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IUBMB CommentsA multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
The expected taxonomic range for this enzyme is: Streptomyces carzinostaticus
Synonyms
neocarzinostatin naphthoate synthase, more
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naphthoic acid synthase
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ncsB
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NNS
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid forming)
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
Products: -
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: -
Products: -
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
Products: -
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: -
Products: -
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
Products: -
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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Substrates: the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
Products: -
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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metabolism
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the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
metabolism
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the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus
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NCSB_STRCZ
1753
0
187220
Swiss-Prot
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expression in Streptomyces lividans TK24 and Streptomyces coelicolor YU105
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Sthapit, B.; Oh, T.J.; Lamichhane, R.; Liou, K.; Lee, H.C.; Kim, C.G.; Sohng, J.K.
Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus
FEBS Lett.
566
201-206
2004
Streptomyces carzinostaticus, Streptomyces carzinostaticus ATCC 15944
brenda
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