMRI
Lahiri, S.; Park, H.; Laviad, E.L.; Lu, X.; Bittman, R.; Futerman, A.H.
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
J. Biol. Chem.
284
16090-16098
2009
Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
Mullen, T.D.; Jenkins, R.W.; Clarke, C.J.; Bielawski, J.; Hannun, Y.A.; Obeid, L.M.
Ceramide synthase-dependent ceramide generation and programmed cell death involvement of salvage pathway in regulating postmitochondrial events
J. Biol. Chem.
286
15929-15942
2011
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Laviad, E.L.; Kelly, S.; Merrill, A.H.; Futerman, A.H.
Modulation of ceramide synthase activity via dimerization
J. Biol. Chem.
287
21025-21033
2012
Homo sapiens (Q8N5B7)
Sassa, T.; Hirayama, T.; Kihara, A.
Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region
J. Biol. Chem.
291
7477-7487
2016
Homo sapiens (Q8IU89), Homo sapiens (Q8N5B7), Homo sapiens (Q96G23), Homo sapiens (Q9HA82), Homo sapiens (Q9NTG7), Mus musculus (Q924Z4), Mus musculus
Xu, Z.; Zhou, J.; McCoy, D.M.; Mallampalli, R.K.
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
J. Lipid Res.
46
1229-1238
2005
Mus musculus (Q9D6K9), Mus musculus, Mus musculus C57BL/6 (Q9D6K9)
Mizutani, Y.; Kihara, A.; Chiba, H.; Tojo, H.; Igarashi, Y.
2-Hydroxy-ceramide synthesis by ceramide synthase family enzymatic basis for the preference of FA chain length
J. Lipid Res.
49
2356-2364
2008
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Shimeno, H.; Soeda, S.; Sakamoto, M.; Kouchi, T.; Kowakame, T.; Kihara, T.
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
Lipids
33
601-605
1998
Bos taurus (A0A3Q1MVP2), Bos taurus
Merrill, A.H.; Wang, E.
Enzymes of ceramide biosynthesis
Methods Enzymol.
209
427-437
1992
Bos taurus, Rattus norvegicus
Lim, X.Y.; Pickford, R.; Don, A.S.
Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry
Methods Mol. Biol.
1376
11-22
2016
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
White-Gilbertson, S.; Mullen, T.; Senkal, C.; Lu, P.; Ogretmen, B.; Obeid, L.; Voelkel-Johnson, C.
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
Oncogene
28
1132-1141
2009
Homo sapiens (Q6ZMG9)
Sharma, S.; Ahmed, M.; Akhter, Y.
The revelation of selective sphingolipid pathway inhibition mechanism on fumonisin toxin binding to ceramide synthases in susceptible organisms and survival mechanism in resistant species
Biochimie
149
41-50
2018
Trichoderma guizhouense (A0A1T3CVR0), Trichoderma guizhouense, Saccharomyces cerevisiae (P38703), Saccharomyces cerevisiae
Munshi, M.; Gardin, J.; Singh, A.; Luberto, C.; Rieger, R.; Bouklas, T.; Fries, B.; Del Poeta, M.
The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Cell Rep.
22
1392-1400
2018
Cryptococcus neoformans var. grubii (J9VFF7), Cryptococcus neoformans var. grubii (J9VMM2), Cryptococcus neoformans var. grubii (J9VQN5)
Williams, B.; Correnti, J.; Oranu, A.; Lin, A.; Scott, V.; Annoh, M.; Beck, J.; Furth, E.; Mitchell, V.; Senkal, C.E.; Obeid, L.; Carr, R.M.
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis
FASEB J.
32
130-142
2018
Homo sapiens (Q6ZMG9), Homo sapiens, Mus musculus (Q8C172), Mus musculus
Kim, M.H.; Ahn, H.K.; Lee, E.J.; Kim, S.J.; Kim, Y.R.; Park, J.W.; Park, W.J.
Hepatic inflammatory cytokine production can be regulated by modulating sphingomyelinase and ceramide synthase 6
Int. J. Mol. Med.
39
453-462
2017
Mus musculus (Q8C172)
Tidhar, R.; Zelnik, I.; Volpert, G.; Ben-Dor, S.; Kelly, S.; Merrill, A.; Futerman, A.
Eleven residues determine the acyl chain specificity of ceramide synthases
J. Biol. Chem.
293
9912-9921
2018
Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
Megyeri, M.; Prasad, R.; Volpert, G.; Sliwa-Gonzalez, A.; Haribowo, A.; Aguilera-Romero, A.; Riezman, H.; Barral, Y.; Futerman, A.; Schuldiner, M.
Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
J. Cell Sci.
132
jcs228411
2019
Saccharomyces cerevisiae
html completed
