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Disease on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
1-acylglycerophosphocholine o-acyltransferase deficiency
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet.
ER phospholipid composition modulates lipogenesis during feeding and in obesity.
LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.
Lysophosphatidylcholine acyltransferase 3 deficiency impairs 3T3L1 cell adipogenesis through activating Wnt/?-catenin pathway.
Macrophage Lysophosphatidylcholine Acyltransferase 3 Deficiency-Mediated Inflammation Is Not Sufficient to Induce Atherosclerosis in a Mouse Model.
Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds.
Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism.
Abetalipoproteinemia
Molecular species of phosphatidylcholine in abetalipoproteinemia: effect of lecithin:cholesterol acyltransferase and lysolecithin acyltransferase.
Acute Lung Injury
Adenovector-mediated gene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats.
Adenocarcinoma
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.
Adenoma
Transmembrane orientation of palmitoyl-CoA: lysophosphatidylcholine acyltransferase in microsomes isolated from an alveolar type II cell adenoma and rat liver.
Asthma
Lyso-PAF acetyltransferase activity in neutrophils of patients during acute asthma and after recovery.
Atherosclerosis
A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity.
Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet.
LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.
Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
Macrophage Lysophosphatidylcholine Acyltransferase 3 Deficiency-Mediated Inflammation Is Not Sufficient to Induce Atherosclerosis in a Mouse Model.
Phospholipid Remodeling in Physiology and Disease.
Breast Neoplasms
Expression and clinicopathological significance of AOC4P, PRNCR1, and PCAT1 lncRNAs in breast cancer.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence.
Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.
Carcinogenesis
Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients.
LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2.
The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.
Carcinoma
A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity.
Differential lysophosphatidylcholine acyltransferase 1 (LPCAT1) expression confers aggressiveness and independently predicts recurrence in bladder urothelial carcinomas.
Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539.
Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma.
Carcinoma, Hepatocellular
Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.
LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
Regulation of LPCAT3 by LXR.
TGF-?-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.
Carcinoma, Non-Small-Cell Lung
GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
Carcinoma, Renal Cell
Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539.
Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma.
Cardiomyopathies
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Cardiomyopathy, Dilated
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction.
Cardiomyopathy, Hypertrophic
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Cholangiocarcinoma
Long noncoding RNA PCAT1 regulates extrahepatic cholangiocarcinoma progression via the Wnt/?-catenin-signaling pathway.
PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
Cholelithiasis
Lysophosphatidylcholine acyltransferase activity during experimental cholelithiasis.
Colorectal Neoplasms
Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
lncRNA-PCAT1 rs2632159 polymorphism could be a biomarker for colorectal cancer susceptibility.
LPCAT2 controls chemoresistance in colorectal cancer.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.
Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.
Coronary Artery Disease
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction.
Demyelinating Diseases
Structural specificity in demyelination induced by lysophospholipids.
Endometrial Neoplasms
LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2.
PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion.
Endometriosis
SNP rs710886 A>G in long noncoding RNA PCAT1 is associated with the risk of endometriosis by modulating expression of multiple stemness-related genes via microRNA-145 signaling pathway.
Esophageal Neoplasms
Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients.
Esophageal Squamous Cell Carcinoma
Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Fatty Liver
A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity.
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.
Glioma
Knockdown of long non-coding RNA PCAT1 in glioma stem cells promotes radiation sensitivity.
Glucose Intolerance
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.
Heart Diseases
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Hepatitis C
Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus: impact on production of lipo-viro-particles.
Hepatomegaly
Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase.
Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver.
Hyperglycemia
Liver-specific overexpression of LPCAT3 reduces postprandial hyperglycemia and improves lipoprotein metabolic profile in mice.
Hyperlipidemias
Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice.
Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism.
Hyperthyroidism
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Hypothyroidism
ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status.
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Infections
Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.
Infertility
On the Role of DGAT1 in Seed Glycerolipid Metabolic Network and Critical Stages of Plant Development in Arabidopsis.
Influenza, Human
Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.
Insulin Resistance
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.
Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle.
Laryngeal Neoplasms
Long non-coding RNA PCAT1 promotes cell migration and invasion in human laryngeal cancer by sponging miR-210-3p.
Leukemia, Myeloid, Acute
Identification of LPCAT1 expression as a potential prognostic biomarker guiding treatment choice in acute myeloid leukemia.
Liver Diseases
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
Phospholipid Remodeling in Physiology and Disease.
Lung Neoplasms
GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer.
Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
Lymphatic Metastasis
PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion.
Lymphoma, B-Cell
LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
Melanoma
Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study.
Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells.
Muscular Diseases
Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding.
Myocardial Infarction
Aerobic exercise alleviates oxidative stress-induced apoptosis in kidneys of myocardial infarction mice by inhibiting ALCAT1 and activating FNDC5/Irisin signaling pathway.
Myocardial Ischemia
Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.
Neoplasm Metastasis
LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma.
LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2.
Long non-coding RNA PCAT1 promotes cell migration and invasion in human laryngeal cancer by sponging miR-210-3p.
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway.
PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion.
The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma.
Neoplasms
A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer.
Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway and Phospholipid Remodeling.
Differential lysophosphatidylcholine acyltransferase 1 (LPCAT1) expression confers aggressiveness and independently predicts recurrence in bladder urothelial carcinomas.
Expression and clinicopathological significance of AOC4P, PRNCR1, and PCAT1 lncRNAs in breast cancer.
GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition.
High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers.
Increased prostatic lysophosphatidylcholine acyltransferase activity in human prostate cancer: a marker for malignancy.
Knockdown of lncRNA PCAT1 Enhances Radiosensitivity of Cervical Cancer by Regulating miR-128/GOLM1 Axis.
LncRNA PCAT1 and its genetic variant rs1902432 are associated with prostate cancer risk.
LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer.
lncRNAs in Non-Malignant Tissue Have Prognostic Value in Colorectal Cancer.
Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539.
Long non-coding RNA PCAT1 promotes cell migration and invasion in human laryngeal cancer by sponging miR-210-3p.
Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.
LPCAT1 overexpression promotes the progression of hepatocellular carcinoma.
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence.
MechRNA: prediction of lncRNA mechanisms from RNA-RNA and RNA-protein interactions.
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.
Palliation of bone cancer pain by antagonists of platelet-activating factor receptors.
PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion.
PCAT1 promotes the proliferative and migratory potentials of ovarian cancer via targeting NEK2.
PCAT1/miR-129/ABCB1 axis confers chemoresistance in non-small cell lung cancer.
PCAT1: An oncogenic lncRNA in diverse cancers and a putative therapeutic target.
Phospholipid Remodeling in Physiology and Disease.
The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma.
The association of rs710886 in lncRNA PCAT1 with bladder cancer risk in a Chinese population.
The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma.
Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.
Nephrotic Syndrome
Abnormal acyltransferase activities and accelerated cholesteryl ester transfer in patients with nephrotic syndrome.
Non-alcoholic Fatty Liver Disease
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
Phospholipid Remodeling in Physiology and Disease.
Obesity
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle.
Two-week administration of engineered Escherichia coli establishes persistent resistance to diet-induced obesity even without antibiotic pre-treatment.
Osteosarcoma
The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma.
Ovarian Neoplasms
PCAT1 promotes the proliferative and migratory potentials of ovarian cancer via targeting NEK2.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Peritonitis
Alterations of the composition and metabolism of pulmonary surfactant phospholipids induced by experimental peritonitis in rats.
phosphatidylcholine-sterol o-acyltransferase deficiency
Low density lipoprotein-activated lysolecithin acylation by human plasma lecithin-cholesterol acyltransferase. Identity of lysolecithin acyltransferase and lecithin-cholesterol acyltransferase.
Prostatic Hyperplasia
Evaluation of the plasma level of long non-coding RNA PCAT1 in prostatic hyperplasia and newly diagnosed prostate cancer patients.
Prostatic Neoplasms
A Prostate Cancer Risk SNP Upregulates the Tumorigenic lncRNA PCAT1.
A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer.
Correction: A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes.
Evaluation of the plasma level of long non-coding RNA PCAT1 in prostatic hyperplasia and newly diagnosed prostate cancer patients.
High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers.
Increased prostatic lysophosphatidylcholine acyltransferase activity in human prostate cancer: a marker for malignancy.
LncRNA PCAT1 activates AKT and NF-?B signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKK? complex.
LncRNA PCAT1 and its genetic variant rs1902432 are associated with prostate cancer risk.
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.
The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer.
The Role of Long Non-coding RNA Prostate Cancer-Associated Transcript 1 in Prostate Cancer.
Pulmonary Fibrosis
Lysocardiolipin acyltransferase regulates TGF-? mediated lung fibroblast differentiation.
The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
Rectal Neoplasms
lncRNA-PCAT1 rs2632159 polymorphism could be a biomarker for colorectal cancer susceptibility.
Renal Insufficiency, Chronic
Paricalcitol effects on activities and metabolism of Platelet Activating Factor and on inflammatory cytokines in hemodialysis patients.
Retinal Degeneration
AAV-Mediated Lysophosphatidylcholine Acyltransferase 1 (Lpcat1) Gene Replacement Therapy Rescues Retinal Degeneration in rd11 Mice.
Retinal Diseases
Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation.
Rhinitis, Allergic
LPCAT2 Methylation, a Novel Biomarker for the Severity of Cedar Pollen Allergic Rhinitis in Japan.
Sepsis
Alteration of Lysophosphatidylcholine-Related Metabolic Parameters in the Plasma of Mice with Experimental Sepsis.
Lysophospholipid acyltransferases in monocyte inflammatory responses and sepsis.
Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery.
Starvation
Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.
Stomach Neoplasms
Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population.
Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer.
Urinary Bladder Neoplasms
The association of rs710886 in lncRNA PCAT1 with bladder cancer risk in a Chinese population.
Uterine Cervical Neoplasms
Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer.
Knockdown of lncRNA PCAT1 Enhances Radiosensitivity of Cervical Cancer by Regulating miR-128/GOLM1 Axis.
Virus Diseases
Phospholipid Remodeling in Physiology and Disease.