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Information on EC 2.3.1.235 - tetracenomycin F2 synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.235 tetracenomycin F2 synthase
IUBMB Comments
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.
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Word Map
The expected taxonomic range for this enzyme is: Streptomyces glaucescens
Reaction Schemes
10
=
+
10
+
10
+
2
Synonyms
type ii polyketide synthase, tcm f2, tcm pks, tcmk protein, tcmn polyketide cyclase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
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