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Information on EC 2.3.1.234 - N6-L-threonylcarbamoyladenine synthase and Organism(s) Pyrococcus abyssi and UniProt Accession Q9UXT7

for references in articles please use BRENDA:EC2.3.1.234
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EC Tree
IUBMB Comments
The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg .
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Pyrococcus abyssi
UNIPROT: Q9UXT7
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The taxonomic range for the selected organisms is: Pyrococcus abyssi
The enzyme appears in selected viruses and cellular organisms
Synonyms
EC 2.6.99.4, Kae1, Qri7, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, t6A synthase, tRNA N6-adenosine threonylcarbamoyltransferase, TsaD, YdiE, ygjD, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Kae1
Kae1 is part of a conserved protein complex named kinase, endopeptidase and other proteins of small size (KEOPS)
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
L-threonylcarbamoyladenylate:adenine37 in tRNA N6-L-threonylcarbamoyltransferase
The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-threonylcarbamoyladenylate + adenine37 in tRNA
AMP + N6-L-threonylcarbamoyladenine37 in tRNA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-threonylcarbamoyladenylate + adenine37 in tRNA
AMP + N6-L-threonylcarbamoyladenine37 in tRNA
show the reaction diagram
the enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
Kae1 is part of a conserved protein complex named kinase, endopeptidase and other proteins of small size (KEOPS)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Perrochia, L.; Crozat, E.; Hecker, A.; Zhang, W.; Bareille, J.; Collinet, B.; van Tilbeurgh, H.; Forterre, P.; Basta, T.
In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya
Nucleic Acids Res.
41
1953-1964
2013
Pyrococcus abyssi (Q9UXT7), Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543 (Q9UXT7)
Manually annotated by BRENDA team